Identification
HMDB Protein ID CDBP03929
Secondary Accession Numbers Not Available
Name Serine/threonine-protein kinase/endoribonuclease IRE2
Description Not Available
Synonyms
  1. Endoplasmic reticulum-to-nucleus signaling 2
  2. Endoribonuclease
  3. IRE1b
  4. Inositol-requiring protein 2
  5. Ire1-beta
  6. Serine/threonine-protein kinase
  7. hIRE2p
Gene Name ERN2
Protein Type Enzyme
Biological Properties
General Function Involved in endoribonuclease activity, producing 5'-phosphomonoesters
Specific Function Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins
GO Classification
Function
catalytic activity
endoribonuclease activity, producing 5'-phosphomonoesters
hydrolase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
adenyl ribonucleotide binding
atp binding
protein kinase activity
protein serine/threonine kinase activity
nuclease activity
hydrolase activity, acting on ester bonds
endonuclease activity
binding
endoribonuclease activity
Process
rna metabolic process
phosphorus metabolic process
phosphate metabolic process
metabolic process
macromolecule metabolic process
cellular macromolecule metabolic process
rna processing
cellular metabolic process
protein amino acid phosphorylation
mrna processing
phosphorylation
Cellular Location
  1. Endoplasmic reticulum membrane
  2. Single-pass type I membrane protein
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 16p12.2
SNPs ERN2
Gene Sequence
>2925 bp
ATGAGAAGGGCGGGGATCGGCGAGGACTCCAGGCTGGGGTTGCAGGCCCAGCCAGGGGCG
GAGCCTTCTCCGGGTCGGGCGGGGACAGAGCGCTCCCTTGGAGGCACCCAGGGACCTGGC
CAGCCGTGCAGCTGCCCAGGCGCTATGGCGAGTGCGGTCAGGGGGTCGAGGCCGTGGCCC
CGGCTGGGGCTCCAGCTCCAGTTCGCGGCGCTGCTGCTCGGGACGCTGAGTCCACAGGTT
CATACTCTCAGGCCAGAGAACCTCCTGCTGGTGTCCACCTTGGATGGAAGTCTCCACGCA
CTAAGCAAGCAGACAGGGGACCTGAAGTGGACTCTGAGGGATGATCCCGTCATCGAAGGA
CCAATGTACGTCACAGAAATGGCCTTTCTCTCTGACCCAGCAGATGGCAGCCTGTACATC
TTGGGGACCCAAAAACAACAGGGATTAATGAAACTGCCATTCACCATCCCTGAGCTGGTT
CATGCCTCTCCCTGCCGCAGCTCTGATGGGGTCTTCTACACAGGCCGGAAGCAGGATGCC
TGGTTTGTGGTGGACCCTGAGTCAGGGGAGACCCAGATGACACTGACCACAGAGGGTCCC
TCCACCCCCCGCCTCTACATTGGCCGAACACAGTATACGGTCACCATGCATGACCCAAGA
GCCCCAGCCCTGCGCTGGAACACCACCTACCGCCGCTACTCAGCGCCCCCCATGGATGGC
TCACCTGGGAAATACATGAGCCACCTGGCGTCCTGCGGGATGGGCCTGCTGCTCACTGTG
GACCCAGGAAGCGGGACGGTGCTGTGGACACAGGACCTGGGCGTGCCTGTGATGGGCGTC
TACACCTGGCACCAGGACGGCCTGCGCCAGCTGCCGCATCTCACGCTGGCTCGAGACACT
CTGCATTTCCTCGCCCTCCGCTGGGGCCACATCCGACTGCCTGCCTCAGGCCCCCGGGAC
ACAGCCACCCTCTTCTCTACCTTGGACACCCAGCTGCTAATGACGCTGTATGTGGGGAAG
GATGAAACTGGCTTCTATGTCTCTAAAGCACTGGTCCACACAGGAGTGGCCCTGGTGCCT
CGTGGACTGACCCTGGCCCCCGCAGATGGCCCCACCACAGATGAGGTGACACTCCAAGTC
TCAGGAGAGCGAGAGGGCTCACCCAGCACTGCTGTTAGATACCCCTCAGGCAGTGTGGCC
CTCCCAAGCCAGTGGCTGCTCATTGGACACCACGAGCTACCCCCAGTCCTGCACACCACC
ATGCTGAGGGTCCATCCCACCCTGGGGAGTGGAACTGCAGAGACAAGACCTCCAGAGAAT
ACCCAGGCCCCAGCCTTCTTCTTGGAGCTATTGAGCCTGAGCCGAGAGAAACTTTGGGAC
TCCGAGCTGCATCCAGAAGAAAAAACTCCAGACTCTTACTTGGGGCTGGGACCCCAAGAC
