Identification |
HMDB Protein ID
| CDBP03303 |
Secondary Accession Numbers
| Not Available |
Name
| Tau-tubulin kinase 1 |
Description
| Not Available |
Synonyms
|
- Brain-derived tau kinase
|
Gene Name
| TTBK1 |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in protein kinase activity |
Specific Function
| Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU |
GO Classification
|
Function |
binding |
catalytic activity |
transferase activity |
transferase activity, transferring phosphorus-containing groups |
kinase activity |
nucleoside binding |
purine nucleoside binding |
adenyl nucleotide binding |
adenyl ribonucleotide binding |
atp binding |
protein kinase activity |
Process |
phosphate metabolic process |
metabolic process |
cellular metabolic process |
protein amino acid phosphorylation |
phosphorylation |
phosphorus metabolic process |
|
Cellular Location
|
- Cytoplasm
|
Pathways
|
Not Available
|
Gene Properties |
Chromosome Location
| Chromosome:6 |
Locus
| 6p21.1 |
SNPs
| TTBK1 |
Gene Sequence
|
>3966 bp
ATGCAGTGCCTAGCGGCCGCCCTTAAGGACGAAACCAACATGAGTGGGGGAGGGGAGCAG
GCCGACATCCTGCCGGCCAACTACGTGGTCAAGGATCGCTGGAAGGTGCTGAAAAAGATC
GGGGGCGGGGGCTTTGGTGAGATCTACGAGGCCATGGACCTGCTGACCAGGGAGAATGTG
GCCCTCAAGGTGGAGTCAGCCCAGCAGCCCAAGCAGGTCCTCAAGATGGAGGTGGCCGTG
CTCAAGAAGTTGCAAGGGAAGGACCATGTGTGCAGGTTCATTGGCTGTGGCAGGAACGAG
AAGTTTAACTATGTAGTGATGCAGCTCCAGGGCCGGAACCTGGCCGACCTGCGCCGTAGC
CAGCCGCGAGGCACCTTCACGCTGAGCACCACATTGCGGCTGGGCAAGCAGATCTTGGAG
TCCATCGAGGCCATCCACTCTGTGGGCTTCCTGCACCGTGACATCAAGCCTTCAAACTTT
GCCATGGGCAGGCTGCCCTCCACCTACAGGAAGTGCTATATGCTGGACTTCGGGCTGGCC
CGGCAGTACACCAACACCACGGGGGATGTGCGGCCCCCTCGGAATGTGGCCGGGTTTCGA
GGAACGGTTCGCTATGCCTCAGTCAATGCCCACAAGAACCGGGAGATGGGCCGCCACGAC
GACCTGTGGTCCCTCTTCTACATGCTGGTGGAGTTTGCAGTGGGCCAGCTGCCCTGGAGG
AAGATCAAGGACAAGGAACAGGTAGGGATGATCAAGGAGAAGTATGAGCACCGGATGCTG
CTGAAGCACATGCCGTCAGAGTTCCACCTCTTCCTGGACCACATTGCCAGCCTCGACTAC
TTCACCAAGCCCGACTACCAGTTGATCATGTCAGTGTTTGAGAACAGCATGAAGGAGAGG
GGCATTGCCGAGAATGAGGCCTTTGACTGGGAGAAGGCAGGCACCGATGCCCTCCTGTCC
ACGAGCACCTCTACCCCGCCCCAGCAGAACACCCGGCAGACGGCAGCCATGTTTGGGGTG
GTCAATGTGACGCCAGTGCCTGGGGACCTGCTCCGGGAGAACACCGAGGATGTGCTACAG
GGAGAGCACCTGAGTGACCAGGAGAATGCACCCCCAATTCTGCCCGGGAGGCCCTCTGAG
GGGCTGGGCCCCAGTCCCCACCTTGTCCCCCACCCCGGGGGTCCTGAGGCTGAAGTCTGG
GAGGAGACAGATGTCAACCGGAACAAACTCCGGATCAACATCGGCAAAAGCCCCTGTGTG
