Identification
HMDB Protein ID CDBP00594
Secondary Accession Numbers Not Available
Name ADP-sugar pyrophosphatase
Description Not Available
Synonyms
  1. Nucleoside diphosphate-linked moiety X motif 5
  2. Nudix motif 5
  3. YSA1H
  4. 8-oxo-dGDP phosphatase
Gene Name NUDT5
Protein Type Enzyme
Biological Properties
General Function Involved in hydrolase activity
Specific Function Hydrolyzes with similar activities ADP-ribose ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP. Can also hydrolyze other nucleotide sugars with low activity.
GO Classification
Biological Process
nucleotide metabolic process
D-ribose catabolic process
ribonucleoside diphosphate catabolic process
Cellular Component
intracellular
Function
catalytic activity
hydrolase activity
Molecular Function
ADP-sugar diphosphatase activity
snoRNA binding
nucleoside-diphosphatase activity
ADP-ribose diphosphatase activity
magnesium ion binding
Cellular Location
  1. Cytoplasmic
Pathways
Gene Properties
Chromosome Location 10
Locus 10p14
SNPs NUDT5
Gene Sequence
>660 bp
ATGGAGAGCCAAGAACCAACGGAATCTTCTCAGAATGGCAAACAGTATATCATTTCAGAG
GAGTTAATTTCAGAAGGAAAATGGGTCAAGCTTGAAAAAACAACGTACATGGATCCTACT
GGTAAAACTAGAACTTGGGAATCAGTGAAACGTACAACCAGGAAAGAGCAGACTGCGGAT
GGTGTCGCGGTCATCCCCGTGCTGCAGAGAACACTTCACTATGAGTGTATCGTTCTGGTG
AAACAGTTCCGACCACCAATGGGGGGCTACTGCATAGAGTTCCCTGCAGGTCTCATAGAT
GATGGTGAAACCCCAGAAGCAGCTGCTCTCCGGGAGCTTGAAGAAGAAACTGGCTACAAA
GGGGACATTGCCGAATGTTCTCCAGCGGTCTGTATGGACCCAGGCTTGTCAAACTGTACT
ATACACATCGTGACAGTCACCATTAACGGAGATGATGCCGAAAACGCAAGGCCGAAGCCA
AAGCCAGGGGATGGAGAGTTTGTGGAAGTCATTTCTTTACCCAAGAATGACCTGCTGCAG
AGACTTGATGCTCTGGTAGCTGAAGAACATCTCACAGTGGACGCCAGGGTCTATTCCTAC
GCTCTAGCGCTGAAACATGCAAATGCAAAGCCATTTGAAGTGCCCTTCTTGAAATTTTAA
Protein Properties
Number of Residues 219
Molecular Weight 24327.41
Theoretical pI 4.937
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>ADP-sugar pyrophosphatase
MESQEPTESSQNGKQYIISEELISEGKWVKLEKTTYMDPTGKTRTWESVKRTTRKEQTAD
GVAVIPVLQRTLHYECIVLVKQFRPPMGGYCIEFPAGLIDDGETPEAAALRELEEETGYK
GDIAECSPAVCMDPGLSNCTIHIVTVTINGDDAENARPKPKPGDGEFVEVISLPKNDLLQ
RLDALVAEEHLTVDARVYSYALALKHANAKPFEVPFLKF
GenBank ID Protein 6288769
UniProtKB/Swiss-Prot ID Q9UKK9
UniProtKB/Swiss-Prot Entry Name NUDT5_HUMAN
PDB IDs
GenBank Gene ID AF155832
GeneCard ID NUDT5
GenAtlas ID NUDT5
HGNC ID HGNC:8052
References
General References Not Available