Identification
HMDB Protein ID CDBP04079
Secondary Accession Numbers Not Available
Name Poly [ADP-ribose] polymerase 14
Description Not Available
Synonyms
  1. B aggressive lymphoma protein 2
  2. PARP-14
  3. ADP-ribosyltransferase diphtheria toxin-like 8
  4. ARTD8
Gene Name PARP14
Protein Type Enzyme
Biological Properties
General Function Involved in NAD+ ADP-ribosyltransferase activity
Specific Function Enhances STAT6-dependent transcription (By similarity). Has ADP-ribosyltransferase activity.
GO Classification
Biological Process
regulation of transcription, DNA-dependent
transcription, DNA-dependent
Cellular Component
cytoplasm
plasma membrane
nucleus
Function
catalytic activity
transferase activity
nad+ adp-ribosyltransferase activity
transferase activity, transferring pentosyl groups
transferase activity, transferring glycosyl groups
Molecular Function
NAD+ ADP-ribosyltransferase activity
Cellular Location
  1. Nucleus
  2. Cytoplasm
Pathways
Gene Properties
Chromosome Location 3
Locus 3q21.1
SNPs PARP14
Gene Sequence
>5406 bp
ATGGCTGTGCCCGGCTCCTTCCCGCTGCTGGTCGAGGGCTCCTGGGGCCCCGACCCCCCG
AAGAACTTGAACACCAAGTTGCAGATGTACTTCCAGAGCCCGAAGAGGTCGGGAGGCGGC
GAGTGTGAGGTCCGCCAGGATCCCAGGAGCCCATCCCGCTTCCTGGTGTTCTTCTACCCG
GAGGACGTTCGGCAGAAGGTTCTGGAGAGAAAAAATCATGAGTTGGTATGGCAAGGAAAA
GGAACATTCAAGTTAACTGTCCAGTTACCTGCAACCCCAGATGAAATCGATCATGTCTTT
GAAGAGGAACTTCTAACAAAAGAATCCAAGACCAAAGAAGATGTTAAAGAACCAGATGTG
TCAGAAGAATTGGATACAAAACTCCCTCTTGATGGTGGATTAGACAAAATGGAAGATATC
CCAGAGGAATGTGAAAATATTTCCTCTTTGGTGGCATTTGAAAACCTCAAGGCAAATGTG
ACTGACATAATGCTAATCTTGTTAGTGGAGAACATAAGTGGCCTGTCTAATGATGACTTT
CAAGTGGAAATAATAAGAGATTTTGATGTTGCTGTTGTTACCTTTCAAAAGCACATAGAT
ACTATAAGATTTGTTGATGATTGTACCAAGCACCATTCAATTAAACAACTTCAGCTTTCT
CCAAGACTTCTGGAAGTGACAAACACAATCAGGGTTGAAAACCTGCCACCTGGTGCTGAT
GACTACAGTTTAAAACTTTTCTTTGAAAATCCCTATAATGGAGGGGGAAGAGTTGCCAAT
GTTGAATATTTTCCTGAAGAGAGTTCAGCTCTGATTGAATTTTTTGACAGAAAAGTGTTA
GACACCATCATGGCCACAAAACTCGACTTCAATAAAATGCCACTTTCTGTGTTCCCATAC
TATGCCTCATTGGGCACAGCCTTGTATGGAAAGGAGAAGCCTCTGATCAAGCTTCCAGCA
CCATTTGAAGAGTCACTAGATCTTCCCTTATGGAAGTTCTTACAGAAAAAGAATCACCTC
ATTGAGGAGATAAACGATGAAATGAGGCGTTGTCACTGTGAGCTCACGTGGTCCCAACTC
