Cannabis Compound Database: Showing Compound Card for NAD (CDB004868)

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Identification Taxonomy Ontology Physical properties Spectra Protein target Pathways Concentrations Links References enzymes (238)transporters (8) Show 353 proteins XML

Record Information

Version

1.0

Created at

2020-04-17 18:45:04 UTC

Updated at

2020-11-18 16:38:53 UTC

CannabisDB ID

CDB004868

Secondary Accession Numbers

Not Available

Cannabis Compound Identification

Common Name

NAD

Description

NAD+, also known as codehydrogenase I or coenzyme I, belongs to the class of organic compounds known as (5'->5')-dinucleotides. These are dinucleotides where the two bases are connected via a (5'->5')-phosphodiester linkage. NAD+ is a very strong basic compound (based on its pKa). In humans, NAD+ is involved in citric acid cycle. Outside of the human body, NAD+ has been detected, but not quantified in, several different foods, such as garden tomato, devilfish, saffrons, cloud ear fungus, and bog bilberries. This could make NAD+ a potential biomarker for the consumption of these foods. NAD is expected to be in Cannabis as all living plants are known to produce and metabolize it.

Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
Codehydrogenase I	ChEBI
Coenzyme I	ChEBI
Cozymase I	ChEBI
Diphosphopyridine nucleotide	ChEBI
DPN	ChEBI
Nadide	ChEBI
NICOTINAMIDE-adenine-dinucleotide	ChEBI
Adenine dinucleotide, dihydronicotinamide	MeSH
NAD	MeSH
Nicotinamide-adenine dinucleotide	MeSH
Nucleotide, diphosphopyridine	MeSH
Dihydronicotinamide adenine dinucleotide	MeSH
NADH	MeSH
Nicotinamide adenine dinucleotide	MeSH
Dinucleotide, nicotinamide-adenine	MeSH
Dinucleotide, dihydronicotinamide adenine	MeSH
Adenine-nicotinamide dinucleotide	HMDB
NAD+	HMDB
Oxidized diphosphopyridine nucleotide	HMDB
beta-Diphosphopyridine nucleotide	HMDB
beta-NAD	HMDB
beta-NAD+	HMDB
beta-Nicotinamide adenine dinucleotide	HMDB
beta-Nicotinamide adenine dinucleotide hydrate	HMDB
β-Diphosphopyridine nucleotide	HMDB
β-NAD	HMDB
β-NAD+	HMDB
β-Nicotinamide adenine dinucleotide	HMDB
β-Nicotinamide adenine dinucleotide hydrate	HMDB

Chemical Formula

C₂₁H₂₇N₇O₁₄P₂

Average Molecular Weight

663.43

Monoisotopic Molecular Weight

663.1091

IUPAC Name

1-[(2R,3R,4S,5R)-5-({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphono}oxy)(hydroxy)phosphoryl]oxy}methyl)-3,4-dihydroxyoxolan-2-yl]-3-(C-hydroxycarbonimidoyl)-1lambda5-pyridin-1-ylium

Traditional Name

1-[(2R,3R,4S,5R)-5-{[({[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphono}oxy(hydroxy)phosphoryl)oxy]methyl}-3,4-dihydroxyoxolan-2-yl]-3-(C-hydroxycarbonimidoyl)-1lambda5-pyridin-1-ylium

CAS Registry Number

53-84-9

SMILES

NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP([O-])(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O

InChI Identifier

InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1

InChI Key

BAWFJGJZGIEFAR-NNYOXOHSSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as (5'->5')-dinucleotides. These are dinucleotides where the two bases are connected via a (5'->5')-phosphodiester linkage.

Kingdom

Organic compounds

Super Class

Nucleosides, nucleotides, and analogues

Class

(5'->5')-dinucleotides

Sub Class

Not Available

Direct Parent

(5'->5')-dinucleotides

Alternative Parents

Substituents

(5'->5')-dinucleotide
Purine nucleotide sugar
Purine ribonucleoside diphosphate
Purine ribonucleoside monophosphate
Nicotinamide-nucleotide
Pyridine nucleotide
Pentose-5-phosphate
Pentose phosphate
Glycosyl compound
N-glycosyl compound
6-aminopurine
Monosaccharide phosphate
Organic pyrophosphate
Purine
Imidazopyrimidine
Nicotinamide
Monoalkyl phosphate
Aminopyrimidine
Monosaccharide
N-substituted imidazole
Organic phosphoric acid derivative
Imidolactam
Phosphoric acid ester
Alkyl phosphate
Pyrimidine
Pyridinium
Pyridine
Tetrahydrofuran
Azole
Imidazole
Heteroaromatic compound
Secondary alcohol
Carboximidic acid derivative
Carboximidic acid
Organoheterocyclic compound
Oxacycle
Azacycle
Hydrocarbon derivative
Organopnictogen compound
Organic oxide
Organic zwitterion
Primary amine
Organonitrogen compound
Amine
Organic nitrogen compound
Alcohol
Organic oxygen compound
Organooxygen compound
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

NAD (CHEBI:44215 )

Ontology

Physiological effect

Health effect:

Health condition:

Pellagra

Disposition

Source:

Endogenous

Biological location:

Physical Properties

State

Solid

Experimental Properties

Property	Value	Reference
Melting Point	140.0 - 142.0 °C	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	752.5 mg/mL	Not Available
logP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	-1.2	ALOGPS
logP	-10	ChemAxon
logS	-2.5	ALOGPS
pKa (Strongest Acidic)	1.85	ChemAxon
pKa (Strongest Basic)	6.38	ChemAxon
Physiological Charge	-1	ChemAxon
Hydrogen Acceptor Count	16	ChemAxon
Hydrogen Donor Count	8	ChemAxon
Polar Surface Area	322.08 Å²	ChemAxon
Rotatable Bond Count	11	ChemAxon
Refractivity	151.81 m³·mol⁻¹	ChemAxon
Polarizability	58.5 Å³	ChemAxon
Number of Rings	5	ChemAxon
Bioavailability	No	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	Yes	ChemAxon

