| Identification |
|---|
| HMDB Protein ID
| CDBP03060 |
| Secondary Accession Numbers
| Not Available |
| Name
| NADPH oxidase 5 |
| Description
| Not Available |
| Synonyms
|
Not Available
|
| Gene Name
| NOX5 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in calcium ion binding |
| Specific Function
| Calcium-dependent NADPH oxidase that generates superoxide. Also functions as a calcium-dependent proton channel and may regulate redox-dependent processes in lymphocytes and spermatozoa. May play a role in cell growth and apoptosis |
| GO Classification
|
| Component |
| cell part |
| membrane part |
| intrinsic to membrane |
| integral to membrane |
| Function |
| catalytic activity |
| transition metal ion binding |
| nucleoside binding |
| purine nucleoside binding |
| adenyl nucleotide binding |
| electron carrier activity |
| iron ion binding |
| oxidoreductase activity |
| fad or fadh2 binding |
| calcium ion binding |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| Process |
| metabolic process |
| oxidation reduction |
|
| Cellular Location
|
- Membrane
- Multi-pass membrane protein (Potential)
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 15q23 |
| SNPs
| NOX5 |
| Gene Sequence
|
>2298 bp
ATGAACACATCTGGAGACCCAGCCCAGACGGGCCCTGAAGGCTGTAGAGGCACCATGAGT
GCCGAGGAGGATGCCAGGTGGCTCCGGTGGGTGACTCAGCAGTTTAAGACCATTGCAGGA
GAAGATGGGGAGATCAGCCTGCAAGAATTCAAAGCAGCTCTGCATGTGAAAGAGTCCTTC
TTTGCAGAGCGATTCTTTGCCCTATTTGACTCCGATAGAAGTGGCACCATCACCCTCCAG
GAGCTGCAGGAGGCACTGACCCTGCTCATCCATGGCAGCCCCATGGACAAACTCAAATTC
CTCTTCCAGGTGTATGACATCGATGTGTGTGCACGGCAGGGGGCGTCTGCAGGTACAGAG
TGGGGTGCTGGGGCAGGCCCGCACTGGGCTTCATCCCCACTCGGGACAGGCAGTGGCTCC
ATTGACCCGGATGAGCTGCGCACTGTGCTGCAGTCGTGTCTGCGCGAGAGCGCCATCTCG
CTGCCTGACGAGAAGCTGGACCAGCTGACGCTGGCGCTCTTCGAATCGGCCGACGCGGAC
GGCAACGGGGCCATCACCTTCGAGGAGCTCCGGGACGAGCTGCAGCGCTTCCCCGGAGTC
ATGGAGAACCTGACCATCAGCGCTGCCCACTGGCTGACGGCCCCCGCCCCCCGCCCACGC
CCGCGCCGGCCGCGCCAGCTGACCCGCGCCTACTGGCACAACCACCGCAGCCAGCTGTTC
TGCCTGGCCACCTATGCAGGCCTCCACGTGCTGCTCTTCGGGCTGGCGGCCAGCGCGCAC
CGGGACCTCGGCGCCAGCGTCATGGTGGCCAAGGGCTGCGGCCAGTGCCTCAACTTCGAC
TGCAGCTTCATCGCGGTGCTGATGCTCAGACGCTGCCTCACCTGGCTGCGGGCCACGTGG
CTGGCTCAAGTCCTACCACTGGACCAGAACATCCAGTTCCACCAGCTTATGGGCTACGTG
GTAGTGGGGCTGTCCCTCGTGCACACCGTGGCTCACACTGTGAACTTTGTACTCCAGGCT
CAGGCGGAGGCCAGCCCTTTCCAGTTCTGGGAGCTGCTGCTCACCACGAGGCCTGGCATT
GGCTGGGTACACGGTTCGGCCTCCCCGACAGGTGTCGCTCTGCTGCTGCTGCTCCTCCTC
ATGTTCATCTGCTCCAGTTCCTGCATCCGCAGGAGTGGCCACTTTGAGGTGTTCTATTGG
