| Identification |
|---|
| HMDB Protein ID
| CDBP00582 |
| Secondary Accession Numbers
| Not Available |
| Name
| Bis(5'-adenosyl)-triphosphatase |
| Description
| Not Available |
| Synonyms
|
- AP3A hydrolase
- AP3Aase
- Diadenosine 5',5'''-P1,P3-triphosphate hydrolase
- Dinucleosidetriphosphatase
- Fragile histidine triad protein
|
| Gene Name
| FHIT |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in catalytic activity |
| Specific Function
| Cleaves A-5'-PPP-5'A to yield AMP and ADP. Possible tumor suppressor for specific tissues.
|
| GO Classification
|
| Biological Process |
| nucleotide metabolic process |
| DNA replication |
| diadenosine triphosphate catabolic process |
| Cellular Component |
| cytosol |
| cytoplasm |
| plasma membrane |
| nucleus |
| intracellular membrane-bounded organelle |
| Function |
| catalytic activity |
| Molecular Function |
| nickel cation binding |
| bis(5'-adenosyl)-triphosphatase activity |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Small cell lung cancer | Not Available |  | | Non-small cell lung cancer | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 3 |
| Locus
| 3p14.2 |
| SNPs
| FHIT |
| Gene Sequence
|
>444 bp
ATGTCGTTCAGATTTGGCCAACATCTCATCAAGCCCTCTGTAGTGTTTCTCAAAACAGAA
CTGTCCTTCGCTCTTGTGAATAGGAAACCTGTGGTACCAGGACATGTCCTTGTGTGCCCG
CTGCGGCCAGTGGAGCGCTTCCATGACCTGCGTCCTGATGAAGTGGCCGATTTGTTTCAG
ACGACCCAGAGAGTCGGGACAGTGGTGGAAAAACATTTCCATGGGACCTCTCTCACCTTT
TCCATGCAGGATGGCCCCGAAGCCGGACAGACTGTGAAGCACGTTCACGTCCATGTTCTT
CCCAGGAAGGCTGGAGACTTTCACAGGAATGACAGCATCTATGAGGAGCTCCAGAAACAT
GACAAGGAGGACTTTCCTGCCTCTTGGAGATCAGAGGAGGAAATGGCAGCAGAAGCCGCA
GCTCTGCGGGTCTACTTTCAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 147 |
| Molecular Weight
| 16858.11 |
| Theoretical pI
| 7.073 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Bis(5'-adenosyl)-triphosphatase
MSFRFGQHLIKPSVVFLKTELSFALVNRKPVVPGHVLVCPLRPVERFHDLRPDEVADLFQ
TTQRVGTVVEKHFHGTSLTFSMQDGPEAGQTVKHVHVHVLPRKAGDFHRNDSIYEELQKH
DKEDFPASWRSEEEMAAEAAALRVYFQ
|
| External Links |
|---|
| GenBank ID Protein
| 261278358 |
| UniProtKB/Swiss-Prot ID
| P49789 |
| UniProtKB/Swiss-Prot Entry Name
| FHIT_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| NM_001166243.1 |
| GeneCard ID
| FHIT |
| GenAtlas ID
| FHIT |
| HGNC ID
| HGNC:3701 |
| References |
|---|
| General References
| Not Available |