| Identification |
|---|
| HMDB Protein ID
| CDBP00889 |
| Secondary Accession Numbers
| Not Available |
| Name
| Protein O-mannosyl-transferase 1 |
| Description
| Not Available |
| Synonyms
|
- Dolichyl-phosphate-mannose--protein mannosyltransferase 1
|
| Gene Name
| POMT1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in mannosyltransferase activity |
| Specific Function
| Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. Coexpression of both POMT1 and POMT2 is necessary for enzyme activity, expression of either POMT1 or POMT2 alone is insufficient.
|
| GO Classification
|
| Biological Process |
| multicellular organismal development |
| extracellular matrix organization |
| protein O-linked glycosylation |
| Cellular Component |
| sarcoplasmic reticulum |
| acrosomal vesicle |
| integral to membrane |
| endoplasmic reticulum membrane |
| Component |
| membrane |
| cell part |
| Function |
| catalytic activity |
| transferase activity |
| mannosyltransferase activity |
| transferase activity, transferring hexosyl groups |
| transferase activity, transferring glycosyl groups |
| Molecular Function |
| metal ion binding |
| mannosyltransferase activity |
| dolichyl-phosphate-mannose-protein mannosyltransferase activity |
| Process |
| macromolecule modification |
| protein modification process |
| protein amino acid glycosylation |
| metabolic process |
| macromolecule metabolic process |
| protein amino acid o-linked glycosylation |
|
| Cellular Location
|
- Endoplasmic reticulum membrane
- Multi-pass membrane protein
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | protein glycosylation | Not Available | Not Available | | Other types of O-glycan biosynthesis | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 9 |
| Locus
| 9q34.1 |
| SNPs
| POMT1 |
| Gene Sequence
|
>2244 bp
ATGTGGGGATTTTTGAAGCGCCCTGTAGTGGTGACGGCTGACATCAACTTGAGCCTTGTG
GCCCTGACTGGGATGGGGTTACTGAGCCGGCTGTGGCGACTCACCTACCCGCGGGCTGTG
GTTTTTGACGAAGTATATTATGGGCAGTACATCTCTTTTTACATGAAACAAATCTTCTTC
TTGGATGACAGTGGGCCGCCATTTGGCCACATGGTGCTGGCCTTGGGAGGTTATTTAGGA
GGATTCGATGGCAATTTTTTGTGGAACAGAATTGGAGCAGAATACAGTAGCAACGTGCCT
GTGTGGTCCCTGCGCCTGCTGCCAGCACTCGCGGGGGCCTTGTCGGTCCCCATGGCCTAC
CAGATAGTGTTGGAGCTCCACTTTTCTCATTGTGCCGCCATGGGAGCTGCTCTGTTGATG
CTTATCAAGAATGCTCTCATCACTCAGTCAAGGCTAATGCTTTTGGAATCAGTGTTAATA
TTTTTCAATCTATTGGCCGTGTTGTCCTACCTGAAGTTCTTCAACTGCCAAAAGCACAGC
CCTTTTTCTCTGAGCTGGTGGTTCTGGCTAACACTGACAGGGGTCGCTTGTTCCTGTGCA
GTGGGCATCAAGTACATGGGTGTGTTCACGTACGTGCTCGTGCTGGGTGTTGCAGCTGTC
CATGCCTGGCACCTGCTTGGAGACCAGACTTTGTCCAATGTAGGTGCTGATGTCCAGTGC
TGCATGAGGCCGGCCTGTATGGGGCAGATGCGGATGTCACAGGGGGTCTGTGTGTTCTGT
CACTTGCTCGCCCGAGCAGTGGCTTTGCTGGTCATCCCGGTCGTCCTGTACTTACTGTTC
