Cannabis Compound Database: Showing Protein Ribosomal protein S6 kinase alpha-2 (CDBP01089)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 compounds

Identification

HMDB Protein ID

CDBP01089

Secondary Accession Numbers

Not Available

Name

Ribosomal protein S6 kinase alpha-2

Description

Not Available

Synonyms

90 kDa ribosomal protein S6 kinase 2
MAP kinase-activated protein kinase 1c
MAPK-activated protein kinase 1c
MAPKAP kinase 1c
MAPKAPK-1c
RSK-3
Ribosomal S6 kinase 3
S6K-alpha-2
p90-RSK 2
p90RSK2
pp90RSK3

Gene Name

RPS6KA2

Protein Type

Enzyme

Biological Properties

General Function

Involved in protein serine/threonine kinase activity

Specific Function

Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB

GO Classification

Function
protein kinase activity
protein serine/threonine kinase activity
ion binding
cation binding
metal ion binding
binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
adenyl ribonucleotide binding
atp binding
magnesium ion binding
Process
phosphorus metabolic process
phosphate metabolic process
metabolic process
signaling process
signal transmission
cellular metabolic process
protein amino acid phosphorylation
phosphorylation
signal transmission via phosphorylation event
intracellular protein kinase cascade

Cellular Location

Nucleus

Pathways

Not Available

Gene Properties

Chromosome Location

Chromosome:6

Locus

6q27

SNPs

RPS6KA2

Gene Sequence

>2202 bp
ATGGACCTGAGCATGAAGAAGTTCGCCGTGCGCAGGTTCTTCTCTGTGTACCTGCGCAGG
AAGTCGCGCTCCAAGAGCTCCAGCCTGAGCCGGCTCGAGGAAGAAGGCGTCGTGAAGGAG
ATAGACATCAGCCATCATGTGAAGGAGGGCTTTGAGAAGGCAGATCCTTCCCAGTTTGAG
CTGCTGAAGGTTTTAGGACAAGGATCCTATGGAAAGGTGTTCCTGGTGAGGAAGGTGAAG
GGGTCCGACGCTGGGCAGCTCTACGCCATGAAGGTCCTTAAGAAAGCCACCCTAAAAGTT
CGGGACCGAGTGAGATCGAAGATGGAGAGAGACATCTTGGCAGAAGTGAATCACCCCTTC
ATTGTGAAGCTTCATTATGCCTTTCAGACGGAAGGAAAGCTCTACCTGATCCTGGACTTC
CTGCGGGGAGGGGACCTCTTCACCCGGCTCTCCAAAGAGGTCATGTTCACGGAGGAGGAT
GTCAAGTTCTACCTGGCTGAGCTGGCCTTGGCTTTAGACCATCTCCACAGCCTGGGGATC
ATCTACAGAGATCTGAAGCCTGAGAACATCCTCCTGGATGAAGAGGGGCACATTAAGATC
ACAGATTTCGGCCTGAGTAAGGAGGCCATTGACCACGACAAGAGAGCGTACTCCTTCTGC
GGGACGATCGAGTACATGGCGCCCGAGGTGGTGAACCGGCGAGGACACACGCAGAGTGCC
GACTGGTGGTCCTTCGGCGTGCTCATGTTTGAGATGCTCACGGGGTCCCTGCCGTTCCAG
GGGAAGGACAGGAAGGAGACCATGGCTCTCATCCTCAAAGCCAAGCTGGGGATGCCGCAG
TTCCTCAGTGGGGAGGCACAGAGTTTGCTGCGAGCTCTCTTCAAACGGAACCCCTGCAAC
CGGCTGGGTGCTGGCATTGACGGAGTGGAGGAAATTAAGCGCCATCCCTTCTTTGTGACC
ATAGACTGGAACACGCTGTACCGGAAGGAGATCAAGCCACCGTTCAAACCAGCAGTGGGC
AGGCCTGAGGACACCTTCCACTTTGACCCCGAGTTCACAGCGCGGACGCCCACAGACTCT
CCTGGCGTCCCCCCGAGTGCAAACGCTCATCACCTGTTTAGAGGATTCAGCTTTGTGGCC
TCAAGCCTGATCCAGGAGCCCTCACAGCAAGATCTGCACAAAGTCCCAGTTCACCCAATC
GTGCAGCAGTTACACGGGAACAACATCCACTTCACCGATGGCTACGAGATCAAGGAGGAC
ATCGGGGTGGGCTCCTACTCAGTGTGCAAGCGATGTGTGCATAAAGCCACAGACACCGAG
TATGCCGTGAAGATCATTGATAAGAGCAAGAGAGACCCCTCGGAAGAGATTGAGATCCTC
CTGCGGTACGGCCAGCACCCGAACATCATCACCCTCAAGGATGTCTATGATGATGGCAAG
TTTGTGTACCTGGTAATGGAGCTGATGCGTGGTGGGGAGCTCCTGGACCGCATCCTCCGG
CAGAGATACTTCTCGGAGCGCGAAGCCAGTGACGTCCTGTGCACCATCACCAAGACCATG
GACTACCTCCATTCCCAGGGGGTTGTTCATCGAGACCTGAAGCCGAGTAACATCCTGTAC
AGGGATGAGTCGGGGAGCCCAGAATCCATCCGAGTCTGCGACTTCGGCTTTGCCAAGCAG
CTGCGCGCGGGGAACGGGCTGCTCATGACACCCTGCTACACGGCCAATTTCGTGGCCCCG
GAGGTCCTGAAGCGTCAAGGCTATGATGCGGCGTGTGACATCTGGAGTTTGGGGATCCTG
TTGTACACCATGCTGGCAGGATTTACCCCTTTTGCAAATGGGCCAGACGATACCCCTGAG
GAGATTCTGGCGCGGATCGGCAGTGGGAAGTATGCCCTTTCTGGGGGAAACTGGGACTCG
ATATCTGACGCAGCTAAAGACGTCGTGTCCAAGATGCTCCACGTGGACCCTCATCAGCGC
CTGACGGCGATGCAAGTGCTCAAACACCCGTGGGTGGTCAACAGAGAGTACCTGTCCCCA
AACCAGCTCAGCCGACAGGACGTGCACCTGGTGAAGGGCGCGATGGCCGCCACCTACTTT
GCTCTAAACAGAACACCTCAGGCCCCGCGGCTGGAGCCCGTGCTGTCATCCAACCTGGCT
CAGCGCAGAGGCATGAAGAGACTCACGTCCACGCGGCTGTAG

