Identification
HMDB Protein ID CDBP00383
Secondary Accession Numbers Not Available
Name Glyoxylate reductase/hydroxypyruvate reductase
Description Not Available
Synonyms
  1. SubName: Glyoxylate reductase/hydroxypyruvate reductase, isoform CRA_b
  2. SubName: cDNA, FLJ96788, Homo sapiens glyoxylate reductase/hydroxypyruvate reductase(GRHPR), mRNA
Gene Name GRHPR
Protein Type Enzyme
Biological Properties
General Function Involved in oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Specific Function Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate oxidizes D-glycerate to hydroxypyruvate.
GO Classification
Biological Process
cellular nitrogen compound metabolic process
glyoxylate metabolic process
protein oligomerization
excretion
Cellular Component
peroxisomal matrix
Function
oxidoreductase activity, acting on ch-oh group of donors
oxidoreductase activity
binding
nucleotide binding
catalytic activity
nad or nadh binding
oxidoreductase activity, acting on the ch-oh group of donors, nad or nadp as acceptor
cofactor binding
Molecular Function
NAD binding
glycerate dehydrogenase activity
glyoxylate reductase (NADP) activity
hydroxypyruvate reductase activity
protein homodimerization activity
NADPH binding
Process
metabolic process
Cellular Location Not Available
Pathways
Gene Properties
Chromosome Location 9
Locus 9q12
SNPs GRHPR
Gene Sequence
>987 bp
ATGAGACCGGTGCGACTCATGAAGGTGTTCGTCACCCGCAGGATACCCGCCGAGGGTAGG
GTCGCGCTCGCCCGGGCGGCAGACTGTGAGGTGGAGCAGTGGGACTCGGATGAGCCCATC
CCTGCCAAGGAGCTAGAGCGAGGTGTGGCGGGGGCCCACGGCCTGCTCTGCCTCCTCTCC
GACCACGTGGACAAGAGGATCCTGGATGCTGCAGGGGCCAATCTCAAAGTCATCAGCACC
ATGTCTGTGGGCATCGACCACTTGGCTTTGGATGAAATCAAGAAGCGTGGGATCCGAGTT
GGCTACACCCCAGATGTCCTGACAGATACCACCGCCGAACTCGCAGTCTCCCTGCTACTT
ACCACCTGCCGCCGGTTGCCGGAGGCCATCGAGGAAGTGAAGAATGGTGGCTGGACCTCG
TGGAAGCCCCTCTGGCTGTGTGGCTATGGACTCACGCAGAGCACTGTCGGCATCATCGGG
CTGGGGCGCATAGGCCAGGCCATTGCTCGGCGTCTGAAACCATTCGGTGTCCAGAGATTT
CTGTACACAGGGCGCCAGCCCAGGCCTGAGGAAGCAGCAGAATTCCAGGCAGAGTTTGTG
TCTACCCCTGAGCTGGCTGCCCAATCTGATTTCATCGTCGTGGCCTGCTCCTTAACACCT
GCAACCGAGGGACTCTGCAACAAGGACTTCTTCCAGAAGATGAAGGAAACAGCTGTGTTC
ATCAACATCAGCAGGGGCGACGTCGTAAACCAGGACGACCTGTACCAGGCCTTGGCCAGT
GGTAAGATTGCAGCTGCTGGACTGGATGTGACGAGCCCAGAACCACTGCCTACAAACCAC
CCTCTCCTGACCCTGAAGAACTGTGTGATTCTGCCCCACATTGGCAGTGCCACCCACAGA
ACCCGCAACACCATGTCCTTGTTGGCAGCTAACAACTTGCTGGCTGGCCTGAGAGGGGAG
CCGATGCCTAGTGAACTCAAGCTGTAG
Protein Properties
Number of Residues 328
Molecular Weight 35667.875
Theoretical pI 7.382
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Glyoxylate reductase/hydroxypyruvate reductase
MRPVRLMKVFVTRRIPAEGRVALARAADCEVEQWDSDEPIPAKELERGVAGAHGLLCLLS
DHVDKRILDAAGANLKVISTMSVGIDHLALDEIKKRGIRVGYTPDVLTDTTAELAVSLLL
TTCRRLPEAIEEVKNGGWTSWKPLWLCGYGLTQSTVGIIGLGRIGQAIARRLKPFGVQRF
LYTGRQPRPEEAAEFQAEFVSTPELAAQSDFIVVACSLTPATEGLCNKDFFQKMKETAVF
INISRGDVVNQDDLYQALASGKIAAAGLDVTSPEPLPTNHPLLTLKNCVILPHIGSATHR
TRNTMSLLAANNLLAGLRGEPMPSELKL
GenBank ID Protein 6002730
UniProtKB/Swiss-Prot ID Q9UBQ7
UniProtKB/Swiss-Prot Entry Name GRHPR_HUMAN
PDB IDs
GenBank Gene ID AF134895
GeneCard ID GRHPR
GenAtlas ID GRHPR
HGNC ID HGNC:4570
References
General References Not Available