Identification
HMDB Protein ID CDBP03942
Secondary Accession Numbers Not Available
Name Inositol monophosphatase 3
Description Not Available
Synonyms
  1. IMP 3
  2. IMPase 3
  3. Inositol monophosphatase domain-containing protein 1
  4. Inositol-1(or 4)-monophosphatase 3
  5. Myo-inositol monophosphatase A3
  6. Golgi 3-prime phosphoadenosine 5-prime phosphate 3-prime phosphatase
  7. Golgi-resident PAP phosphatase
  8. gPAPP
Gene Name IMPAD1
Protein Type Enzyme
Biological Properties
General Function Involved in inositol or phosphatidylinositol phosphatase activity
Specific Function May play a role in the formation of skeletal elements derived through endochondral ossification, possibly by clearing adenosine 3',5'-bisphosphate produced by Golgi sulfotransferases during glycosaminoglycan sulfation (By similarity).
GO Classification
Biological Process
inositol biosynthetic process
phosphatidylinositol phosphorylation
chondrocyte development
embryonic digit morphogenesis
post-embryonic development
chondroitin sulfate metabolic process
endochondral ossification
Cellular Component
Golgi apparatus
integral to membrane
Function
inositol or phosphatidylinositol phosphatase activity
hydrolase activity, acting on ester bonds
catalytic activity
hydrolase activity
phosphoric ester hydrolase activity
phosphatase activity
Molecular Function
metal ion binding
inositol monophosphate 1-phosphatase activity
inositol monophosphate 3-phosphatase activity
inositol monophosphate 4-phosphatase activity
3'-nucleotidase activity
3'(2'),5'-bisphosphate nucleotidase activity
Cellular Location
  1. Membrane
  2. Single-pass membrane protein (Potential)
Pathways
Gene Properties
Chromosome Location 8
Locus 8q12.1
SNPs IMPAD1
Gene Sequence
>1080 bp
ATGGCCCCCATGGGCATCCGCCTTTCCCCACTGGGGGTGGCAGTGTTTTGTCTGCTGGGG
CTCGGCGTGCTCTACCACCTCTACTCGGGCTTCTTGGCCGGCCGCTTCAGCCTCTTCGGC
CTGGGCGGCGAGCCTGGCGGCGGCGCGGCGGGGCCCGCGGCCGCGGCCGATGGGGGCACC
GTGGACTTGCGCGAGATGCTGGCTGTGTCAGTGCTGGCCGCAGTCCGCGGCGGCGACGAG
GTGAGGCGCGTCCGCGAGAGCAACGTCCTCCACGAGAAGTCCAAGGGGAAGACGCGCGAG
GGAGCCGAGGACAAGATGACCAGCGGCGACGTGCTGTCCAACCGCAAGATGTTCTACCTG
CTCAAGACCGCCTTCCCCAGCGTCCAGATTAATACTGAGGAACACGTGGATGCAGCTGAT
CAGGAGGTTATCTTGTGGGATCATAAGATTCCTGAGGATATCCTAAAGGAAGTAACTACT
CCTAAAGAGGTACCAGCAGAAAGTGTTACTGTCTGGATTGACCCACTTGATGCTACACAG
GAATATACAGAGGATCTTCGAAAGTACGTCACTACTATGGTGTGTGTGGCTGTAAATGGT
AAACCCATGCTAGGAGTTATACATAAGCCATTTTCCGAATATACAGCTTGGGCAATGGTA
GATGGTGGTTCAAATGTGAAAGCCCGCTCTTCCTACAATGAGAAGACCCCAAGGATCGTT
GTGTCTCGTTCCCATTCAGGGATGGTCAAACAGGTCGCTCTTCAGACTTTTGGAAACCAG
ACTACAATTATCCCAGCTGGTGGTGCTGGTTATAAAGTTTTAGCACTTTTGGATGTGCCT
GATAAGAGTCAAGAAAAAGCTGATTTATACATCCATGTGACATACATCAAAAAGTGGGAT
ATATGTGCTGGTAATGCCATCTTAAAAGCCCTAGGGGGGCATATGACTACCCTGAGTGGT
GAAGAAATCAGTTACACTGGTTCAGACGGCATTGAAGGGGGACTCCTTGCTAGCATCAGA
ATGAACCACCAGGCCCTGGTCAGAAAACTCCCAGATCTAGAAAAGACAGGACATAAATGA
Protein Properties
Number of Residues 359
Molecular Weight 38681.15
Theoretical pI 6.864
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Inositol monophosphatase 3
MAPMGIRLSPLGVAVFCLLGLGVLYHLYSGFLAGRFSLFGLGGEPGGGAAGPAAAADGGT
VDLREMLAVSVLAAVRGGDEVRRVRESNVLHEKSKGKTREGAEDKMTSGDVLSNRKMFYL
LKTAFPSVQINTEEHVDAADQEVILWDHKIPEDILKEVTTPKEVPAESVTVWIDPLDATQ
EYTEDLRKYVTTMVCVAVNGKPMLGVIHKPFSEYTAWAMVDGGSNVKARSSYNEKTPRIV
VSRSHSGMVKQVALQTFGNQTTIIPAGGAGYKVLALLDVPDKSQEKADLYIHVTYIKKWD
ICAGNAILKALGGHMTTLSGEEISYTGSDGIEGGLLASIRMNHQALVRKLPDLEKTGHK
GenBank ID Protein 7020510
UniProtKB/Swiss-Prot ID Q9NX62
UniProtKB/Swiss-Prot Entry Name IMPA3_HUMAN
PDB IDs Not Available
GenBank Gene ID AK000428
GeneCard ID IMPAD1
GenAtlas ID IMPAD1
HGNC ID HGNC:26019
References
General References Not Available