Cannabis Compound Database: Showing Protein Isocitrate dehydrogenase [NADP] cytoplasmic (CDBP00841)

Identification Biological properties Gene properties Protein properties External links References XML Show 7 compounds

Identification

HMDB Protein ID

CDBP00841

Secondary Accession Numbers

Not Available

Name

Isocitrate dehydrogenase [NADP] cytoplasmic

Description

Not Available

Synonyms

Cytosolic NADP-isocitrate dehydrogenase
IDH
IDP
NADP(+)-specific ICDH
Oxalosuccinate decarboxylase

Gene Name

IDH1

Protein Type

Enzyme

Biological Properties

General Function

Involved in magnesium ion binding

Specific Function

Not Available

GO Classification

Biological Process
response to oxidative stress
2-oxoglutarate metabolic process
glutathione metabolic process
glyoxylate cycle
NADPH regeneration
tricarboxylic acid cycle
isocitrate metabolic process
cellular lipid metabolic process
Cellular Component
cytosol
mitochondrion
peroxisomal matrix
Function
ion binding
cation binding
metal ion binding
binding
nucleotide binding
catalytic activity
isocitrate dehydrogenase activity
isocitrate dehydrogenase (nadp+) activity
magnesium ion binding
nad or nadh binding
oxidoreductase activity, acting on the ch-oh group of donors, nad or nadp as acceptor
oxidoreductase activity, acting on ch-oh group of donors
oxidoreductase activity
Molecular Function
NAD binding
magnesium ion binding
isocitrate dehydrogenase (NADP+) activity
Process
metabolic process
isocitrate metabolic process
cellular metabolic process
organic acid metabolic process
oxoacid metabolic process
carboxylic acid metabolic process
oxidation reduction

Cellular Location

Cytoplasm
Peroxisome

Pathways

Name	SMPDB/Pathwhiz	KEGG
Citrate cycle (TCA cycle)	Not Available
2-Oxocarboxylic acid metabolism	Not Available
Peroxisome	Not Available
Warburg Effect		Not Available
The oncogenic action of 2-hydroxyglutarate		Not Available

Gene Properties

Chromosome Location

Locus

2q33.3

SNPs

IDH1

Gene Sequence

>1245 bp
ATGTCCAAAAAAATCAGTGGCGGTTCTGTGGTAGAGATGCAAGGAGATGAAATGACACGA
ATCATTTGGGAATTGATTAAAGAGAAACTCATTTTTCCCTACGTGGAATTGGATCTACAT
AGCTATGATTTAGGCATAGAGAATCGTGATGCCACCAACGACCAAGTCACCAAGGATGCT
GCAGAAGCTATAAAGAAGCATAATGTTGGCGTCAAATGTGCCACTATCACTCCTGATGAG
AAGAGGGTTGAGGAGTTCAAGTTGAAACAAATGTGGAAATCACCAAATGGCACCATACGA
AATATTCTGGGTGGCACGGTCTTCAGAGAAGCCATTATCTGCAAAAATATCCCCCGGCTT
GTGAGTGGATGGGTAAAACCTATCATCATAGGTCGTCATGCTTATGGGGATCAATACAGA
GCAACTGATTTTGTTGTTCCTGGGCCTGGAAAAGTAGAGATAACCTACACACCAAGTGAC
GGAACCCAAAAGGTGACATACCTGGTACATAACTTTGAAGAAGGTGGTGGTGTTGCCATG
GGGATGTATAATCAAGATAAGTCAATTGAAGATTTTGCACACAGTTCCTTCCAGATGGCT
CTGTCTAAGGGTTGGCCTTTGTATCTGAGCACCAAAAACACTATTCTGAAGATATATGAT
GGGCGTTTTAAAGACATCTTTCAGGAGATATATGACAAGCAGTACAAGTCCCAGTTTGAA
GCTCAAAAGATCTGGTATGAGCATAGGCTCATCGACGACATGGTGGCCCAAGCTATGAAA
TCAGAGGGAGGCTTCATCTGGGCCTGTAAAAACTATGATGGTGACGTGCAGTCGGACTCT
GTGGCCCAAGGGTATGGCTCTCTCGGCATGATGACCAGCGTGCTGGTTTGTCCAGATGGC
AAGACAGTAGAAGCAGAGGCTGCCCACGGGACTGTAACCCGTCACTACCGCATGTACCAG
AAAGGACAGGAGACGTCCACCAACCTCATTGCTTCCATTTTTGCCTGGACCAGAGGGTTA
GCCCACAGAGCAAAGCTTGATAACAATAAAGAGCTTGCCTTCTTTGCAAATGCTTTGGAA
GAAGTCTCTATTGAGACAATTGAGGCTGGCTTCATGACCAAGGACTTGGCTGCTTGCATT
AGAGGTTTACCCAATGTGCAACGTTCTGACTACTTGAATACATTTGAGTTCATGGATAAA
CTTGGAGAAAACTTGAAGATCAAACTAGCTCAGGCCAAACTTTAA

Protein Properties

Number of Residues

414

Molecular Weight

46659.005

Theoretical pI

7.0

Pfam Domain Function

Iso_dh (PF00180 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Isocitrate dehydrogenase [NADP] cytoplasmic
MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDA
AEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL
VSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAM
GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE
AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG
KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE
EVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL

External Links

GenBank ID Protein

3641398

UniProtKB/Swiss-Prot ID

O75874

UniProtKB/Swiss-Prot Entry Name

IDHC_HUMAN

PDB IDs