Identification
HMDB Protein ID CDBP04000
Secondary Accession Numbers Not Available
Name Nuclear inhibitor of protein phosphatase 1
Description Not Available
Synonyms
  1. ARD-1
  2. Activator of RNA decay
  3. NIPP-1
  4. Protein phosphatase 1 regulatory inhibitor subunit 8
Gene Name PPP1R8
Protein Type Enzyme
Biological Properties
General Function Involved in DNA binding
Specific Function Isoform Gamma is a site-specific single-strand endoribonuclease that cleaves single strand RNA 3' to purines and pyrimidines in A+U-rich regions. It generates 5'-phosphate termini at the site of cleavage. This isoform does not inhibit PP-1. May be implicated in mRNA splicing
GO Classification Not Available
Cellular Location
  1. Isoform Gamma:Cytoplasm
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 1p35
SNPs PPP1R8
Gene Sequence
>1056 bp
ATGGCGGCAGCCGCGAACTCCGGCTCTAGCCTCCCGCTGTTCGACTGCCCAACCTGGGCA
GGTAAGCCCCCTCCCGGTTTACATCTGGATGTAGTCAAAGGAGACAAACTAATTGAGAAA
CTGATTATTGATGAGAAGAAGTATTACTTATTTGGGAGAAACCCTGATTTGTGTGACTTT
ACCATTGACCACCAGTCTTGCTCTCGGGTCCATGCTGCACTTGTCTACCACAAGCATCTG
AAGAGAGTTTTCCTGATAGATCTCAACAGTACACACGGCACTTTCTTGGGTCACATTCGG
TTGGAACCTCACAAGCCTCAGCAAATTCCCATCGATTCCACGGTCTCATTTGGCGCATCC
ACAAGGGCATACACTCTGCGCGAGAAGCCTCAGACATTGCCATCGGCTGTGAAAGGAGAT
GAGAAGATGGGTGGAGAGGATGATGAACTCAAGGGCTTACTGGGGCTTCCAGAGGAGGAA
ACTGAGCTTGATAACCTGACAGAGTTCAACACTGCCCACAACAAGCGGATTTCTACCCTT
ACCATTGAGGAGGGAAATCTGGACATTCAAAGACCAAAGAGGAAGAGGAAGAACTCACGG
GTGACATTCAGTGAGGATGATGAGATCATCAACCCAGAGGATGTGGATCCCTCAGTTGGT
CGATTCAGGAACATGGTGCAAACTGCAGTGGTCCCAGTCAAGAAGAAGCGTGTGGAGGGC
CCTGGCTCCCTGGGCCTGGAGGAATCAGGGAGCAGGCGCATGCAGAACTTTGCCTTCAGC
GGAGGACTCTACGGGGGCCTGCCCCCCACACACAGTGAAGCAGGCTCCCAGCCACATGGC
ATCCATGGGACAGCACTCATCGGTGGCTTGCCCATGCCATACCCAAACCTTGCCCCTGAT
GTGGACTTGACTCCTGTTGTGCCGTCAGCAGTGAACATGAACCCTGCACCAAACCCTGCA
GTCTATAACCCTGAAGCTGTAAATGAACCCAAGAAGAAGAAATATGCAAAAGAGGCTTGG
CCAGGCAAGAAGCCCACACCTTCCTTGCTGATTTGA
Protein Properties
Number of Residues 351
Molecular Weight 38478.5
Theoretical pI 7.42
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence
>Nuclear inhibitor of protein phosphatase 1
MAAAANSGSSLPLFDCPTWAGKPPPGLHLDVVKGDKLIEKLIIDEKKYYLFGRNPDLCDF
TIDHQSCSRVHAALVYHKHLKRVFLIDLNSTHGTFLGHIRLEPHKPQQIPIDSTVSFGAS
TRAYTLREKPQTLPSAVKGDEKMGGEDDELKGLLGLPEEETELDNLTEFNTAHNKRISTL
TIEEGNLDIQRPKRKRKNSRVTFSEDDEIINPEDVDPSVGRFRNMVQTAVVPVKKKRVEG
PGSLGLEESGSRRMQNFAFSGGLYGGLPPTHSEAGSQPHGIHGTALIGGLPMPYPNLAPD
VDLTPVVPSAVNMNPAPNPAVYNPEAVNEPKKKKYAKEAWPGKKPTPSLLI
GenBank ID Protein 4883485
UniProtKB/Swiss-Prot ID Q12972
UniProtKB/Swiss-Prot Entry Name PP1R8_HUMAN
PDB IDs Not Available
GenBank Gene ID AF061958
GeneCard ID PPP1R8
GenAtlas ID PPP1R8
HGNC ID HGNC:9296
References
General References Not Available