Cannabis Compound Database: Showing Protein ATP-dependent RNA helicase SUPV3L1, mitochondrial (CDBP04029)

Identification Biological properties Gene properties Protein properties External links References XML Show 5 compounds

Identification

HMDB Protein ID

CDBP04029

Secondary Accession Numbers

Not Available

Name

ATP-dependent RNA helicase SUPV3L1, mitochondrial

Description

Not Available

Synonyms

SUV3-like protein 1
Suppressor of var1 3-like protein 1

Gene Name

SUPV3L1

Protein Type

Enzyme

Biological Properties

General Function

Involved in nucleic acid binding

Specific Function

Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. ATPase and ATP-dependent multisubstrate helicase, able to unwind double stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect cells from apoptosis. Associates with mitochondrial DNA.

GO Classification

Biological Process
mitochondrion morphogenesis
negative regulation of apoptotic process
chromatin maintenance
mitochondrial mRNA surveillance
mitochondrial ncRNA surveillance
positive regulation of cell growth
mitochondrial mRNA catabolic process
mitochondrial RNA 3'-end processing
positive regulation of mitochondrial RNA catabolic process
DNA recombination
Cellular Component
nucleus
mitochondrial degradosome
mitochondrial nucleoid
Function
hydrolase activity
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
adenyl ribonucleotide binding
atp binding
nucleic acid binding
nucleoside-triphosphatase activity
helicase activity
hydrolase activity, acting on acid anhydrides
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
pyrophosphatase activity
binding
catalytic activity
Molecular Function
DNA helicase activity
DNA binding
ATP-dependent RNA helicase activity
double-stranded RNA binding
ATP binding
3'-5' RNA helicase activity

Cellular Location

Nucleus
Mitochondrion matrix

Pathways

Not Available

Gene Properties

Chromosome Location

Locus

10q22.1

SNPs

SUPV3L1

Gene Sequence

>2361 bp
ATGTCCTTCTCCCGTGCCCTATTGTGGGCTCGGCTCCCGGCGGGGCGCCAGGCTGGCCAC
CGGGCAGCCATCTGCTCTGCCCTTCGTCCCCACTTTGGGCCCTTTCCCGGGGTTCTGGGG
CAAGTTTCTGTCCTTGCCACCGCCTCCTCCTCTGCCTCCGGTGGCTCCAAAATACCAAAC
ACGTCCTTGTTCGTGCCCCTGACTGTGAAACCTCAGGGCCCCAGCGCCGACGGCGACGTC
GGGGCCGAGCTAACCCGGCCTCTGGACAAGAATGAAGTAAAGAAGGTCTTAGACAAATTT
TACAAGAGGAAAGAAATTCAGAAACTGGGTGCTGATTATGGACTTGATGCTCGTCTCTTC
CACCAAGCTTTCATAAGCTTTAGAAATTATATTATGCAGTCTCATTCCCTGGATGTGGAC
ATTCACATTGTTTTGAATGATATTTGCTTCGGTGCAGCTCATGCGGATGATTTATTCCCA
TTTTTCTTGAGACATGCCAAACAAATATTTCCTGTGTTGGACTGTAAGGATGATCTACGT
AAAATCAGCGACTTAAGAATACCACCTAACTGGTACCCAGATGCTAGAGCCATGCAGCGG
AAGATAATATTTCATTCAGGCCCCACAAACAGTGGAAAGACTTATCACGCAATCCAGAAA
TACTTCTCAGCAAAGTCTGGAGTGTATTGTGGCCCTCTAACATCACTGGCACATGAGATC
TTCGAAAAGAGTAATGCTGCTGGCGTGCCATGTGACTTGGAGACAGGTGAAGAGCGTGTG
ACAGTTCAGCCAAATGGGAAACAGGCTTCACATGTTTCTTGTACAGTTGAGATGTGCAGT
GTTACAACTCCTTATGAAGTGGCTGTAATTGATGAAATTCAAATGATTAGAGATCCAGCC
AGAGGATGGGCCTGGACCAGAGCACTTCTAGGACTGTGTGCTGAAGAGGTTCATTTGTGT
GGAGAACCTGCTGCTATTGACCTGGTGATGGAGCTTATGTACACAACGGGGGAGGAAGTG
GAGGTTCGAGACTATAAGAGGCTTACCCCCATTTCTGTGCTGGACCATGCACTAGAATCT
TTAGATAACCTTCGGCCTGGGGACTGCATTGTCTGTTTTAGCAAGAATGATATTTATTCT
GTGAGTCGGCAGATTGAAATTCGGGGATTAGAATCAGCTGTTATATATGGCAGTCTCCCA
CCTGGGACCAAACTTGCTCAAGCAAAAAAGTTTAATGATCCCAATGACCCATGCAAAATC
TTGGTTGCTACAGATGCAATTGGCATGGGACTTAATTTGAGCATAAGGAGAATTATTTTT
TACTCCCTTATAAAGCCCAGTATCAATGAAAAGGGAGAGAGAGAACTAGAACCAATCACA
ACCTCTCAAGCCCTGCAGATTGCTGGCAGAGCTGGCAGATTCAGCTCACGGTTTAAAGAA
GGAGAGGTTACAACAATGAATCATGAAGATCTCAGTTTATTAAAGGAAATTTTGAAGAGG
CCTGTGGATCCTATAAGGGCAGCTGGTCTTCATCCAACTGCTGAGCAGATTGAAATGTTT
GCCTACCATCTCCCTGATGCAACACTGTCCAATCTCATTGATATTTTTGTAGACTTTTCA
CAAGTTGATGGGCAGTATTTTGTCTGCAATATGGATGATTTTAAATTTTCTGCAGAGTTG
ATCCAGCATATTCCACTAAGTCTGCGAGTGAGGTATGTTTTCTGCACAGCTCCTATCAAC
AAGAAGCAGCCTTTTGTGTGTTCTTCACTGTTACAGTTTGCCAGGCAGTATAGCAGGAAT
GAGCCCCTGACCTTTGCATGGTTACGCCGATACATCAAATGGCCTTTACTTCCACCTAAG
AATATTAAAGACCTCATGGATCTTGAAGCTGTCCACGATGTCTTGGATCTTTACTTGTGG
CTAAGCTACCGATTTATGGATATGTTTCCAGATGCCAGCCTTATTCGAGATCTCCAGAAA
GAACTAGATGGTATTATCCAAGATGGTGTGCACAATATCACTAAATTGATTAAAATGTCT
GAGACGCATAAGCTGTTGAATTTGGAGGGCTTTCCATCAGGGAGCCAGTCACGATTGTCA
GGAACCTTAAAGAGCCAAGCTAGAAGGACACGCGGCACCAAAGCTCTAGGGAGTAAAGCT
ACTGAGCCACCCAGCCCCGATGCAGGAGAGCTGTCCCTTGCTTCCAGATTGGTGCAGCAA
GGACTCCTCACTCCAGACATGCTGAAACAGCTAGAAAAAGAGTGGATGACACAACAAACT
GAACACAACAAAGAAAAAACAGAGTCTGGGACTCATCCAAAAGGGACGAGAAGAAAGAAG
AAGGAACCTGATTCGGACTAG

