| Identification |
|---|
| HMDB Protein ID
| CDBP04017 |
| Secondary Accession Numbers
| Not Available |
| Name
| Ribonuclease H1 |
| Description
| Not Available |
| Synonyms
|
- RNase H1
- Ribonuclease H type II
|
| Gene Name
| RNASEH1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in nucleic acid binding |
| Specific Function
| Endonuclease that specifically degrades the RNA of RNA- DNA hybrids |
| GO Classification
|
| Function |
| metal ion binding |
| hydrolase activity, acting on ester bonds |
| binding |
| catalytic activity |
| endoribonuclease activity, producing 5'-phosphomonoesters |
| hydrolase activity |
| ribonuclease h activity |
| magnesium ion binding |
| nucleic acid binding |
| nuclease activity |
| endonuclease activity |
| endoribonuclease activity |
| ion binding |
| cation binding |
|
| Cellular Location
|
- Cytoplasm (Potential)
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:2 |
| Locus
| 2p25 |
| SNPs
| RNASEH1 |
| Gene Sequence
|
>861 bp
ATGAGCTGGCTTCTGTTCCTGGCCCACAGAGTCGCCTTGGCCGCCTTGCCCTGCCGCCGC
GGCTCTCGCGGGTTCGGGATGTTCTATGCCGTGAGGAGGGGCCGCAAGACCGGGGTCTTT
CTGACCTGGAATGAGTGCAGAGCACAGGTGGACCGGTTTCCTGCTGCCAGATTTAAGAAG
TTTGCCACAGAGGATGAGGCCTGGGCCTTTGTCAGGAAATCTGCAAGCCCGGAAGTTTCA
GAAGGGCATGAAAATCAACATGGACAAGAATCGGAGGCGAAAGCCAGCAAGCGACTCCGT
GAGCCACTGGATGGAGATGGACATGAAAGCGCAGAGCCGTATGCAAAGCACATGAAGCCG
AGCGTGGAGCCGGCGCCTCCAGTTAGCAGAGACACGTTTTCCTACATGGGAGACTTCGTC
GTCGTCTACACTGATGGCTGCTGCTCCAGTAATGGGCGTAGAAGGCCGCGAGCAGGAATC
GGCGTTTACTGGGGGCCAGGCCATCCTTTAAATGTAGGCATTAGACTTCCTGGGCGGCAG
ACAAACCAAAGAGCGGAAATTCATGCAGCCTGCAAAGCCATTGAACAAGCAAAGACTCAA
AACATCAATAAACTGGTTCTGTATACAGACAGTATGTTTACGATAAATGGTATAACTAAC
TGGGTTCAAGGTTGGAAGAAAAATGGGTGGAAGACAAGTGCAGGGAAAGAGGTGATCAAC
AAAGAGGACTTTGTGGCACTGGAGAGGCTTACCCAGGGGATGGACATTCAGTGGATGCAT
GTTCCTGGTCATTCGGGATTTATAGGCAATGAAGAAGCTGACAGATTAGCCAGAGAAGGA
GCTAAACAATCGGAAGACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 286 |
| Molecular Weight
| 32064.0 |
| Theoretical pI
| 9.6 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Ribonuclease H1
MSWLLFLAHRVALAALPCRRGSRGFGMFYAVRRGRKTGVFLTWNECRAQVDRFPAARFKK
FATEDEAWAFVRKSASPEVSEGHENQHGQESEAKASKRLREPLDGDGHESAEPYAKHMKP
SVEPAPPVSRDTFSYMGDFVVVYTDGCCSSNGRRRPRAGIGVYWGPGHPLNVGIRLPGRQ
TNQRAEIHAACKAIEQAKTQNINKLVLYTDSMFTINGITNWVQGWKKNGWKTSAGKEVIN
KEDFVALERLTQGMDIQWMHVPGHSGFIGNEEADRLAREGAKQSED
|
| External Links |
|---|
| GenBank ID Protein
| 62420309 |
| UniProtKB/Swiss-Prot ID
| O60930 |
| UniProtKB/Swiss-Prot Entry Name
| RNH1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AC108488 |
| GeneCard ID
| RNASEH1 |
| GenAtlas ID
| RNASEH1 |
| HGNC ID
| HGNC:18466 |
| References |
|---|
| General References
| Not Available |