Spectra

EI-MS/GC-MS

Type	Description	Splash Key	View
Predicted GC-MS	NAD, TMS_1_1, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	NAD, TMS_1_2, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	NAD, TMS_1_3, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	NAD, TMS_1_4, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	NAD, TMS_1_5, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	NAD, TMS_1_6, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	NAD, TMS_1_7, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	NAD, TMS_2_1, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	NAD, TMS_2_2, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	NAD, TMS_2_3, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	NAD, TMS_2_4, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	NAD, TMS_2_5, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	NAD, TMS_2_6, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	NAD, TMS_2_7, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	NAD, TMS_2_8, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	NAD, TMS_2_9, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	NAD, TMS_2_10, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	NAD, TMS_2_11, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	NAD, TMS_2_12, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	NAD, TMS_2_13, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	NAD, TMS_2_14, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	NAD, TMS_2_15, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	NAD, TMS_2_16, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	NAD, TMS_2_17, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	NAD, TMS_2_18, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum

MS/MS

Type	Description	Splash Key	View
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)	splash10-03di-0000029000-870aa620464a4fedbe8d	2019-11-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)	splash10-002r-0930610000-ccd233f26036136ba3e8	2019-11-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)	splash10-000i-0900000000-ec77ba41ae7dbcfd08a2	2019-11-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-00dl-0219003700-2f52e3c5db41066a112c	2019-11-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-0uk9-0301009000-a3d0c464e56f6e320c80	2019-11-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-00dl-0000090000-c18a7719161c63a71938	2019-11-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-0udi-0000009000-1dde5b221786fe375304	2019-11-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-0002-0911001000-bd16ca8021ab63e9e290	2019-11-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-001i-0900000000-662adda5a00fce5c5017	2019-11-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-03di-0900000000-a2724dbab2ca6eb7e8da	2019-11-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-00dl-0400090000-19bb49ef6fe960f224d2	2019-11-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-006x-0011297400-efee4fe3a4cf024c960a	2019-11-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-004i-0028900000-8ec9bcaf25513495b979	2019-11-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-0a4i-0011953000-577487fb6aff29c77330	2019-11-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-00di-0000009000-e1d0afb4e7926a0f845e	2019-11-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-0006-0001092010-1dcbca7a5ffe61f23e50	2019-11-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-004i-0028900000-764e3ecea72fe178a87e	2019-11-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-004i-0018900000-3b774fba9b96129baa6c	2019-11-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-0006-0000090000-d4236efb9eec36017416	2019-11-22	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-03di-0000009000-3cb1cc8e613a3e179149	2016-08-01	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-014j-0000009000-4bd400c0be81ab938465	2016-08-01	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-0006-6920102000-5fc300f474c5dc2b8600	2016-08-01	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-03di-0000009000-96d7faa48cdd181798a0	2016-08-03	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-03di-1100109000-f496601a0ac75ae3d4a5	2016-08-03	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-003s-9201000000-c06274c9b4d1b70a9ce2	2016-08-03	View Spectrum

NMR

Type	Description	View
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, experimental)	Spectrum
1D NMR	¹H NMR Spectrum (1D, D₂O, experimental)	Spectrum
1D NMR	¹H NMR Spectrum (1D, D₂O, experimental)	Spectrum
1D NMR	¹H NMR Spectrum (1D, D₂O, experimental)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, D₂O, experimental)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Spectrum
2D NMR	[¹H, ¹H]-TOCSY. Unexported temporarily by An Chi on Oct 15, 2021 until json or nmrML file is generated. 2D NMR Spectrum (experimental)	Spectrum
2D NMR	[¹H, ¹³C]-HSQC NMR Spectrum (2D, 600 MHz, H₂O, experimental)	Spectrum

Pathways

Name	SMPDB/Pathwhiz	KEGG
Ammonia Recycling
Glycolysis
Citric Acid Cycle
Gluconeogenesis
Glutamate Metabolism