CTGCTGGCAGCTAGCCTCACTGCTGTCCTCCTGGGAGGGTGGATTCTCTTTGTGATGAGG
CAGCAACAGCCGCAGGTGGTGGAGAAGCAGCAGGAGACCCCCCTGGCACCTGCAGACTTT
GCTCACATCTCCCAGGATGCCCAGTCCCTGCACTCGGGGGCCAGCCGGAGGAGCCAGAAG
AGGCTTCAGAGTCCCTCAAAGCAAGCCCAGCCACTCGACGACCCTGAAGCTGAGCAACTC
ACCGTAGTGGGGAAGATTTCCTTCAATCCCAAGGACGTGCTGGGCCGCGGGGCAGGCGGG
ACTTTCGTTTTCCGGGGACAGTTTGAGGGACGGGCAGTGGCTGTCAAGCGGCTCCTCCGC
GAGTGCTTTGGCCTGGTTCGGCGGGAAGTTCAACTGCTGCAGGAGTCTGACAGGCACCCC
AACGTGCTCCGCTACTTCTGCACCGAGCGGGGACCCCAGTTCCACTACATTGCCCTGGAG
CTCTGCCGGGCCTCCTTGCAGGAGTACGTAGAAAACCCGGACCTGGATCGCGGGGGTCTG
GAGCCCGAGGTCGTGCTGCAGCAGCTGATGTCTGGCCTGGCCCACCTGCACTCTTTACAC
ATAGTGCACCGGGACCTGAAGCCAGGAAATATTCTCATCACCGGGCCTGACAGCCAGGGC
CTGGGCAGAGTGGTGCTCTCAGACTTCGGCCTCTGCAAGAAGCTGCCTGCTGGCCGCTGT
AGCTTCAGCCTCCACTCCGGCATCCCCGGCACGGAAGGCTGGATGGCGCCCGAGCTTCTG
CAGCTCCTGCCACCAGACAGTCCTACCAGCGCTGTGGACATCTTCTCTGCAGGCTGCGTG
TTCTACTACGTGCTTTCTGGTGGCAGCCACCCCTTTGGAGACAGTCTTTATCGCCAGGCA
AACATCCTCACAGGGGCTCCCTGTCTGGCTCACCTGGAGGAAGAGGTCCACGACAAGGTG
GTTGCCCGGGACCTGGTTGGAGCCATGTTGAGCCCACTGCCGCAGCCACGCCCCTCTGCC
CCCCAGGTGCTGGCCCACCCCTTCTTTTGGAGCAGAGCCAAGCAACTCCAGTTCTTCCAG
GACGTCAGTGACTGGCTGGAGAAGGAGTCCGAGCAGGAGCCCCTGGTGAGGGCACTGGAG
GCGGGAGGCTGCGCAGTGGTCCGGGACAACTGGCACGAGCACATCTCCATGCCGCTGCAG
ACAGATCTGAGAAAGTTCCGGTCCTATAAGGGGACATCAGTGCGAGACCTGCTCCGTGCT
GTGAGGAACAAGAAGCACCACTACAGGGAGCTCCCAGTTGAGGTGCGACAGGCACTCGGC
CAAGTCCCTGATGGCTTCGTCCAGTACTTCACAAACCGCTTCCCACGGCTGCTCCTCCAC
ACGCACCGAGCCATGAGGAGCTGCGCCTCTGAGAGCCTCTTCCTGCCCTACTACCCGCCA
GACTCAGAGGCCAGGAGGCCATGCCCTGGGGCCACAGGGAGGTGA
Protein Properties
Number of Residues 926
Molecular Weight 102465.2
Theoretical pI 7.13
Pfam Domain Function
Signals
  • ["1-34"]
Transmembrane Regions
  • ["431-451"]
Protein Sequence
>Serine/threonine-protein kinase/endoribonuclease IRE2
MASAVRGSRPWPRLGLQLQFAALLLGTLSPQVHTLRPENLLLVSTLDGSLHALSKQTGDL
KWTLRDDPVIEGPMYVTEMAFLSDPADGSLYILGTQKQQGLMKLPFTIPELVHASPCRSS
DGVFYTGRKQDAWFVVDPESGETQMTLTTEGPSTPRLYIGRTQYTVTMHDPRAPALRWNT
TYRRYSAPPMDGSPGKYMSHLASCGMGLLLTVDPGSGTVLWTQDLGVPVMGVYTWHQDGL
RQLPHLTLARDTLHFLALRWGHIRLPASGPQDTATLFSTLDTQLLMTLYVGKDETGFYVS
KALVHTGVALVPRGLTLAPADGPTTDEVTLQVSGEREGSPSTAVRYPSGSVALPSQWLLI
GHHELPPVLHTTMLRVHPTLGSGTAETRPPENTQAPAFFLELLSLSREKLWDSELHPEEK
TPDSYLGLGPQDLLAASLTAVLLGGWILFVMRQQQPQVVEKQQETPLAPADFAHISQDAQ
SLHSGATRRSQKRLQSPSKQAQPLDDPEAEQLTVVGKISFNPKDVLGRGAGGTFVFRGQF
EGRAVAVKRLLRECFGLVRREVQLLQESDRHPNVLRYFCTERGPQFHYIALELCRASLQE
YVENPDLDRGGLEPEVVLQQLMSGLAHLHSLHIVHRDLKPGNILITGPDSQGLGRVVLSD
FGLCKKLPAGRCSFSLHSGIPGTEGWMAPELLQLLPPDSPTSAVDIFSAGCVFYYVLSGG
SHPFGDSLYRQANILTGAPCLAHLEEEVHDKVVARDLVGAMLSPLPQPRPSAPQVLAHPF
FWSRAKQLQFFQDVSDWLEKESEQEPLVRALEAGGCAVVRDNWHEHISMPLQTDLRKFRS
YKGTSVRDLLRAVRNKKHHYRELPVEVRQALGQVPDGFVQYFTNRFPRLLLHTHRAMRSC
ASESLFLPYYPPDSEARRPCPGATGR
GenBank ID Protein 145312265
UniProtKB/Swiss-Prot ID Q76MJ5
UniProtKB/Swiss-Prot Entry Name ERN2_HUMAN
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID ERN2
GenAtlas ID ERN2
HGNC ID HGNC:16942
References
General References Not Available