Identification |
HMDB Protein ID
| CDBP04079 |
Secondary Accession Numbers
| Not Available |
Name
| Poly [ADP-ribose] polymerase 14 |
Description
| Not Available |
Synonyms
|
- B aggressive lymphoma protein 2
- PARP-14
- ADP-ribosyltransferase diphtheria toxin-like 8
- ARTD8
|
Gene Name
| PARP14 |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in NAD+ ADP-ribosyltransferase activity |
Specific Function
| Enhances STAT6-dependent transcription (By similarity). Has ADP-ribosyltransferase activity.
|
GO Classification
|
Biological Process |
regulation of transcription, DNA-dependent |
transcription, DNA-dependent |
Cellular Component |
cytoplasm |
plasma membrane |
nucleus |
Function |
catalytic activity |
transferase activity |
nad+ adp-ribosyltransferase activity |
transferase activity, transferring pentosyl groups |
transferase activity, transferring glycosyl groups |
Molecular Function |
NAD+ ADP-ribosyltransferase activity |
|
Cellular Location
|
- Nucleus
- Cytoplasm
|
Pathways
|
Not Available
|
Gene Properties |
Chromosome Location
| 3 |
Locus
| 3q21.1 |
SNPs
| PARP14 |
Gene Sequence
|
>5406 bp
ATGGCTGTGCCCGGCTCCTTCCCGCTGCTGGTCGAGGGCTCCTGGGGCCCCGACCCCCCG
AAGAACTTGAACACCAAGTTGCAGATGTACTTCCAGAGCCCGAAGAGGTCGGGAGGCGGC
GAGTGTGAGGTCCGCCAGGATCCCAGGAGCCCATCCCGCTTCCTGGTGTTCTTCTACCCG
GAGGACGTTCGGCAGAAGGTTCTGGAGAGAAAAAATCATGAGTTGGTATGGCAAGGAAAA
GGAACATTCAAGTTAACTGTCCAGTTACCTGCAACCCCAGATGAAATCGATCATGTCTTT
GAAGAGGAACTTCTAACAAAAGAATCCAAGACCAAAGAAGATGTTAAAGAACCAGATGTG
TCAGAAGAATTGGATACAAAACTCCCTCTTGATGGTGGATTAGACAAAATGGAAGATATC
CCAGAGGAATGTGAAAATATTTCCTCTTTGGTGGCATTTGAAAACCTCAAGGCAAATGTG
ACTGACATAATGCTAATCTTGTTAGTGGAGAACATAAGTGGCCTGTCTAATGATGACTTT
CAAGTGGAAATAATAAGAGATTTTGATGTTGCTGTTGTTACCTTTCAAAAGCACATAGAT
ACTATAAGATTTGTTGATGATTGTACCAAGCACCATTCAATTAAACAACTTCAGCTTTCT
CCAAGACTTCTGGAAGTGACAAACACAATCAGGGTTGAAAACCTGCCACCTGGTGCTGAT
GACTACAGTTTAAAACTTTTCTTTGAAAATCCCTATAATGGAGGGGGAAGAGTTGCCAAT
GTTGAATATTTTCCTGAAGAGAGTTCAGCTCTGATTGAATTTTTTGACAGAAAAGTGTTA
GACACCATCATGGCCACAAAACTCGACTTCAATAAAATGCCACTTTCTGTGTTCCCATAC
TATGCCTCATTGGGCACAGCCTTGTATGGAAAGGAGAAGCCTCTGATCAAGCTTCCAGCA
CCATTTGAAGAGTCACTAGATCTTCCCTTATGGAAGTTCTTACAGAAAAAGAATCACCTC
ATTGAGGAGATAAACGATGAAATGAGGCGTTGTCACTGTGAGCTCACGTGGTCCCAACTC
