Identification
HMDB Protein ID CDBP01063
Secondary Accession Numbers Not Available
Name Microtubule-associated serine/threonine-protein kinase 1
Description Not Available
Synonyms
  1. Syntrophin-associated serine/threonine-protein kinase
Gene Name MAST1
Protein Type Enzyme
Biological Properties
General Function Involved in protein serine/threonine kinase activity
Specific Function Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins
GO Classification
Function
protein binding
protein kinase activity
ion binding
protein serine/threonine kinase activity
cation binding
metal ion binding
binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
adenyl ribonucleotide binding
atp binding
magnesium ion binding
Process
phosphorus metabolic process
phosphate metabolic process
metabolic process
cellular metabolic process
protein amino acid phosphorylation
phosphorylation
Cellular Location
  1. Cell membrane
  2. Cytoplasm
  3. Peripheral membrane protein
  4. Cytoplasmic side
  5. cytoskeleton
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 19p13.2
SNPs MAST1
Gene Sequence
>4713 bp
ATGTCTGACTCTCTCTGGACCGCGCTTTCTAATTTCTCGATGCCCTCCTTCCCCGGCGGC
AGTATGTTCCGCCGCACCAAGAGCTGCCGCACCAGTAATCGGAAAAGCCTCATCCTGACC
AGCACTTCACCCACGCTACCGAGACCCCACTCCCCGCTGCCAGGTCACCTAGGCAGCAGT
CCCCTGGACAGCCCCCGAAACTTCTCCCCCAACACCCCCGCCCACTTCTCGTTTGCCTCC
TCCCGAAGGGCGGACGGACGCCGGTGGTCTCTGGCCTCGCTCCCTTCATCTGGCTATGGC
ACCAACACGCCCAGTTCCACCGTCTCGTCCTCCTGCTCCTCCCAGGAGCGCCTTCACCAG
CTGCCCTACCAGCCCACGGTGGACGAGCTCCACTTCCTCTCCAAACACTTCGGGAGCACC
GAGAGCATCACAGACGAGGATGGTGGCCGTCGCTCCCCAGCCGTGCGGCCCCGCTCACGG
AGCCTCAGCCCCGGGCGCTCCCCCTCCTCCTACGACAACGAGATCGTGATGATGAATCAC
GTCTACAAGGAGAGGTTCCCGAAGGCCACTGCGCAGATGGAGGAGAAGCTGCGCGACTTT
ACCCGCGCCTACGAACCCGACAGCGTTCTGCCTCTGGCCGATGGCGTGCTCAGCTTCATC
CACCACCAGATCATCGAGCTGGCCCGGGACTGCCTGACCAAGTCCCGTGACGGCCTCATC
ACCACGGTCTACTTCTATGAATTGCAGGAGAACCTGGAGAAGCTCCTTCAAGACGCCTAT
GAACGCTCTGAGAGCTTGGAGGTGGCCTTCGTTACTCAGCTGGTGAAGAAGTTGCTTATT
ATCATCTCACGCCCTGCGAGGCTGCTGGAGTGCCTGGAATTCAACCCCGAGGAGTTCTAC
