Identification |
HMDB Protein ID
| CDBP03374 |
Secondary Accession Numbers
| Not Available |
Name
| Protein prune homolog |
Description
| Not Available |
Synonyms
|
- DRES-17
- DRES17
- Drosophila-related expressed sequence 17
- HTcD37
- hPrune
|
Gene Name
| PRUNE |
Protein Type
| Metal Binding |
Biological Properties |
General Function
| Involved in pyrophosphatase activity |
Specific Function
| Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, is able to induce cell motility and acts as a negative regulator of NME1.
|
GO Classification
|
Cellular Component |
focal adhesion |
cytoplasm |
nucleus |
Component |
cell part |
intracellular part |
cytoplasm |
Function |
metal ion binding |
binding |
catalytic activity |
hydrolase activity |
transition metal ion binding |
hydrolase activity, acting on acid anhydrides |
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides |
pyrophosphatase activity |
manganese ion binding |
ion binding |
cation binding |
Molecular Function |
manganese ion binding |
inorganic diphosphatase activity |
|
Cellular Location
|
- Nucleus
- Cytoplasm
- Cell junction
- focal adhesion
|
Pathways
|
Not Available
|
Gene Properties |
Chromosome Location
| 1 |
Locus
| 1q21 |
SNPs
| PRUNE |
Gene Sequence
|
>1362 bp
ATGGAGGACTACCTGCAGGGTTGTCGAGCTGCTCTGCAGGAGTCCCGACCTCTACATGTT
GTGCTGGGAAATGAAGCCTGTGATTTGGACTCCACAGTGTCTGCTCTTGCCCTGGCTTTT
TACCTAGCAAAGACAACTGAGGCTGAGGAAGTCTTTGTGCCAGTTTTAAATATAAAACGT
TCTGAACTACCTCTGCGAGGTGACATTGTCTTCTTTCTTCAGAAGGTTCATATTCCAGAG
AGTATCTTGATTTTTCGGGATGAGATTGACCTCCATGCATTATACCAGGCTGGCCAACTC
ACCCTCATCCTTGTCGACCATCATATCTTATCCAAAAGTGACACAGCCCTAGAGGAGGCA
GTAGCAGAGGTGCTAGACCATCGACCCATCGAGCCGAAACACTGCCCTCCCTGCCATGTT
TCAGTTGAGCTGGTGGGGTCCTGTGCTACCCTGGTGACCGAGAGAATCCTGCAGGGGGCA
CCAGAGATCTTGGACAGGCAAACTGCAGCCCTTCTGCATGGAACCATCATCCTGGACTGT
GTCAACATGGACCTTAAAATTGGAAAGGCAACCCCAAAGGACAGCAAATATGTGGAGAAA
CTAGAGGCCCTTTTCCCAGACCTACCCAAGAGAAATGATATATTTGATTCCCTACAAAAG
GTAAAGTTTGATGTATCAGGACTGACCACTGAGCAGATGCTGAGAAAAGACCAGAAGACT
ATCTATAGACAAGGCGTCAAGGTGGCCATTAGTGCAATATATATGGATTTGGAGGCCTTT
CTGCAGAGGTCTAACCTCCTTGCAGATCTCCATGCTTTCTGCCAGGCTCACAGCTATGAT
GTCCTGGTTGCCATGACTATCTTTTTCAACACTCACAATGAGCCAGTGCGGCAGTTGGCT
ATTTTCTGTCCCCATGTGGCACTCCAAACAACGATCTGTGAAGTCCTGGAACGCTCCCAC
TCTCCACCCCTGAAGCTGACCCCTGCCTCAAGTACCCACCCTAACCTCCATGCCTATCTT
CAAGGCAACACCCAGGTCTCTCGAAAGAAACTTCTGCCCCTGCTCCAGGAAGCCCTGTCA
GCATATTTTGACTCCATGAAGATCCCTTCAGGACAGCCTGAGACAGCAGATGTGTCCAGG
GAGCAAGTGGACAAGGAATTGGACAGGGCAAGTAACTCCCTGATTTCTGGACTGAGTCAA
GATGAGGAGGACCCTCCGCTGCCCCCGACGCCCATGAACAGCTTGGTGGATGAGTGCCCT
CTAGATCAGGGGCTGCCTAAACTCTCTGCTGAGGCCGTCTTCGAGAAGTGCAGTCAGATC
TCACTGTCACAGTCTACCACAGCCTCCCTGTCCAAGAAGTGA
|
Protein Properties |
Number of Residues
| 453 |
Molecular Weight
| 50199.04 |
Theoretical pI
| 5.502 |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>Protein prune homolog
MEDYLQGCRAALQESRPLHVVLGNEACDLDSTVSALALAFYLAKTTEAEEVFVPVLNIKR
SELPLRGDIVFFLQKVHIPESILIFRDEIDLHALYQAGQLTLILVDHHILSKSDTALEEA
VAEVLDHRPIEPKHCPPCHVSVELVGSCATLVTERILQGAPEILDRQTAALLHGTIILDC
VNMDLKIGKATPKDSKYVEKLEALFPDLPKRNDIFDSLQKAKFDVSGLTTEQMLRKDQKT
IYRQGVKVAISAIYMDLEAFLQRSNLLADLHAFCQAHSYDVLVAMTIFFNTHNEPVRQLA
IFCPHVALQTTICEVLERSHSPPLKLTPASSTHPNLHAYLQGNTQVSRKKLLPLLQEALS
AYFDSMKIPSGQPETADVSREQVDKELDRASNSLISGLSQDEEDPPLPPTPMNSLVDECP
LDQGLPKLSAEAVFEKCSQISLSQSTTASLSKK
|
External Links |
GenBank ID Protein
| 4007408 |
UniProtKB/Swiss-Prot ID
| Q86TP1 |
UniProtKB/Swiss-Prot Entry Name
| PRUNE_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| AF051907 |
GeneCard ID
| PRUNE |
GenAtlas ID
| PRUNE |
HGNC ID
| HGNC:13420 |
References |
General References
| Not Available |