| Identification |
|---|
| HMDB Protein ID
| CDBP03933 |
| Secondary Accession Numbers
| Not Available |
| Name
| Eyes absent homolog 4 |
| Description
| Not Available |
| Synonyms
|
Not Available
|
| Gene Name
| EYA4 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in catalytic activity |
| Specific Function
| Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye (By similarity).
|
| GO Classification
|
| Biological Process |
| sensory perception of sound |
| DNA repair |
| anatomical structure morphogenesis |
| chromatin modification |
| middle ear morphogenesis |
| visual perception |
| regulation of transcription, DNA-dependent |
| transcription, DNA-dependent |
| peptidyl-tyrosine dephosphorylation |
| Cellular Component |
| cytoplasm |
| nucleus |
| Function |
| catalytic activity |
| Molecular Function |
| metal ion binding |
| protein tyrosine phosphatase activity |
| Process |
| metabolic process |
| multicellular organismal process |
| multicellular organismal development |
|
| Cellular Location
|
- Nucleus
- Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 6 |
| Locus
| 6q23 |
| SNPs
| EYA4 |
| Gene Sequence
|
>1920 bp
ATGGAAGACTCCCAGGATTTAAATGAACAATCAGTAAAGAAAACGTGCACAGAATCAGAT
GTTTCACAATCTCAGAATTCCAGGTCTATGGAAATGCAGGACCTAGCAAGTCCTCATACT
CTTGTTGGAGGTGGTGATACTCCAGGTAGCTCCAAACTGGAAAAATCTAATCTCAGCAGC
ACATCAGTTACTACAAATGGGACAGGAGGGGAAAACATGACTGTTTTAAACACAGCAGAC
TGGTTGCTGAGTTGCAACACCCCCTCTTCTGCAACAATGTCTCTTCTTGCAGTCAAAACA
GAGCCCTTGAACAGCAGTGAAACCACAGCCACGACTGGAGATGGAGCGCTTGACACTTTT
ACTGGGTCAGTAATTACAAGTAGTGGCTACAGCCCCAGATCAGCACATCAGTATTCCCCA
CAGCTGTATCCTTCCAAGCCCTATCCACACATTCTTTCTACACCAGCAGCTCAAACAATG
TCTGCCTATGCAGGCCAGACTCAGTATTCGGGGATGCAGCAGCCAGCCGTCTACACAGCC
TACTCACAGACAGGACAGCCCTACAGCTTGCCCACTTACGATTTGGGTGTGATGTTGCCA
GCCATCAAGACAGAGAGTGGACTTTCCCAAACTCAGTCCCCATTACAGAGTGGCTGCCTC
AGTTACAGCCCAGGGTTCTCTACCCCACAGCCAGGCCAGACACCTTATTCTTACCAAATG
CCAGGTTCTAGTTTTGCACCATCATCTACTATTTATGCAAATAATTCAGTTTCCAATTCA
ACGAATTTCAGTGGTTCACAACAGGATTATCCATCCTATACAGCCTTTGGCCAAAACCAG
TATGCACAGTATTATTCAGCATCAACGTATGGAGCGTATATGACATCGAATAACACAGCC
GATGGCACACCCTCTTCAACCTCTACTTATCAGTTGCAGGAATCTCTCCCAGGACTGACT
AACCAACCAGGAGAGTTCGATACCATGCAGAGTCCCTCCACACCCATCAAAGATCTTGAT
GAGAGAACCTGTAGGAGTTCTGGGTCAAAGTCCAGAGGAAGAGGCCGGAAAAATAATCCC
TCCCCGCCTCCTGATAGTGACCTGGAGCGTGTGTTTGTCTGGGATTTGGATGAAACCATC
ATTGTTTTTCACTCACTGCTCACCGGGTCTTATGCACAGAAGTATGGCAAGGATCCCCCC
ATGGCTGTAACCCTTGGACTCCGCATGGAAGAAATGATTTTTAATCTTGCTGATACTCAT
TTGTTTTTTAATGATTTAGAGGAGTGTGATCAAGTTCATATAGATGATGTTTCCTCTGAT
GATAATGGGCAGGACTTAAGTACCTACAGTTTTGCAACTGATGGCTTCCATGCAGCTGCA
AGTAGTGCAAACCTTTGTTTGCCAACAGGTGTAAGAGGAGGGGTTGACTGGATGAGGAAG
TTGGCTTTTCGTTACAGAAGAGTAAAAGAATTATATAACACCTACAAGAACAACGTTGGA
GGACTCCTTGGCCCTGCCAAGAGGGATGCCTGGCTACAGTTAAGGGCAGAGATTGAAGGT
CTGACAGATTCCTGGCTAACAAATGCACTTAAGTCTTTATCAATTATTAGCACTAGGAGT
AACTGCATAAATGTCTTGGTAACGACAACTCAACTGATCCCAGCACTTGCGAAGGTTCTA
CTCTATAGTTTAGGAGGTGCTTTCCCCATTGAGAATATTTACAGTGCAACTAAAATAGGA
AAAGAAAGTTGCTTTGAACGAATAATGCAAAGGTTTGGCAGAAAAGTAGTGTATGTTGTA
ATTGGGGATGGTGTAGAAGAAGAACAGGCAGCAAAAAAGCACAACATGCCCTTCTGGAGG
ATATCCAGTCACTCAGACCTCCTGGCTCTCCACCAAGCACTGGAATTAGAGTATTTGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 639 |
| Molecular Weight
| 69504.46 |
| Theoretical pI
| 5.2 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Eyes absent homolog 4
MEDSQDLNEQSVKKTCTESDVSQSQNSRSMEMQDLASPHTLVGGGDTPGSSKLEKSNLSS
TSVTTNGTGGENMTVLNTADWLLSCNTPSSATMSLLAVKTEPLNSSETTATTGDGALDTF
TGSVITSSGYSPRSAHQYSPQLYPSKPYPHILSTPAAQTMSAYAGQTQYSGMQQPAVYTA
YSQTGQPYSLPTYDLGVMLPAIKTESGLSQTQSPLQSGCLSYSPGFSTPQPGQTPYSYQM
PGSSFAPSSTIYANNSVSNSTNFSGSQQDYPSYTAFGQNQYAQYYSASTYGAYMTSNNTA
DGTPSSTSTYQLQESLPGLTNQPGEFDTMQSPSTPIKDLDERTCRSSGSKSRGRGRKNNP
SPPPDSDLERVFVWDLDETIIVFHSLLTGSYAQKYGKDPPMAVTLGLRMEEMIFNLADTH
LFFNDLEECDQVHIDDVSSDDNGQDLSTYSFATDGFHAAASSANLCLPTGVRGGVDWMRK
LAFRYRRVKELYNTYKNNVGGLLGPAKRDAWLQLRAEIEGLTDSWLTNALKSLSIISTRS
NCINVLVTTTQLIPALAKVLLYSLGGAFPIENIYSATKIGKESCFERIMQRFGRKVVYVV
IGDGVEEEQAAKKHNMPFWRISSHSDLLALHQALELEYL
|
| External Links |
|---|
| GenBank ID Protein
| 98991760 |
| UniProtKB/Swiss-Prot ID
| O95677 |
| UniProtKB/Swiss-Prot Entry Name
| EYA4_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_004100.4 |
| GeneCard ID
| EYA4 |
| GenAtlas ID
| EYA4 |
| HGNC ID
| HGNC:3522 |
| References |
|---|
| General References
| Not Available |