| Identification |
|---|
| HMDB Protein ID
| CDBP04028 |
| Secondary Accession Numbers
| Not Available |
| Name
| Serine/threonine-protein kinase 36 |
| Description
| Not Available |
| Synonyms
|
- Fused homolog
|
| Gene Name
| STK36 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in binding |
| Specific Function
| Serine/threonine protein kinase required for postnatal development, possibly by regulating the homeostasis of cerebral spinal fluid or ciliary function. Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization. GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur |
| GO Classification
|
| Function |
| protein kinase activity |
| protein serine/threonine kinase activity |
| binding |
| catalytic activity |
| transferase activity |
| transferase activity, transferring phosphorus-containing groups |
| kinase activity |
| nucleoside binding |
| purine nucleoside binding |
| adenyl nucleotide binding |
| adenyl ribonucleotide binding |
| atp binding |
| Process |
| phosphorus metabolic process |
| phosphate metabolic process |
| metabolic process |
| cellular metabolic process |
| protein amino acid phosphorylation |
| phosphorylation |
|
| Cellular Location
|
- Nucleus
- Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:2 |
| Locus
| 2q35 |
| SNPs
| STK36 |
| Gene Sequence
|
>3948 bp
ATGGAAAAGTACCACGTGTTGGAGATGATTGGAGAAGGCTCTTTTGGGAGGGTGTACAAG
GGTCGAAGAAAATACAGTGCTCAGGTCGTGGCCCTGAAGTTCATCCCAAAATTGGGGCGC
TCAGAGAAGGAGCTGAGGAATTTGCAACGAGAGATTGAAATAATGCGGGGTCTGCGGCAT
CCCAACATTGTGCATATGCTTGACAGCTTTGAAACTGATAAAGAGGTGGTGGTGGTGACA
GACTATGCTGAGGGAGAGCTCTTTCAGATCCTAGAAGATGACGGAAAACTTCCTGAAGAC
CAGGTTCAGGCCATTGCTGCCCAGTTGGTGTCAGCCCTGTACTATCTGCATTCCCACCGC
ATCCTACACCGAGATATGAAGCCTCAGAACATCCTCCTCGCCAAGGGTGGTGGCATCAAG
CTCTGTGACTTTGGATTTGCCCGGGCTATGAGCACCAATACAATGGTGCTGACATCCATC
AAAGGCACACCACTCTATATGTCTCCAGAGCTGGTGGAGGAGCGACCATACGACCACACA
GCGGACCTCTGGTCTGTTGGCTGCATACTATATGAACTGGCAGTAGGCACCCCTCCCTTC
TATGCTACAAGCATCTTTCAGCTGGTCAGCCTCATTCTCAAGGACCCTGTGCGCTGGCCC
TCAACCATCAGTCCCTGCTTTAAGAACTTCCTGCAGGGACTGCTCACCAAAGACCCACGG
CAGCGACTGTCCTGGCCAGACCTCTTATATCACCCCTTTATTGCTGGTCATGTCACCATA
ATAACTGAGCCAGCAGGCCCAGATTTGGGGACCCCATTCACCAGCCGCCTACCCCCAGAA
CTTCAGGTCCTAAAGGACGAACAGGCCCATCGGTTGGCCCCCAAGGGTAATCAGTCTCGC
ATCTTGACTCAGGCCTATAAACGCATGGCTGAGGAGGCCATGCAGAAGAAACATCAGAAC
ACAGGACCTGCCCTTGAGCAAGAGGACAAGACCAGCAAGGTGGCTCCTGGCACAGCCCCT
CTGCCCAGACTCGGGGCCACTCCTCAGGAATCAAGCCTCCTGGCCGGGATCTTAGCCTCA