Protein Targets

Enzymes

Protein Name	Gene Name	Locus	Uniprot ID	Details
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial	PDHB	3p21.1-p14.2	P11177	details
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial	PDHA1	Xp22.1	P08559	details
Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial	PDHA2	4q22-q23	P29803	details
Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	ALDH6A1	14q24.3	Q02252	details
Dihydrolipoyl dehydrogenase, mitochondrial	DLD	7q31-q32	P09622	details
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial	DLAT	11q23.1	P10515	details
Aldo-keto reductase family 1 member C4	AKR1C4	10p15.1	P17516	details
15-hydroxyprostaglandin dehydrogenase [NAD(+)]	HPGD	4q34-q35	P15428	details
Tyrosinase	TYR	11q14-q21	P14679	details
Aldose reductase	AKR1B1	7q35	P15121	details
Short-chain specific acyl-CoA dehydrogenase, mitochondrial	ACADS	12q24.31	P16219	details
NADH-ubiquinone oxidoreductase chain 1	MT-ND1		P03886	details
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1	NDUFB1	14q32.12	O75438	details
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1	6q22-q23	P22413	details
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	1q23	O75306	details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12	NDUFA12	12q22	Q9UI09	details
NADH-cytochrome b5 reductase 3	CYB5R3	22q13.2	P00387	details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	NDUFA1		O15239	details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2	NDUFA4L2	12q13.3	Q9NRX3	details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3	NDUFA3	19q13.42	O95167	details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8	NDUFA8	9q33.2	P51970	details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4	NDUFA4	7p21.3	O00483	details
NADH-ubiquinone oxidoreductase chain 4L	MT-ND4L		P03901	details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11	NDUFA11	19p13.3	Q86Y39	details
Lathosterol oxidase	SC5DL	11q23.3	O75845	details
NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial	NDUFS4	5q11.1	O43181	details
Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	6p25.2	P16083	details
NADH-ubiquinone oxidoreductase chain 5	MT-ND5		P03915	details
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	11p11.11	O75489	details
NADH dehydrogenase [ubiquinone] iron-sulfur protein 5	NDUFS5	1p34.2-p33	O43920	details
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial	NDUFV2	18p11.22	P19404	details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial	NDUFA10	2q37.3	O95299	details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6	NDUFA6	22q13.2	P56556	details
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4	NDUFB4	3q13.33	O95168	details
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial	NDUFS8	11q13	O00217	details
NADH-ubiquinone oxidoreductase chain 2	MT-ND2		P03891	details
Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial	ALDH4A1	1p36	P30038	details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7	NDUFA7	19p13.2	O95182	details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2	NDUFA2	5q31	O43678	details
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial	NDUFS1	2q33-q34	P28331	details
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial	NDUFB5	3q26.33	O43674	details
NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	11q14.1	O95298	details
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3	NDUFB3	2q31.3	O43676	details
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7	NDUFB7	19p13.12	P17568	details
Acyl carrier protein, mitochondrial	NDUFAB1	16p12.2	O14561	details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	NDUFA5	7q32	Q16718	details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial	NDUFA9	12p13.3	Q16795	details
NADH-ubiquinone oxidoreductase chain 4	MT-ND4		P03905	details
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	19p13.3	O75251	details
Xanthine dehydrogenase/oxidase	XDH	2p23.1	P47989	details
NADH-ubiquinone oxidoreductase chain 3	MT-ND3		P03897	details
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial	NDUFV1	11q13	P49821	details
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9	NDUFB9	8q13.3	Q9Y6M9	details
Methylenetetrahydrofolate reductase	MTHFR	1p36.3	P42898	details
NADH-ubiquinone oxidoreductase chain 6	MT-ND6		P03923	details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	NDUFA13	19p13.2	Q9P0J0	details
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial	NDUFS6	5p15.33	O75380	details
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3	6q22	O14638	details
Glutathione reductase, mitochondrial	GSR	8p21.1	P00390	details
Retinal dehydrogenase 1	ALDH1A1	9q21.13	P00352	details
Retinal dehydrogenase 2	ALDH1A2	15q21.3	O94788	details
Deoxyhypusine synthase	DHPS	19p13.2	P49366	details
Succinate-semialdehyde dehydrogenase, mitochondrial	ALDH5A1	6p22	P51649	details
Squalene synthase	FDFT1	8p23.1-p22	P37268	details
Methylsterol monooxygenase 1	MSMO1	4q32-q34	Q15800	details
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating	NSDHL	Xq28	Q15738	details
4-trimethylaminobutyraldehyde dehydrogenase	ALDH9A1	1q23.1	P49189	details
Aldehyde dehydrogenase, dimeric NADP-preferring	ALDH3A1	17p11.2	P30838	details
Alpha-aminoadipic semialdehyde dehydrogenase	ALDH7A1	5q31	P49419	details
Aldehyde dehydrogenase family 1 member A3	ALDH1A3	15q26.3	P47895	details
Aldehyde dehydrogenase, mitochondrial	ALDH2	12q24.2	P05091	details