CACCTGCTGGAGGCGGCCGAAGGACACGCCAAGGAGGGCCACCTTGTGAAGACGGACATC
CCCCGCTACATCATCCGCCAGCTGGGCCTCACCCGTGACCCCTTTCCAGATGTGGTGCAT
CTGGAGGAACAGGACAGTGGTGGTTCCAACACCCCTGAGCAAGACGATCTCTCTGAGGGC
CGCAGCAGCAAGGCCAAGAAACCGCCGGGGGAGAATGACTTCGATACCATCAAGCTCATA
AGCAACGGTGCCTACGGCGCTGTCTACCTGGTGCGGCACCGCGACACGCGGCAGCGCTTT
GCCATGAAAAAGATCAACAAGCAGAACTTGATCCTCCGCAACCAGATCCAGCAGGCCTTT
GTGGAGCGCGATATCCTCACCTTCGCCGAGAACCCGTTTGTGGTCGGCATGTTCTGCTCC
TTTGAGACTCGGCGCCACCTCTGCATGGTCATGGAATATGTGGAAGGCGGCGACTGTGCC
ACCCTGCTGAAGAATATTGGAGCGCTGCCCGTAGAGATGGCCCGCATGTACTTTGCTGAG
ACGGTGCTAGCCCTGGAGTATTTGCACAACTATGGCATCGTGCACCGCGACCTCAAGCCT
GACAACCTCCTTATCACCTCCATGGGTCACATCAAGCTCACAGATTTCGGCCTCTCCAAG
ATGGGGCTCATGAGCCTCACCACCAACTTATATGAAGGCCACATCGAGAAGGACGCCCGA
GAGTTCCTGGACAAACAGGTGTGTGGGACCCCAGAGTACATCGCGCCCGAGGTCATCCTG
CGTCAAGGCTACGGCAAGCCAGTGGACTGGTGGGCTATGGGGATCATCCTCTACGAGTTC
CTGGTGGGCTGTGTGCCCTTCTTCGGAGACACACCAGAGGAGCTATTTGGACAGGTCATC
AGTGATGACATCCTGTGGCCCGAGGGGGATGAGGCCCTACCTACGGAGGCCCAACTCCTC
ATATCCAGCCTCCTGCAGACCAACCCTCTGGTCAGGCTTGGGGCAGGCGGCGCTTTTGAG
GTGAAGCAGCACAGTTTCTTTCGAGACCTGGACTGGACAGGGCTGCTGAGGCAGAAGGCC
GAGTTCATCCCCCACCTAGAGTCGGAAGATGACACTAGCTACTTTGACACCCGCTCAGAC
AGGTATCACCACGTGAACTCCTATGACGAGGATGACACGACGGAGGAGGAGCCCGTGGAA
ATCCGCCAGTTCTCTTCCTGCTCTCCGCGCTTCAGCAAGGTGTATAGCAGCATGGAGCAG
CTGTCGCAGCACGAGCCCAAGACCCCAGTAGCAGCTGCAGGGAGCAGCAAGCGGGAGCCG
AGCACCAAGGGCCCCGAGGAGAAGGTGGCCGGCAAGCGGGAGGGGCTGGGCGGCCTGACC
CTGCGTGAGAAGACCTGGAGAGGGGGCTCTCCGGAGATCAAGCGATTCTCCGCGTCCGAG
GCCAGTTTCCTGGAGGGAGAGGCCAGTCCCCCTTTGGGCGCCCGCCGCCGTTTCTCGGCG
CTGCTGGAGCCCAGCCGCTTCAGCGCCCCCCAAGAGGACGAGGATGAGGCCCGGCTGCGC
AGGCCTCCCCGGCCCAGCTCCGACCCCGCGGGATCCCTGGATGCACGGGCCCCCAAAGAG
GAGACTCAAGGGGAAGGCACCTCCAGCGCCGGGGACTCCGAGGCCACTGACCGTCCACGC
CCAGGTGACCTCTGCCCACCCTCGAAGGATGGGGATGCATCAGGCCCAAGGGCTACCAAT
GACTTGGTTCTGCGCCGGGCGCGGCACCAGCAGATGTCAGGGGATGTGGCAGTAGAGAAG
AGGCCTTCTCGAACTGGGGGCAAAGTCATCAAATCAGCCTCAGCCACTGCCTTATCTGTC
ATGATTCCTGCAGTGGACCCACATGGAAGTTCACCCCTTGCTAGTCCCATGTCTCCACGA