GAATTGAAGAGCAGCTGGGCTAAATCAGGGACTGGAGAGGTGCCCTCTGCACCTCGGGAA
AACCGGACCACCCCAGATTGTGAACGAGCATTCCCAGAGGAGAGGCCAGAGGTGCTGGGC
CAGCGGAGCACTGATGTAGTGGACCTGGAAAATGAGGAGCCAGACAGTGACAATGAGTGG
CAGCACCTGCTAGAGACCACTGAGCCTGTGCCTATTCAACTGAAGGCTCCTCTCACCTTG
CTGTGTAATCCTGACTTCTGCCAGCGCATCCAGAGTCAGCTGCATGAAGCTGGAGGGCAG
ATCCTGAAAGGCATCTTGGAGGGTGCTTCCCACATCCTGCCTGCATTCCGGGTCCTGAGC
AGTCTTCTCTCCAGCTGCAGTGATTCTGTTGCCTTGTATTCCTTCTGCCGGGAGGCAGGG
CTTCCTGGGCTGCTGCTGAGTCTACTCAGGCACAGTCAGGAGAGCAACAGCCTCCAGCAG
CAATCTTGGTATGGGACCTTCTTACAGGACCTGATGGCTGTGATTCAGGCCTACTTTGCC
TGTACCTTCAATCTGGAGAGGAGCCAGACAAGTGACAGCCTGCAGGTGTTTCAGGAGGCT
GCCAACCTTTTTCTGGACCTGTTGGGGAAACTGCTGGCCCAACCAGATGACTCTGAGCAG
ACTTTGCGGAGGGACAGCCTTATGTGCTTTACTGTCCTGTGCGAAGCCATGGATGGGAAC
AGCCGGGCCATCTCCAAAGCCTTTTACTCCAGCTTGCTGACGACACAGCAGGTTGTCTTG
GATGGGCTCCTTCATGGCTTGACAGTTCCACAGCTCCCTGTCCACACTCCCCAAGGAGCC
CCGCAAGTGAGCCAGCCACTGCGAGAGCAGAGTGAGGATATACCTGGAGCCATTTCCTCT
GCCCTGGCAGCCATATGCACTGCTCCTGTGGGACTGCCCGACTGCTGGGATGCCAAGGAG
CAGGTCTGTTGGCATTTGGCAAATCAGCTAACTGAAGACAGCAGCCAGCTCAGGCCATCC
CTCATCTCTGGCCTGCAGCATCCCATCCTGTGCCTGCACCTTCTCAAGGTTCTATACTCC
TGCTGCCTTGTCAGTGAGGGCCTGTGCCGTCTTCTGGGGCAGGAGCCCCTGGCCTTGGAA
TCCCTGTTTATGTTGATTCAGGGCAAGGTAAAAGTAGTAGATTGGGAAGAGTCTACTGAA
GTGACACTCTACTTCCTCTCCCTTCTTGTCTTTCGGCTCCAAAACCTGCCTTGTGGAATG
GAGAAGCTAGGCAGTGACGTTGCTACTCTCTTTACCCATTCGCATGTCGTCTCTCTTGTG
AGTGCAGCAGCCTGTCTATTGGGACAGCTTGGTCAGCAAGGGGTGACCTTTGACCTCCAG
CCCATGGAATGGATGGCTGCAGCCACACATGCCTTGTCTGCCCCTGCAGAGGTTCGGTTG
ACTCCACCAGGTAGTTGTGGATTCTATGATGGCCTCCTTATCCTTCTGTTGCAGCTCCTC
ACTGAGCAGGGGAAGGCTAGCCTAATCAGGGATATGTCCAGTTCAGAAATGTGGACCGTT
TTGTGGCACCGCTTCTCCATGGTCCTGAGGCTCCCCGAGGAGGCATCTGCACAGGAAGGG
GAGCTTTCGCTATCCAGTCCACCAAGCCCTGAGCCAGACTGGACACTGATTTCTCCCCAG
GGCATGGCAGCCCTGCTGAGCCTGGCCATGGCCACCTTTACCCAGGAGCCCCAGTTATGC
CTGAGCTGCCTGTCCCAGCATGGAAGTATCCTCATGTCCATCCTGAAGCATCTGCTTTGC
CCCAGCTTCCTGAATCAACTGCGCCAGGCGCCTCATGGGTCTGAGTTTCTCCCTGTCGTG
GTGCTCTCTGTCTGCCAGCTCCTTTGCTTCCCCTTTGCGCTGGACATGGATGCTGACCTC
CTTATAGGTGTCTTGGCCGACCTCAGGGACTCAGAAGTTGCAGCCCATCTGCTGCAGGTC
TGCTGCTACCATCTTCCGTTGATGCAAGTGGAGCTGCCCATCAGCCTTCTCACACGCCTG
GCCCTCATGGATCCCACCTCTCTCAACCAGTTTGTGAACACAGTGTCTGCCTCCCCTAGA
ACCATCGTCTCGTTTCTCTCAGTTGCCCTCCTGAGTGACCAGCCACTGTTGACCTCCGAC
CTTCTCTCTCTGCTGGCCCATACTGCCAGGGTCCTGTCTCCCAGCCACTTGTCCTTTATC
CAAGAGCTTCTGGCTGGCTCTGATGAATCCTATCGGCCCCTGCGCAGCCTCCTGGGCCAC
CCAGAGAATTCTGTGCGGGCACACACTTATAGGCTCCTGGGACACTTGCTCCAACACAGC
ATGGCCCTGCGTGGGGCACTGCAGAGCCAGTCTGGACTGCTCAGCCTTCTGCTGCTTGGG