Fatty aldehyde dehydrogenase	ALDH3A2	17p11.2	P51648	details
Aldehyde dehydrogenase X, mitochondrial	ALDH1B1	9p11.1	P30837	details
Pyrroline-5-carboxylate reductase 1, mitochondrial	PYCR1	17q25.3	P32322	details
Pyrroline-5-carboxylate reductase 2	PYCR2	1q42.12	Q96C36	details
Kynureninase	KYNU	2q22.2	Q16719	details
Nicotinamide mononucleotide adenylyltransferase 1	NMNAT1	1p36.22	Q9HAN9	details
Nicotinamide mononucleotide adenylyltransferase 3	NMNAT3	3q23	Q96T66	details
Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	16p11.2	Q15274	details
Nicotinamide mononucleotide adenylyltransferase 2	NMNAT2	1q25	Q9BZQ4	details
Aldo-keto reductase family 1 member C3	AKR1C3	10p15-p14	P42330	details
3-hydroxyacyl-CoA dehydrogenase type-2	HSD17B10	Xp11.2	Q99714	details
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial	HADH	4q22-q26	Q16836	details
GDP-mannose 4,6 dehydratase	GMDS	6p25	O60547	details
Aldo-keto reductase family 1 member C1	AKR1C1	10p15-p14	Q04828	details
Aldo-keto reductase family 1 member C2	AKR1C2	10p15-p14	P52895	details
Glyoxylate reductase/hydroxypyruvate reductase	GRHPR	9q12	Q9UBQ7	details
3-hydroxyisobutyrate dehydrogenase, mitochondrial	HIBADH	7p15.2	P31937	details
2-oxoglutarate dehydrogenase, mitochondrial	OGDH	7p14-p13	Q02218	details
Estradiol 17-beta-dehydrogenase 2	HSD17B2	16q24.1-q24.2	P37059	details
Estradiol 17-beta-dehydrogenase 8	HSD17B8	6p21.3	Q92506	details
11-cis retinol dehydrogenase	RDH5	12q13-q14	Q92781	details
Sorbitol dehydrogenase	SORD	15q15.3	Q00796	details
Alcohol dehydrogenase [NADP(+)]	AKR1A1	1p33-p32	P14550	details
Alcohol dehydrogenase 4	ADH4	4q22	P08319	details
D-beta-hydroxybutyrate dehydrogenase, mitochondrial	BDH1	3q29	Q02338	details
Aldehyde dehydrogenase family 3 member B2	ALDH3B2	11q13	P48448	details
Aldehyde dehydrogenase family 3 member B1	ALDH3B1	11q13	P43353	details
Dihydropteridine reductase	QDPR	4p15.31	P09417	details
Estradiol 17-beta-dehydrogenase 11	HSD17B11	4q22.1	Q8NBQ5	details
7-dehydrocholesterol reductase	DHCR7	11q13.4	Q9UBM7	details
Putative adenosylhomocysteinase 3	AHCYL2	7q32.1	Q96HN2	details
Adenosylhomocysteinase	AHCY	20q11.22	P23526	details
Putative adenosylhomocysteinase 2	AHCYL1	1p13.2	O43865	details
Glutamate dehydrogenase 2, mitochondrial	GLUD2	Xq24-q25	P49448	details
Aminomethyltransferase, mitochondrial	AMT	3p21.2-p21.1	P48728	details
Glyceraldehyde-3-phosphate dehydrogenase, testis-specific	GAPDHS	19q13.12	O14556	details
Glutamate dehydrogenase 1, mitochondrial	GLUD1	10q23.3	P00367	details
Glyceraldehyde-3-phosphate dehydrogenase	GAPDH	12p13	P04406	details
Biliverdin reductase A	BLVRA	7p13	P53004	details
Flavin reductase (NADPH)	BLVRB	19q13.1-q13.2	P30043	details
Adenylate cyclase type 7	ADCY7	16q12.1	P51828	details
Adenylate cyclase type 4	ADCY4	14q12	Q8NFM4	details
Adenylate cyclase type 6	ADCY6	12q12-q13	O43306	details
Adenylate cyclase type 5	ADCY5	3q21.1	O95622	details
Adenylate cyclase type 8	ADCY8	8q24	P40145	details
Adenylate cyclase type 9	ADCY9	16p13.3	O60503	details
Adenylate cyclase type 3	ADCY3	2p23.3	O60266	details
Adenylate cyclase type 1	ADCY1	7p13-p12	Q08828	details
Corticosteroid 11-beta-dehydrogenase isozyme 2	HSD11B2	16q22	P80365	details
Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	1q32-q41	P28845	details
Alcohol dehydrogenase class-3	ADH5	4q23	P11766	details
Alcohol dehydrogenase 1B	ADH1B	4q23	P00325	details
Alcohol dehydrogenase class 4 mu/sigma chain	ADH7	4q23-q24	P40394	details
Alcohol dehydrogenase 1A	ADH1A	4q23	P07327	details
Alcohol dehydrogenase 6	ADH6	4q23	P28332	details
Alcohol dehydrogenase 1C	ADH1C	4q23	P00326	details
Dihydrofolate reductase	DHFR	5q11.2-q13.2	P00374	details
Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic	GPD1	12q12-q13	P21695	details
Estradiol 17-beta-dehydrogenase 1	HSD17B1	17q11-q21	P14061	details
3-keto-steroid reductase	HSD17B7	1q23	P56937	details
Alpha-aminoadipic semialdehyde synthase, mitochondrial	AASS	7q31.3	Q9UDR5	details
Malate dehydrogenase, mitochondrial	MDH2	7cen-q22	P40926	details
Malate dehydrogenase, cytoplasmic	MDH1	2p13.3	P40925	details
Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	3p21.2	P12268	details
Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	7q31.3-q32	P20839	details
L-lactate dehydrogenase A-like 6A	LDHAL6A	11p15.1	Q6ZMR3	details
Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial	IDH3B	20p13	O43837	details
Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial	IDH3A	15q25.1-q25.2	P50213	details
Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial	IDH3G	Xq28	P51553	details
Tankyrase-2	TNKS2	10q23.3	Q9H2K2	details
dTDP-D-glucose 4,6-dehydratase	TGDS	13q32.1	O95455	details
NAD-dependent protein deacetylase sirtuin-6	SIRT6	19p13.3	Q8N6T7	details
UDP-glucose 4-epimerase	GALE	1p36-p35	Q14376	details
Poly [ADP-ribose] polymerase 3	PARP3	3p21.31-p21.1	Q9Y6F1	details
Ecto-ADP-ribosyltransferase 3	ART3	4p15.1-p14	Q13508	details
UDP-glucose 6-dehydrogenase	UGDH	4p15.1	O60701	details
Ecto-ADP-ribosyltransferase 5	ART5	11p15.4	Q96L15	details
GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1	ART1	11p15	P52961	details
NAD(P) transhydrogenase, mitochondrial	NNT	5p12	Q13423	details
Tankyrase-1	TNKS	8p23.1	O95271	details
Poly [ADP-ribose] polymerase 1	PARP1	1q41-q42	P09874	details
Urocanate hydratase	UROC1	3q21.3	Q96N76	details
ADP-ribosyl cyclase 2	BST1	4p15	Q10588	details
Poly [ADP-ribose] polymerase 2	PARP2	14q11.2-q12	Q9UGN5	details
