Identification
HMDB Protein ID CDBP03303
Secondary Accession Numbers Not Available
Name Tau-tubulin kinase 1
Description Not Available
Synonyms
  1. Brain-derived tau kinase
Gene Name TTBK1
Protein Type Enzyme
Biological Properties
General Function Involved in protein kinase activity
Specific Function Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU
GO Classification
Function
binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
adenyl ribonucleotide binding
atp binding
protein kinase activity
Process
phosphate metabolic process
metabolic process
cellular metabolic process
protein amino acid phosphorylation
phosphorylation
phosphorus metabolic process
Cellular Location
  1. Cytoplasm
Pathways
Gene Properties
Chromosome Location Chromosome:6
Locus 6p21.1
SNPs TTBK1
Gene Sequence
>3966 bp
ATGCAGTGCCTAGCGGCCGCCCTTAAGGACGAAACCAACATGAGTGGGGGAGGGGAGCAG
GCCGACATCCTGCCGGCCAACTACGTGGTCAAGGATCGCTGGAAGGTGCTGAAAAAGATC
GGGGGCGGGGGCTTTGGTGAGATCTACGAGGCCATGGACCTGCTGACCAGGGAGAATGTG
GCCCTCAAGGTGGAGTCAGCCCAGCAGCCCAAGCAGGTCCTCAAGATGGAGGTGGCCGTG
CTCAAGAAGTTGCAAGGGAAGGACCATGTGTGCAGGTTCATTGGCTGTGGCAGGAACGAG
AAGTTTAACTATGTAGTGATGCAGCTCCAGGGCCGGAACCTGGCCGACCTGCGCCGTAGC
CAGCCGCGAGGCACCTTCACGCTGAGCACCACATTGCGGCTGGGCAAGCAGATCTTGGAG
TCCATCGAGGCCATCCACTCTGTGGGCTTCCTGCACCGTGACATCAAGCCTTCAAACTTT
GCCATGGGCAGGCTGCCCTCCACCTACAGGAAGTGCTATATGCTGGACTTCGGGCTGGCC
CGGCAGTACACCAACACCACGGGGGATGTGCGGCCCCCTCGGAATGTGGCCGGGTTTCGA
GGAACGGTTCGCTATGCCTCAGTCAATGCCCACAAGAACCGGGAGATGGGCCGCCACGAC
GACCTGTGGTCCCTCTTCTACATGCTGGTGGAGTTTGCAGTGGGCCAGCTGCCCTGGAGG
AAGATCAAGGACAAGGAACAGGTAGGGATGATCAAGGAGAAGTATGAGCACCGGATGCTG
CTGAAGCACATGCCGTCAGAGTTCCACCTCTTCCTGGACCACATTGCCAGCCTCGACTAC
TTCACCAAGCCCGACTACCAGTTGATCATGTCAGTGTTTGAGAACAGCATGAAGGAGAGG
GGCATTGCCGAGAATGAGGCCTTTGACTGGGAGAAGGCAGGCACCGATGCCCTCCTGTCC
ACGAGCACCTCTACCCCGCCCCAGCAGAACACCCGGCAGACGGCAGCCATGTTTGGGGTG
GTCAATGTGACGCCAGTGCCTGGGGACCTGCTCCGGGAGAACACCGAGGATGTGCTACAG
GGAGAGCACCTGAGTGACCAGGAGAATGCACCCCCAATTCTGCCCGGGAGGCCCTCTGAG
GGGCTGGGCCCCAGTCCCCACCTTGTCCCCCACCCCGGGGGTCCTGAGGCTGAAGTCTGG
GAGGAGACAGATGTCAACCGGAACAAACTCCGGATCAACATCGGCAAAAGCCCCTGTGTG
GAGGAGGAACAGAGCCGAGGCATGGGGGTCCCCAGCTCCCCAGTGCGTGCCCCCCCAGAC
TCCCCCACAACCCCAGTCCGTTCTCTGCGCTACCGGAGGGTGAACAGCCCTGAGTCAGAA
