| Identification |
|---|
| HMDB Protein ID
| CDBP01063 |
| Secondary Accession Numbers
| Not Available |
| Name
| Microtubule-associated serine/threonine-protein kinase 1 |
| Description
| Not Available |
| Synonyms
|
- Syntrophin-associated serine/threonine-protein kinase
|
| Gene Name
| MAST1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein serine/threonine kinase activity |
| Specific Function
| Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins |
| GO Classification
|
| Function |
| protein binding |
| protein kinase activity |
| ion binding |
| protein serine/threonine kinase activity |
| cation binding |
| metal ion binding |
| binding |
| catalytic activity |
| transferase activity |
| transferase activity, transferring phosphorus-containing groups |
| kinase activity |
| nucleoside binding |
| purine nucleoside binding |
| adenyl nucleotide binding |
| adenyl ribonucleotide binding |
| atp binding |
| magnesium ion binding |
| Process |
| phosphorus metabolic process |
| phosphate metabolic process |
| metabolic process |
| cellular metabolic process |
| protein amino acid phosphorylation |
| phosphorylation |
|
| Cellular Location
|
- Cell membrane
- Cytoplasm
- Peripheral membrane protein
- Cytoplasmic side
- cytoskeleton
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 19p13.2 |
| SNPs
| MAST1 |
| Gene Sequence
|
>4713 bp
ATGTCTGACTCTCTCTGGACCGCGCTTTCTAATTTCTCGATGCCCTCCTTCCCCGGCGGC
AGTATGTTCCGCCGCACCAAGAGCTGCCGCACCAGTAATCGGAAAAGCCTCATCCTGACC
AGCACTTCACCCACGCTACCGAGACCCCACTCCCCGCTGCCAGGTCACCTAGGCAGCAGT
CCCCTGGACAGCCCCCGAAACTTCTCCCCCAACACCCCCGCCCACTTCTCGTTTGCCTCC
TCCCGAAGGGCGGACGGACGCCGGTGGTCTCTGGCCTCGCTCCCTTCATCTGGCTATGGC
ACCAACACGCCCAGTTCCACCGTCTCGTCCTCCTGCTCCTCCCAGGAGCGCCTTCACCAG
CTGCCCTACCAGCCCACGGTGGACGAGCTCCACTTCCTCTCCAAACACTTCGGGAGCACC
GAGAGCATCACAGACGAGGATGGTGGCCGTCGCTCCCCAGCCGTGCGGCCCCGCTCACGG
AGCCTCAGCCCCGGGCGCTCCCCCTCCTCCTACGACAACGAGATCGTGATGATGAATCAC
GTCTACAAGGAGAGGTTCCCGAAGGCCACTGCGCAGATGGAGGAGAAGCTGCGCGACTTT
ACCCGCGCCTACGAACCCGACAGCGTTCTGCCTCTGGCCGATGGCGTGCTCAGCTTCATC
CACCACCAGATCATCGAGCTGGCCCGGGACTGCCTGACCAAGTCCCGTGACGGCCTCATC