NAD kinase	NADK	1p36.33	O95544	details
ADP-ribosyl cyclase 1	CD38	4p15	P28907	details
Ecto-ADP-ribosyltransferase 4	ART4	12p13-p12	Q93070	details
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial	MTHFD2	2p13.1	P13995	details
Adenylate cyclase type 2	ADCY2	5p15.3	Q08462	details
D-3-phosphoglycerate dehydrogenase	PHGDH	1p12	O43175	details
C-1-tetrahydrofolate synthase, cytoplasmic	MTHFD1	14q24	P11586	details
Poly [ADP-ribose] polymerase 4	PARP4	13q11	Q9UKK3	details
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial	NDUFB11		Q9NX14	details
Prostaglandin reductase 1	PTGR1	9q31.3	Q14914	details
NAD(P)H dehydrogenase [quinone] 1	NQO1	16q22.1	P15559	details
Proline dehydrogenase 1, mitochondrial	PRODH	22q11.21	O43272	details
Kynurenine 3-monooxygenase	KMO	1q42-q44	O15229	details
17-beta-hydroxysteroid dehydrogenase type 6	HSD17B6	12q13	O14756	details
Pyrroline-5-carboxylate reductase 3	PYCRL	8q24.3	Q53H96	details
Retinol dehydrogenase 16	RDH16	12q13.3	O75452	details
Glycine cleavage system H protein, mitochondrial	GCSH		P23434	details
Dual oxidase 2	DUOX2	15q15.3	Q9NRD8	details
UDP-glucuronic acid decarboxylase 1	UXS1	2q12.2	Q8NBZ7	details
Glutamine-dependent NAD(+) synthetase	NADSYN1	11q13.4	Q6IA69	details
L-lactate dehydrogenase B chain	LDHB	12p12.2-p12.1	P07195	details
L-lactate dehydrogenase C chain	LDHC	11p15.1	P07864	details
L-lactate dehydrogenase A chain	LDHA	11p15.4	P00338	details
L-lactate dehydrogenase A-like 6B	LDHAL6B	15q22.2	Q9BYZ2	details
Nicotinamide riboside kinase 1	NMRK1	9q21.13	Q9NWW6	details
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1	HSD3B1	1p13.1	P14060	details
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2	HSD3B2	1p13.1	P26439	details
3 beta-hydroxysteroid dehydrogenase type 7	HSD3B7	16p11.2	Q9H2F3	details
Inositol-3-phosphate synthase 1	ISYNA1	19p13.11	Q9NPH2	details
Dual oxidase 1	DUOX1	15q15.3	Q9NRD9	details
3-hydroxybutyrate dehydrogenase type 2	BDH2	4q24	Q9BUT1	details
Glycerol-3-phosphate dehydrogenase 1-like protein	GPD1L	3p22.3	Q8N335	details
Probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2	MTHFD2L	4q13.3	Q9H903	details
NADH-cytochrome b5 reductase 1	CYB5R1	1q32.1	Q9UHQ9	details
NADH-cytochrome b5 reductase 2	CYB5R2	11p15.4	Q6BCY4	details
Cytochrome b5 reductase 4	CYB5R4	6pter-q22.33	Q7L1T6	details
NADH-cytochrome b5 reductase-like	CYB5RL	1p32.3	Q6IPT4	details
Probable saccharopine dehydrogenase	SCCPDH	1q44	Q8NBX0	details
Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase	MTHFD2	2p13.1	Q7Z650	details
Kynurenine formamidase	AFMID	17q25.3	Q63HM1	details
Acyl-CoA synthetase family member 4	AASDH	4q12	Q4L235	details
Aminoadipate-semialdehyde synthase	AASS	7q31.3	A4D0W4	details
Peroxisomal NADH pyrophosphatase NUDT12	NUDT12	5q21.2	Q9BQG2	details
Inosine-5'-monophosphate dehydrogenase	IMPDH1	7q31.3-q32	A4D0Z6	details
Metalloreductase STEAP3	STEAP3	2q14.2	Q658P3	details
All-trans-retinol 13,14-reductase	RETSAT	2p11.2	Q6NUM9	details
Metalloreductase STEAP1	STEAP1	7q21	Q9UHE8	details
Metalloreductase STEAP2	STEAP2	7q21	Q8NFT2	details
Metalloreductase STEAP4	STEAP4	7q21.12	Q687X5	details
Peroxisomal coenzyme A diphosphatase NUDT7	NUDT7	16q23.1	P0C024	details
Aldehyde dehydrogenase family 8 member A1	ALDH8A1	6q23.2	Q9H2A2	details
Putative L-aspartate dehydrogenase	ASPDH	19q13.33	A6ND91	details
Estradiol 17-beta-dehydrogenase 12	HSD17B12	11p11.2	Q53GQ0	details
17-beta-hydroxysteroid dehydrogenase 14	HSD17B14	19q13.33	Q9BPX1	details
Nicotinamide phosphoribosyltransferase	NAMPT	7q22.3	P43490	details
Nicotinamide riboside kinase 2	NMRK2	19p13.3	Q9NPI5	details
Poly [ADP-ribose] polymerase 10	PARP10	8q24.3	Q53GL7	details
Poly [ADP-ribose] polymerase 11	PARP11	12p13.3	Q9NR21	details
Poly [ADP-ribose] polymerase 12	PARP12	7q34	Q9H0J9	details
Poly [ADP-ribose] polymerase 14	PARP14	3q21.1	Q460N5	details
Poly [ADP-ribose] polymerase 15	PARP15	3q21.1	Q460N3	details
Mono [ADP-ribose] polymerase PARP16	PARP16	15q22.31	Q8N5Y8	details
Poly [ADP-ribose] polymerase 6	PARP6	15q23	Q2NL67	details
Poly [ADP-ribose] polymerase 8	PARP8	5q11.1	Q8N3A8	details
Poly [ADP-ribose] polymerase 9	PARP9	3q21	Q8IXQ6	details
TCDD-inducible poly [ADP-ribose] polymerase	TIPARP	3q25.31	Q7Z3E1	details
Nicotinate phosphoribosyltransferase	NAPRT1	8q24.3	Q6XQN6	details
Prostaglandin reductase 2	PTGR2	14q24.3	Q8N8N7	details
NAD-dependent protein deacetylase sirtuin-1	SIRT1	10q21.3	Q96EB6	details
NAD-dependent protein deacetylase sirtuin-2	SIRT2	19q13	Q8IXJ6	details
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	SIRT3	11p15.5	Q9NTG7	details
NAD-dependent protein deacetylase sirtuin-4	SIRT4	12q	Q9Y6E7	details
NAD-dependent protein deacylase sirtuin-5, mitochondrial	SIRT5	6p23	Q9NXA8	details
NAD-dependent protein deacetylase sirtuin-7	SIRT7	17q25	Q9NRC8	details
tRNA 2'-phosphotransferase 1	TRPT1	11q13.1	Q86TN4	details
2-oxoglutarate dehydrogenase-like, mitochondrial	OGDHL		Q9ULD0	details
NADH dehydrogenase (Ubiquinone) 1 beta subcomplex, 2, 8kDa	NDUFB2	7q34	A4D1T5	details
L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	AASDHPPT	11q22	Q9NRN7	details
14 kDa phosphohistidine phosphatase	PHPT1		Q9NRX4	details
Aldo-keto reductase family 1 member B10	AKR1B10		O60218	details
Dihydrofolate reductase, mitochondrial	DHFRL1	3q11.1	Q86XF0	details
NAD kinase domain-containing protein 1, mitochondrial	NADKD1	5p13.2	Q4G0N4	details
Epidermal retinol dehydrogenase 2	SDR16C5	8q12.1	Q8N3Y7	details