AGTGGTAAAGTTACCATCAGACCAGCAGCCACCTTAGTCAATGAAGGAAGACCGAGAATC
AAGACCTGGCAGGCAGATACTTCCACAACACTCTCTAGCATCAGGTCTAAATATAAAGTC
AACCCAATTAAAGTGGATCCAACAATGTGGGACACCATAAAAAATGATGTGAAAGATGAC
AGGATTTTGATTGAGTTTGATACACTTAAGGAGATGGTAATCTTAGCAGGGAAATCAGAG
GATGTCCAAAGCATTGAGGTACAAGTCAGGGAGTTAATAGAAAGCACTACTCAAAAAATT
AAAAGGGAAGAGCAAAGTTTGAAGGAAAAAATGATCATTTCTCCAGGCAGGTATTTTCTT
TTGTGTCACAGCAGTCTACTGGACCATTTACTCACGGAGTGCCCAGAGATAGAGATTTGT
TACGATAGAGTCACTCAACACTTGTGCTTGAAAGGACCTAGTGCAGATGTGTATAAAGCA
AAGTGTGAAATCCAGGAAAAGGTGTACACCATGGCTCAGAAAAACATTCAGGTTTCTCCT
GAGATTTTTCAGTTTTTGCAACAGGTAAACTGGAAAGAATTCTCTAAGTGTCTTTTCATA
GCACAGAAGATTCTTGCACTTTATGAGCTAGAGGGTACAACTGTTCTCTTAACCAGCTGT
TCTTCTGAAGCCCTGTTAGAAGCAGAAAAGCAAATGCTCAGTGCCTTAAATTATAAGCGC
ATTGAAGTTGAGAACAAAGAAGTTCTTCATGGCAAGAAATGGAAAGGGCTCACTCACAAT
TTGCTTAAGAAACAAAATTCCTCCCCAAACACTGTAATCATCAATGAGTTAACTTCAGAA
ACCACAGCTGAAGTCATCATTACAGGCTGTGTAAAAGAAGTAAATGAAACCTATAAATTG
CTTTTTAACTTCGTTGAACAAAACATGAAAATAGAGAGACTGGTTGAAGTAAAGCCTTCC
TTAGTTATTGACTATTTAAAGACAGAAAAGAAGCTATTCTGGCCAAAGATAAAGAAGGTA
AATGTGCAGGTAAGTTTCAATCCTGAGAACAAACAAAAAGGCATTTTACTAACTGGCTCA
AAGACCGAAGTACTGAAGGCAGTGGACATTGTCAAGCAAGTCTGGGATTCAGTCTGTGTT
AAAAGTGTCCATACTGATAAGCCAGGAGCCAAGCAGTTCTTCCAGGATAAAGCACGGTTT
TATCAAAGTGAGATCAAACGGTTGTTTGGTTGTTACATTGAACTACAGGAGAATGAAGTA
ATGAAGGAGGGAGGCAGCCCCGCTGGGCAGAAGTGCTTCTCTCGGACAGTCTTGGCCCCT
GGCGTTGTGCTGATTGTGCAGCAGGGTGACTTGGCACGGCTTCCTGTCGATGTGGTGGTG
AATGCATCTAATGAGGACCTTAAGCATTATGGTGGCCTGGCCGCTGCGCTCTCAAAAGCA
GCTGGCCCTGAGCTCCAGGCCGACTGTGACCAGATAGTGAAGAGAGAGGGCAGACTCCTA
CCGGGCAATGCCACCATCTCCAAGGCAGGAAAGCTGCCCTACCACCACGTGATCCATGCA
GTGGGGCCCCGCTGGAGCGGATATGAGGCCCCGAGGTGTGTGTACCTATTAAGGAGAGCT
GTGCAACTCAGTCTCTGTCTAGCCGAAAAATACAAGTACCGATCCATAGCCATCCCAGCT
ATTAGTTCTGGAGTCTTTGGCTTTCCCTTAGGCCGATGCGTGGAGACCATTGTTTCTGCC
ATCAAGGAAAACTTCCAATTCAAGAAGGATGGACACTGCTTGAAAGAAATCTACCTTGTG
GATGTATCTGAGAAGACTGTTGAGGCCTTTGCAGAAGCTGTGAAAACTGTATTTAAAGCC
ACCCTGCCAGATACAGCTGCCCCGCCAGGTTTACCACCAGCAGCAGCGGGGCCTGGGAAA
ACATCATGGGAAAAAGGAAGCCTGGTGTCCCCGGGAGGCCTGCAGATGCTGTTGGTGAAA
GAGGGTGTGCAGAATGCTAAGACCGATGTTGTTGTCAACTCCGTTCCCTTGGATCTCGTG
CTTAGTAGAGGGCCTCTTTCTAAGTCCCTCTTGGAAAAAGCTGGACCAGAGCTCCAGGAG
GAATTGGACACAGTTGGACAAGGGGTGGCTGTCAGCATGGGCACAGTGCTCAAAACCAGC