AGGCTGTCCACGGCGGACGGGCGAGTGGAGCTACCTGAGAGGAGGTCACGGATGGATCTG
CCTGGCTCGCCCTCGCGCCAGGCCTGCTCCTCTCAGCCAGCCCAGATGCTGTCAGTGGAC
ACAGGCCACGCTGACCGACAGGCCAGTGGCCGCATGGACGTGTCAGCCTCTGTGGAGCAG
GAGGCCCTGAGCAACGCCTTCCGCTCGGTGCCGCTGGCTGAGGAGGAGGATTTCGACAGC
AAAGAGTGGGTCATCATCGACAAGGAGACGGAGCTCAAGGACTTCCCTCCAGGGGCTGAG
CCCAGCACATCGGGCACCACGGATGAGGAGCCCGAGGAGCTGCGGCCACTGCCCGAGGAG
GGCGAAGAGCGGCGGCGGCTGGGGGCAGAGCCCACCGTCCGGCCCCGGGGACGCAGCATG
CAGGCGCTGGCGGAGGAGGACCTGCAGCATTTGCCGCCCCAGCCCCTGCCACCCCAGCTG
AGCCAGGGCGATGGCCGTTCCGAGACGTCACAGCCCCCCACGCCTGGCAGCCCTTCCCAC
TCACCCCTGCACTCGGGACCCCGCCCTCGACGGAGAGAGTCGGACCCCACAGGCCCACAG
AGACAGGTGTTCTCCGTGGCGCCCCCATTTGAGGTGAATGGCCTCCCACGAGCTGTGCCT
CTGAGTCTGCCCTACCAGGACTTCAAAAGAGACCTCTCCGATTACCGAGAACGGGCGCGG
TTGCTCAACAGGGTCCGGAGGGTGGGCTTCTCGCACATGCTGCTCACCACCCCCCAGGTC
CCACTGGCTCCTGTTCAGCCTCAGGCTAATGGGAAGGAGGAAGAGGAGGAGGAGGAGGAA
GATGAGGAAGAGGAAGAAGAGGATGAGGAAGAAGAAGAGGAGGAAGAGGAAGAGGAGGAG
GAAGAAGAGGAGGAGGAGGAAGAGGAGGAGGAGGCTGCAGCGGCAGTTGCCTTGGGGGAG
GTGCTGGGGCCTCGTAGTGGCTCCAGCAGTGAGGGGAGTGAGAGGAGCACTGACCGGAGC
CAGGAGGGTGCCCCGTCCACGCTGCTGGCAGACGATCAGAAGGAGTCCAGGGGCCGGGCC
TCCATGGCCGATGGGGACCTGGAGCCTGAGGAGGGCTCCAAAACGCTGGTGCTTGTCTCT
CCTGGCGACATGAAGAAGTCGCCCGTCACTGCCGAACTGGCCCCCGACCCCGACCTGGGC
ACCCTGGCTGCCCTCACTCCTCAGCATGAGCGGCCCCAGCCCACGGGCAGCCAGCTGGAC
GTATCTGAGCCAGGCACCCTGTCCTCTGTCCTCAAGTCTGAGCCCAAGCCCCCGGGGCCT
GGGGCAGGGCTGGGGGCCGGGACAGTGACCACAGGGGTCGGGGGCGTGGCAGTCACCTCC
TCACCCTTCACCAAAGTTGAGAGGACCTTTGTGCACATTGCGGAGAAAACCCACCTCAAC
GTCATGTCTTCCGGTGGACAAGCCTTGCGGTCTGAGGAGTTCAGCGCTGGGGGCGAGCTG
GGTCTGGAGCTGGCCTCTGATGGGGGCGCTGTGGAGGAGGGGGCCCGAGCGCCCCTGGAG
AACGGCCTCGCCCTGTCAGGGCTGAATGGGGCTGAGATAGAGGGCTCTGCCCTGTCTGGG
GCCCCCCGGGAAACCCCCTCAGAGATGGCCACAAACTCACTGCCCAATGGCCCGGCCCTT
GCAGACGGGCCAGCCCCGGTGTCCCCGCTGGAGCCAAGCCCTGAGAAAGTGGCCACCATC
TCCCCCAGACGCCATGCTATGCCAGGCTCTCGCCCCAGGAGCCGTATCCCTGTCCTGCTC
TCTGAGGAGGACACGGGCTCGGAGCCCTCAGGCTCACTGTCGGCCAAAGAGCGGTGGAGC
AAGCGGGCTCGGCCGCAGCAGGACCTGGCGCGGCTGGTGATGGAGAAGAGGCAGGGCCGC
CTGCTGTTGCGGCTGGCCTCAGGGGCCTCGTCCTCCTCCAGTGAGGAGCAGCGCCGTGCC
TCTGAGACCCTCTCAGGCACGGGCTCTGAGGAGGACACGCCCGCCTCTGAGCCGGCAGCG
GCCTTGCCCAGGAAGAGCGGGAGGGCAGCCGCCACCAGGAGCCGGATTCCCCGCCCCATT
GGCCTCCGCATGCCCATGCCTGTTGCAGCCCAGCAGCCCGCCAGCAGATCCCATGGCGCG