TCTCTGTCCTCCAACCCATCCTCACGGGACTCCTCACCCAGCCGGGACTACTCACCAGCT
GTCAGTGGGCTCCGCTCCCCCATCACCATCCAGCGCTCGGGCAAGAAGTATGGCTTCACA
CTGCGTGCCATCCGTGTCTACATGGGTGACACGGATGTCTATAGTGTCCACCACATTGTC
TGGCATGTGGAGGAAGGAGGCCCAGCCCAGGAGGCAGGACTCTGTGCTGGGGACCTCATC
ACCCACGTGAATGGGGAGCCTGTGCATGGCATGGTGCATCCTGAGGTCGTGGAGCTGATC
CTTAAGAGTGGCAACAAGGTAGCAGTGACCACAACGCCCTTCGAAAATACCTCTATCCGC
ATTGGTCCCGCAAGGCGCAGCAGCTACAAGGCTAAAATGGCTCGGAGGAACAAGCGACCC
TCCGCCAAGGAGGGCCAGGAGAGCAAGAAGCGCAGCTCCCTCTTCCGGAAGATCACGAAG
CAGTCGAACCTGCTGCATACTAGCCGCTCGCTGTCGTCGCTGAACCGCTCGCTGTCATCC
AGCGATAGTCTCCCGGGCTCGCCTACGCACGGGCTGCCGGCGCGCTCGCCCACGCACAGC
TACCGCTCCACGCCTGACTCCGCCTACCTAGGCGCCTCATCCCAGAGCAGCTCCCCAGCC
TCGAGCACGCCCAACTCGCCTGCGTCGTCGGCGTCGCACCACATTCGGCCCAGCACGCTG
CACGGACTGTCGCCAAAGCTCCATCGCCAGTACCGCTCTGCGCGATGCAAGTCGGCCGGC
AACATCCCTCTATCGCCGCTGGCACACACGCCGTCCCCCACGCAGGCGTCACCGCCGCCA
CTGCCGGGCCACACGGTGGGCAGCTCGCACACTACTCAGAGCTTCCCGGCCAAACTGCAC
TCATCGCCTCCCGTCGTGCGCCCGCGCCCCAAGAGTGCCGAGCCCCCTCGCTCGCCGCTC
CTCAAGCGCGTGCAGTCGGCCGAGAAGCTGGGAGCCTCTTTGAGTGCGGACAAGAAGGGC
GCGCTGCGCAAACACAGCCTCGAGGTGGGCCACCCGGATTTCCGCAAGGACTTCCATGGC
GAGCTGGCGCTGCATAGCCTTGCCGAGTCCGACGGTGAGACGCCCCCAGTCGAGGGCCTT
GGCGCGCCCCGGCAGGTCGCCGTCCGCCGCCTGGGCCGACAGGAGTCACCTTTGAGCCTG
GGCGCGGACCCGTTGCTGCCCGAGGGTGCCTCCAGGCCACCAGTGTCGAGCAAGGAGAAG
GAATCCCCGGGGGGCGCCGAGGCGTGCACCCCACCCCGCGCGACGACCCCCGGTGGCCGG
ACCCTGGAGCGGGACGTCGGCTGCACGCGGCATCAGAGCGTGCAGACGGAGGATGGCACT
GGCGGGATGGCCAGGGCTGTGGCCAAGGCGGCGCTGAGCCCGGTGCAGGAACACGAGACA
GGCCGGCGCAGCAGCTCTGGCGAGGCGGGCACACCCCTGGTACCCATTGTCGTAGAGCCT
GCGCGGCCCGGGGCTAAGGCTGTGGTGCCTCAGCCTCTGGGCGCGGACTCCAAGGGGTTG
CAGGAACCCGCACCCCTGGCGCCTTCCGTGCCCGAGGCCCCCCGGGGCCGGGAGCGCTGG
GTGTTGGAGGTGGTGGAGGAGCGCACCACGCTGAGCGGTCCTCGCTCCAAGCCCGCCTCC
CCAAAGCTCTCCCCGGAGCCCCAGACACCCTCCCTAGCCCCAGCGAAGTGCAGTGCACCC
AGCAGTGCAGTGACCCCAGTCCCACCCGCATCCCTCTTGGGCTCAGGCACCAAGCCTCAA
GTGGGGCTGACCTCCCGGTGCCCTGCTGAAGCTGTGCCCCCAGCAGGCCTGACCAAAAAA
GGAGTGTCCAGTCCCGCACCCCCGGGACCATAG
Protein Properties
Number of Residues 1570
Molecular Weight 170675.2
Theoretical pI 8.6