Transporters

Protein Name	Gene Name	Locus	Uniprot ID	Details
Aldo-keto reductase family 1 member C4	AKR1C4	10p15.1	P17516	details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11	NDUFA11	19p13.3	Q86Y39	details
Acyl carrier protein, mitochondrial	NDUFAB1	16p12.2	O14561	details
Putative adenosylhomocysteinase 2	AHCYL1	1p13.2	O43865	details
Tricarboxylate transport protein, mitochondrial	SLC25A1	22q11.21	P53007	details
Transient receptor potential cation channel subfamily M member 2	TRPM2	21q22.3	O94759	details
Glycerol-3-phosphate dehydrogenase 1-like protein	GPD1L	3p22.3	Q8N335	details
Acyl-CoA synthetase family member 4	AASDH	4q12	Q4L235	details

Metal Bindings

Protein Name	Gene Name	Locus	Uniprot ID	Details
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1	6q22-q23	P22413	details
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	1q23	O75306	details
Lathosterol oxidase	SC5DL	11q23.3	O75845	details
Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	6p25.2	P16083	details
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial	NDUFV2	18p11.22	P19404	details
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial	NDUFS8	11q13	O00217	details
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial	NDUFS1	2q33-q34	P28331	details
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	19p13.3	O75251	details
Xanthine dehydrogenase/oxidase	XDH	2p23.1	P47989	details
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial	NDUFV1	11q13	P49821	details
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3	6q22	O14638	details
Methylsterol monooxygenase 1	MSMO1	4q32-q34	Q15800	details
Cytochrome P450 4A11	CYP4A11	1p33	Q02928	details
Sorbitol dehydrogenase	SORD	15q15.3	Q00796	details
Alcohol dehydrogenase 4	ADH4	4q22	P08319	details
Biliverdin reductase A	BLVRA	7p13	P53004	details
Adenylate cyclase type 7	ADCY7	16q12.1	P51828	details
Adenylate cyclase type 4	ADCY4	14q12	Q8NFM4	details
Adenylate cyclase type 6	ADCY6	12q12-q13	O43306	details
Adenylate cyclase type 5	ADCY5	3q21.1	O95622	details
Adenylate cyclase type 8	ADCY8	8q24	P40145	details
Adenylate cyclase type 9	ADCY9	16p13.3	O60503	details
Adenylate cyclase type 3	ADCY3	2p23.3	O60266	details
Adenylate cyclase type 1	ADCY1	7p13-p12	Q08828	details
Alcohol dehydrogenase class-3	ADH5	4q23	P11766	details
Alcohol dehydrogenase 1B	ADH1B	4q23	P00325	details
Alcohol dehydrogenase class 4 mu/sigma chain	ADH7	4q23-q24	P40394	details
Alcohol dehydrogenase 1A	ADH1A	4q23	P07327	details
Alcohol dehydrogenase 6	ADH6	4q23	P28332	details
Alcohol dehydrogenase 1C	ADH1C	4q23	P00326	details
NADP-dependent malic enzyme	ME1	6q12	P48163	details
NADP-dependent malic enzyme, mitochondrial	ME3	11cen-q22.3	Q16798	details
NAD-dependent malic enzyme, mitochondrial	ME2	18q21	P23368	details
Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	3p21.2	P12268	details
Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	7q31.3-q32	P20839	details
Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial	IDH3B	20p13	O43837	details
Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial	IDH3A	15q25.1-q25.2	P50213	details
Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial	IDH3G	Xq28	P51553	details
Tankyrase-2	TNKS2	10q23.3	Q9H2K2	details
NAD-dependent protein deacetylase sirtuin-6	SIRT6	19p13.3	Q8N6T7	details
Tankyrase-1	TNKS	8p23.1	O95271	details
Poly [ADP-ribose] polymerase 1	PARP1	1q41-q42	P09874	details
NAD kinase	NADK	1p36.33	O95544	details
Adenylate cyclase type 2	ADCY2	5p15.3	Q08462	details
Prostaglandin reductase 1	PTGR1	9q31.3	Q14914	details
Dual oxidase 2	DUOX2	15q15.3	Q9NRD8	details
Nicotinamide riboside kinase 1	NMRK1	9q21.13	Q9NWW6	details
Dual oxidase 1	DUOX1	15q15.3	Q9NRD9	details
Cytochrome b5 reductase 4	CYB5R4	6pter-q22.33	Q7L1T6	details
Cytochrome P450 4A22	CYP4A22	1p33	Q5TCH4	details
Peroxisomal NADH pyrophosphatase NUDT12	NUDT12	5q21.2	Q9BQG2	details
Metalloreductase STEAP3	STEAP3	2q14.2	Q658P3	details
Metalloreductase STEAP1	STEAP1	7q21	Q9UHE8	details
Metalloreductase STEAP2	STEAP2	7q21	Q8NFT2	details
Metalloreductase STEAP4	STEAP4	7q21.12	Q687X5	details
Peroxisomal coenzyme A diphosphatase NUDT7	NUDT7	16q23.1	P0C024	details
Nicotinamide riboside kinase 2	NMRK2	19p13.3	Q9NPI5	details
Poly [ADP-ribose] polymerase 12	PARP12	7q34	Q9H0J9	details
TCDD-inducible poly [ADP-ribose] polymerase	TIPARP	3q25.31	Q7Z3E1	details
Prostaglandin reductase 2	PTGR2	14q24.3	Q8N8N7	details
NAD-dependent protein deacetylase sirtuin-1	SIRT1	10q21.3	Q96EB6	details
NAD-dependent protein deacetylase sirtuin-2	SIRT2	19q13	Q8IXJ6	details
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	SIRT3	11p15.5	Q9NTG7	details
NAD-dependent protein deacetylase sirtuin-4	SIRT4	12q	Q9Y6E7	details
NAD-dependent protein deacylase sirtuin-5, mitochondrial	SIRT5	6p23	Q9NXA8	details
NAD-dependent protein deacetylase sirtuin-7	SIRT7	17q25	Q9NRC8	details
L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	AASDHPPT	11q22	Q9NRN7	details