AGCTGGAATCTGGACTGTCGCTATGTGCTTCACGTGGTAGCTCCGGAGTGGAGAAATGGT
AGCACATCTTCACTCAAGATAATGGAAGACATAATCAGAGAATGTATGGAGATCACTGAG
AGCTTGTCCTTAAAATCAATTGCATTTCCAGCAATAGGAACAGGAAACTTGGGATTTCCT
AAAAACATATTCGCTGAATTAATCATTTCAGAGGTGTTCAAATTTAGTAGCAAGAATCAG
CTGAAAACTTTACAAGAGGTTCACTTTCTGCTGCACCCGAGTGATCATGAAAATATTCAG
GCATTTTCAGATGAATTTGCCAGAAGGGCTAATGGAAATCTCGTCAGTGACAAAATTCCG
AAGGCTAAAGATACACAAGGTTTTTATGGGACTGTTTCTAGCCCTGATTCAGGTGTGTAT
GAAATGAAGATTGGCTCCATCATCTTCCAGGTGGCTTCTGGAGATATCACGAAAGAAGAG
GCAGATGTGATTGTAAATTCAACATCAAACTCATTCAATCTCAAAGCAGGGGTCTCCAAA
GCAATTTTAGAATGTGCTGGACAAAATGTAGAAAGGGAATGTTCTCAGCAAGCTCAGCAG
CGCAAAAATGATTATATAATCACCGGAGGTGGATTTTTGAGGTGCAAGAATATCATTCAT
GTAATTGGTGGAAATGATGTCAAGAGTTCAGTTTCCTCTGTTTTGCAGGAGTGTGAAAAA
AAAAATTACTCATCCATTTGCCTCCCAGCCATTGGGACAGGAAATGCCAAACAACACCCA
GATAAGGTTGCTGAAGCCATAATTGATGCCATTGAAGACTTTGTCCAGAAAGGATCAGCC
CAGTCTGTGAAAAAAGTTAAAGTTGTTATCTTTCTGCCTCAAGTACTGGATGTGTTTTAT
GCCAACATGAAGAAAAGAGAAGGGACTCAGCTTTCTTCCCAACAGTCTGTGATGTCTAAA
CTTGCATCATTTTTGGGCTTTTCAAAGCAATCTCCCCAAAAAAAGAATCATTTGGTTTTG
GAAAAGAAAACAGAATCAGCAACTTTTCGGGTGTGTGGTGAAAATGTCACGTGTGTGGAA
TATGCTATCTCCTGGCTACAAGACCTGATTGAAAAAGAACAGTGTCCTTACACCAGTGAA
GATGAGTGCATCAAAGACTTTGATGAAAAGGAGTATCAGGAGTTGAATGAGCTGCAGAAG
AAGTTAAATATTAACATTTCCCTGGACCATAAGAGACCTTTGATTAAGGTTTTGGGAATT
AGCAGAGATGTGATGCAGGCTAGAGATGAAATTGAGGCGATGATCAAGAGAGTTCGATTG
GCCAAAGAACAGGAATCCCGGGCAGATTGTATCAGTGAGTTTATAGAATGGCAGTATAAT
GACAATAACACTTCTCATTGTTTTAACAAAATGACCAATCTGAAATTAGAGGATGCAAGG
AGAGAAAAGAAAAAAACAGTTGATGTCAAAATTAATCATCGGCACTACACAGTGAACTTG
AACACATACACTGCCACAGACACAAAGGGCCACAGTTTATCTGTTCAGCGCCTCACGAAA
TCCAAAGTTGACATCCCTGCACACTGGAGTGATATGAAGCAGCAGAATTTCTGTGTGGTG
GAGCTGCTGCCTAGTGATCCTGAGTACAACACGGTGGCAAGCAAGTTTAATCAGACCTGC
TCACACTTCAGAATAGAGAAGATTGAGAGGATCCAGAATCCAGATCTCTGGAATAGCTAC
CAGGCAAAGAAAAAAACTATGGATGCCAAGAATGGCCAGACAATGAATGAGAAGCAACTC
TTCCATGGGACAGATGCCGGCTCCGTGCCACACGTCAATCGAAATGGCTTTAACCGCAGC
TATGCCGGAAAGAATGCTGTGGCATATGGAAAGGGAACCTATTTTGCTGTCAATGCCAAT
TATTCTGCCAATGATACGTACTCCAGACCAGATGCAAATGGGAGAAAGCATGTGTATTAT
GTGCGAGTACTTACTGGAATCTATACACATGGAAATCATTCATTAATTGTGCCTCCTTCA
AAGAACCCTCAAAATCCTACTGACCTGTATGACACTGTCACAGATAATGTGCACCATCCA
AGTTTATTTGTGGCATTTTATGACTACCAAGCATACCCAGAGTACCTTATTACGTTTAGA
AAATAA
|
Protein Properties |