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence
>Microtubule-associated serine/threonine-protein kinase 1
MSDSLWTALSNFSMPSFPGGSMFRRTKSCRTSNRKSLILTSTSPTLPRPHSPLPGHLGSS
PLDSPRNFSPNTPAHFSFASSRRADGRRWSLASLPSSGYGTNTPSSTVSSSCSSQERLHQ
LPYQPTVDELHFLSKHFGSTESITDEDGGRRSPAVRPRSRSLSPGRSPSSYDNEIVMMNH
VYKERFPKATAQMEEKLRDFTRAYEPDSVLPLADGVLSFIHHQIIELARDCLTKSRDGLI
TTVYFYELQENLEKLLQDAYERSESLEVAFVTQLVKKLLIIISRPARLLECLEFNPEEFY
HLLEAAEGHAKEGHLVKTDIPRYIIRQLGLTRDPFPDVVHLEEQDSGGSNTPEQDDLSEG
RSSKAKKPPGENDFDTIKLISNGAYGAVYLVRHRDTRQRFAMKKINKQNLILRNQIQQAF
VERDILTFAENPFVVGMFCSFETRRHLCMVMEYVEGGDCATLLKNIGALPVEMARMYFAE
TVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKMGLMSLTTNLYEGHIEKDAR
EFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVI
SDDILWPEGDEALPTEAQLLISSLLQTNPLVRLGAGGAFEVKQHSFFRDLDWTGLLRQKA
EFIPHLESEDDTSYFDTRSDRYHHVNSYDEDDTTEEEPVEIRQFSSCSPRFSKVYSSMEQ
LSQHEPKTPVAAAGSSKREPSTKGPEEKVAGKREGLGGLTLREKTWRGGSPEIKRFSASE
ASFLEGEASPPLGARRRFSALLEPSRFSAPQEDEDEARLRRPPRPSSDPAGSLDARAPKE
ETQGEGTSSAGDSEATDRPRPGDLCPPSKDGDASGPRATNDLVLRRARHQQMSGDVAVEK
RPSRTGGKVIKSASATALSVMIPAVDPHGSSPLASPMSPRSLSSNPSSRDSSPSRDYSPA
VSGLRSPITIQRSGKKYGFTLRAIRVYMGDTDVYSVHHIVWHVEEGGPAQEAGLCAGDLI
THVNGEPVHGMVHPEVVELILKSGNKVAVTTTPFENTSIRIGPARRSSYKAKMARRNKRP
SAKEGQESKKRSSLFRKITKQSNLLHTSRSLSSLNRSLSSSDSLPGSPTHGLPARSPTHS
YRSTPDSAYLGASSQSSSPASSTPNSPASSASHHIRPSTLHGLSPKLHRQYRSARCKSAG
NIPLSPLAHTPSPTQASPPPLPGHTVGSSHTTQSFPAKLHSSPPVVRPRPKSAEPPRSPL
LKRVQSAEKLGASLSADKKGALRKHSLEVGHPDFRKDFHGELALHSLAESDGETPPVEGL
GAPRQVAVRRLGRQESPLSLGADPLLPEGASRPPVSSKEKESPGGAEACTPPRATTPGGR
TLERDVGCTRHQSVQTEDGTGGMARAVAKAALSPVQEHETGRRSSSGEAGTPLVPIVVEP
ARPGAKAVVPQPLGADSKGLQEPAPLAPSVPEAPRGRERWVLEVVEERTTLSGPRSKPAS
PKLSPEPQTPSLAPAKCSAPSSAVTPVPPASLLGSGTKPQVGLTSRCPAEAVPPAGLTKK
GVSSPAPPGP
GenBank ID Protein 45120119
UniProtKB/Swiss-Prot ID Q9Y2H9
UniProtKB/Swiss-Prot Entry Name MAST1_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_014975.2
GeneCard ID MAST1
GenAtlas ID MAST1
HGNC ID HGNC:19034
References
General References Not Available