Identification
HMDB Protein ID CDBP04007
Secondary Accession Numbers Not Available
Name Protein phosphatase 1K, mitochondrial
Description Not Available
Synonyms
  1. PP2C domain-containing protein phosphatase 1K
  2. PP2C-kappa
  3. PP2C-like mitochondrial protein
  4. PP2C-type mitochondrial phosphoprotein phosphatase
  5. PTMP
  6. Protein phosphatase 2C isoform kappa
Gene Name PPM1K
Protein Type Enzyme
Biological Properties
General Function Involved in catalytic activity
Specific Function Regulates the mitochondrial permeability transition pore and is essential for cellular survival and development.
GO Classification
Biological Process
protein dephosphorylation
Cellular Component
mitochondrial matrix
mitochondrion
Component
macromolecular complex
protein complex
protein serine/threonine phosphatase complex
Function
phosphatase activity
protein serine/threonine phosphatase activity
phosphoprotein phosphatase activity
hydrolase activity, acting on ester bonds
catalytic activity
hydrolase activity
phosphoric ester hydrolase activity
Molecular Function
protein serine/threonine phosphatase activity
metal ion binding
Process
phosphorus metabolic process
phosphate metabolic process
dephosphorylation
protein amino acid dephosphorylation
metabolic process
cellular metabolic process
Cellular Location
  1. Mitochondrion matrix
Pathways
Gene Properties
Chromosome Location 4
Locus 4q22.1
SNPs PPM1K
Gene Sequence
>1119 bp
ATGTCAACAGCTGCCTTAATTACTTTGGTCAGAAGTGGTGGGAACCAGGTGAGAAGGAGA
GTGCTGCTAAGCTCCCGCCTGCTGCAGGACGACAGGCGGGTGACACCCACGTGCCACAGC
TCCACTTCAGAGCCTAGGTGTTCTCGGTTTGACCCAGATGGTAGTGGGAGTCCAGCTACC
TGGGACAATTTTGGGATCTGGGATAACCGCATTGATGAGCCAATTCTGCTGCCACCCAGC
ATTAAGTATGGCAAGCCAATTCCCAAAATCAGCTTGGAAAATGTGGGGTGCGCCTCACAG
ATTGGCAAACGGAAAGAGAATGAAGATCGGTTTGACTTCGCTCAGCTGACAGATGAGGTC
CTGTACTTTGCAGTGTATGATGGACACGGTGGACCTGCAGCAGCTGATTTCTGTCATACC
CACATGGAGAAATGTATTATGGATTTGCTTCCTAAGGAGAAGAACTTGGAAACTCTGTTG
ACCTTGGCTTTTCTAGAAATAGATAAAGCCTTTTCGAGTCATGCCCGCCTGTCTGCTGAT
GCAACTCTTCTGACCTCTGGGACTACTGCAACAGTAGCCCTATTGCGAGATGGTATTGAA
CTGGTTGTAGCCAGTGTTGGGGACAGCCGGGCTATTTTGTGTAGAAAAGGAAAACCCATG
AAGCTGACCATTGACCATACTCCAGAAAGAAAAGATGAAAAAGAAAGGATCAAGAAATGT
GGTGGTTTTGTAGCTTGGAATAGTTTGGGGCAGCCTCACGTAAATGGCAGGCTTGCAATG
ACAAGAAGTATTGGAGATTTGGACCTTAAGACCAGTGGTGTCATAGCAGAACCTGAAACT
AAGAGGATTAAGTTACATCATGCTGATGACAGCTTCCTGGTCCTCACCACAGATGGAATT
AACTTCATGGTGAATAGTCAAGAGATTTGTGACTTTGTCAATCAGTGCCATGATCCCAAC
GAAGCAGCCCATGCGGTGACTGAACAGGCAATACAGTACGGTACTGAGGATAACAGTACT
GCAGTAGTAGTGCCTTTTGGTGCCTGGGGAAAATATAAGAACTCTGAAATCAACTTCTCA
TTCAGCAGAAGCTTTGCCTCCAGTGGACGATGGGCCTGA
Protein Properties
Number of Residues 372
Molecular Weight 40996.965
Theoretical pI 6.742
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Protein phosphatase 1K, mitochondrial
MSTAALITLVRSGGNQVRRRVLLSSRLLQDDRRVTPTCHSSTSEPRCSRFDPDGSGSPAT
WDNFGIWDNRIDEPILLPPSIKYGKPIPKISLENVGCASQIGKRKENEDRFDFAQLTDEV
LYFAVYDGHGGPAAADFCHTHMEKCIMDLLPKEKNLETLLTLAFLEIDKAFSSHARLSAD
ATLLTSGTTATVALLRDGIELVVASVGDSRAILCRKGKPMKLTIDHTPERKDEKERIKKC
GGFVAWNSLGQPHVNGRLAMTRSIGDLDLKTSGVIAEPETKRIKLHHADDSFLVLTTDGI
NFMVNSQEICDFVNQCHDPNEAAHAVTEQAIQYGTEDNSTAVVVPFGAWGKYKNSEINFS
FSRSFASSGRWA
GenBank ID Protein 167466276
UniProtKB/Swiss-Prot ID Q8N3J5
UniProtKB/Swiss-Prot Entry Name PPM1K_HUMAN
PDB IDs
GenBank Gene ID NM_152542.3
GeneCard ID PPM1K
GenAtlas ID PPM1K
HGNC ID HGNC:25415
References
General References Not Available