ACCACGGTCTACTTCTATGAATTGCAGGAGAACCTGGAGAAGCTCCTTCAAGACGCCTAT
GAACGCTCTGAGAGCTTGGAGGTGGCCTTCGTTACTCAGCTGGTGAAGAAGTTGCTTATT
ATCATCTCACGCCCTGCGAGGCTGCTGGAGTGCCTGGAATTCAACCCCGAGGAGTTCTAC
CACCTGCTGGAGGCGGCCGAAGGACACGCCAAGGAGGGCCACCTTGTGAAGACGGACATC
CCCCGCTACATCATCCGCCAGCTGGGCCTCACCCGTGACCCCTTTCCAGATGTGGTGCAT
CTGGAGGAACAGGACAGTGGTGGTTCCAACACCCCTGAGCAAGACGATCTCTCTGAGGGC
CGCAGCAGCAAGGCCAAGAAACCGCCGGGGGAGAATGACTTCGATACCATCAAGCTCATA
AGCAACGGTGCCTACGGCGCTGTCTACCTGGTGCGGCACCGCGACACGCGGCAGCGCTTT
GCCATGAAAAAGATCAACAAGCAGAACTTGATCCTCCGCAACCAGATCCAGCAGGCCTTT
GTGGAGCGCGATATCCTCACCTTCGCCGAGAACCCGTTTGTGGTCGGCATGTTCTGCTCC
TTTGAGACTCGGCGCCACCTCTGCATGGTCATGGAATATGTGGAAGGCGGCGACTGTGCC
ACCCTGCTGAAGAATATTGGAGCGCTGCCCGTAGAGATGGCCCGCATGTACTTTGCTGAG
ACGGTGCTAGCCCTGGAGTATTTGCACAACTATGGCATCGTGCACCGCGACCTCAAGCCT
GACAACCTCCTTATCACCTCCATGGGTCACATCAAGCTCACAGATTTCGGCCTCTCCAAG
ATGGGGCTCATGAGCCTCACCACCAACTTATATGAAGGCCACATCGAGAAGGACGCCCGA
GAGTTCCTGGACAAACAGGTGTGTGGGACCCCAGAGTACATCGCGCCCGAGGTCATCCTG
CGTCAAGGCTACGGCAAGCCAGTGGACTGGTGGGCTATGGGGATCATCCTCTACGAGTTC
CTGGTGGGCTGTGTGCCCTTCTTCGGAGACACACCAGAGGAGCTATTTGGACAGGTCATC
AGTGATGACATCCTGTGGCCCGAGGGGGATGAGGCCCTACCTACGGAGGCCCAACTCCTC
ATATCCAGCCTCCTGCAGACCAACCCTCTGGTCAGGCTTGGGGCAGGCGGCGCTTTTGAG
GTGAAGCAGCACAGTTTCTTTCGAGACCTGGACTGGACAGGGCTGCTGAGGCAGAAGGCC
GAGTTCATCCCCCACCTAGAGTCGGAAGATGACACTAGCTACTTTGACACCCGCTCAGAC
AGGTATCACCACGTGAACTCCTATGACGAGGATGACACGACGGAGGAGGAGCCCGTGGAA
ATCCGCCAGTTCTCTTCCTGCTCTCCGCGCTTCAGCAAGGTGTATAGCAGCATGGAGCAG
CTGTCGCAGCACGAGCCCAAGACCCCAGTAGCAGCTGCAGGGAGCAGCAAGCGGGAGCCG
AGCACCAAGGGCCCCGAGGAGAAGGTGGCCGGCAAGCGGGAGGGGCTGGGCGGCCTGACC
CTGCGTGAGAAGACCTGGAGAGGGGGCTCTCCGGAGATCAAGCGATTCTCCGCGTCCGAG
GCCAGTTTCCTGGAGGGAGAGGCCAGTCCCCCTTTGGGCGCCCGCCGCCGTTTCTCGGCG
CTGCTGGAGCCCAGCCGCTTCAGCGCCCCCCAAGAGGACGAGGATGAGGCCCGGCTGCGC
AGGCCTCCCCGGCCCAGCTCCGACCCCGCGGGATCCCTGGATGCACGGGCCCCCAAAGAG
GAGACTCAAGGGGAAGGCACCTCCAGCGCCGGGGACTCCGAGGCCACTGACCGTCCACGC
CCAGGTGACCTCTGCCCACCCTCGAAGGATGGGGATGCATCAGGCCCAAGGGCTACCAAT
GACTTGGTTCTGCGCCGGGCGCGGCACCAGCAGATGTCAGGGGATGTGGCAGTAGAGAAG
AGGCCTTCTCGAACTGGGGGCAAAGTCATCAAATCAGCCTCAGCCACTGCCTTATCTGTC