Receptors

Protein Name	Gene Name	Locus	Uniprot ID	Details
15-hydroxyprostaglandin dehydrogenase [NAD(+)]	HPGD	4q34-q35	P15428	details
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1	6q22-q23	P22413	details
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3	6q22	O14638	details
Retinal dehydrogenase 2	ALDH1A2	15q21.3	O94788	details
Aldo-keto reductase family 1 member C3	AKR1C3	10p15-p14	P42330	details
Aldo-keto reductase family 1 member C2	AKR1C2	10p15-p14	P52895	details
Adenylate cyclase type 7	ADCY7	16q12.1	P51828	details
Adenylate cyclase type 4	ADCY4	14q12	Q8NFM4	details
Adenylate cyclase type 6	ADCY6	12q12-q13	O43306	details
Adenylate cyclase type 5	ADCY5	3q21.1	O95622	details
Adenylate cyclase type 8	ADCY8	8q24	P40145	details
Adenylate cyclase type 9	ADCY9	16p13.3	O60503	details
Adenylate cyclase type 3	ADCY3	2p23.3	O60266	details
Adenylate cyclase type 1	ADCY1	7p13-p12	Q08828	details
Alcohol dehydrogenase class 4 mu/sigma chain	ADH7	4q23-q24	P40394	details
Tankyrase-2	TNKS2	10q23.3	Q9H2K2	details
Tankyrase-1	TNKS	8p23.1	O95271	details
Poly [ADP-ribose] polymerase 1	PARP1	1q41-q42	P09874	details
ADP-ribosyl cyclase 1	CD38	4p15	P28907	details
Adenylate cyclase type 2	ADCY2	5p15.3	Q08462	details
Transient receptor potential cation channel subfamily M member 2	TRPM2	21q22.3	O94759	details
TCDD-inducible poly [ADP-ribose] polymerase	TIPARP	3q25.31	Q7Z3E1	details
NAD-dependent protein deacetylase sirtuin-1	SIRT1	10q21.3	Q96EB6	details
14 kDa phosphohistidine phosphatase	PHPT1		Q9NRX4	details
Myotubularin-related protein 2	MTMR2		Q13614	details

Transcriptional Factors

Protein Name	Gene Name	Locus	Uniprot ID	Details
Dihydrofolate reductase	DHFR	5q11.2-q13.2	P00374	details
NAD-dependent protein deacetylase sirtuin-6	SIRT6	19p13.3	Q8N6T7	details
Tankyrase-1	TNKS	8p23.1	O95271	details
Poly [ADP-ribose] polymerase 1	PARP1	1q41-q42	P09874	details
ADP-ribosyl cyclase 1	CD38	4p15	P28907	details
Forkhead box protein O4	FOXO4		P98177	details
Nicotinamide phosphoribosyltransferase	NAMPT	7q22.3	P43490	details
Poly [ADP-ribose] polymerase 14	PARP14	3q21.1	Q460N5	details
Poly [ADP-ribose] polymerase 15	PARP15	3q21.1	Q460N3	details
NAD-dependent protein deacetylase sirtuin-1	SIRT1	10q21.3	Q96EB6	details
NAD-dependent protein deacetylase sirtuin-2	SIRT2	19q13	Q8IXJ6	details
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	SIRT3	11p15.5	Q9NTG7	details
NAD-dependent protein deacetylase sirtuin-4	SIRT4	12q	Q9Y6E7	details
NAD-dependent protein deacylase sirtuin-5, mitochondrial	SIRT5	6p23	Q9NXA8	details
NAD-dependent protein deacetylase sirtuin-7	SIRT7	17q25	Q9NRC8	details

Concentrations Data

Not Available

External Links

HMDB ID

HMDB0000902

DrugBank ID

DB14128

Phenol Explorer Compound ID

Not Available

FoodDB ID

KNApSAcK ID

Chemspider ID

KEGG Compound ID

BioCyc ID

BiGG ID

Not Available

Wikipedia Link

Nicotinamide_adenine_dinucleotide

METLIN ID

Not Available

PubChem Compound

5892

PDB ID

Not Available

ChEBI ID

44215

References

General References

Not Available

Only showing the first 10 proteins. There are 353 proteins in total.