GAGGAGGAACAGAGCCGAGGCATGGGGGTCCCCAGCTCCCCAGTGCGTGCCCCCCCAGAC
TCCCCCACAACCCCAGTCCGTTCTCTGCGCTACCGGAGGGTGAACAGCCCTGAGTCAGAA
AGGCTGTCCACGGCGGACGGGCGAGTGGAGCTACCTGAGAGGAGGTCACGGATGGATCTG
CCTGGCTCGCCCTCGCGCCAGGCCTGCTCCTCTCAGCCAGCCCAGATGCTGTCAGTGGAC
ACAGGCCACGCTGACCGACAGGCCAGTGGCCGCATGGACGTGTCAGCCTCTGTGGAGCAG
GAGGCCCTGAGCAACGCCTTCCGCTCGGTGCCGCTGGCTGAGGAGGAGGATTTCGACAGC
AAAGAGTGGGTCATCATCGACAAGGAGACGGAGCTCAAGGACTTCCCTCCAGGGGCTGAG
CCCAGCACATCGGGCACCACGGATGAGGAGCCCGAGGAGCTGCGGCCACTGCCCGAGGAG
GGCGAAGAGCGGCGGCGGCTGGGGGCAGAGCCCACCGTCCGGCCCCGGGGACGCAGCATG
CAGGCGCTGGCGGAGGAGGACCTGCAGCATTTGCCGCCCCAGCCCCTGCCACCCCAGCTG
AGCCAGGGCGATGGCCGTTCCGAGACGTCACAGCCCCCCACGCCTGGCAGCCCTTCCCAC
TCACCCCTGCACTCGGGACCCCGCCCTCGACGGAGAGAGTCGGACCCCACAGGCCCACAG
AGACAGGTGTTCTCCGTGGCGCCCCCATTTGAGGTGAATGGCCTCCCACGAGCTGTGCCT
CTGAGTCTGCCCTACCAGGACTTCAAAAGAGACCTCTCCGATTACCGAGAACGGGCGCGG
TTGCTCAACAGGGTCCGGAGGGTGGGCTTCTCGCACATGCTGCTCACCACCCCCCAGGTC
CCACTGGCTCCTGTTCAGCCTCAGGCTAATGGGAAGGAGGAAGAGGAGGAGGAGGAGGAA
GATGAGGAAGAGGAAGAAGAGGATGAGGAAGAAGAAGAGGAGGAAGAGGAAGAGGAGGAG
GAAGAAGAGGAGGAGGAGGAAGAGGAGGAGGAGGCTGCAGCGGCAGTTGCCTTGGGGGAG
GTGCTGGGGCCTCGTAGTGGCTCCAGCAGTGAGGGGAGTGAGAGGAGCACTGACCGGAGC
CAGGAGGGTGCCCCGTCCACGCTGCTGGCAGACGATCAGAAGGAGTCCAGGGGCCGGGCC
TCCATGGCCGATGGGGACCTGGAGCCTGAGGAGGGCTCCAAAACGCTGGTGCTTGTCTCT
CCTGGCGACATGAAGAAGTCGCCCGTCACTGCCGAACTGGCCCCCGACCCCGACCTGGGC
ACCCTGGCTGCCCTCACTCCTCAGCATGAGCGGCCCCAGCCCACGGGCAGCCAGCTGGAC
GTATCTGAGCCAGGCACCCTGTCCTCTGTCCTCAAGTCTGAGCCCAAGCCCCCGGGGCCT
GGGGCAGGGCTGGGGGCCGGGACAGTGACCACAGGGGTCGGGGGCGTGGCAGTCACCTCC
TCACCCTTCACCAAAGTTGAGAGGACCTTTGTGCACATTGCGGAGAAAACCCACCTCAAC
GTCATGTCTTCCGGTGGACAAGCCTTGCGGTCTGAGGAGTTCAGCGCTGGGGGCGAGCTG
GGTCTGGAGCTGGCCTCTGATGGGGGCGCTGTGGAGGAGGGGGCCCGAGCGCCCCTGGAG
AACGGCCTCGCCCTGTCAGGGCTGAATGGGGCTGAGATAGAGGGCTCTGCCCTGTCTGGG
GCCCCCCGGGAAACCCCCTCAGAGATGGCCACAAACTCACTGCCCAATGGCCCGGCCCTT
GCAGACGGGCCAGCCCCGGTGTCCCCGCTGGAGCCAAGCCCTGAGAAAGTGGCCACCATC
TCCCCCAGACGCCATGCTATGCCAGGCTCTCGCCCCAGGAGCCGTATCCCTGTCCTGCTC
TCTGAGGAGGACACGGGCTCGGAGCCCTCAGGCTCACTGTCGGCCAAAGAGCGGTGGAGC
AAGCGGGCTCGGCCGCAGCAGGACCTGGCGCGGCTGGTGATGGAGAAGAGGCAGGGCCGC
CTGCTGTTGCGGCTGGCCTCAGGGGCCTCGTCCTCCTCCAGTGAGGAGCAGCGCCGTGCC
TCTGAGACCCTCTCAGGCACGGGCTCTGAGGAGGACACGCCCGCCTCTGAGCCGGCAGCG
GCCTTGCCCAGGAAGAGCGGGAGGGCAGCCGCCACCAGGAGCCGGATTCCCCGCCCCATT
GGCCTCCGCATGCCCATGCCTGTTGCAGCCCAGCAGCCCGCCAGCAGATCCCATGGCGCG