CTTGGAGACAAGGATCCTGTTGTGCGGTGCAGTGCCAGCTTTGCTGTGGGCAATGCAGCC
TACCAGGCTGGTCCTCTGGGACCTGCCCTGGCAGCTGCAGTGCCCAGTATGACCCAGCTG
CTTGGAGATCCTCAGGCTGGTATCCGGCGCAATGTTGCATCAGCTCTGGGCAACTTGGGA
CCTGAAGGTTTGGGAGAGGAGCTGTTACAGTGCGAAGTACCCCAGCGGCTCCTAGAAATG
GCATGTGGAGACCCCCAGCCAAATGTGAAGGAGGCTGCCCTCATTGCCCTCCGGAGCCTG
CAACAGGAGCCTGGCATCCATCAGGTACTGGTGTCCCTGGGTGCCAGTGAGAAACTATCC
TTGCTCTCTCTGGGGAATCAGTCACTGCCACACAGCAGTCCTAGGCCTGCCTCTGCCAAA
CACTGCAGGAAACTCATTCACCTCCTGAGGCCAGCCCATAGCATGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 1315 |
| Molecular Weight
| 143993.6 |
| Theoretical pI
| 5.77 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Serine/threonine-protein kinase 36
MEKYHVLEMIGEGSFGRVYKGRRKYSAQVVALKFIPKLGRSEKELRNLQREIEIMRGLRH
PNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPEDQVQAIAAQLVSALYYLHSHR
ILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTSIKGTPLYMSPELVEERPYDHT
ADLWSVGCILYELAVGTPPFYATSIFQLVSLILKDPVRWPSTISPCFKNFLQGLLTKDPR
QRLSWPDLLYHPFIAGHVTIITEPAGPDLGTPFTSRLPPELQVLKDEQAHRLAPKGNQSR
ILTQAYKRMAEEAMQKKHQNTGPALEQEDKTSKVAPGTAPLPRLGATPQESSLLAGILAS
ELKSSWAKSGTGEVPSAPRENRTTPDCERAFPEERPEVLGQRSTDVVDLENEEPDSDNEW
QHLLETTEPVPIQLKAPLTLLCNPDFCQRIQSQLHEAGGQILKGILEGASHILPAFRVLS
SLLSSCSDSVALYSFCREAGLPGLLLSLLRHSQESNSLQQQSWYGTFLQDLMAVIQAYFA
CTFNLERSQTSDSLQVFQEAANLFLDLLGKLLAQPDDSEQTLRRDSLMCFTVLCEAMDGN
SRAISKAFYSSLLTTQQVVLDGLLHGLTVPQLPVHTPQGAPQVSQPLREQSEDIPGAISS
ALAAICTAPVGLPDCWDAKEQVCWHLANQLTEDSSQLRPSLISGLQHPILCLHLLKVLYS
CCLVSEGLCRLLGQEPLALESLFMLIQGKVKVVDWEESTEVTLYFLSLLVFRLQNLPCGM
EKLGSDVATLFTHSHVVSLVSAAACLLGQLGQQGVTFDLQPMEWMAAATHALSAPAEVRL
TPPGSCGFYDGLLILLLQLLTEQGKASLIRDMSSSEMWTVLWHRFSMVLRLPEEASAQEG
ELSLSSPPSPEPDWTLISPQGMAALLSLAMATFTQEPQLCLSCLSQHGSILMSILKHLLC
PSFLNQLRQAPHGSEFLPVVVLSVCQLLCFPFALDMDADLLIGVLADLRDSEVAAHLLQV
CCYHLPLMQVELPISLLTRLALMDPTSLNQFVNTVSASPRTIVSFLSVALLSDQPLLTSD
LLSLLAHTARVLSPSHLSFIQELLAGSDESYRPLRSLLGHPENSVRAHTYRLLGHLLQHS
MALRGALQSQSGLLSLLLLGLGDKDPVVRCSASFAVGNAAYQAGPLGPALAAAVPSMTQL
LGDPQAGIRRNVASALGNLGPEGLGEELLQCEVPQRLLEMACGDPQPNVKEAALIALRSL
QQEPGIHQVLVSLGASEKLSLLSLGNQSLPHSSPRPASAKHCRKLIHLLRPAHSM
|
| External Links |
|---|
| GenBank ID Protein
| 217330634 |
| UniProtKB/Swiss-Prot ID
| Q9NRP7 |
| UniProtKB/Swiss-Prot Entry Name
| STK36_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_015690.3 |
| GeneCard ID
| STK36 |
| GenAtlas ID
| STK36 |
| HGNC ID
| HGNC:17209 |
| References |
|---|
| General References
| Not Available |