Show All

Enzymes

Enzyme Details

1. Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

General function:: Involved in catalytic activity
Specific function:: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.
Gene Name:: PDHB
Uniprot ID:: P11177
Molecular weight:: 39233.1

Enzyme Details

2. Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

General function:: Involved in oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Specific function:: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.
Gene Name:: PDHA1
Uniprot ID:: P08559
Molecular weight:: 43295.255

Enzyme Details

3. Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial

General function:: Involved in oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Specific function:: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.
Gene Name:: PDHA2
Uniprot ID:: P29803
Molecular weight:: 42932.855

Enzyme Details

4. Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial

General function:: Involved in oxidoreductase activity
Specific function:: Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA.
Gene Name:: ALDH6A1
Uniprot ID:: Q02252
Molecular weight:: 57839.31

Enzyme Details

5. Dihydrolipoyl dehydrogenase, mitochondrial

General function:: Involved in oxidoreductase activity
Specific function:: Lipoamide dehydrogenase is a component of the glycine cleavage system as well as of the alpha-ketoacid dehydrogenase complexes. Involved in the hyperactivation of spermatazoa during capacitation and in the spermatazoal acrosome reaction.
Gene Name:: DLD
Uniprot ID:: P09622
Molecular weight:: 54176.91

Enzyme Details

6. Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

General function:: Involved in acyltransferase activity
Specific function:: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.
Gene Name:: DLAT
Uniprot ID:: P10515
Molecular weight:: 68996.03

Enzyme Details

7. Aldo-keto reductase family 1 member C4

General function:: Involved in oxidoreductase activity
Specific function:: Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha-androstan-3-alpha,17-beta-diol (3-alpha-diol). Also has some 20-alpha-hydroxysteroid dehydrogenase activity. The biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leads to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route.
Gene Name:: AKR1C4
Uniprot ID:: P17516
Molecular weight:: 37094.57

Enzyme Details

8. 15-hydroxyprostaglandin dehydrogenase [NAD(+)]

General function:: Involved in oxidoreductase activity
Specific function:: Prostaglandin inactivation. Contributes to the regulation of events that are under the control of prostaglandin levels. Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. Inhibits in vivo proliferation of colon cancer cells.
Gene Name:: HPGD
Uniprot ID:: P15428
Molecular weight:: 28977.105

Enzyme Details

9. Tyrosinase

General function:: Involved in oxidoreductase activity
Specific function:: This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the rate-limiting conversions of tyrosine to DOPA, DOPA to DOPA-quinone and possibly 5,6-dihydroxyindole to indole-5,6 quinone.
Gene Name:: TYR
Uniprot ID:: P14679
Molecular weight:: 60392.69

Enzyme Details

10. Aldose reductase

General function:: Involved in oxidoreductase activity
Specific function:: Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
Gene Name:: AKR1B1
Uniprot ID:: P15121
Molecular weight:: 35853.125

Transporters

Enzyme Details

1. Aldo-keto reductase family 1 member C4

General function:: Involved in oxidoreductase activity
Specific function:: Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha-androstan-3-alpha,17-beta-diol (3-alpha-diol). Also has some 20-alpha-hydroxysteroid dehydrogenase activity. The biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leads to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route.
Gene Name:: AKR1C4
Uniprot ID:: P17516
Molecular weight:: 37094.57

Enzyme Details

2. NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11

General function:: Involved in protein transporter activity
Specific function:: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Gene Name:: NDUFA11
Uniprot ID:: Q86Y39
Molecular weight:: 14852.0

Enzyme Details

3. Acyl carrier protein, mitochondrial

General function:: Involved in acyl carrier activity
Specific function:: Carrier of the growing fatty acid chain in fatty acid biosynthesis in mitochondria. Accessory and non-catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain
Gene Name:: NDUFAB1
Uniprot ID:: O14561
Molecular weight:: 17417.1

Enzyme Details

4. Putative adenosylhomocysteinase 2

General function:: Involved in adenosylhomocysteinase activity
Specific function:: Not Available
Gene Name:: AHCYL1
Uniprot ID:: O43865
Molecular weight:: 53753.0

Enzyme Details

5. Tricarboxylate transport protein, mitochondrial

General function:: Involved in transporter activity
Specific function:: Involved in citrate-H(+)/malate exchange. Important for the bioenergetics of hepatic cells as it provides a carbon source for fatty acid and sterol biosyntheses, and NAD+ for the glycolytic pathway
Gene Name:: SLC25A1
Uniprot ID:: P53007
Molecular weight:: 34012.5

Enzyme Details

6. Transient receptor potential cation channel subfamily M member 2

General function:: Involved in ion channel activity
Specific function:: Nonselective, voltage-independent cation channel mediating sodium and calcium ion influx in response to oxidative stress. Extracellular calcium passes through the channel and acts from the intracellular side as a positive regulator in channel activation. Activated by ADP-ribose, nicotinamide adenine dinucleotide (NAD(+)), reactive nitrogen species and arachidonic acid. Inactivated by intracellular ATP. Confers susceptibility to cell death following oxidative stress. Isoform 2 does not seem to be regulated by ADPR. Has ADP-ribose pyrophosphatase activity.
Gene Name:: TRPM2
Uniprot ID:: O94759
Molecular weight:: 171224.9

Enzyme Details

7. Glycerol-3-phosphate dehydrogenase 1-like protein

General function:: Involved in oxidoreductase activity
Specific function:: Plays a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3-phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current; cardiac sodium current may also be reduced due to alterations of NAD(H) balance induced by DPD1L.
Gene Name:: GPD1L
Uniprot ID:: Q8N335
Molecular weight:: 38418.44

Enzyme Details

8. Acyl-CoA synthetase family member 4

General function:: Involved in acyl carrier activity
Specific function:: Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA
Gene Name:: AASDH
Uniprot ID:: Q4L235
Molecular weight:: 122596.1

Only showing the first 10 proteins. There are 353 proteins in total.

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Showing Compound Card for NAD (CDB004868)

Structure for CDB004868 (NAD)

Enzymes

Transporters