GCCCCAGCATTGGACACAGCCATCACCAGCAGGCTCCAGCTGCAGACGCCCCCAGGGTCG
GCCACTGCTGCTGACCTCCGCCCCAAACAACCTCCTGGCCGCGGCCTGGGCCCAGGGCGA
GCCCAAGCCGGAGCCAGGCCCCCAGCGCCGCGCAGCCCGCGCCTCCCCGCGTCCACATCC
GCCGCGCGCAATGCCAGCGCGTCCCCCCGGAGCCAGTCCCTGTCCCGCAGAGAGAGCCCC
TCCCCCTCGCACCAGGCCCGGCCCGGGGTCCCCCCGCCCCGGGGCGTCCCGCCGGCCCGG
GCCCAGCCTGATGGCACCCCCTCCCCCGGGGGCTCCAAGAAAGGACCCAGAGGGAAACTC
CAGGCTCAGCGCGCAACAACCAAAGGCCGGGCAGGAGGCGCGGAGGGCCGGGCTGGGGCC
AGATAA
|
Protein Properties |
Number of Residues
| 1321 |
Molecular Weight
| 142735.8 |
Theoretical pI
| 5.3 |
Pfam Domain Function
|
|
Signals
|
|
Transmembrane Regions
|
|
Protein Sequence
|
>Tau-tubulin kinase 1
MQCLAAALKDETNMSGGGEQADILPANYVVKDRWKVLKKIGGGGFGEIYEAMDLLTRENV
ALKVESAQQPKQVLKMEVAVLKKLQGKDHVCRFIGCGRNEKFNYVVMQLQGRNLADLRRS
QPRGTFTLSTTLRLGKQILESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLA
RQYTNTTGDVRPPRNVAGFRGTVRYASVNAHKNREMGRHDDLWSLFYMLVEFAVGQLPWR
KIKDKEQVGMIKEKYEHRMLLKHMPSEFHLFLDHIASLDYFTKPDYQLIMSVFENSMKER
GIAENEAFDWEKAGTDALLSTSTSTPPQQNTRQTAAMFGVVNVTPVPGDLLRENTEDVLQ
GEHLSDQENAPPILPGRPSEGLGPSPHLVPHPGGPEAEVWEETDVNRNKLRINIGKSPCV
EEEQSRGMGVPSSPVRAPPDSPTTPVRSLRYRRVNSPESERLSTADGRVELPERRSRMDL
PGSPSRQACSSQPAQMLSVDTGHADRQASGRMDVSASVEQEALSNAFRSVPLAEEEDFDS
KEWVIIDKETELKDFPPGAEPSTSGTTDEEPEELRPLPEEGEERRRLGAEPTVRPRGRSM
QALAEEDLQHLPPQPLPPQLSQGDGRSETSQPPTPGSPSHSPLHSGPRPRRRESDPTGPQ
RQVFSVAPPFEVNGLPRAVPLSLPYQDFKRDLSDYRERARLLNRVRRVGFSHMLLTTPQV
PLAPVQPQANGKEEEEEEEEDEEEEEEDEEEEEEEEEEEEEEEEEEEEEEEAAAAVALGE
VLGPRSGSSSEGSERSTDRSQEGAPSTLLADDQKESRGRASMADGDLEPEEGSKTLVLVS
PGDMKKSPVTAELAPDPDLGTLAALTPQHERPQPTGSQLDVSEPGTLSSVLKSEPKPPGP
GAGLGAGTVTTGVGGVAVTSSPFTKVERTFVHIAEKTHLNVMSSGGQALRSEEFSAGGEL
GLELASDGGAVEEGARAPLENGLALSGLNGAEIEGSALSGAPRETPSEMATNSLPNGPAL
ADGPAPVSPLEPSPEKVATISPRRHAMPGSRPRSRIPVLLSEEDTGSEPSGSLSAKERWS
KRARPQQDLARLVMEKRQGRLLLRLASGASSSSSEEQRRASETLSGTGSEEDTPASEPAA
ALPRKSGRAAATRSRIPRPIGLRMPMPVAAQQPASRSHGAAPALDTAITSRLQLQTPPGS
ATAADLRPKQPPGRGLGPGRAQAGARPPAPRSPRLPASTSAARNASASPRSQSLSRRESP
SPSHQARPGVPPPRGVPPARAQPDGTPSPGGSKKGPRGKLQAQRATTKGRAGGAEGRAGA
R
|
External Links |
GenBank ID Protein
| 58761548 |
UniProtKB/Swiss-Prot ID
| Q5TCY1 |
UniProtKB/Swiss-Prot Entry Name
| TTBK1_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| NM_032538.1 |
GeneCard ID
| TTBK1 |
GenAtlas ID
| TTBK1 |
HGNC ID
| HGNC:19140 |
References |
General References
| Not Available |