| Identification |
|---|
| HMDB Protein ID
| CDBP03932 |
| Secondary Accession Numbers
| Not Available |
| Name
| Eyes absent homolog 3 |
| Description
| Not Available |
| Synonyms
|
Not Available
|
| Gene Name
| EYA3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in catalytic activity |
| Specific Function
| Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1, and seems to coactivate SIX2, SIX4 and SIX5. The repression of precursor cell proliferation in myoblasts by SIX1 is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex and seems to be dependent on EYA3 phosphatase activity (By similarity). May be involved in development of the eye.
|
| GO Classification
|
| Biological Process |
| response to ionizing radiation |
| double-strand break repair |
| anatomical structure morphogenesis |
| histone dephosphorylation |
| positive regulation of DNA repair |
| visual perception |
| regulation of transcription, DNA-dependent |
| transcription, DNA-dependent |
| multicellular organismal development |
| Cellular Component |
| cytoplasm |
| nucleus |
| transcription factor complex |
| Function |
| catalytic activity |
| Molecular Function |
| protein tyrosine/serine/threonine phosphatase activity |
| metal ion binding |
| chromatin binding |
| protein tyrosine phosphatase activity |
| Process |
| metabolic process |
| multicellular organismal process |
| multicellular organismal development |
|
| Cellular Location
|
- Nucleus
- Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 1 |
| Locus
| 1p36 |
| SNPs
| EYA3 |
| Gene Sequence
|
>1722 bp
ATGGAAGAAGAGCAAGATTTACCAGAGCAACCAGTGAAAAAAGCCAAGATGCAGGAATCA
GGAGAGCAAACTATAAGTCAAGTAAGCAATCCAGATGTCAGTGATCAGAAGCCTGAAACA
TCAAGCCTTGCTTCAAACCTTCCCATGTCAGAGGAAATTATGACATGCACCGATTACATC
CCTCGCTCATCCAATGATTATACCTCACAAATGTATTCTGCAAAACCTTATGCACATATT
CTCTCAGTTCCTGTTTCGGAAACTGCTTACCCTGGACAGACTCAATACCAGACACTACAG
CAGACTCAACCCTATGCTGTCTACCCTCAGGCAACCCAAACGTATGGACTACCTCCTTTT
GGTGCATTGTGGCCAGGTATGAAACCTGAAAGTGGTTTAATTCAGACTCCATCTCCAAGT
CAACACAGTGTTCTTACCTGCACTACAGGGTTAACCACAAGCCAGCCAAGCCCAGCACAT
TATTCTTATCCCATTCAAGCTTCAAGCACAAATGCCAGCCTGATATCTACTTCTTCTACA
ATTGCCAATATTCCAGCAGCAGCAGTAGCCAGCATCTCAAACCAGGATTATCCCACCTAT
ACTATTCTTGGTCAGAATCAGTACCAGGCCTGCTACCCCAGCTCCAGCTTTGGAGTCACA
GGTCAGACTAACAGTGATGCAGAGAGCACCACATTAGCAGCAACCACATACCAGTCGGAG
AAGCCTAGTGTCATGGCGCCTGCACCTGCAGCACAGAGACTTTCCTCTGGAGACCCTTCT
ACAAGTCCATCTTTGTCCCAGACTACACCAAGTAAAGATACTGATGATCAGTCCAGGAAA
AACATGACTAGCAAGAACCGGGGCAAGAGGAAAGCTGATGCCACTTCTTCCCAAGACAGT
GAATTAGAACGGGTATTTCTGTGGGACTTGGATGAAACCATCATCATCTTCCACTCACTT
CTTACTGGATCCTATGCCCAGAAATATGGAAAGGACCCAACAGTAGTGATTGGCTCAGGT
TTAACAATGGAAGAAATGATTTTTGAAGTGGCTGATACTCATCTATTTTTCAATGACTTA
GAGGAGTGTGACCAGGTACATGTGGAAGATGTGGCTTCTGATGACAATGGCCAAGACTTG
AGCAACTACAGTTTCTCAACAGATGGTTTCAGTGGCTCAGGAGGTAGTGGCAGCCATGGT
TCATCTGTGGGTGTTCAGGGAGGTGTGGACTGGATGAGGAAACTAGCTTTCCGCTACCGG
AAAGTGAGAGAAATCTATGATAAGCATAAAAGCAACGTGGGTGGTCTCCTCAGTCCCCAG
AGGAAGGAAGCACTGCAGAGATTAAGAGCAGAAATTGAAGTTTTAACAGATTCCTGGTTA
GGAACTGCATTAAAGTCCTTACTTCTCATCCAGTCCAGAAAGAATTGTGTGAATGTTCTG
ATCACTACCACCCAGCTGGTTCCAGCCCTGGCCAAGGTTCTCCTATATGGACTAGGAGAA
ATATTTCCTATTGAGAACATCTATAGTGCTACCAAAATTGGTAAGGAGAGCTGCTTTGAG
AGAATTGTGTCAAGGTTTGGAAAGAAAGTCACATATGTAGTGATTGGAGATGGACGAGAT
GAAGAAATTGCAGCCAAACAGCACAACATGCCTTTCTGGAGGATCACAAACCATGGAGAC
CTAGTATCCCTTCACCAGGCTTTAGAGCTTGATTTTCTCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 573 |
| Molecular Weight
| 62662.3 |
| Theoretical pI
| 5.213 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Eyes absent homolog 3
MEEEQDLPEQPVKKAKMQESGEQTISQVSNPDVSDQKPETSSLASNLPMSEEIMTCTDYI
PRSSNDYTSQMYSAKPYAHILSVPVSETAYPGQTQYQTLQQTQPYAVYPQATQTYGLPPF
GALWPGMKPESGLIQTPSPSQHSVLTCTTGLTTSQPSPAHYSYPIQASSTNASLISTSST
IANIPAAAVASISNQDYPTYTILGQNQYQACYPSSSFGVTGQTNSDAESTTLAATTYQSE
KPSVMAPAPAAQRLSSGDPSTSPSLSQTTPSKDTDDQSRKNMTSKNRGKRKADATSSQDS
ELERVFLWDLDETIIIFHSLLTGSYAQKYGKDPTVVIGSGLTMEEMIFEVADTHLFFNDL
EECDQVHVEDVASDDNGQDLSNYSFSTDGFSGSGGSGSHGSSVGVQGGVDWMRKLAFRYR
KVREIYDKHKSNVGGLLSPQRKEALQRLRAEIEVLTDSWLGTALKSLLLIQSRKNCVNVL
ITTTQLVPALAKVLLYGLGEIFPIENIYSATKIGKESCFERIVSRFGKKVTYVVIGDGRD
EEIAAKQHNMPFWRITNHGDLVSLHQALELDFL
|
| External Links |
|---|
| GenBank ID Protein
| 26667243 |
| UniProtKB/Swiss-Prot ID
| Q99504 |
| UniProtKB/Swiss-Prot Entry Name
| EYA3_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_001990.2 |
| GeneCard ID
| EYA3 |
| GenAtlas ID
| EYA3 |
| HGNC ID
| HGNC:3521 |
| References |
|---|
| General References
| Not Available |