| Identification |
|---|
| HMDB Protein ID
| CDBP03937 |
| Secondary Accession Numbers
| Not Available |
| Name
| Galactose-3-O-sulfotransferase 3 |
| Description
| Not Available |
| Synonyms
|
- Beta-galactose-3-O-sulfotransferase 3
- Gal-beta-1, 3-GalNAc 3'-sulfotransferase 3
- Gal3ST-3
- Gal3ST3
|
| Gene Name
| GAL3ST3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in galactosylceramide sulfotransferase activity |
| Specific Function
| Transfers a sulfate to position 3 of non-reducing beta- galactosyl residues in N-glycans and core2-branched O-glycans. Has high activity towards Gal-beta-1,4-GlcNAc, Gal-beta-1,4(Fuc-alpha- 1,3)GlcNAc and lower activity towards Gal-beta-1,3(Fuc-alpha- 1,4)GlcNAc |
| GO Classification
|
| Component |
| golgi apparatus |
| cell part |
| membrane part |
| intrinsic to membrane |
| organelle |
| membrane-bounded organelle |
| intracellular membrane-bounded organelle |
| integral to membrane |
| Function |
| galactosylceramide sulfotransferase activity |
| catalytic activity |
| transferase activity |
| transferase activity, transferring sulfur-containing groups |
| sulfotransferase activity |
| galactose 3-o-sulfotransferase activity |
| Process |
| metabolic process |
| biosynthetic process |
|
| Cellular Location
|
- Golgi apparatus
- Golgi stack membrane
- Single-pass type II membrane protein (Probable)
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 11q13.1 |
| SNPs
| GAL3ST3 |
| Gene Sequence
|
>1296 bp
ATGCCACCCATCCTCCAGCGCCTGCAGCAGGCCACCAAGATGATGAGCCGCCGGAAAATC
CTGCTGCTGGTGCTAGGGTGCAGCACCGTAAGCCTTCTCATCCACCAGGGGGCGCAGCTC
AGCTGGTACCCCAAGCTGTTCCCCTTGAGCTGCCCTCCTCTGCGGAACTCGCCGCCGCGC
CCCAAGCACATGACTGTGGCCTTCCTGAAGACTCACAAGACGGCAGGCACGACGGTGCAG
AACATCCTGTTTCGCTTTGCCGAGCGCCACAACCTGACGGTGGCCCTGCCGCACCCGAGC
TGCGAGCACCAGTTCTGCTACCCCCGCAACTTCTCGGCGCACTTCGTGCACCCGGCCACG
CGGCCGCCGCACGTGCTGGCCAGCCACCTGCGCTTCGACCGTGCGGAGCTGGAGCGCCTC
ATGCCGCCCAGCACCGTCTATGTCACCATCCTGCGCGAGCCGGCCGCCATGTTCGAGTCG
CTCTTCAGCTACTACAACCAGTACTGCCCGGCCTTCCGGCGCGTGCCCAACGCCTCGCTC
GAGGCCTTCCTGCGCGCGCCCGAGGCATACTACCGCGCTGGCGAGCACTTCGCCATGTTC
GCACACAACACGCTGGCCTACGACCTGGGCGGCGACAATGAGCGCAGCCCGCGCGACGAC
GCCGCCTACCTGGCGGGCCTCATCCGCCAGGTGGAGGAGGTTTTCTCGCTCGTCATGATC
GCCGAGTACTTCGACGAGTCGCTAGTGCTGCTGCGGCGCCTACTGGCCTGGGACCTGGAC
GACGTGCTCTACGCCAAGCTCAACGCGCGCGCCGCCAGCTCGCGCCTGGCCGCCATCCCC
GCGGCGCTGGCGCGGGCGGCGCGCACCTGGAACGCCCTGGACGCCGGCCTCTACGACCAC
TTCAACGCCACCTTCTGGCGCCACGTGGCGCGCGCGGGCCGCGCGTGCGTGGAGCGCGAG
GCGCGCGAGCTGCGCGAGGCCCGCCAGCGCCTACTGCGGCGCTGCTTCGGGGACGAGCCA
CTGCTGCGGCCTGCCGCGCAGATCCGCACCAAGCAGCTGCAGCCATGGCAGCCCAGCCGC
AAGGTGGACATTATGGGCTATGACCTGCCCGGCGGCGGCGCCGGCCCGGCCACCGAGGCC
TGCCTCAAGCTGGCCATGCCCGAGGTCCAGTACTCGAACTACCTGTTGCGCAAGCAGAAG
CGCCGGGGCGGTGCGCGGGCTCGGCCCGAGCCCGTCCTGGACAATCCCCCGCCTCGGCCC
ATCCGAGTGCTGCCTCGCGGCCCTCAAGGTCCCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 431 |
| Molecular Weight
| 48955.1 |
| Theoretical pI
| 10.31 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Galactose-3-O-sulfotransferase 3
MPPILQRLQQATKMMSRRKILLLVLGCSTVSLLIHQGAQLSWYPKLFPLSCPPLRNSPPR
PKHMTVAFLKTHKTAGTTVQNILFRFAERHNLTVALPHPSCEHQFCYPRNFSAHFVHPAT
RPPHVLASHLRFDRAELERLMPPSTVYVTILREPAAMFESLFSYYNQYCPAFRRVPNASL
EAFLRAPEAYYRAGEHFAMFAHNTLAYDLGGDNERSPRDDAAYLAGLIRQVEEVFSLVMI
AEYFDESLVLLRRLLAWDLDDVLYAKLNARAASSRLAAIPAALARAARTWNALDAGLYDH
FNATFWRHVARAGRACVEREARELREARQRLLRRCFGDEPLLRPAAQIRTKQLQPWQPSR
KVDIMGYDLPGGGAGPATEACLKLAMPEVQYSNYLLRKQKRRGGARARPEPVLDNPPPRP
IRVLPRGPQGP
|
| External Links |
|---|
| GenBank ID Protein
| 14625435 |
| UniProtKB/Swiss-Prot ID
| Q96A11 |
| UniProtKB/Swiss-Prot Entry Name
| G3ST3_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB053232 |
| GeneCard ID
| GAL3ST3 |
| GenAtlas ID
| GAL3ST3 |
| HGNC ID
| HGNC:24144 |
| References |
|---|
| General References
| Not Available |