Identification |
HMDB Protein ID
| CDBP03926 |
Secondary Accession Numbers
| Not Available |
Name
| Enolase-phosphatase E1 |
Description
| Not Available |
Synonyms
|
- 2,3-diketo-5-methylthio-1-phosphopentane phosphatase
- MASA homolog
|
Gene Name
| ENOPH1 |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in catalytic activity |
Specific Function
| Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
|
GO Classification
|
Biological Process |
L-methionine salvage from methylthioadenosine |
polyamine metabolic process |
Cellular Component |
cytosol |
nucleus |
Function |
phosphoglycolate phosphatase activity |
ion binding |
cation binding |
metal ion binding |
hydrolase activity, acting on ester bonds |
binding |
catalytic activity |
hydrolase activity |
phosphoric ester hydrolase activity |
phosphatase activity |
acireductone synthase activity |
Molecular Function |
magnesium ion binding |
acireductone synthase activity |
phosphoglycolate phosphatase activity |
Process |
cellular amino acid biosynthetic process |
metabolic process |
cellular metabolic process |
amino acid salvage |
l-methionine salvage from methylthioadenosine |
cellular amino acid and derivative metabolic process |
cellular amino acid metabolic process |
|
Cellular Location
|
- Nucleus
- Cytoplasm
|
Pathways
|
Name | SMPDB/Pathwhiz | KEGG | L-methionine biosynthesis via salvage pathway | Not Available | Not Available | Cysteine and methionine metabolism | Not Available | |
|
Gene Properties |
Chromosome Location
| 4 |
Locus
| 4q21.22 |
SNPs
| ENOPH1 |
Gene Sequence
|
>786 bp
ATGGTCGTGCTTTCGGTCCCCGCCGAAGTCACCGTGATCCTGTTAGATATCGAAGGTACC
ACAACCCCGATTGCTTTCGTGAAGGACATTTTATTTCCTTACATCGAAGAAAATGTTAAA
GAGTATCTGCAGACACATTGGGAAGAAGAGGAGTGCCAGCAGGATGTCAGTCTTTTGAGG
AAACAGGCTGAAGAGGACGCCCACCTGGATGGGGCTGTTCCTATCCCTGCAGCATCTGGG
AATGGAGTGGATGATCTGCAACAGATGATCCAGGCCGTGGTAGATAATGTGTGCTGGCAG
ATGTCCCTGGATCGAAAGACCACTGCACTCAAACAGCTGCAGGGCCACATGTGGAGGGCG
GCATTCACAGCTGGGCGCATGAAAGCAGAGTTCTTTGCAGATGTAGTTCCAGCAGTCAGG
AAGTGGAGAGAGGCCGGAATGAAGGTGTACATCTATTCCTCAGGGAGTGTGGAGGCACAG
AAACTGTTATTCGGGCATTCTACGGAGGGAGATATTCTTGAGCTTGTTGATGGTCACTTT
GATACCAAGATTGGACACAAAGTAGAGAGTGAAAGTTACCGAAAGATTGCAGACAGCATT
GGGTGCTCAACCAACAACATTTTGTTTCTGACAGATGTTACTCGAGAGGCCAGTGCTGCT
GAGGAAGCAGATGTGCACGTAGCTGTGGTGGTGAGACCAGGCAACGCAGGATTAACAGAT
GATGAGAAGACTTACTACAGCCTCATCACATCCTTCAGTGAACTATACCTGCCTTCCTCA
ACCTAG
|
Protein Properties |
Number of Residues
| 261 |
Molecular Weight
| 28932.44 |
Theoretical pI
| 4.778 |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>Enolase-phosphatase E1
MVVLSVPAEVTVILLDIEGTTTPIAFVKDILFPYIEENVKEYLQTHWEEEECQQDVSLLR
KQAEEDAHLDGAVPIPAASGNGVDDLQQMIQAVVDNVCWQMSLDRKTTALKQLQGHMWRA
AFTAGRMKAEFFADVVPAVRKWREAGMKVYIYSSGSVEAQKLLFGHSTEGDILELVDGHF
DTKIGHKVESESYRKIADSIGCSTNNILFLTDVTREASAAEEADVHVAVVVRPGNAGLTD
DEKTYYSLITSFSELYLPSST
|
External Links |
GenBank ID Protein
| Not Available |
UniProtKB/Swiss-Prot ID
| Q9UHY7 |
UniProtKB/Swiss-Prot Entry Name
| ENOPH_HUMAN |
PDB IDs
|
|
GenBank Gene ID
| AF113125 |
GeneCard ID
| ENOPH1 |
GenAtlas ID
| ENOPH1 |
HGNC ID
| HGNC:24599 |
References |
General References
| Not Available |