ATGATTCCTGCAGTGGACCCACATGGAAGTTCACCCCTTGCTAGTCCCATGTCTCCACGA
TCTCTGTCCTCCAACCCATCCTCACGGGACTCCTCACCCAGCCGGGACTACTCACCAGCT
GTCAGTGGGCTCCGCTCCCCCATCACCATCCAGCGCTCGGGCAAGAAGTATGGCTTCACA
CTGCGTGCCATCCGTGTCTACATGGGTGACACGGATGTCTATAGTGTCCACCACATTGTC
TGGCATGTGGAGGAAGGAGGCCCAGCCCAGGAGGCAGGACTCTGTGCTGGGGACCTCATC
ACCCACGTGAATGGGGAGCCTGTGCATGGCATGGTGCATCCTGAGGTCGTGGAGCTGATC
CTTAAGAGTGGCAACAAGGTAGCAGTGACCACAACGCCCTTCGAAAATACCTCTATCCGC
ATTGGTCCCGCAAGGCGCAGCAGCTACAAGGCTAAAATGGCTCGGAGGAACAAGCGACCC
TCCGCCAAGGAGGGCCAGGAGAGCAAGAAGCGCAGCTCCCTCTTCCGGAAGATCACGAAG
CAGTCGAACCTGCTGCATACTAGCCGCTCGCTGTCGTCGCTGAACCGCTCGCTGTCATCC
AGCGATAGTCTCCCGGGCTCGCCTACGCACGGGCTGCCGGCGCGCTCGCCCACGCACAGC
TACCGCTCCACGCCTGACTCCGCCTACCTAGGCGCCTCATCCCAGAGCAGCTCCCCAGCC
TCGAGCACGCCCAACTCGCCTGCGTCGTCGGCGTCGCACCACATTCGGCCCAGCACGCTG
CACGGACTGTCGCCAAAGCTCCATCGCCAGTACCGCTCTGCGCGATGCAAGTCGGCCGGC
AACATCCCTCTATCGCCGCTGGCACACACGCCGTCCCCCACGCAGGCGTCACCGCCGCCA
CTGCCGGGCCACACGGTGGGCAGCTCGCACACTACTCAGAGCTTCCCGGCCAAACTGCAC
TCATCGCCTCCCGTCGTGCGCCCGCGCCCCAAGAGTGCCGAGCCCCCTCGCTCGCCGCTC
CTCAAGCGCGTGCAGTCGGCCGAGAAGCTGGGAGCCTCTTTGAGTGCGGACAAGAAGGGC
GCGCTGCGCAAACACAGCCTCGAGGTGGGCCACCCGGATTTCCGCAAGGACTTCCATGGC
GAGCTGGCGCTGCATAGCCTTGCCGAGTCCGACGGTGAGACGCCCCCAGTCGAGGGCCTT
GGCGCGCCCCGGCAGGTCGCCGTCCGCCGCCTGGGCCGACAGGAGTCACCTTTGAGCCTG
GGCGCGGACCCGTTGCTGCCCGAGGGTGCCTCCAGGCCACCAGTGTCGAGCAAGGAGAAG
GAATCCCCGGGGGGCGCCGAGGCGTGCACCCCACCCCGCGCGACGACCCCCGGTGGCCGG
ACCCTGGAGCGGGACGTCGGCTGCACGCGGCATCAGAGCGTGCAGACGGAGGATGGCACT
GGCGGGATGGCCAGGGCTGTGGCCAAGGCGGCGCTGAGCCCGGTGCAGGAACACGAGACA
GGCCGGCGCAGCAGCTCTGGCGAGGCGGGCACACCCCTGGTACCCATTGTCGTAGAGCCT
GCGCGGCCCGGGGCTAAGGCTGTGGTGCCTCAGCCTCTGGGCGCGGACTCCAAGGGGTTG
CAGGAACCCGCACCCCTGGCGCCTTCCGTGCCCGAGGCCCCCCGGGGCCGGGAGCGCTGG
GTGTTGGAGGTGGTGGAGGAGCGCACCACGCTGAGCGGTCCTCGCTCCAAGCCCGCCTCC
CCAAAGCTCTCCCCGGAGCCCCAGACACCCTCCCTAGCCCCAGCGAAGTGCAGTGCACCC
AGCAGTGCAGTGACCCCAGTCCCACCCGCATCCCTCTTGGGCTCAGGCACCAAGCCTCAA
GTGGGGCTGACCTCCCGGTGCCCTGCTGAAGCTGTGCCCCCAGCAGGCCTGACCAAAAAA
GGAGTGTCCAGTCCCGCACCCCCGGGACCATAG
|
| Protein Properties |
|---|
| Number of Residues
| 1570 |
| Molecular Weight
| 170675.2 |