ACTCACCTGTCCTACCTCCTCGTGTGGCTTCTGCTCATCTTTCATGGGCCCAACTTCTGG
AAGTGGCTGCTGGTGCCTGGAATCTTGTTTTTCCTGGAGAAGGCCATCGGACTGGCAGTG
TCCCGCATGGCAGCCGTGTGCATCATGGAAGTCAACCTCCTCCCCTCCAAGGTCACTCAT
CTCCTCATCAAGCGGCCCCCTTTTTTTCACTATAGACCTGGTGACTACTTGTATCTGAAC
ATCCCCACCATTGCTCGCTATGAGTGGCACCCCTTCACCATCAGCAGTGCTCCTGAGCAG
AAAGACACTATCTGGCTGCACATTCGGTCCCAAGGCCAGTGGACAAACAGGCTGTATGAG
TCCTTCAAGGCATCAGACCCACTGGGCCGTGGTTCTAAGAGGCTGTCGAGGAGTGTGACA
ATGAGAAAGAGTCAAAGGTCGTCCAAGGGCTCTGAGATACTTTTGGAGAAACACAAATTC
TGTAACATCAAGTGCTACATCGATGGGCCTTATGGGACCCCCACCCGCAGGATCTTTGCC
TCTGAGCATGCCGTGCTCATCGGGGCAGGCATCGGCATCACCCCCTTTGCTTCCATTCTG
CAGAGTATCATGTACAGGCACCAGAAAAGAAAGCATACTTGCCCCAGCTGCCAGCACTCC
TGGATCGAAGGTGTCCAAGACAACATGAAGCTCCATAAGGTGGACTTTATCTGGATCAAC
AGAGACCAGCGGTCTTTCGAGTGGTTTGTGAGCCTGCTGACTAAACTGGAGATGGACCAG
GCCGAGGAGGCTCAATACGGCCGCTTCCTGGAGCTGCATATGTACATGACATCTGCACTG
GGCAAGAATGACATGAAGGCCATTGGCCTGCAGATGGCCCTTGACCTCCTGGCCAACAAG
GAGAAGAAAGACTCCATCACGGGGCTGCAGACGCGCACCCAGCCTGGGCGGCCTGACTGG
AGCAAGGTGTTCCAGAAAGTGGCTGCTGAGAAGAAGGGCAAGGTGCAGGTCTTCTTCTGT
GGCTCCCCAGCTCTGGCCAAGGTGCTGAAGGGCCATTGTGAGAAGTTCGGCTTCAGATTT
TTCCAAGAGAATTTCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 765 |
| Molecular Weight
| 86438.1 |
| Theoretical pI
| 8.72 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["239-259", "267-289", "318-338", "363-383", "395-417", "435-455", "584-604"]
|
| Protein Sequence
|
>NADPH oxidase 5
MNTSGDPAQTGPEGCRGTMSAEEDARWLRWVTQQFKTIAGEDGEISLQEFKAALHVKESF
FAERFFALFDSDRSGTITLQELQEALTLLIHGSPMDKLKFLFQVYDIDVCARQGASAGTE
WGAGAGPHWASSPLGTGSGSIDPDELRTVLQSCLRESAISLPDEKLDQLTLALFESADAD
GNGAITFEELRDELQRFPGVMENLTISAAHWLTAPAPRPRPRRPRQLTRAYWHNHRSQLF
CLATYAGLHVLLFGLAASAHRDLGASVMVAKGCGQCLNFDCSFIAVLMLRRCLTWLRATW
LAQVLPLDQNIQFHQLMGYVVVGLSLVHTVAHTVNFVLQAQAEASPFQFWELLLTTRPGI
GWVHGSASPTGVALLLLLLLMFICSSSCIRRSGHFEVFYWTHLSYLLVWLLLIFHGPNFW
KWLLVPGILFFLEKAIGLAVSRMAAVCIMEVNLLPSKVTHLLIKRPPFFHYRPGDYLYLN
IPTIARYEWHPFTISSAPEQKDTIWLHIRSQGQWTNRLYESFKASDPLGRGSKRLSRSVT
MRKSQRSSKGSEILLEKHKFCNIKCYIDGPYGTPTRRIFASEHAVLIGAGIGITPFASIL
QSIMYRHQKRKHTCPSCQHSWIEGVQDNMKLHKVDFIWINRDQRSFEWFVSLLTKLEMDQ
AEEAQYGRFLELHMYMTSALGKNDMKAIGLQMALDLLANKEKKDSITGLQTRTQPGRPDW
SKVFQKVAAEKKGKVQVFFCGSPALAKVLKGHCEKFGFRFFQENF
|
| External Links |
|---|
| GenBank ID Protein
| 296278229 |
| UniProtKB/Swiss-Prot ID
| Q96PH1 |
| UniProtKB/Swiss-Prot Entry Name
| NOX5_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_024505.3 |
| GeneCard ID
| NOX5 |
| GenAtlas ID
| NOX5 |
| HGNC ID
| HGNC:14874 |
| References |
|---|
| General References
| Not Available |