AGTGGTAAAGTTACCATCAGACCAGCAGCCACCTTAGTCAATGAAGGAAGACCGAGAATC
AAGACCTGGCAGGCAGATACTTCCACAACACTCTCTAGCATCAGGTCTAAATATAAAGTC
AACCCAATTAAAGTGGATCCAACAATGTGGGACACCATAAAAAATGATGTGAAAGATGAC
AGGATTTTGATTGAGTTTGATACACTTAAGGAGATGGTAATCTTAGCAGGGAAATCAGAG
GATGTCCAAAGCATTGAGGTACAAGTCAGGGAGTTAATAGAAAGCACTACTCAAAAAATT
AAAAGGGAAGAGCAAAGTTTGAAGGAAAAAATGATCATTTCTCCAGGCAGGTATTTTCTT
TTGTGTCACAGCAGTCTACTGGACCATTTACTCACGGAGTGCCCAGAGATAGAGATTTGT
TACGATAGAGTCACTCAACACTTGTGCTTGAAAGGACCTAGTGCAGATGTGTATAAAGCA
AAGTGTGAAATCCAGGAAAAGGTGTACACCATGGCTCAGAAAAACATTCAGGTTTCTCCT
GAGATTTTTCAGTTTTTGCAACAGGTAAACTGGAAAGAATTCTCTAAGTGTCTTTTCATA
GCACAGAAGATTCTTGCACTTTATGAGCTAGAGGGTACAACTGTTCTCTTAACCAGCTGT
TCTTCTGAAGCCCTGTTAGAAGCAGAAAAGCAAATGCTCAGTGCCTTAAATTATAAGCGC
ATTGAAGTTGAGAACAAAGAAGTTCTTCATGGCAAGAAATGGAAAGGGCTCACTCACAAT
TTGCTTAAGAAACAAAATTCCTCCCCAAACACTGTAATCATCAATGAGTTAACTTCAGAA
ACCACAGCTGAAGTCATCATTACAGGCTGTGTAAAAGAAGTAAATGAAACCTATAAATTG
CTTTTTAACTTCGTTGAACAAAACATGAAAATAGAGAGACTGGTTGAAGTAAAGCCTTCC
TTAGTTATTGACTATTTAAAGACAGAAAAGAAGCTATTCTGGCCAAAGATAAAGAAGGTA
AATGTGCAGGTAAGTTTCAATCCTGAGAACAAACAAAAAGGCATTTTACTAACTGGCTCA
AAGACCGAAGTACTGAAGGCAGTGGACATTGTCAAGCAAGTCTGGGATTCAGTCTGTGTT
AAAAGTGTCCATACTGATAAGCCAGGAGCCAAGCAGTTCTTCCAGGATAAAGCACGGTTT
TATCAAAGTGAGATCAAACGGTTGTTTGGTTGTTACATTGAACTACAGGAGAATGAAGTA
ATGAAGGAGGGAGGCAGCCCCGCTGGGCAGAAGTGCTTCTCTCGGACAGTCTTGGCCCCT
GGCGTTGTGCTGATTGTGCAGCAGGGTGACTTGGCACGGCTTCCTGTCGATGTGGTGGTG
AATGCATCTAATGAGGACCTTAAGCATTATGGTGGCCTGGCCGCTGCGCTCTCAAAAGCA
GCTGGCCCTGAGCTCCAGGCCGACTGTGACCAGATAGTGAAGAGAGAGGGCAGACTCCTA
CCGGGCAATGCCACCATCTCCAAGGCAGGAAAGCTGCCCTACCACCACGTGATCCATGCA
GTGGGGCCCCGCTGGAGCGGATATGAGGCCCCGAGGTGTGTGTACCTATTAAGGAGAGCT
GTGCAACTCAGTCTCTGTCTAGCCGAAAAATACAAGTACCGATCCATAGCCATCCCAGCT
ATTAGTTCTGGAGTCTTTGGCTTTCCCTTAGGCCGATGCGTGGAGACCATTGTTTCTGCC
ATCAAGGAAAACTTCCAATTCAAGAAGGATGGACACTGCTTGAAAGAAATCTACCTTGTG
GATGTATCTGAGAAGACTGTTGAGGCCTTTGCAGAAGCTGTGAAAACTGTATTTAAAGCC
ACCCTGCCAGATACAGCTGCCCCGCCAGGTTTACCACCAGCAGCAGCGGGGCCTGGGAAA
ACATCATGGGAAAAAGGAAGCCTGGTGTCCCCGGGAGGCCTGCAGATGCTGTTGGTGAAA
GAGGGTGTGCAGAATGCTAAGACCGATGTTGTTGTCAACTCCGTTCCCTTGGATCTCGTG
CTTAGTAGAGGGCCTCTTTCTAAGTCCCTCTTGGAAAAAGCTGGACCAGAGCTCCAGGAG
GAATTGGACACAGTTGGACAAGGGGTGGCTGTCAGCATGGGCACAGTGCTCAAAACCAGC
