Identification |
HMDB Protein ID
| CDBP01100 |
Secondary Accession Numbers
| Not Available |
Name
| Serine/threonine-protein kinase haspin |
Description
| Not Available |
Synonyms
|
- Germ cell-specific gene 2 protein
- H-haspin
- Haploid germ cell-specific nuclear protein kinase
|
Gene Name
| GSG2 |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in protein kinase activity |
Specific Function
| Required for normal alignment of chromosomes at metaphase. Phosphorylates histone H3 'Thr-3' during mitosis |
GO Classification
|
Function |
binding |
catalytic activity |
transferase activity |
transferase activity, transferring phosphorus-containing groups |
kinase activity |
nucleoside binding |
purine nucleoside binding |
adenyl nucleotide binding |
adenyl ribonucleotide binding |
atp binding |
protein kinase activity |
Process |
phosphorus metabolic process |
phosphate metabolic process |
metabolic process |
cellular metabolic process |
protein amino acid phosphorylation |
phosphorylation |
|
Cellular Location
|
- Nucleus
|
Pathways
|
Not Available
|
Gene Properties |
Chromosome Location
| Chromosome:1 |
Locus
| 17p13 |
SNPs
| GSG2 |
Gene Sequence
|
>2397 bp
ATGGCGGCTTCGCTCCCGGGACCTGGGAGCCGGCTTTTCCGCACATATGGGGCTGCGGAC
GGCAGGAGACAGCGGCGGCCGGGCCGGGAAGCCGCGCAGTGGTTCCCGCCGCAGGACCGG
AGGCGTTTCTTCAACAGCAGCGGCAGCAGCGACGCCAGCATCGGCGACCCCTCGCAGTCC
GACGATCCTGACGATCCCGACGACCCCGACTTCCCCGGCAGCCCGGTGAGGCGGCGGCGG
AGGCGTCCCGGCGGCCGAGTGCCCAAGGACCGGCCCAGCCTGACCGTGACCCCAAAGCGC
TGGAAGCTGCGAGCTCGCCCAAGCCTAACCGTGACCCCAAGACGCCTGGGGCTGCGAGCT
CGGCCCCCGCAGAAGTGCAGCACACCCTGCGGCCCGCTCCGACTTCCGCCCTTCCCCAGC
CGCGACTCCGGCCGCCTCAGCCCGGACCTCAGCGTGTGCGGCCAGCCCAGGGACGGCGAC
GAGCTGGGCATCAGTGCCTCCCTGTTCAGCTCTCTGGCCTCGCCCTGCCCCGGGTCCCCA
ACGCCAAGGGACAGTGTCATCTCGATCGGCACCTCCGCCTGTCTGGTTGCAGCCTCAGCC
GTCCCGAGCGGCCTCCACCTCCCAGAAGTCTCCCTGGACCGAGCATCTCTCCCCTGCTCC
CAGGAGGAAGCGACAGGAGGAGCCAAGGACACCAGGATGGTCCACCAAACCCGCGCCAGC
CTCAGGTCAGTTCTCTTTGGCCTTATGAACTCAGGAACCCCTGAGGATTCTGAGTTTCGG
GCAGATGGGAAGAATATGAGAGAGTCCTGCTGTAAAAGGAAACTGGTGGTGGGAAATGGA
CCAGAGGGTCCAGGTCTGTCAAGCACAGGCAAGAGGAGGGCCACAGGCCAGGACTCTTGT
CAAGAGAGAGGGCTTCAAGAGGCCGTCCGGAGAGAGCATCAGGAGGCCAGTGTTCCCAAG
GGCCGCATTGTGCCAAGGGGAATAGACAGGCTGGAGAGAACTAGATCAAGCCGGAAGAGC
AAACATCAGGAGGCAACGGAAACCTCTCTCCTCCATTCCCACCGCTTTAAAAAGGGCCAA
AAGCTGGGAAAAGATTCGTTCCCCACCCAGGACCTGACTCCTTTACAGAATGTCTGCTTT
TGGACCAAAACCAGGGCTTCCTTCAGTTTCCACAAGAAGAAAATTGTGACTGATGTGTCA
GAGGTCTGCAGCATCTATACCACTGCCACTTCTCTCTCTGGATCCCTCCTATCAGAATGT
