Cannabis Compound Database: Showing Protein Serine/threonine-protein kinase/endoribonuclease IRE2 (CDBP03929)

Identification Biological properties Gene properties Protein properties External links References XML Show 3 compounds

Identification

HMDB Protein ID

CDBP03929

Secondary Accession Numbers

Not Available

Name

Serine/threonine-protein kinase/endoribonuclease IRE2

Description

Not Available

Synonyms

Endoplasmic reticulum-to-nucleus signaling 2
Endoribonuclease
IRE1b
Inositol-requiring protein 2
Ire1-beta
Serine/threonine-protein kinase
hIRE2p

Gene Name

ERN2

Protein Type

Enzyme

Biological Properties

General Function

Involved in endoribonuclease activity, producing 5'-phosphomonoesters

Specific Function

Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins

GO Classification

Function
catalytic activity
endoribonuclease activity, producing 5'-phosphomonoesters
hydrolase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
adenyl ribonucleotide binding
atp binding
protein kinase activity
protein serine/threonine kinase activity
nuclease activity
hydrolase activity, acting on ester bonds
endonuclease activity
binding
endoribonuclease activity
Process
rna metabolic process
phosphorus metabolic process
phosphate metabolic process
metabolic process
macromolecule metabolic process
cellular macromolecule metabolic process
rna processing
cellular metabolic process
protein amino acid phosphorylation
mrna processing
phosphorylation

Cellular Location

Endoplasmic reticulum membrane
Single-pass type I membrane protein

Pathways

Not Available

Gene Properties

Chromosome Location

Chromosome:1

Locus

16p12.2

SNPs

ERN2

Gene Sequence

>2925 bp
ATGAGAAGGGCGGGGATCGGCGAGGACTCCAGGCTGGGGTTGCAGGCCCAGCCAGGGGCG
GAGCCTTCTCCGGGTCGGGCGGGGACAGAGCGCTCCCTTGGAGGCACCCAGGGACCTGGC
CAGCCGTGCAGCTGCCCAGGCGCTATGGCGAGTGCGGTCAGGGGGTCGAGGCCGTGGCCC
CGGCTGGGGCTCCAGCTCCAGTTCGCGGCGCTGCTGCTCGGGACGCTGAGTCCACAGGTT
CATACTCTCAGGCCAGAGAACCTCCTGCTGGTGTCCACCTTGGATGGAAGTCTCCACGCA
CTAAGCAAGCAGACAGGGGACCTGAAGTGGACTCTGAGGGATGATCCCGTCATCGAAGGA
CCAATGTACGTCACAGAAATGGCCTTTCTCTCTGACCCAGCAGATGGCAGCCTGTACATC
TTGGGGACCCAAAAACAACAGGGATTAATGAAACTGCCATTCACCATCCCTGAGCTGGTT
CATGCCTCTCCCTGCCGCAGCTCTGATGGGGTCTTCTACACAGGCCGGAAGCAGGATGCC
TGGTTTGTGGTGGACCCTGAGTCAGGGGAGACCCAGATGACACTGACCACAGAGGGTCCC
TCCACCCCCCGCCTCTACATTGGCCGAACACAGTATACGGTCACCATGCATGACCCAAGA
GCCCCAGCCCTGCGCTGGAACACCACCTACCGCCGCTACTCAGCGCCCCCCATGGATGGC
TCACCTGGGAAATACATGAGCCACCTGGCGTCCTGCGGGATGGGCCTGCTGCTCACTGTG
GACCCAGGAAGCGGGACGGTGCTGTGGACACAGGACCTGGGCGTGCCTGTGATGGGCGTC
TACACCTGGCACCAGGACGGCCTGCGCCAGCTGCCGCATCTCACGCTGGCTCGAGACACT
CTGCATTTCCTCGCCCTCCGCTGGGGCCACATCCGACTGCCTGCCTCAGGCCCCCGGGAC
ACAGCCACCCTCTTCTCTACCTTGGACACCCAGCTGCTAATGACGCTGTATGTGGGGAAG
GATGAAACTGGCTTCTATGTCTCTAAAGCACTGGTCCACACAGGAGTGGCCCTGGTGCCT
CGTGGACTGACCCTGGCCCCCGCAGATGGCCCCACCACAGATGAGGTGACACTCCAAGTC
TCAGGAGAGCGAGAGGGCTCACCCAGCACTGCTGTTAGATACCCCTCAGGCAGTGTGGCC
CTCCCAAGCCAGTGGCTGCTCATTGGACACCACGAGCTACCCCCAGTCCTGCACACCACC
ATGCTGAGGGTCCATCCCACCCTGGGGAGTGGAACTGCAGAGACAAGACCTCCAGAGAAT
ACCCAGGCCCCAGCCTTCTTCTTGGAGCTATTGAGCCTGAGCCGAGAGAAACTTTGGGAC
TCCGAGCTGCATCCAGAAGAAAAAACTCCAGACTCTTACTTGGGGCTGGGACCCCAAGAC
CTGCTGGCAGCTAGCCTCACTGCTGTCCTCCTGGGAGGGTGGATTCTCTTTGTGATGAGG
CAGCAACAGCCGCAGGTGGTGGAGAAGCAGCAGGAGACCCCCCTGGCACCTGCAGACTTT
GCTCACATCTCCCAGGATGCCCAGTCCCTGCACTCGGGGGCCAGCCGGAGGAGCCAGAAG
AGGCTTCAGAGTCCCTCAAAGCAAGCCCAGCCACTCGACGACCCTGAAGCTGAGCAACTC
ACCGTAGTGGGGAAGATTTCCTTCAATCCCAAGGACGTGCTGGGCCGCGGGGCAGGCGGG
ACTTTCGTTTTCCGGGGACAGTTTGAGGGACGGGCAGTGGCTGTCAAGCGGCTCCTCCGC
GAGTGCTTTGGCCTGGTTCGGCGGGAAGTTCAACTGCTGCAGGAGTCTGACAGGCACCCC
AACGTGCTCCGCTACTTCTGCACCGAGCGGGGACCCCAGTTCCACTACATTGCCCTGGAG
CTCTGCCGGGCCTCCTTGCAGGAGTACGTAGAAAACCCGGACCTGGATCGCGGGGGTCTG
GAGCCCGAGGTCGTGCTGCAGCAGCTGATGTCTGGCCTGGCCCACCTGCACTCTTTACAC
ATAGTGCACCGGGACCTGAAGCCAGGAAATATTCTCATCACCGGGCCTGACAGCCAGGGC
CTGGGCAGAGTGGTGCTCTCAGACTTCGGCCTCTGCAAGAAGCTGCCTGCTGGCCGCTGT
AGCTTCAGCCTCCACTCCGGCATCCCCGGCACGGAAGGCTGGATGGCGCCCGAGCTTCTG
CAGCTCCTGCCACCAGACAGTCCTACCAGCGCTGTGGACATCTTCTCTGCAGGCTGCGTG
TTCTACTACGTGCTTTCTGGTGGCAGCCACCCCTTTGGAGACAGTCTTTATCGCCAGGCA
AACATCCTCACAGGGGCTCCCTGTCTGGCTCACCTGGAGGAAGAGGTCCACGACAAGGTG
GTTGCCCGGGACCTGGTTGGAGCCATGTTGAGCCCACTGCCGCAGCCACGCCCCTCTGCC
CCCCAGGTGCTGGCCCACCCCTTCTTTTGGAGCAGAGCCAAGCAACTCCAGTTCTTCCAG
GACGTCAGTGACTGGCTGGAGAAGGAGTCCGAGCAGGAGCCCCTGGTGAGGGCACTGGAG
GCGGGAGGCTGCGCAGTGGTCCGGGACAACTGGCACGAGCACATCTCCATGCCGCTGCAG
ACAGATCTGAGAAAGTTCCGGTCCTATAAGGGGACATCAGTGCGAGACCTGCTCCGTGCT
GTGAGGAACAAGAAGCACCACTACAGGGAGCTCCCAGTTGAGGTGCGACAGGCACTCGGC
CAAGTCCCTGATGGCTTCGTCCAGTACTTCACAAACCGCTTCCCACGGCTGCTCCTCCAC
ACGCACCGAGCCATGAGGAGCTGCGCCTCTGAGAGCCTCTTCCTGCCCTACTACCCGCCA
GACTCAGAGGCCAGGAGGCCATGCCCTGGGGCCACAGGGAGGTGA

