| Identification |
|---|
| HMDB Protein ID
| CDBP04004 |
| Secondary Accession Numbers
| Not Available |
| Name
| Protein phosphatase 1E |
| Description
| Not Available |
| Synonyms
|
- Ca(2+)/calmodulin-dependent protein kinase phosphatase N
- CaMKN
- CaMKP-N
- CaMKP-nucleus
- Partner of PIX 1
- Partner of PIX-alpha
- Partner of PIXA
|
| Gene Name
| PPM1E |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in catalytic activity |
| Specific Function
| Protein phosphatase that inactivates multifunctional CaM kinases such as CAMK4 and CAMK2 (By similarity). Dephosphorylates and inactivates PAK. May play a role in the inhibition of actin fiber stress breakdown and in morphological changes driven by TNK2/CDC42.
|
| GO Classification
|
| Biological Process |
| cellular response to drug |
| peptidyl-threonine dephosphorylation |
| negative regulation of protein kinase activity |
| positive regulation of stress fiber assembly |
| Cellular Component |
| cytoplasm |
| nucleolus |
| protein complex |
| Component |
| macromolecular complex |
| protein complex |
| protein serine/threonine phosphatase complex |
| Function |
| hydrolase activity, acting on ester bonds |
| catalytic activity |
| hydrolase activity |
| phosphoric ester hydrolase activity |
| phosphatase activity |
| protein serine/threonine phosphatase activity |
| phosphoprotein phosphatase activity |
| Molecular Function |
| protein serine/threonine phosphatase activity |
| metal ion binding |
| Process |
| phosphorus metabolic process |
| phosphate metabolic process |
| dephosphorylation |
| protein amino acid dephosphorylation |
| metabolic process |
| cellular metabolic process |
|
| Cellular Location
|
- Nucleus
- Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| PPM1E |
| Gene Sequence
|
>2301 bp
ATGGCCGGCTGCATCCCTGAGGAGAAAACTTACCGGCGCTTCCTGGAGCTATTCCTGGGC
GAGTTTCGCGGACCGTGCGGCGGCGGCGAGCCGGAGCCGGAACCCGAACCCGAACCCGAA
CCCGAACCCGAACCCGAGTCCGAGCCCGAGCCCGAACCTGAACTGGTAGAAGCTGAGGCG
GCCGAGGCTTCGGTAGAGGAACCCGGGGAGGAGGCGGCCACGGTAGCCGCGACGGAGGAG
GGGGACCAGGAGCAAGACCCGGAGCCCGAGGAGGAGGCGGCGGTTGAGGGTGAGGAGGAG
GAGGAGGGCGCGGCGACGGCGGCGGCAGCCCCGGGGCACTCGGCCGTGCCGCCGCCGCCG
CCCCAGCTGCCGCCTTTGCCCCCGCTCCCGCGACCGCTGTCAGAGCGCATCACCCCGCGA
CCGCTGTCAGAGCGCATCACCCGCGAGGAGGTGGAGGGCGAAAGCCTGGACCTGTGCCTG
CAGCAGCTCTACAAATATAATTGCCCTTCCTTTTTGGCTGCTGCTTTAGCCAGAGCCACA
TCAGATGAAGTCCTTCAGAGTGATCTTTCTGCACATTATATCCCAAAGGAAACGGATGGC
ACAGAAGGGACTGTGGAGATTGAGACAGTGAAATTGGCCCGTTCTGTCTTCAGCAAACTA
CACGAGATTTGCTGCAGCTGGGTGAAAGACTTCCCCCTCCGCAGGAGACCCCAGCTTTAT
TATGAGACATCAATCCATGCCATCAAAAACATGCGCAGGAAAATGGAGGACAAACATGTC
TGCATTCCTGACTTTAATATGCTCTTCAACCTAGAGGACCAGGAAGAACAAGCTTACTTT
GCAGTGTTTGATGGCCATGGGGGAGTAGATGCTGCTATTTATGCCTCCATTCACCTCCAC
