Showing Protein Diphosphoinositol polyphosphate phosphohydrolase 3-alpha (CDBP03985)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 4 compounds
Identification
HMDB Protein ID CDBP03985
Secondary Accession Numbers Not Available
Name Diphosphoinositol polyphosphate phosphohydrolase 3-alpha
Description Not Available
Synonyms
  1. DIPP-3-alpha
  2. DIPP3-alpha
  3. Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 3-alpha
  4. Nucleoside diphosphate-linked moiety X motif 10
  5. Nudix motif 10
  6. hAps2
  7. hDIPP3alpha
  8. Diadenosine hexaphosphate hydrolase (AMP-forming)
Gene Name NUDT10
Protein Type Enzyme
Biological Properties
General Function Involved in hydrolase activity
Specific Function Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate.
GO Classification
Cellular Component
cytoplasm
Function
catalytic activity
hydrolase activity
Molecular Function
diphosphoinositol-polyphosphate diphosphatase activity
inositol diphosphate tetrakisphosphate diphosphatase activity
inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity
inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity
inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity
inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity
inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity
inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity
metal ion binding
Cellular Location
  1. Cytoplasm (Probable)
Pathways
Gene Properties
Chromosome Location X
Locus Xp11.23
SNPs NUDT10
Gene Sequence 
>495 bp
ATGAAGTGCAAACCCAACCAGACACGGACCTACGACCCCGAGGGGTTCAAGAAGCGGGCG
GCGTGCCTGTGCTTCCGGAGCGAGCGCGAGGACGAGGTCCTGTTAGTGAGTAGCAGCCGG
TACCCGGACCGCTGGATCGTGCCGGGCGGGGGCATGGAGCCCGAGGAGGAGCCGGGCGGT
GCGGCGGTCCGAGAGGTGTACGAAGAGGCGGGAGTCAAGGGGAAGTTAGGCCGGCTCCTG
GGCGTCTTCGAACAGAACCAGGACCCCAAGCACAGAACGTACGTGTATGTACTGACTGTC
ACGGAGCTGCTGGAGGATTGGGAAGATTCGGTTAGCATTGGGAGGAAGCGAGAGTGGTTC
AAAGTCGAAGATGCCATCAAGGTTCTCCAGTGCCACAAGCCCGTGCACGCCGAATATCTG
GAGAAACTAAAGCTGGGCGGTTCCCCAACCAATGGAAACTCCATGGCCCCATCCTCGCCA
GATAGCGATCCCTAG
Protein Properties
Number of Residues 164
Molecular Weight 18499.765
Theoretical pI 5.678
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence 
>Diphosphoinositol polyphosphate phosphohydrolase 3-alpha
MKCKPNQTRTYDPEGFKKRAACLCFRSEREDEVLLVSSSRYPDRWIVPGGGMEPEEEPGG
AAVREVYEEAGVKGKLGRLLGVFEQNQDPKHRTYVYVLTVTELLEDWEDSVSIGRKREWF
KVEDAIKVLQCHKPVHAEYLEKLKLGGSPTNGNSMAPSSPDSDP
GenBank ID Protein 21591549
UniProtKB/Swiss-Prot ID Q8NFP7
UniProtKB/Swiss-Prot Entry Name NUD10_HUMAN
PDB IDs
GenBank Gene ID AF469196
GeneCard ID NUDT10
GenAtlas ID NUDT10
HGNC ID HGNC:17621
References
General References Not Available