Protein Properties

Number of Residues

733

Molecular Weight

83238.0

Theoretical pI

8.96

Pfam Domain Function

Pkinase (PF00069 )
Pkinase_C (PF00433 )

Signals

["None"]

Transmembrane Regions

["None"]

Protein Sequence

>Ribosomal protein S6 kinase alpha-2
MDLSMKKFAVRRFFSVYLRRKSRSKSSSLSRLEEEGVVKEIDISHHVKEGFEKADPSQFE
LLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKMERDILAEVNHPF
IVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGI
IYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVNRRGHTQSA
DWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSGEAQSLLRALFKRNPCN
RLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFHFDPEFTARTPTDS
PGVPPSANAHHLFRGFSFVASSLIQEPSQQDLHKVPVHPIVQQLHGNNIHFTDGYEIKED
IGVGSYSVCKRCVHKATDTEYAVKIIDKSKRDPSEEIEILLRYGQHPNIITLKDVYDDGK
FVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDLKPSNILY
RDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGIL
LYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPHQR
LTAMQVLKHPWVVNREYLSPNQLSRQDVHLVKGAMAATYFALNRTPQAPRLEPVLSSNLA
QRRGMKRLTSTRL

External Links

GenBank ID Protein

19923570

UniProtKB/Swiss-Prot ID

Q15349

UniProtKB/Swiss-Prot Entry Name

KS6A2_HUMAN

PDB IDs

Not Available

GenBank Gene ID

NM_021135.4

GeneCard ID