TTCTACGTCCACTTGATTCTAGTCTTCCGCTCTGGGCCCCACGACCAAATCATGTCCAGT
GCCTTCCAGGCCAGCTTAGAGGGAGGACTAGCTCGGATCACCCAGGGTCAGCCACTGGAG
GTGGCCTTTGGGTCCCAGGTCACTCTGAGGAACGTCTTTGGGAAACCTGTGCCCTGCTGG
CTTCATTCCCACCAGGACACCTACCCCATGATATATGAGAACGGCCGAGGCAGCTCCCAC
CAGCAACAGGTGACCTGTTACCCCTTCAAAGACGTCAATAACTGGTGGATTGTAAAGGAT
CCCAGGAGGCACCAGCTGGTGGTGAGCAGCCCTCCGAGACCTGTGAGGCACGGGGACATG
GTGCAGCTGGTCCACGGCATGACCACCCGCTCCCTGAACACGCATGATGTTGCAGCCCCC
CTGAGCCCCCATTCACAGGAGGTCTCCTGCTACATTGACTATAACATCTCCATGCCCGCC
CAGAACCTCTGGAGACTGGAAATTGTGAACAGAGGATCTGACACAGACGTCTGGAAGACC
ATCCTCTCAGAGGTCCGCTTTGTGCACGTGAACACTTCCGCTGTCTTAAAGCTGAGCGGG
GCTCACCTCCCTGACTGGGGGTATCGGCAACTGGAGATCGTCGGGGAGAAGCTGTCCCGG
GGCTACCACGGGAGCACGGTGTGGAACGTGGAGGAGCACCGATACGGCGCGAGCCAGGAG
CAGAGGGAGCGGGAACGGGAGCTGCACTCACCTGCGCAGGTGGACGTCAGCAGGAACCTC
AGCTTCATGGCGAGATTCTCGGAGCTGCAGTGGAGGATGCTGGCGCTGAGAAGTGATGAC
TCGGAACACAAGTACAGCTCCAGCCCACTGGAGTGGGTCACCCTGGACACCAATATTGCC
TACTGGCTGCACCCCAGGACCAGCGCTCAGATCCACCTACTTGGAAACATAGTGATCTGG
GTTTCGGGCAGCCTCGCTCTGGCCATCTACGCCCTGCTGTCCTTGTGGTACCTGCTCCGA
CGGCGAAGAAATGTCCATGACCTCCCTCAGGATGCCTGGCTGCGCTGGGTGCTGGCTGGG
GCGCTGTGTGCCGGTGGCTGGGCAGTGAACTACCTCCCGTTCTTCCTGATGGAGAAGACA
CTCTTCCTCTACCACTACCTGCCCGCACTCACCTTCCAAATCCTTCTGCTCCCTGTGGTC
CTGCAGCACATCAGCGACCACCTGTGCAGGTCCCAGCTCCAGAGGAATTCTTTCAGCGCC
CTGGTGGTGGCCTGGTACTCCTCCGCGTGCCACGTGTCCAACACGCTGCGCCCACTCACC
TACGGGGACAAGTCACTCTCGCCACATGAACTCAAGGCCCTTCGCTGGAAAGACAGCTGG
GACATCTTGATCCGAAAACACTAG
|
| Protein Properties |
|---|
| Number of Residues
| 747 |
| Molecular Weight
| 82566.18 |
| Theoretical pI
| 8.509 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Protein O-mannosyl-transferase 1
MWGFLKRPVVVTADINLSLVALTGMGLLSRLWRLTYPRAVVFDEVYYGQYISFYMKQIFF
LDDSGPPFGHMVLALGGYLGGFDGNFLWNRIGAEYSSNVPVWSLRLLPALAGALSVPMAY
QIVLELHFSHCAAMGAALLMLIENALITQSRLMLLESVLIFFNLLAVLSYLKFFNCQKHS
PFSLSWWFWLTLTGVACSCAVGIKYMGVFTYVLVLGVAAVHAWHLLGDQTLSNVGADVQC
CMRPACMGQMRMSQGVCVFCHLLARAVALLVIPVVLYLLFFYVHLILVFRSGPHDQIMSS
AFQASLEGGLARITQGQPLEVAFGSQVTLRNVFGKPVPCWLHSHQDTYPMIYENGRGSSH
QQQVTCYPFKDVNNWWIVKDPRRHQLVVSSPPRPVRHGDMVQLVHGMTTRSLNTHDVAAP
LSPHSQEVSCYIDYNISMPAQNLWRLEIVNRGSDTDVWKTILSEVRFVHVNTSAVLKLSG
AHLPDWGYRQLEIVGEKLSRGYHGSTVWNVEEHRYGASQEQRERERELHSPAQVDVSRNL
SFMARFSELQWRMLALRSDDSEHKYSSSPLEWVTLDTNIAYWLHPRTSAQIHLLGNIVIW
VSGSLALAIYALLSLWYLLRRRRNVHDLPQDAWLRWVLAGALCAGGWAVNYLPFFLMEKT
LFLYHYLPALTFQILLLPVVLQHISDHLCRSQLQRSIFSALVVAWYSSACHVSNTLRPLT
YGDKSLSPHELKALRWKDSWDILIRKH
|
| External Links |
|---|
| GenBank ID Protein
| 5257116 |
| UniProtKB/Swiss-Prot ID
| Q9Y6A1 |
| UniProtKB/Swiss-Prot Entry Name
| POMT1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF095136 |
| GeneCard ID
| POMT1 |
| GenAtlas ID
| POMT1 |
| HGNC ID
| HGNC:9202 |
| References |
|---|
| General References
| Not Available |