TCAAACCGGCCTGTCATGAACAGAACAAGTGGTGCTCCGTCCTCTTGGCACTCCTCCTCT
ATGTATTTGCTAAGCCCCTTAAACACTCTAAGTATTTCAAACAAAAAGGCATCTGATGCT
GAAAAGGTTTATGGGGAATGCAGTCAGAAGGGTCCTGTCCCCTTTAGCCATTGCCTTCCC
ACAGAAAAACTGCAACGCTGTGAGAAGATTGGGGAAGGGGTGTTTGGCGAAGTGTTTCAA
ACAATTGCTGATCACACACCCGTAGCCATAAAAATCATTGCTATTGAAGGACCAGATTTA
GTCAATGGATCCCATCAGAAAACCTTTGAGGAAATCCTGCCAGAGATCATCATCTCCAAA
GAGTTGAGCCTCTTATCCGGTGAAGTGTGCAACCGCACAGAAGGCTTTATCGGGCTGAAC
TCAGTGCACTGTGTCCAGGGATCTTACCCTCCCTTGCTCCTCAAAGCCTGGGATCACTAT
AATTCAACCAAAGGCTCTGCAAATGACCGGCCTGATTTTTTTAAAGACGACCAGCTCTTC
ATTGTGCTGGAATTTGAGTTTGGAGGGATTGACTTAGAGCAAATGCGAACCAAGTTGTCT
TCCTTGGCTACTGCAAAGAGCATTCTACACCAGCTCACAGCCTCCCTCGCAGTGGCAGAG
GCATCACTGCGCTTTGAGCACCGAGACTTACACTGGGGGAACGTGCTCTTAAAGAAAACC
AGCCTCAAAAAACTCCACTACACCCTCAATGGGAAGAGCAGCACTATCCCCAGCTGTGGG
TTGCAAGTGAGCATCATTGACTACACCCTGTCGCGCTTGGAACGGGATGGGATTGTGGTT
TTCTGTGACGTTTCCATGGATGAGGACCTGTTTACCGGTGACGGTGACTACCAGTTTGAC
ATCTACAGGCTCATGAAGAAGGAGAATAACAACCGCTGGGGTGAATATCACCCTTATAGT
AATGTGCTCTGGTTACATTACCTGACAGACAAGATGCTGAAACAAATGACCTTCAAGACT
AAATGTAACACTCCTGCCATGAAGCAAATTAAGAGAAAAATCCAGGAGTTCCACAGGACA
ATGCTGAACTTCAGCTCTGCCACTGACTTGCTCTGCCAGCACAGTCTGTTTAAGTAA
|
Protein Properties |
Number of Residues
| 798 |
Molecular Weight
| 88494.6 |
Theoretical pI
| 9.57 |
Pfam Domain Function
|
|
Signals
|
|
Transmembrane Regions
|
|
Protein Sequence
|
>Serine/threonine-protein kinase haspin
MAASLPGPGSRLFRTYGAADGRRQRRPGREAAQWFPPQDRRRFFNSSGSSDASIGDPSQS
DDPDDPDDPDFPGSPVRRRRRRPGGRVPKDRPSLTVTPKRWKLRARPSLTVTPRRLGLRA
RPPQKCSTPCGPLRLPPFPSRDSGRLSPDLSVCGQPRDGDELGISASLFSSLASPCPGSP
TPRDSVISIGTSACLVAASAVPSGLHLPEVSLDRASLPCSQEEATGGAKDTRMVHQTRAS
LRSVLFGLMNSGTPEDSEFRADGKNMRESCCKRKLVVGNGPEGPGLSSTGKRRATGQDSC
QERGLQEAVRREHQEASVPKGRIVPRGIDRLERTRSSRKSKHQEATETSLLHSHRFKKGQ
KLGKDSFPTQDLTPLQNVCFWTKTRASFSFHKKKIVTDVSEVCSIYTTATSLSGSLLSEC
SNRPVMNRTSGAPSSWHSSSMYLLSPLNTLSISNKKASDAEKVYGECSQKGPVPFSHCLP
TEKLQRCEKIGEGVFGEVFQTIADHTPVAIKIIAIEGPDLVNGSHQKTFEEILPEIIISK
ELSLLSGEVCNRTEGFIGLNSVHCVQGSYPPLLLKAWDHYNSTKGSANDRPDFFKDDQLF
IVLEFEFGGIDLEQMRTKLSSLATAKSILHQLTASLAVAEASLRFEHRDLHWGNVLLKKT
SLKKLHYTLNGKSSTIPSCGLQVSIIDYTLSRLERDGIVVFCDVSMDEDLFTGDGDYQFD
IYRLMKKENNNRWGEYHPYSNVLWLHYLTDKMLKQMTFKTKCNTPAMKQIKRKIQEFHRT
MLNFSSATDLLCQHSLFK
|
External Links |
GenBank ID Protein
| Not Available |
UniProtKB/Swiss-Prot ID
| Q8TF76 |
UniProtKB/Swiss-Prot Entry Name
| HASP_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| AB039834 |
GeneCard ID
| GSG2 |
GenAtlas ID
| GSG2 |
HGNC ID
| HGNC:19682 |
References |
General References
| Not Available |