Cannabis Compound Database: Showing Protein Nucleoside diphosphate kinase 3 (CDBP00109)

Identification Biological properties Gene properties Protein properties External links References XML Show 13 compounds

Identification

HMDB Protein ID

CDBP00109

Secondary Accession Numbers

Not Available

Name

Nucleoside diphosphate kinase 3

Description

Not Available

Synonyms

DR-nm23
NDK 3
NDP kinase 3
NDPKC
Nucleoside diphosphate kinase C
nm23-H3

Gene Name

NME3

Protein Type

Enzyme

Biological Properties

General Function

Involved in nucleoside diphosphate kinase activity

Specific Function

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Probably has a role in normal hematopoiesis by inhibition of granulocyte differentiation and induction of apoptosis.

GO Classification

Biological Process
apoptotic process
CTP biosynthetic process
GTP biosynthetic process
UTP biosynthetic process
induction of apoptosis
Cellular Component
mitochondrion
Function
transferase activity, transferring phosphorus-containing groups
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
adenyl ribonucleotide binding
atp binding
nucleoside diphosphate kinase activity
binding
catalytic activity
phosphotransferase activity, phosphate group as acceptor
transferase activity
Molecular Function
metal ion binding
ATP binding
nucleoside diphosphate kinase activity
Process
purine ribonucleoside triphosphate biosynthetic process
gtp biosynthetic process
metabolic process
nitrogen compound metabolic process
cellular nitrogen compound metabolic process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
nucleobase, nucleoside and nucleotide metabolic process
nucleoside phosphate metabolic process
nucleotide metabolic process
pyrimidine nucleotide metabolic process
ctp biosynthetic process
pyrimidine nucleotide biosynthetic process
pyrimidine nucleoside triphosphate biosynthetic process
pyrimidine ribonucleoside triphosphate biosynthetic process
utp biosynthetic process
purine nucleotide metabolic process
purine nucleotide biosynthetic process
purine nucleoside triphosphate biosynthetic process

Cellular Location

Not Available

Pathways

Not Available

Gene Properties

Chromosome Location

Locus

16q13.3

SNPs

NME3

Gene Sequence

>510 bp
ATGATCTGCCTGGTGCTGACCATCTTCGCTAACCTCTTCCCCGCGGCCTGCACCGGCGCA
CACGAACGCACCTTCCTGGCCGTGAAGCCGGACGGCGTGCAGCGGCGGCTGGTGGGCGAG
ATTGTGCGGCGCTTCGAGAGGAAGGGCTTCAAGTTGGTGGCGCTGAAGCTGGTGCAGGCC
TCCGAGGAGCTGCTGCGTGAGCACTACGCCGAGCTGCGTGAACGCCCGTTCTACGGCCGC
CTTGTCAAGTATATGGCCTCCGGGCCGGTGGTGGCCATGGTTTGGCAGGGGCTGGACGTG
GTGCGCACCTCGCGGGCGCTCATCGGAGCCACGAACCCGGCCGACGCCCCGCCCGGCACC
ATCCGCGGGGATTTCTGCATCGAGGTTGGCAAGAACCTGATTCACGGCAGCGACTCGGTG
GAGAGTGCCCGCCGCGAGATCGCTCTCTGGTTCCGCGCAGACGAGCTCCTCTGCTGGGAG
GACAGCGCTGGGCACTGGCTGTATGAGTAG

Protein Properties

Number of Residues

169

Molecular Weight

19014.85

Theoretical pI

7.834

Pfam Domain Function

NDK (PF00334 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Nucleoside diphosphate kinase 3
MICLVLTIFANLFPAACTGAHERTFLAVKPDGVQRRLVGEIVRRFERKGFKLVALKLVQA
SEELLREHYAELRERPFYGRLVKYMASGPVVAMVWQGLDVVRTSRALIGATNPADAPPGT
IRGDFCIEVGKNLIHGSDSVESARREIALWFRADELLCWEDSAGHWLYE

External Links

GenBank ID Protein

14336763

UniProtKB/Swiss-Prot ID

Q13232

UniProtKB/Swiss-Prot Entry Name

NDK3_HUMAN

PDB IDs