| Identification |
|---|
| HMDB Protein ID
| CDBP01052 |
| Secondary Accession Numbers
| Not Available |
| Name
| Inositol monophosphatase 2 |
| Description
| Not Available |
| Synonyms
|
- IMP 2
- IMPase 2
- Inositol-1(or 4)-monophosphatase 2
- Myo-inositol monophosphatase A2
|
| Gene Name
| IMPA2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in inositol or phosphatidylinositol phosphatase activity |
| Specific Function
| Can use myo-inositol monophosphates, scylloinositol 1,4-diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. Has been implicated as the pharmacological target for lithium Li(+) action in brain.
|
| GO Classification
|
| Biological Process |
| inositol phosphate dephosphorylation |
| phosphatidylinositol phosphorylation |
| signal transduction |
| inositol biosynthetic process |
| Cellular Component |
| cytoplasm |
| Function |
| hydrolase activity, acting on ester bonds |
| catalytic activity |
| hydrolase activity |
| phosphoric ester hydrolase activity |
| phosphatase activity |
| inositol or phosphatidylinositol phosphatase activity |
| Molecular Function |
| metal ion binding |
| inositol monophosphate 1-phosphatase activity |
| inositol monophosphate 3-phosphatase activity |
| inositol monophosphate 4-phosphatase activity |
|
| Cellular Location
|
- Cytoplasmic
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | myo-inositol biosynthesis | Not Available | Not Available | | Phosphatidylinositol signaling system | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 18 |
| Locus
| 18p11.2 |
| SNPs
| IMPA2 |
| Gene Sequence
|
>867 bp
ATGAAGCCGAGCGGCGAGGACCAGGCGGCGCTGGCGGCCGGCCCCTGGGAGGAGTGCTTC
CAGGCGGCCGTGCAGCTGGCGCTGCGGGCAGGACAGATCATCAGAAAAGCCCTTACTGAG
GAAAAACGTGTCTCAACAAAAACATCAGCTGCAGATCTTGTGACAGAAACAGATCACCTT
GTGGAAGATTTAATTATTTCTGAGTTGCGAGAGAGGTTTCCTTCACACAGGTTCATTGCA
GAAGAGGCCGCGGCTTCTGGGGCCAAGTGTGTGCTCACCCACAGCCCGACGTGGATCATC
GACCCCATCGACGGCACCTGCAATTTTGTGCACAGATTCCCGACTGTGGCGGTTAGCATT
GGATTTGCTGTTCGACAAGAGCTTGAATTCGGAGTGATTTACCACTGCACAGAGGAGCGG
CTGTACACGGGCCGGCGGGGTCGGGGCGCCTTCTGCAATGGCCAGCGGCTCCGGGTCTCC
GGGGAGACAGATCTCTCAAAGGCCTTGGTTCTGACAGAAATTGGCCCCAAACGTGACCCT
GCGACCCTGAAGCTGTTCCTGAGTAACATGGAGCGGCTGCTGCATGCCAAGGCGCATGGG
GTCCGAGTGATTGGAAGCTCCACATTGGCACTCTGCCACCTGGCCTCAGGGGCCGCGGAT
GCCTATTACCAGTTTGGCCTGCACTGCTGGGATCTGGCGGCTGCCACAGTCATCATCAGA
GAAGCAGGCGGCATCGTGATAGACACTTCGGGTGGACCCCTCGACCTCATGGCTTGCAGA
GTGGTTGCGGCCAGCACCCGGGAGATGGCGATGCTCATAGCTCAGGCCTTACAGACCATT
AACTATGGGCGGGATGATGAGAAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 288 |
| Molecular Weight
| 31320.525 |
| Theoretical pI
| 6.61 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Inositol monophosphatase 2
MKPSGEDQAALAAGPWEECFQAAVQLALRAGQIIRKALTEEKRVSTKTSAADLVTETDHL
VEDLIISELRERFPSHRFIAEEAAASGAKCVLTHSPTWIIDPIDGTCNFVHRFPTVAVSI
GFAVRQELEFGVIYHCTEERLYTGRRGRGAFCNGQRLRVSGETDLSKALVLTEIGPKRDP
ATLKLFLSNMERLLHAKAHGVRVIGSSTLALCHLASGAADAYYQFGLHCWDLAAATVIIR
EAGGIVIDTSGGPLDLMACRVVAASTREMAMLIAQALQTINYGRDDEK
|
| External Links |
|---|
| GenBank ID Protein
| 2406666 |
| UniProtKB/Swiss-Prot ID
| O14732 |
| UniProtKB/Swiss-Prot Entry Name
| IMPA2_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AF014398 |
| GeneCard ID
| IMPA2 |
| GenAtlas ID
| IMPA2 |
| HGNC ID
| HGNC:6051 |
| References |
|---|
| General References
| Not Available |