GTTAACTTAGTCCGCCAGGAGATGTTCCCCCATGATCCTGCTGAGGCCCTGTGCAGGGCC
TTCCGGGTCACTGATGAGCGGTTTGTGCAGAAAGCAGCCAGGGAGAGCTTAAGATGTGGG
ACCACAGGAGTGGTGACTTTCATCAGAGGCAACATGCTACATGTGGCCTGGGTGGGTGAT
TCCCAGGTTATGCTTGTGAGAAAGGGCCAAGCTGTTGAACTAATGAAGCCACACAAACCA
GACAGAGAGGATGAAAAGCAGAGAATTGAGGCCCTTGGAGGTTGCATAGTCTGGTTTGGT
GCCTGGAGGGTGAATGGAAGTCTGTCGGTTTCCAGAGCTATTGGAGATGCTGAACATAAG
CCATATATCTGTGGGGATGCAGATTCTGCCTCCACTGTTCTGGATGGGACCGAAGACTAC
CTCATTCTGGCCTGTGATGGCTTCTATGACACCGTGAACCCTGATGAGGCAGTGAAAGTT
GTGTCCGACCACCTGAAAGAGAATAATGGAGACAGCAGCATGGTTGCCCACAAATTAGTG
GCATCAGCTCGTGATGCTGGGTCAAGTGATAACATCACGGTTATTGTGGTATTCCTGAGG
GACATGAACAAAGCTGTAAATGTTAGTGAGGAATCAGATTGGACAGAGAACTCTTTTCAA
GGAGGGCAAGAAGATGGTGGGGATGATAAGGAGAATCATGGAGAGTGCAAACGCCCTTGG
CCTCAGCACCAGTGCTCAGCACCAGCCGACCTAGGCTATGATGGGCGTGTGGATTCATTC
ACTGATAGAACTAGCCTGAGCCCAGGGTCCCAAATCAACGTGCTGGAAGACCCAGGCTAC
CTAGATCTCACACAAATAGAAGCAAGCAAACCTCACAGTGCCCAGTTTTTGCTACCAGTT
GAGATGTTTGGTCCTGGTGCACCAAAGAAAGCAAATCTTATTAATGAGTTAATGATGGAG
AAAAAATCAGTTCAGTCATCATTGCCTGAATGGAGTGGTGCTGGAGAGTTTCCCACTGCT
TTCAATTTGGGTTCAACAGGGGAGCAGATATACAGAATGCAGAGCTTGTCTCCTGTCTGT
TCAGGGTTGGAAAATGAACAGTTCAAATCCCCGGGAAACAGAGTTTCTAGATTGTCTCAT
TTACGCCACCACTACTCAAAGAAGTGGCACAGATTCAGGTTTAATCCAAAGTTTTATTCA
TTTCTCTCTGCTCAAGAGCCTTCCCACAAAATAGGCACTAGCCTGTCCTCACTTACTGGA
AGTGGGAAGAGAAATAGGATAAGAAGTTCTCTGCCATGGAGGCAAAATAGTTGGAAAGGG
TACAGTGAAAACATGAGGAAGCTCAGAAAGACTCATGATATTCCATGCCCAGATCTTCCT
TGGAGCTATAAAATAGAATAA
|
| Protein Properties |
|---|
| Number of Residues
| 766 |
| Molecular Weight
| Not Available |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Protein phosphatase 1E
MAGCIPEEKTYRRFLELFLGEFRGPCGGGEPEPEPEPEPEPEPEPESEPEPEPELVEAEA
AEASVEEPGEEAATVAATEEGDQEQDPEPEEEAAVEGEEEEEGAATAAAAPGHSAVPPPP
PQLPPLPPLPRPLSERITPRPLSERITREEVEGESLDLCLQQLYKYNCPSFLAAALARAT
SDEVLQSDLSAHYIPKETDGTEGTVEIETVKLARSVFSKLHEICCSWVKDFPLRRRPQLY
YETSIHAIKNMRRKMEDKHVCIPDFNMLFNLEDQEEQAYFAVFDGHGGVDAAIYASIHLH
VNLVRQEMFPHDPAEALCRAFRVTDERFVQKAARESLRCGTTGVVTFIRGNMLHVAWVGD
SQVMLVRKGQAVELMKPHKPDREDEKQRIEALGGCIVWFGAWRVNGSLSVSRAIGDAEHK
PYICGDADSASTVLDGTEDYLILACDGFYDTVNPDEAVKVVSDHLKENNGDSSMVAHKLV
ASARDAGSSDNITVIVVFLRDMNKAVNVSEESDWTENSFQGGQEDGGDDKENHGECKRPW
PQHQCSAPADLGYDGRVDSFTDRTSLSPGSQINVLEDPGYLDLTQIEASKPHSAQFLLPV
EMFGPGAPKKANLINELMMEKKSVQSSLPEWSGAGEFPTAFNLGSTGEQIYRMQSLSPVC
SGLENEQFKSPGNRVSRLSHLRHHYSKKWHRFRFNPKFYSFLSAQEPSHKIGTSLSSLTG
SGKRNRIRSSLPWRQNSWKGYSENMRKLRKTHDIPCPDLPWSYKIE
|
| External Links |
|---|
| GenBank ID Protein
| 7839557 |
| UniProtKB/Swiss-Prot ID
| Q8WY54 |
| UniProtKB/Swiss-Prot Entry Name
| PPM1E_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF260269 |
| GeneCard ID
| PPM1E |
| GenAtlas ID
| PPM1E |
| HGNC ID
| HGNC:19322 |
| References |
|---|
| General References
| Not Available |