Number of Residues
| 1720 |
Molecular Weight
| 202798.68 |
Theoretical pI
| 7.181 |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>Poly [ADP-ribose] polymerase 14
MAVPGSFPLLVEGSWGPDPPKNLNTKLQMYFQSPKRSGGGECEVRQDPRSPSRFLVFFYP
EDVRQKVLERKNHELVWQGKGTFKLTVQLPATPDEIDHVFEEELLTKESKTKEDVKEPDT
IRFVDDCTKHHSIKQLQLSPRLLEVTNTIRVENLPPGADDYSLKLFFENPYNGGGRVANV
EYFPEESSALIEFFDRKVLDTIMATKLDFNKMPLSVFPYYASLGTALYGKEKPLIKLPAP
FEESLDLPLWKFLQKKNHLIEEINDEMRRCHCELTWSQLSGKVTIRPAATLVNEGRPRIK
TWQADTSTTLSSIRSKYKVNPIKVDPTMWDTIKNDVKDDRILIEFDTLKEMVILAGKSED
VQSIEVQVRELIESTTQKIKREEQSLKEKMIISPGRYFLLCHSSLLDHLLTECPEIEICY
DRVTQHLCLKGPSADVYKAKCEIQEKVYTMAQKNIQVSPEIFQFLQQVNWKEFSKCLFIA
QKILALYELEGTTVLLTSCSSEALLEAEKQMLSALNYKRIEVENKEVLHGKKWKGLTHNL
LKKQNSSPNTVIINELTSETTAEVIITGCVKEVNETYKLLFNFVEQNMKIERLVEVKPSL
VIDYLKTEKKLFWPKIKKVNVQVSFNPENKQKGILLTGSKTEVLKAVDIVKQVWDSVCVK
SVHTDKPGAKQFFQDKARFYQSEIKRLFGCYIELQENEVMKEGGSPAGQKCFSRTVLAPG
VVLIVQQGDLARLPVDVVVNASNEDLKHYGGLAAALSKAAGPELQADCDQIVKREGRLLP
GNATISKAGKLPYHHVIHAVGPRWSGYEAPRCVYLLRRAVQLSLCLAEKYKYRSIAIPAI
SSGVFGFPLGRCVETIVSAIKENFQFKKDGHCLKEIYLVDVSEKTVEAFAEAVKTVFKAT
LPDTAAPPGLPPAAAGPGKTSWEKGSLVSPGGLQMLLVKEGVQNAKTDVVVNSVPLDLVL
SRGPLSKSLLEKAGPELQEELDTVGQGVAVSMGTVLKTSSWNLDCRYVLHVVAPEWRNGS
TSSLKIMEDIIRECMEITESLSLKSIAFPAIGTGNLGFPKNIFAELIISEVFKFSSKNQL
KTLQEVHFLLHPSDHENIQAFSDEFARRANGNLVSDKIPKAKDTQGFYGTVSSPDSGVYE
MKIGSIIFQVASGDITKEEADVIVNSTSNSFNLKAGVSKAILECAGQNVERECSQQAQQR
KNDYIITGGGFLRCKNIIHVIGGNDVKSSVSSVLQECEKKNYSSICLPAIGTGNAKQHPD
KVAEAIIDAIEDFVQKGSAQSVKKVKVVIFLPQVLDVFYANMKKREGTQLSSQQSVMSKL
ASFLGFSKQSPQKKNHLVLEKKTESATFRVCGENVTCVEYAISWLQDLIEKEQCPYTSED
ECIKDFDEKEYQELNELQKKLNINISLDHKRPLIKVLGISRDVMQARDEIEAMIKRVRLA
KEQESRADCISEFIEWQYNDNNTSHCFNKMTNLKLEDARREKKKTVDVKINHRHYTVNLN
TYTATDTKGHSLSVQRLTKSKVDIPAHWSDMKQQNFCVVELLPSDPEYNTVASKFNQTCS
HFRIEKIERIQNPDLWNSYQAKKKTMDAKNGQTMNEKQLFHGTDAGSVPHVNRNGFNRSY
AGKNAVAYGKGTYFAVNANYSANDTYSRPDANGRKHVYYVRVLTGIYTHGNHSLIVPPSK
NPQNPTDLYDTVTDNVHHPSLFVAFYDYQAYPEYLITFRK
|
External Links |
GenBank ID Protein
| 154813199 |
UniProtKB/Swiss-Prot ID
| Q460N5 |
UniProtKB/Swiss-Prot Entry Name
| PAR14_HUMAN |
PDB IDs
|
|
GenBank Gene ID
| Not Available |
GeneCard ID
| PARP14 |
GenAtlas ID
| PARP14 |
HGNC ID
| HGNC:29232 |
References |
General References
| Not Available |