AGCTGGAATCTGGACTGTCGCTATGTGCTTCACGTGGTAGCTCCGGAGTGGAGAAATGGT
AGCACATCTTCACTCAAGATAATGGAAGACATAATCAGAGAATGTATGGAGATCACTGAG
AGCTTGTCCTTAAAATCAATTGCATTTCCAGCAATAGGAACAGGAAACTTGGGATTTCCT
AAAAACATATTCGCTGAATTAATCATTTCAGAGGTGTTCAAATTTAGTAGCAAGAATCAG
CTGAAAACTTTACAAGAGGTTCACTTTCTGCTGCACCCGAGTGATCATGAAAATATTCAG
GCATTTTCAGATGAATTTGCCAGAAGGGCTAATGGAAATCTCGTCAGTGACAAAATTCCG
AAGGCTAAAGATACACAAGGTTTTTATGGGACTGTTTCTAGCCCTGATTCAGGTGTGTAT
GAAATGAAGATTGGCTCCATCATCTTCCAGGTGGCTTCTGGAGATATCACGAAAGAAGAG
GCAGATGTGATTGTAAATTCAACATCAAACTCATTCAATCTCAAAGCAGGGGTCTCCAAA
GCAATTTTAGAATGTGCTGGACAAAATGTAGAAAGGGAATGTTCTCAGCAAGCTCAGCAG
CGCAAAAATGATTATATAATCACCGGAGGTGGATTTTTGAGGTGCAAGAATATCATTCAT
GTAATTGGTGGAAATGATGTCAAGAGTTCAGTTTCCTCTGTTTTGCAGGAGTGTGAAAAA
AAAAATTACTCATCCATTTGCCTCCCAGCCATTGGGACAGGAAATGCCAAACAACACCCA
GATAAGGTTGCTGAAGCCATAATTGATGCCATTGAAGACTTTGTCCAGAAAGGATCAGCC
CAGTCTGTGAAAAAAGTTAAAGTTGTTATCTTTCTGCCTCAAGTACTGGATGTGTTTTAT
GCCAACATGAAGAAAAGAGAAGGGACTCAGCTTTCTTCCCAACAGTCTGTGATGTCTAAA
CTTGCATCATTTTTGGGCTTTTCAAAGCAATCTCCCCAAAAAAAGAATCATTTGGTTTTG
GAAAAGAAAACAGAATCAGCAACTTTTCGGGTGTGTGGTGAAAATGTCACGTGTGTGGAA
TATGCTATCTCCTGGCTACAAGACCTGATTGAAAAAGAACAGTGTCCTTACACCAGTGAA
GATGAGTGCATCAAAGACTTTGATGAAAAGGAGTATCAGGAGTTGAATGAGCTGCAGAAG
AAGTTAAATATTAACATTTCCCTGGACCATAAGAGACCTTTGATTAAGGTTTTGGGAATT
AGCAGAGATGTGATGCAGGCTAGAGATGAAATTGAGGCGATGATCAAGAGAGTTCGATTG
GCCAAAGAACAGGAATCCCGGGCAGATTGTATCAGTGAGTTTATAGAATGGCAGTATAAT
GACAATAACACTTCTCATTGTTTTAACAAAATGACCAATCTGAAATTAGAGGATGCAAGG
AGAGAAAAGAAAAAAACAGTTGATGTCAAAATTAATCATCGGCACTACACAGTGAACTTG
AACACATACACTGCCACAGACACAAAGGGCCACAGTTTATCTGTTCAGCGCCTCACGAAA
TCCAAAGTTGACATCCCTGCACACTGGAGTGATATGAAGCAGCAGAATTTCTGTGTGGTG
GAGCTGCTGCCTAGTGATCCTGAGTACAACACGGTGGCAAGCAAGTTTAATCAGACCTGC
TCACACTTCAGAATAGAGAAGATTGAGAGGATCCAGAATCCAGATCTCTGGAATAGCTAC
CAGGCAAAGAAAAAAACTATGGATGCCAAGAATGGCCAGACAATGAATGAGAAGCAACTC
TTCCATGGGACAGATGCCGGCTCCGTGCCACACGTCAATCGAAATGGCTTTAACCGCAGC
TATGCCGGAAAGAATGCTGTGGCATATGGAAAGGGAACCTATTTTGCTGTCAATGCCAAT
TATTCTGCCAATGATACGTACTCCAGACCAGATGCAAATGGGAGAAAGCATGTGTATTAT
GTGCGAGTACTTACTGGAATCTATACACATGGAAATCATTCATTAATTGTGCCTCCTTCA
AAGAACCCTCAAAATCCTACTGACCTGTATGACACTGTCACAGATAATGTGCACCATCCA
AGTTTATTTGTGGCATTTTATGACTACCAAGCATACCCAGAGTACCTTATTACGTTTAGA