| Theoretical pI
| 8.6 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Microtubule-associated serine/threonine-protein kinase 1
MSDSLWTALSNFSMPSFPGGSMFRRTKSCRTSNRKSLILTSTSPTLPRPHSPLPGHLGSS
PLDSPRNFSPNTPAHFSFASSRRADGRRWSLASLPSSGYGTNTPSSTVSSSCSSQERLHQ
LPYQPTVDELHFLSKHFGSTESITDEDGGRRSPAVRPRSRSLSPGRSPSSYDNEIVMMNH
VYKERFPKATAQMEEKLRDFTRAYEPDSVLPLADGVLSFIHHQIIELARDCLTKSRDGLI
TTVYFYELQENLEKLLQDAYERSESLEVAFVTQLVKKLLIIISRPARLLECLEFNPEEFY
HLLEAAEGHAKEGHLVKTDIPRYIIRQLGLTRDPFPDVVHLEEQDSGGSNTPEQDDLSEG
RSSKAKKPPGENDFDTIKLISNGAYGAVYLVRHRDTRQRFAMKKINKQNLILRNQIQQAF
VERDILTFAENPFVVGMFCSFETRRHLCMVMEYVEGGDCATLLKNIGALPVEMARMYFAE
TVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKMGLMSLTTNLYEGHIEKDAR
EFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVI
SDDILWPEGDEALPTEAQLLISSLLQTNPLVRLGAGGAFEVKQHSFFRDLDWTGLLRQKA
EFIPHLESEDDTSYFDTRSDRYHHVNSYDEDDTTEEEPVEIRQFSSCSPRFSKVYSSMEQ
LSQHEPKTPVAAAGSSKREPSTKGPEEKVAGKREGLGGLTLREKTWRGGSPEIKRFSASE
ASFLEGEASPPLGARRRFSALLEPSRFSAPQEDEDEARLRRPPRPSSDPAGSLDARAPKE
ETQGEGTSSAGDSEATDRPRPGDLCPPSKDGDASGPRATNDLVLRRARHQQMSGDVAVEK
RPSRTGGKVIKSASATALSVMIPAVDPHGSSPLASPMSPRSLSSNPSSRDSSPSRDYSPA
VSGLRSPITIQRSGKKYGFTLRAIRVYMGDTDVYSVHHIVWHVEEGGPAQEAGLCAGDLI
THVNGEPVHGMVHPEVVELILKSGNKVAVTTTPFENTSIRIGPARRSSYKAKMARRNKRP
SAKEGQESKKRSSLFRKITKQSNLLHTSRSLSSLNRSLSSSDSLPGSPTHGLPARSPTHS
YRSTPDSAYLGASSQSSSPASSTPNSPASSASHHIRPSTLHGLSPKLHRQYRSARCKSAG
NIPLSPLAHTPSPTQASPPPLPGHTVGSSHTTQSFPAKLHSSPPVVRPRPKSAEPPRSPL
LKRVQSAEKLGASLSADKKGALRKHSLEVGHPDFRKDFHGELALHSLAESDGETPPVEGL
GAPRQVAVRRLGRQESPLSLGADPLLPEGASRPPVSSKEKESPGGAEACTPPRATTPGGR
TLERDVGCTRHQSVQTEDGTGGMARAVAKAALSPVQEHETGRRSSSGEAGTPLVPIVVEP
ARPGAKAVVPQPLGADSKGLQEPAPLAPSVPEAPRGRERWVLEVVEERTTLSGPRSKPAS
PKLSPEPQTPSLAPAKCSAPSSAVTPVPPASLLGSGTKPQVGLTSRCPAEAVPPAGLTKK
GVSSPAPPGP
|
| External Links |
|---|
| GenBank ID Protein
| 45120119 |
| UniProtKB/Swiss-Prot ID
| Q9Y2H9 |
| UniProtKB/Swiss-Prot Entry Name
| MAST1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_014975.2 |
| GeneCard ID
| MAST1 |
| GenAtlas ID
| MAST1 |
| HGNC ID
| HGNC:19034 |
| References |
|---|
| General References
| Not Available |