Protein Properties

Number of Residues

786

Molecular Weight

87990.315

Theoretical pI

7.989

Pfam Domain Function

Helicase_C; (PF00271 )
SUV3_C (PF12513 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>ATP-dependent RNA helicase SUPV3L1, mitochondrial
MSFSRALLWARLPAGRQAGHRAAICSALRPHFGPFPGVLGQVSVLATASSSASGGSKIPN
TSLFVPLTVKPQGPSADGDVGAELTRPLDKNEVKKVLDKFYKRKEIQKLGADYGLDARLF
HQAFISFRNYIMQSHSLDVDIHIVLNDICFGAAHADDLFPFFLRHAKQIFPVLDCKDDLR
KISDLRIPPNWYPDARAMQRKIIFHSGPTNSGKTYHAIQKYFSAKSGVYCGPLKLLAHEI
FEKSNAAGVPCDLVTGEERVTVQPNGKQASHVSCTVEMCSVTTPYEVAVIDEIQMIRDPA
RGWAWTRALLGLCAEEVHLCGEPAAIDLVMELMYTTGEEVEVRDYKRLTPISVLDHALES
LDNLRPGDCIVCFSKNDIYSVSRQIEIRGLESAVIYGSLPPGTKLAQAKKFNDPNDPCKI
LVATDAIGMGLNLSIRRIIFYSLIKPSINEKGERELEPITTSQALQIAGRAGRFSSRFKE
GEVTTMNHEDLSLLKEILKRPVDPIRAAGLHPTAEQIEMFAYHLPDATLSNLIDIFVDFS
QVDGQYFVCNMDDFKFSAELIQHIPLSLRVRYVFCTAPINKKQPFVCSSLLQFARQYSRN
EPLTFAWLRRYIKWPLLPPKNIKDLMDLEAVHDVLDLYLWLSYRFMDMFPDASLIRDLQK
ELDGIIQDGVHNITKLIKMSETHKLLNLEGFPSGSQSRLSGTLKSQARRTRGTKALGSKA
TEPPSPDAGELSLASRLVQQGLLTPDMLKQLEKEWMTQQTEHNKEKTESGTHPKGTRRKK
KEPDSD

External Links

GenBank ID Protein

2801555

UniProtKB/Swiss-Prot ID

Q8IYB8

UniProtKB/Swiss-Prot Entry Name

SUV3_HUMAN

PDB IDs