| Identification |
|---|
| HMDB Protein ID
| CDBP01311 |
| Secondary Accession Numbers
| Not Available |
| Name
| 5-formyltetrahydrofolate cyclo-ligase |
| Description
| Not Available |
| Synonyms
|
- 5,10-methenyl-tetrahydrofolate synthetase
- MTHFS
- Methenyl-THF synthetase
|
| Gene Name
| MTHFS |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in ATP binding |
| Specific Function
| Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids.
|
| GO Classification
|
| Biological Process |
| folic acid-containing compound biosynthetic process |
| formate metabolic process |
| tetrahydrofolate metabolic process |
| Cellular Component |
| cytosol |
| plasma membrane |
| Golgi apparatus |
| Function |
| ligase activity |
| cyclo-ligase activity |
| 5-formyltetrahydrofolate cyclo-ligase activity |
| ligase activity, forming carbon-nitrogen bonds |
| binding |
| catalytic activity |
| nucleoside binding |
| purine nucleoside binding |
| adenyl nucleotide binding |
| adenyl ribonucleotide binding |
| atp binding |
| Molecular Function |
| 5-formyltetrahydrofolate cyclo-ligase activity |
| ATP binding |
| folic acid binding |
| Process |
| metabolic process |
| cellular aromatic compound metabolic process |
| folic acid and derivative metabolic process |
| cellular metabolic process |
| folic acid and derivative biosynthetic process |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | One carbon pool by folate | Not Available |  | | Folate Metabolism |    | | | Methotrexate Action Pathway |    | Not Available | | Folate malabsorption, hereditary |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 15 |
| Locus
| 15q25.1 |
| SNPs
| MTHFS |
| Gene Sequence
|
>612 bp
ATGGCGGCGGCAGCGGTGAGCAGCGCCAAGCGTAGCCTGCGGGGAGAGCTGAAGCAGCGT
CTGCGGGCGATGAGTGCCGAGGAGCGGCTACGCCAGTCCCGCGTACTGAGCCAGAAGGTG
ATTGCCCACAGTGAGTATCAAAAGTCCAAAAGAATTTCCATCTTTCTGAGCATGCAAGAT
GAAATTGAGACAGAAGAGATCATCAAGGACATTTTCCAACGAGGCAAAATCTGCTTCATC
CCTCGGTACCGGTTCCAGAGCAATCACATGGATATGGTGAGAATAGAATCACCAGAGGAA
ATTTCTTTACTTCCCAAAACATCCTGGAATATCCCTCAGCCTGGTGAGGGTGATGTTCGG
GAGGAGGCCTTGTCCACAGGGGGACTTGATCTCATCTTCATGCCAGGCCTTGGGTTTGAC
AAACATGGCAACCGACTGGGGAGGGGCAAGGGCTACTATGATGCCTATCTGAAGCGCTGT
TTGCAGCATCAGGAAGTGAAGCCCTACACCCTGGCGTTGGCTTTCAAAGAACAGATTTGC
CTCCAGGTCCCAGTGAATGAAAACGACATGAAGGTAGATGAAGTCCTTTACGAAGACTCG
TCAACAGCTTAA
|
| Protein Properties |
|---|
| Number of Residues
| 203 |
| Molecular Weight
| 16813.995 |
| Theoretical pI
| 4.993 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>5-formyltetrahydrofolate cyclo-ligase
MAAAAVSSAKRSLRGELKQRLRAMSAEERLRQSRVLSQKVIAHSEYQKSKRISIFLSMQD
EIETEEIIKDIFQRGKICFIPRYRFQSNHMDMVRIESPEEISLLPKTSWNIPQPGEGDVR
EEALSTGGLDLIFMPGLGFDKHGNRLGRGKGYYDAYLKRCLQHQEVKPYTLALAFKEQIC
LQVPVNENDMKVDEVLYEDSSTA
|
| External Links |
|---|
| GenBank ID Protein
| 18044285 |
| UniProtKB/Swiss-Prot ID
| P49914 |
| UniProtKB/Swiss-Prot Entry Name
| MTHFS_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| BC019921 |
| GeneCard ID
| MTHFS |
| GenAtlas ID
| MTHFS |
| HGNC ID
| HGNC:7437 |
| References |
|---|
| General References
| Not Available |