Identification |
HMDB Protein ID
| CDBP02010 |
Secondary Accession Numbers
| Not Available |
Name
| Ribonuclease H2 subunit A |
Description
| Not Available |
Synonyms
|
- AGS4
- Aicardi-Goutieres syndrome 4 protein
- RNase H(35)
- RNase H2 subunit A
- RNase HI large subunit
- Ribonuclease HI large subunit
- Ribonuclease HI subunit A
|
Gene Name
| RNASEH2A |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in nucleic acid binding |
Specific Function
| Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging- strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes |
GO Classification
|
Function |
hydrolase activity, acting on ester bonds |
binding |
catalytic activity |
endoribonuclease activity, producing 5'-phosphomonoesters |
hydrolase activity |
ribonuclease h activity |
nucleic acid binding |
nuclease activity |
endonuclease activity |
endoribonuclease activity |
rna binding |
Process |
cellular macromolecule metabolic process |
rna metabolic process |
metabolic process |
macromolecule metabolic process |
|
Cellular Location
|
- Nucleus (Probable)
|
Pathways
|
Not Available
|
Gene Properties |
Chromosome Location
| Chromosome:1 |
Locus
| 19p13.2 |
SNPs
| RNASEH2A |
Gene Sequence
|
>900 bp
ATGGATCTCAGCGAGCTGGAGAGAGACAATACAGGCCGCTGTCGCCTGAGTTCGCCTGTG
CCCGCGGTGTGCCGCAAGGAGCCTTGCGTCCTGGGCGTCGATGAGGCGGGCAGGGGCCCC
GTGCTGGGCCCCATGGTCTACGCCATCTGTTATTGTCCCCTGCCTCGCCTGGCAGATCTG
GAGGCGCTGAAAGTGGCAGACTCAAAGACCCTATTGGAGAGCGAGCGGGAAAGGCTGTTT
GCGAAAATGGAGGACACGGACTTTGTCGGCTGGGCGCTGGATGTGCTGTCTCCAAACCTC
ATCTCTACCAGCATGCTTGGGCGGGTCAAATACAACCTGAACTCCCTGTCACATGATACA
GCCACTGGGCTTATACAGTATGCATTGGACCAGGGCGTGAACGTCACCCAGGTATTCGTG
GACACCGTAGGGATGCCAGAGACATACCAGGCGCAGCTGCAGCAAAGTTTTCCCGGGATT
GAGGTGACGGTCAAGGCCAAAGCAGATGCCCTCTACCCGGTGGTTAGTGCTGCCAGCATC
TGTGCCAAGGTGGCCCGGGACCAGGCCGTGAAGAAATGGCAGTTCGTGGAGAAACTGCAG
GACTTGGATACTGATTATGGCTCAGGCTACCCCAATGATCCCAAGACAAAAGCGTGGTTG
AAGGAGCACGTGGAGCCTGTGTTCGGCTTCCCCCAGTTTGTCCGGTTCAGCTGGCGCACG
GCCCAGACCATCCTGGAGAAAGAGGCGGAAGATGTTATATGGGAGGACTCAGCATCCGAG
AATCAGGAGGGACTCAGGAAGATCACATCCTACTTCCTCAATGAAGGGTCCCAAGCCCGT
CCCCGTTCTTCCCACCGATATTTCCTGGAACGCGGCCTGGAGTCAGCAACCAGCCTCTAG
|
Protein Properties |
Number of Residues
| 299 |
Molecular Weight
| 33394.6 |
Theoretical pI
| 4.88 |
Pfam Domain Function
|
|
Signals
|
|
Transmembrane Regions
|
|
Protein Sequence
|
>Ribonuclease H2 subunit A
MDLSELERDNTGRCRLSSPVPAVCRKEPCVLGVDEAGRGPVLGPMVYAICYCPLPRLADL
EALKVADSKTLLESERERLFAKMEDTDFVGWALDVLSPNLISTSMLGRVKYNLNSLSHDT
ATGLIQYALDQGVNVTQVFVDTVGMPETYQARLQQSFPGIEVTVKAKADALYPVVSAASI
CAKVARDQAVKKWQFVEKLQDLDTDYGSGYPNDPKTKAWLKEHVEPVFGFPQFVRFSWRT
AQTILEKEAEDVIWEDSASENQEGLRKITSYFLNEGSQARPRSSHRYFLERGLESATSL
|
External Links |
GenBank ID Protein
| 3334761 |
UniProtKB/Swiss-Prot ID
| O75792 |
UniProtKB/Swiss-Prot Entry Name
| RNH2A_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| Z97029 |
GeneCard ID
| RNASEH2A |
GenAtlas ID
| RNASEH2A |
HGNC ID
| HGNC:18518 |
References |
General References
| Not Available |