| Identification |
|---|
| HMDB Protein ID
| CDBP00519 |
| Secondary Accession Numbers
| Not Available |
| Name
| Estradiol 17-beta-dehydrogenase 11 |
| Description
| Not Available |
| Synonyms
|
- 17-beta-HSD 11
- 17-beta-HSD XI
- 17-beta-hydroxysteroid dehydrogenase 11
- 17-beta-hydroxysteroid dehydrogenase XI
- 17bHSD11
- 17betaHSD11
- 17betaHSDXI
- CTCL-associated antigen HD-CL-03
- Cutaneous T-cell lymphoma-associated antigen HD-CL-03
- Dehydrogenase/reductase SDR family member 8
- Retinal short-chain dehydrogenase/reductase 2
- retSDR2
|
| Gene Name
| HSD17B11 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in oxidoreductase activity |
| Specific Function
| Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor-associated antigen in cutaneous T-cell lymphoma.
|
| GO Classification
|
| Biological Process |
| steroid biosynthetic process |
| androgen catabolic process |
| Cellular Component |
| extracellular region |
| lipid particle |
| Function |
| binding |
| catalytic activity |
| oxidoreductase activity |
| Molecular Function |
| estradiol 17-beta-dehydrogenase activity |
| steroid dehydrogenase activity |
| nucleotide binding |
| Process |
| metabolic process |
| oxidation reduction |
|
| Cellular Location
|
- Secreted (Potential)
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 4 |
| Locus
| 4q22.1 |
| SNPs
| HSD17B11 |
| Gene Sequence
|
>903 bp
ATGAAATTTCTTCTGGACATCCTCCTGCTTCTCCCGTTACTGATCGTCTGCTCCCTAGAG
TCCTTCGTGAAGCTTTTTATTCCTAAGAGGAGAAAATCAGTCACCGGCGAAATCGTGCTG
ATTACAGGAGCTGGGCATGGAATTGGGAGACTGACTGCCTATGAATTTGCTAAACTTAAA
AGCAAGCTGGTTCTCTGGGATATAAATAAGCATGGACTGGAGGAAACAGCTGCCAAATGC
AAGGGACTGGGTGCCAAGGTTCATACCTTTGTGGTAGACTGCAGCAACCGAGAAGATATT
TACAGCTCTGCAAAGAAGGTGAAGGCAGAAATTGGAGATGTTAGTATTTTAGTAAATAAT
GCTGGTGTAGTCTATACATCAGATTTGTTTGCTACACAAGATCCTCAGATTGAAAAGACT
TTTGAAGTTAATGTACTTGCACATTTCTGGACTACAAAGGCATTTCTTCCTGCAATGACG
AAGAATAACCATGGCCATATTGTCACTGTGGCTTCGGCAGCTGGACATGTCTCGGTCCCC
TTCTTACTGGCTTACTGTTCAAGCAAGTTTGCTGCTGTTGGATTTCATAAAACTTTGACA
GATGAACTGGCTGCCTTACAAATAACTGGAGTCAAAACAACATGTCTGTGTCCTAATTTC
GTAAACACTGGCTTCATCAAAAATCCAAGTACAAGTTTGGGACCCACTCTGGAACCTGAG
GAAGTGGTAAACAGGCTGATGCATGGGATTCTGACTGAGCAGAAGATGATTTTTATTCCA
TCTTCTATAGCTTTTTTAACAACATTGGAAAGGATCCTTCCTGAGCGTTTCCTGGCAGTT
TTAAAACAAAAAATCAGTGTTAAGTTTGATGCAGTTATTGGATATAAAATGAAAGCGCAA
TAA
|
| Protein Properties |
|---|
| Number of Residues
| 300 |
| Molecular Weight
| 32935.525 |
| Theoretical pI
| 9.07 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Estradiol 17-beta-dehydrogenase 11
MKFLLDILLLLPLLIVCSLESFVKLFIPKRRKSVTGEIVLITGAGHGIGRLTAYEFAKLK
SKLVLWDINKHGLEETAAKCKGLGAKVHTFVVDCSNREDIYSSAKKVKAEIGDVSILVNN
AGVVYTSDLFATQDPQIEKTFEVNVLAHFWTTKAFLPAMTKNNHGHIVTVASAAGHVSVP
FLLAYCSSKFAAVGFHKTLTDELAALQITGVKTTCLCPNFVNTGFIKNPSTSLGPTLEPE
EVVNRLMHGILTEQKMIFIPSSIAFLTTLERILPERFLAVLKQKISVKFDAVIGYKMKAQ
|
| External Links |
|---|
| GenBank ID Protein
| 142976729 |
| UniProtKB/Swiss-Prot ID
| Q8NBQ5 |
| UniProtKB/Swiss-Prot Entry Name
| DHB11_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| NM_016245.3 |
| GeneCard ID
| HSD17B11 |
| GenAtlas ID
| HSD17B11 |
| HGNC ID
| HGNC:22960 |
| References |
|---|
| General References
| Not Available |