Protein Properties

Number of Residues

926

Molecular Weight

102465.2

Theoretical pI

7.13

Pfam Domain Function

Pkinase (PF00069 )
Ribonuc_2-5A (PF06479 )

Signals

["1-34"]

Transmembrane Regions

["431-451"]

Protein Sequence

>Serine/threonine-protein kinase/endoribonuclease IRE2
MASAVRGSRPWPRLGLQLQFAALLLGTLSPQVHTLRPENLLLVSTLDGSLHALSKQTGDL
KWTLRDDPVIEGPMYVTEMAFLSDPADGSLYILGTQKQQGLMKLPFTIPELVHASPCRSS
DGVFYTGRKQDAWFVVDPESGETQMTLTTEGPSTPRLYIGRTQYTVTMHDPRAPALRWNT
TYRRYSAPPMDGSPGKYMSHLASCGMGLLLTVDPGSGTVLWTQDLGVPVMGVYTWHQDGL
RQLPHLTLARDTLHFLALRWGHIRLPASGPQDTATLFSTLDTQLLMTLYVGKDETGFYVS
KALVHTGVALVPRGLTLAPADGPTTDEVTLQVSGEREGSPSTAVRYPSGSVALPSQWLLI
GHHELPPVLHTTMLRVHPTLGSGTAETRPPENTQAPAFFLELLSLSREKLWDSELHPEEK
TPDSYLGLGPQDLLAASLTAVLLGGWILFVMRQQQPQVVEKQQETPLAPADFAHISQDAQ
SLHSGATRRSQKRLQSPSKQAQPLDDPEAEQLTVVGKISFNPKDVLGRGAGGTFVFRGQF
EGRAVAVKRLLRECFGLVRREVQLLQESDRHPNVLRYFCTERGPQFHYIALELCRASLQE
YVENPDLDRGGLEPEVVLQQLMSGLAHLHSLHIVHRDLKPGNILITGPDSQGLGRVVLSD
FGLCKKLPAGRCSFSLHSGIPGTEGWMAPELLQLLPPDSPTSAVDIFSAGCVFYYVLSGG
SHPFGDSLYRQANILTGAPCLAHLEEEVHDKVVARDLVGAMLSPLPQPRPSAPQVLAHPF
FWSRAKQLQFFQDVSDWLEKESEQEPLVRALEAGGCAVVRDNWHEHISMPLQTDLRKFRS
YKGTSVRDLLRAVRNKKHHYRELPVEVRQALGQVPDGFVQYFTNRFPRLLLHTHRAMRSC
ASESLFLPYYPPDSEARRPCPGATGR

External Links

GenBank ID Protein

145312265

UniProtKB/Swiss-Prot ID

Q76MJ5

UniProtKB/Swiss-Prot Entry Name

ERN2_HUMAN

PDB IDs

Not Available

GenBank Gene ID

Not Available

GeneCard ID