| Identification |
|---|
| HMDB Protein ID
| CDBP03947 |
| Secondary Accession Numbers
| Not Available |
| Name
| Inward rectifier potassium channel 13 |
| Description
| Not Available |
| Synonyms
|
- Inward rectifier K(+) channel Kir7.1
- Potassium channel, inwardly rectifying subfamily J member 13
|
| Gene Name
| KCNJ13 |
| Protein Type
| Transporter |
| Biological Properties |
|---|
| General Function
| Involved in inward rectifier potassium channel activity |
| Specific Function
| Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ13 has a very low single channel conductance, low sensitivity to block by external barium and cesium, and no dependence of its inward rectification properties on the internal blocking particle magnesium |
| GO Classification
|
| Component |
| membrane |
| cell part |
| Function |
| potassium channel activity |
| voltage-gated potassium channel activity |
| transmembrane transporter activity |
| substrate-specific transmembrane transporter activity |
| ion transmembrane transporter activity |
| transporter activity |
| ion channel activity |
| inward rectifier potassium channel activity |
| cation channel activity |
| Process |
| establishment of localization |
| transport |
| monovalent inorganic cation transport |
| potassium ion transport |
| ion transport |
| cation transport |
|
| Cellular Location
|
- Membrane
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:2 |
| Locus
| 2q37 |
| SNPs
| KCNJ13 |
| Gene Sequence
|
>1083 bp
ATGGACAGCAGTAATTGCAAAGTTATTGCTCCTCTCCTAAGTCAAAGATACCGGAGGATG
GTCACCAAGGATGGCCACAGCACACTTCAAATGGATGGCGCTCAAAGAGGTCTTGCATAT
CTTCGAGATGCTTGGGGAATCCTAATGGACATGCGCTGGCGTTGGATGATGTTGGTCTTT
TCTGCTTCTTTTGTTGTCCACTGGCTTGTCTTTGCAGTGCTCTGGTATGTTCTGGCTGAG
ATGAATGGTGATCTGGAACTAGATCATGATGCCCCACCTGAAAACCACACTATCTGTGTC
AAGTATATCACCAGTTTCACAGCTGCATTCTCCTTCTCCCTGGAGACACAACTCACAATT
GGTTATGGTACCATGTTCCCCAGTGGTGACTGTCCAAGTGCAATCGCCTTACTTGCCATA
CAAATGCTCCTAGGCCTCATGCTAGAGGCTTTTATCACAGGTGCTTTTGTGGCGAAGATT
GCCCGGCCAAAAAATCGAGCTTTTTCAATTCGCTTTACTGACATAGCAGTAGTAGCTCAC
ATGGATGGCAAACCTAATCTTATCTTCCAAGTGGCCAACACCCGACCTAGCCCTCTAACC
AGTGTCCGGGTCTCAGCTGTACTCTATCAGGAAAGAGAAAATGGCAAACTCTACCAGACC
AGTGTGGATTTCCACCTTGATGGCATCAGTTCTGACGAATGTCCATTCTTCATCTTTCCA
CTAACGTACTATCACTCCATTACACCATCAAGTCCTCTGGCTACTCTGCTCCAGCATGAA
AATCCTTCTCACTTTGAATTAGTTGTATTCCTTTCAGCAATGCAGGAGGGCACTGGAGAA
ATATGCCAAAGGAGGACATCCTACCTACCGTCTGAAATCATGTTACATCACTGTTTTGCA
TCTCTGTTGACCCGAGGTTCCAAAGGTGAATATCAAATCAAGATGGAGAATTTTGACAAG
ACTGTCCCTGAATTTCCAACTCCTCTGGTTTCTAAAAGCCCAAACAGGACTGACCTGGAT
ATCCACATCAATGGACAAAGCATTGACAATTTTCAGATCTCTGAAACAGGACTGACAGAA
TAA
|
| Protein Properties |
|---|
| Number of Residues
| 360 |
| Molecular Weight
| 40529.2 |
| Theoretical pI
| 6.23 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Inward rectifier potassium channel 13
MDSSNCKVIAPLLSQRYRRMVTKDGHSTLQMDGAQRGLAYLRDAWGILMDMRWRWMMLVF
SASFVVHWLVFAVLWYVLAEMNGDLELDHDAPPENHTICVKYITSFTAAFSFSLETQLTI
GYGTMFPSGDCPSAIALLAIQMLLGLMLEAFITGAFVAKIARPKNRAFSIRFTDTAVVAH
MDGKPNLIFQVANTRPSPLTSVRVSAVLYQERENGKLYQTSVDFHLDGISSDECPFFIFP
LTYYHSITPSSPLATLLQHENPSHFELVVFLSAMQEGTGEICQRRTSYLPSEIMLHHCFA
SLLTRGSKGEYQIKMENFDKTVPEFPTPLVSKSPNRTDLDIHINGQSIDNFQISETGLTE
|
| External Links |
|---|
| GenBank ID Protein
| 3650320 |
| UniProtKB/Swiss-Prot ID
| O60928 |
| UniProtKB/Swiss-Prot Entry Name
| IRK13_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AJ007557 |
| GeneCard ID
| KCNJ13 |
| GenAtlas ID
| KCNJ13 |
| HGNC ID
| HGNC:6259 |
| References |
|---|
| General References
| Not Available |