Showing Protein Crossover junction endonuclease EME1 (CDBP03924)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 compounds
Identification
HMDB Protein ID CDBP03924
Secondary Accession Numbers Not Available
Name Crossover junction endonuclease EME1
Description Not Available
Synonyms
  1. MMS4 homolog
  2. hMMS4
Gene Name EME1
Protein Type Enzyme
Biological Properties
General Function Involved in DNA binding
Specific Function Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'- flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks
GO Classification
Function
nucleic acid binding
dna binding
nuclease activity
hydrolase activity, acting on ester bonds
binding
catalytic activity
hydrolase activity
protein binding
Process
metabolic process
macromolecule metabolic process
cellular macromolecule metabolic process
dna metabolic process
Cellular Location
  1. Nucleus
  2. nucleolus
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 17q21.33
SNPs EME1
Gene Sequence 
>1713 bp
ATGGCTCTAAAGAAGTCATCACCCTCACTGGATTCTGGTGATAGTGACTCTGAGGAGTTG
CCAACATTTGCCTTTCTGAAGAAGGAACCATCTTCAACAAAGAGGAGACAGCCTGAAAGG
GAAGAGAAGATTGTAGTGGTTGACATCTCAGATTGTGAAGCCTCCTGTCCTCCAGCACCA
GAGTTATTTTCACCACCTGTCCCAGACATAGCTGAAACTGTCACACAAACACAGCCAGTC
AGGTTGCTAAGCAGTGAAAGTGAAGATGAAGAAGAATTTATTCCTCTGGCTCAAAGGCTT
ACATGTAAGTTTCTGACCCACAAGCAACTGAGCCCTGAGGACTCTAGCTCCCCAGTTAAA
AGTGTTTTGGATCATCAAAATAATGAAGGTGCATCATGTGACTGGAAAAAGCCCTTTCCA
AAGATCCCTGAAGTTCCCCTCCATGATACCCCAGAGAGGAGTGCAGCAGATAACAAGGAC
CTGATCTTAGATCCATGCTGTCAGCTTCCAGCCTACCTGTCTACCTGCCCTGGCCAGAGC
AGCAGCTTGGCAGTAACCAAAACAAATTCTGACATCCTTCCACCCCAGAAGAAAACCAAG
CCGAGTCAGAAGGTCCAGGGAAGAGGCTCACACGGATGCCAGCAGCAGAGACAAGCAAGG
CAGAAGGAAAGCACCCTGAGAAGACAGGAAAGAAAGAATGCAGCACTGGTTACCAGGATG
AAAGCCCAGAGGCCAGAGGAATGCTTAAAACACATCATTGTAGTGCTGGATCCAGTGCTC
TTACAGATGGAAGGTGGGGGCCAGCTCCTAGGAGCACTGCAGACCATGGAGTGCCGCTGT
GTGATTGAGGCGCAGGCTGTGCCTTGCAGTGTCACTTGGAGGAGAAGGGCTGGGCCGTCT
GAGGACAGAGAGGACTGGGTGGAGGAGCCAACAGTACTGGTGTTGCTCCGGGCAGAGGCA
TTTGTGTCCATGATCGACAATGGAAAGCAGGGAAGCCTGGACAGCACTATGAAAGGGAAG
GAAACGCTTCAGGGCTTTGTAACTGACATCACAGCAAAGACAGCAGGGAAAGCTCTGTCA
CTGGTGATTGTGGATCAGGAGAAATGCTTCAGTGCTCAGAATCCTCCAAGAAGAGGGAAA
CAGGGAGCAAATAAACAGACCAAGAAGCAGCAGCAGAGACAACCAGAGGCCAGCATAGGG
TCCATGGTATCCAGGGTAGACGCTGAAGAGGCATTGGTGGATCTGCAGCTACACACAGAA
GCCCAGGCTCAAATTGTGCAGAGCTGGAAAGAGCTGGCCGACTTCACATGCGCATTCACA
AAGGCTGTGGCTGAGGCGCCCTTCAAGAAGCTCCGAGATGAAACTACCTTCTCCTTCTGT
CTGGAGAGTGACTGGGCTGGAGGGGTGAAGGTGGACCTTGCTGGCAGGGGACTCGCACTA
GTCTGGAGGAGACAGATTCAGCAGCTGAACCGAGTCAGCCTGGAAATGGCCAGTGCAGTT
GTGAATGCCTATCCCTCCCCACAGCTCCTGGTACAGGCTTATCAGCAGTGTTTTTCGGAT
AAAGAACGCCAGAATTTGCTCGCAGACATACAGGTGCGCCGTGGGGAAGGTGTGACATCC
ACTTCTCGCCGCATTGGACCAGAACTATCCAGGCGTATCTACCTTCAGATGACCACTTTA
CAGCCACATCTCTCTTTAGATAGTGCTGACTGA
Protein Properties
Number of Residues 570
Molecular Weight 63251.3
Theoretical pI 7.06
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence 
>Crossover junction endonuclease EME1
MALKKSSPSLDSGDSDSEELPTFAFLKKEPSSTKRRQPEREEKIVVVDISDCEASCPPAP
ELFSPPVPEIAETVTQTQPVRLLSSESEDEEEFIPLAQRLTCKFLTHKQLSPEDSSSPVK
SVLDHQNNEGASCDWKKPFPKIPEVPLHDTPERSAADNKDLILDPCCQLPAYLSTCPGQS
SSLAVTKTNSDILPPQKKTKPSQKVQGRGSHGCRQQRQARQKESTLRRQERKNAALVTRM
KAQRPEECLKHIIVVLDPVLLQMEGGGQLLGALQTMECRCVIEAQAVPCSVTWRRRAGPS
EDREDWVEEPTVLVLLRAEAFVSMIDNGKQGSLDSTMKGKETLQGFVTDITAKTAGKALS
LVIVDQEKCFSAQNPPRRGKQGANKQTKKQQQRQPEASIGSMVSRVDAEEALVDLQLHTE
AQAQIVQSWKELADFTCAFTKAVAEAPFKKLRDETTFSFCLESDWAGGVKVDLAGRGLAL
VWRRQIQQLNRVSLEMASAVVNAYPSPQLLVQAYQQCFSDKERQNLLADIQVRRGEGVTS
TSRRIGPELSRRIYLQMTTLQPHLSLDSAD
GenBank ID Protein 16550776
UniProtKB/Swiss-Prot ID Q96AY2
UniProtKB/Swiss-Prot Entry Name EME1_HUMAN
PDB IDs Not Available
GenBank Gene ID AK055926
GeneCard ID EME1
GenAtlas ID EME1
HGNC ID HGNC:24965
References
General References Not Available