AAATAA
Protein Properties
Number of Residues 1720
Molecular Weight 202798.68
Theoretical pI 7.181
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Poly [ADP-ribose] polymerase 14
MAVPGSFPLLVEGSWGPDPPKNLNTKLQMYFQSPKRSGGGECEVRQDPRSPSRFLVFFYP
EDVRQKVLERKNHELVWQGKGTFKLTVQLPATPDEIDHVFEEELLTKESKTKEDVKEPDT
IRFVDDCTKHHSIKQLQLSPRLLEVTNTIRVENLPPGADDYSLKLFFENPYNGGGRVANV
EYFPEESSALIEFFDRKVLDTIMATKLDFNKMPLSVFPYYASLGTALYGKEKPLIKLPAP
FEESLDLPLWKFLQKKNHLIEEINDEMRRCHCELTWSQLSGKVTIRPAATLVNEGRPRIK
TWQADTSTTLSSIRSKYKVNPIKVDPTMWDTIKNDVKDDRILIEFDTLKEMVILAGKSED
VQSIEVQVRELIESTTQKIKREEQSLKEKMIISPGRYFLLCHSSLLDHLLTECPEIEICY
DRVTQHLCLKGPSADVYKAKCEIQEKVYTMAQKNIQVSPEIFQFLQQVNWKEFSKCLFIA
QKILALYELEGTTVLLTSCSSEALLEAEKQMLSALNYKRIEVENKEVLHGKKWKGLTHNL
LKKQNSSPNTVIINELTSETTAEVIITGCVKEVNETYKLLFNFVEQNMKIERLVEVKPSL
VIDYLKTEKKLFWPKIKKVNVQVSFNPENKQKGILLTGSKTEVLKAVDIVKQVWDSVCVK
SVHTDKPGAKQFFQDKARFYQSEIKRLFGCYIELQENEVMKEGGSPAGQKCFSRTVLAPG
VVLIVQQGDLARLPVDVVVNASNEDLKHYGGLAAALSKAAGPELQADCDQIVKREGRLLP
GNATISKAGKLPYHHVIHAVGPRWSGYEAPRCVYLLRRAVQLSLCLAEKYKYRSIAIPAI
SSGVFGFPLGRCVETIVSAIKENFQFKKDGHCLKEIYLVDVSEKTVEAFAEAVKTVFKAT
LPDTAAPPGLPPAAAGPGKTSWEKGSLVSPGGLQMLLVKEGVQNAKTDVVVNSVPLDLVL
SRGPLSKSLLEKAGPELQEELDTVGQGVAVSMGTVLKTSSWNLDCRYVLHVVAPEWRNGS
TSSLKIMEDIIRECMEITESLSLKSIAFPAIGTGNLGFPKNIFAELIISEVFKFSSKNQL
KTLQEVHFLLHPSDHENIQAFSDEFARRANGNLVSDKIPKAKDTQGFYGTVSSPDSGVYE
MKIGSIIFQVASGDITKEEADVIVNSTSNSFNLKAGVSKAILECAGQNVERECSQQAQQR
KNDYIITGGGFLRCKNIIHVIGGNDVKSSVSSVLQECEKKNYSSICLPAIGTGNAKQHPD
KVAEAIIDAIEDFVQKGSAQSVKKVKVVIFLPQVLDVFYANMKKREGTQLSSQQSVMSKL
ASFLGFSKQSPQKKNHLVLEKKTESATFRVCGENVTCVEYAISWLQDLIEKEQCPYTSED
ECIKDFDEKEYQELNELQKKLNINISLDHKRPLIKVLGISRDVMQARDEIEAMIKRVRLA
KEQESRADCISEFIEWQYNDNNTSHCFNKMTNLKLEDARREKKKTVDVKINHRHYTVNLN
TYTATDTKGHSLSVQRLTKSKVDIPAHWSDMKQQNFCVVELLPSDPEYNTVASKFNQTCS
HFRIEKIERIQNPDLWNSYQAKKKTMDAKNGQTMNEKQLFHGTDAGSVPHVNRNGFNRSY
AGKNAVAYGKGTYFAVNANYSANDTYSRPDANGRKHVYYVRVLTGIYTHGNHSLIVPPSK
NPQNPTDLYDTVTDNVHHPSLFVAFYDYQAYPEYLITFRK
GenBank ID Protein 154813199
UniProtKB/Swiss-Prot ID Q460N5
UniProtKB/Swiss-Prot Entry Name PAR14_HUMAN
PDB IDs
GenBank Gene ID Not Available
GeneCard ID PARP14
GenAtlas ID PARP14
HGNC ID HGNC:29232
References
General References Not Available