| Identification |
|---|
| HMDB Protein ID
| CDBP04307 |
| Secondary Accession Numbers
| Not Available |
| Name
| Rho-related GTP-binding protein RhoU |
| Description
| Not Available |
| Synonyms
|
- CDC42-like GTPase 1
- GTP-binding protein-like 1
- Rho GTPase-like protein ARHU
- Ryu GTPase
- WRCH-1
- Wnt-1 responsive Cdc42 homolog 1
|
| Gene Name
| RHOU |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in GTP binding |
| Specific Function
| Acts upstream of PAK1 to regulate the actin cytoskeleton, adhesion turnover and increase cell migration. Stimulates quiescent cells to reenter the cell cycle. Has no detectable GTPase activity but its high intrinsic guanine nucleotide exchange activity suggests it is constitutively GTP- bound |
| GO Classification
|
| Component |
| cell part |
| intracellular |
| Function |
| purine nucleotide binding |
| binding |
| nucleotide binding |
| guanyl nucleotide binding |
| guanyl ribonucleotide binding |
| gtp binding |
| Process |
| signal transduction |
| intracellular signal transduction |
| small gtpase mediated signal transduction |
| biological regulation |
| regulation of biological process |
| regulation of cellular process |
|
| Cellular Location
|
- Cell membrane
- Lipid-anchor
- Lipid-anchor
- Golgi apparatus membrane
- Cytoplasmic side
- Cell junction
- Cell projection
- focal adhesion
- podosome
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 1q42.11-q42.3 |
| SNPs
| RHOU |
| Gene Sequence
|
>777 bp
ATGCCCCCGCAGCAGGGGGACCCCGCGTTCCCCGACCGCTGCGAGGCGCCTCCGGTGCCG
CCGCGTCGGGAGCGCGGTGGACGCGGGGGACGCGGGCCTGGGGAGCCGGGGGGCCGGGGG
CGTGCGGGGGGTGCCGAGGGGCGCGGCGTCAAGTGCGTGCTGGTCGGCGACGGCGCGGTG
GGCAAGACGAGCCTGGTGGTGAGTTACACCACCAACGGCTACCCCACCGAGTACATCCCT
ACTGCCTTCGACAACTTCTCCGCGGTGGTGTCTGTGGATGGGCGGCCCGTGAGACTCCAA
CTCTGTGACACTGCCGGACAGGATGAATTTGACAAGCTGAGGCCTCTCTGCTACACCAAC
ACAGACATCTTCCTGCTCTGCTTCAGTGTCGTGAGCCCCTCATCCTTCCAGAACGTCAGT
GAGAAATGGGTGCCGGAGATTCGATGCCACTGTCCCAAAGCCCCCATCATCCTAGTTGGA
ACGCAGTCGGATCTCAGAGAAGATGTCAAAGTCCTCATTGAGTTGGACAAATGCAAAGAA
AAGCCAGTGCCTGAAGAGGCGGCTAAGCTGTGCGCCGAGGAAATCAAAGCCGCCTCCTAC
ATCGAGTGTTCAGCCTTGACTCAAAAAAACCTCAAAGAGGTCTTTGATGCAGCCATCGTC
GCTGGCATTCAATACTCGGACACTCAGCAACAGCCAAAGAAGTCTAAAAGCAGGACTCCA
GATAAAATGAAAAACCTCTCCAAGTCCTGGTGGAAGAAGTACTGCTGTTTCGTATGA
|
| Protein Properties |
|---|
| Number of Residues
| 258 |
| Molecular Weight
| 28218.0 |
| Theoretical pI
| 8.14 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Rho-related GTP-binding protein RhoU
MPPQQGDPAFPDRCEAPPVPPRRERGGRGGRGPGEPGGRGRAGGAEGRGVKCVLVGDGAV
GKTSLVVSYTTNGYPTEYIPTAFDNFSAVVSVDGRPVRLQLCDTAGQDEFDKLRPLCYTN
TDIFLLCFSVVSPSSFQNVSEKWVPEIRCHCPKAPIILVGTQSDLREDVKVLIELDKCKE
KPVPEEAAKLCAEEIKAASYIECSALTQKNLKEVFDAAIVAGIQYSDTQQQPKKSKSRTP
DKMKNLSKSWWKKYCCFV
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q7L0Q8 |
| UniProtKB/Swiss-Prot Entry Name
| RHOU_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF378087 |
| GeneCard ID
| RHOU |
| GenAtlas ID
| RHOU |
| HGNC ID
| HGNC:17794 |
| References |
|---|
| General References
| Not Available |