GCCCCAGCATTGGACACAGCCATCACCAGCAGGCTCCAGCTGCAGACGCCCCCAGGGTCG
GCCACTGCTGCTGACCTCCGCCCCAAACAACCTCCTGGCCGCGGCCTGGGCCCAGGGCGA
GCCCAAGCCGGAGCCAGGCCCCCAGCGCCGCGCAGCCCGCGCCTCCCCGCGTCCACATCC
GCCGCGCGCAATGCCAGCGCGTCCCCCCGGAGCCAGTCCCTGTCCCGCAGAGAGAGCCCC
TCCCCCTCGCACCAGGCCCGGCCCGGGGTCCCCCCGCCCCGGGGCGTCCCGCCGGCCCGG
GCCCAGCCTGATGGCACCCCCTCCCCCGGGGGCTCCAAGAAAGGACCCAGAGGGAAACTC
CAGGCTCAGCGCGCAACAACCAAAGGCCGGGCAGGAGGCGCGGAGGGCCGGGCTGGGGCC
AGATAA
Protein Properties
Number of Residues 1321
Molecular Weight 142735.8
Theoretical pI 5.3
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence
>Tau-tubulin kinase 1
MQCLAAALKDETNMSGGGEQADILPANYVVKDRWKVLKKIGGGGFGEIYEAMDLLTRENV
ALKVESAQQPKQVLKMEVAVLKKLQGKDHVCRFIGCGRNEKFNYVVMQLQGRNLADLRRS
QPRGTFTLSTTLRLGKQILESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLA
RQYTNTTGDVRPPRNVAGFRGTVRYASVNAHKNREMGRHDDLWSLFYMLVEFAVGQLPWR
KIKDKEQVGMIKEKYEHRMLLKHMPSEFHLFLDHIASLDYFTKPDYQLIMSVFENSMKER
GIAENEAFDWEKAGTDALLSTSTSTPPQQNTRQTAAMFGVVNVTPVPGDLLRENTEDVLQ
GEHLSDQENAPPILPGRPSEGLGPSPHLVPHPGGPEAEVWEETDVNRNKLRINIGKSPCV
EEEQSRGMGVPSSPVRAPPDSPTTPVRSLRYRRVNSPESERLSTADGRVELPERRSRMDL
PGSPSRQACSSQPAQMLSVDTGHADRQASGRMDVSASVEQEALSNAFRSVPLAEEEDFDS
KEWVIIDKETELKDFPPGAEPSTSGTTDEEPEELRPLPEEGEERRRLGAEPTVRPRGRSM
QALAEEDLQHLPPQPLPPQLSQGDGRSETSQPPTPGSPSHSPLHSGPRPRRRESDPTGPQ
RQVFSVAPPFEVNGLPRAVPLSLPYQDFKRDLSDYRERARLLNRVRRVGFSHMLLTTPQV
PLAPVQPQANGKEEEEEEEEDEEEEEEDEEEEEEEEEEEEEEEEEEEEEEEAAAAVALGE
VLGPRSGSSSEGSERSTDRSQEGAPSTLLADDQKESRGRASMADGDLEPEEGSKTLVLVS
PGDMKKSPVTAELAPDPDLGTLAALTPQHERPQPTGSQLDVSEPGTLSSVLKSEPKPPGP
GAGLGAGTVTTGVGGVAVTSSPFTKVERTFVHIAEKTHLNVMSSGGQALRSEEFSAGGEL
GLELASDGGAVEEGARAPLENGLALSGLNGAEIEGSALSGAPRETPSEMATNSLPNGPAL
ADGPAPVSPLEPSPEKVATISPRRHAMPGSRPRSRIPVLLSEEDTGSEPSGSLSAKERWS
KRARPQQDLARLVMEKRQGRLLLRLASGASSSSSEEQRRASETLSGTGSEEDTPASEPAA
ALPRKSGRAAATRSRIPRPIGLRMPMPVAAQQPASRSHGAAPALDTAITSRLQLQTPPGS
ATAADLRPKQPPGRGLGPGRAQAGARPPAPRSPRLPASTSAARNASASPRSQSLSRRESP
SPSHQARPGVPPPRGVPPARAQPDGTPSPGGSKKGPRGKLQAQRATTKGRAGGAEGRAGA
R
GenBank ID Protein 58761548
UniProtKB/Swiss-Prot ID Q5TCY1
UniProtKB/Swiss-Prot Entry Name TTBK1_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_032538.1
GeneCard ID TTBK1
GenAtlas ID TTBK1
HGNC ID HGNC:19140
References
General References Not Available