Identification |
HMDB Protein ID
| CDBP00373 |
Secondary Accession Numbers
| Not Available |
Name
| Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial |
Description
| Not Available |
Synonyms
|
- HCDH
- Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase
- Short-chain 3-hydroxyacyl-CoA dehydrogenase
|
Gene Name
| HADH |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in 3-hydroxyacyl-CoA dehydrogenase activity |
Specific Function
| Plays an essential role in the mitochondrial beta-oxidation of short chain fatty acids. Exerts it highest activity toward 3-hydroxybutyryl-CoA.
|
GO Classification
|
Biological Process |
response to activity |
fatty acid beta-oxidation |
response to insulin stimulus |
response to drug |
negative regulation of insulin secretion |
Cellular Component |
mitochondrial matrix |
nucleus |
mitochondrial inner membrane |
Function |
binding |
nucleotide binding |
catalytic activity |
nad or nadh binding |
oxidoreductase activity, acting on the ch-oh group of donors, nad or nadp as acceptor |
coenzyme binding |
cofactor binding |
nad binding |
3-hydroxyacyl-coa dehydrogenase activity |
oxidoreductase activity, acting on ch-oh group of donors |
oxidoreductase activity |
Molecular Function |
3-hydroxyacyl-CoA dehydrogenase activity |
NAD+ binding |
Process |
metabolic process |
cellular metabolic process |
organic acid metabolic process |
oxoacid metabolic process |
carboxylic acid metabolic process |
monocarboxylic acid metabolic process |
fatty acid metabolic process |
|
Cellular Location
|
- Mitochondrion matrix
|
Pathways
|
Name | SMPDB/Pathwhiz | KEGG | fatty acid beta-oxidation | Not Available | Not Available | Fatty acid elongation | Not Available | ![Map00062](https://www.genome.jp/kegg/misc/thumbnail/map00062.gif) | Butanoate metabolism | Not Available | ![Map00650](https://www.genome.jp/kegg/misc/thumbnail/map00650.gif) | Butyrate Metabolism | ![Thumb](https://smpdb.ca/super_pathway_visualizations/PW000014/thumb) ![Thumb?image type=greyscale](https://smpdb.ca/super_pathway_visualizations/PW000014/thumb?image_type=greyscale) ![Thumb?image type=simple](https://smpdb.ca/super_pathway_visualizations/PW000014/thumb?image_type=simple) | ![Map00650](https://www.genome.jp/kegg/misc/thumbnail/map00650.gif) | Lysine Degradation | ![Thumb](https://smpdb.ca/super_pathway_visualizations/PW000029/thumb) ![Thumb?image type=greyscale](https://smpdb.ca/super_pathway_visualizations/PW000029/thumb?image_type=greyscale) ![Thumb?image type=simple](https://smpdb.ca/super_pathway_visualizations/PW000029/thumb?image_type=simple) | ![Map00310](https://www.genome.jp/kegg/misc/thumbnail/map00310.gif) |
|
Gene Properties |
Chromosome Location
| 4 |
Locus
| 4q22-q26 |
SNPs
| HADH |
Gene Sequence
|
>945 bp
ATGGCCTTCGTCACCAGGCAGTTCATGCGTTCCGTGTCCTCCTCGTCCACCGCCTCGGCC
TCGGCCAAGAAGATAATCGTCAAGCACGTGACGGTCATCGGCGGCGGGCTGATGGGCGCC
GGCATTGCCCAGGTTGCTGCAGCAACTGGTCACACAGTAGTGTTGGTAGACCAGACAGAG
GACATCCTGGCAAAATCCAAAAAGGGAATTGAGGAAAGCCTTAGGAAAGTGGCAAAGAAG
AAGTTTGCAGAAAACCCTAAGGCCGGCGATGAATTTGTGGAGAAGACCCTGAGCACCATA
GCGACCAGCACGGATGCAGCCTCCGTTGTCCACAGCACAGACTTGGTGGTGGAAGCCATC
GTGGAGAATCTGAAGGTGAAAAACGAGCTCTTCAAAAGGCTGGACAAGTTTGCTGCTGAA
CATACAATCTTTGCCAGCAACACTTCCTCCTTGCATATTACAAGCATAGCTAATGCCACC
ACCAGACAAGACCGATTCGCTGGCCTCCATTTCTTCAACCCAGTGCCTGTCATGAAACTT
GTGGAGGTCATTAAAACACCAATGACCAGCCAGAAGACATTTGAATCTTTGGTAGACTTT
AGCAAAGCCCTAGGAAAGCATCCTGTTTCTTGCAAGGACACTCCTGGGTTTATTGTGAAC
CGCCTCCTGGTTCCATACCTCATGGAAGCAATCAGGCTGTATGAACGAGGTGACGCATCC
AAAGAAGACATTGACACTGCTATGAAATTAGGAGCCGGTTACCCCATGGGCCCATTTGAG
CTTCTAGATTATGTCGGACTGGATACTACGAAGTTCATCGTGGATGGGTGGCATGAAATG
GATGCAGAGAACCCATTACATCAGCCCAGCCCATCCTTAAATAAGCTGGTAGCAGAGAAC
AAGTTCGGCAAGAAGACTGGAGAAGGATTTTACAAATACAAGTGA
|
Protein Properties |
Number of Residues
| 314 |
Molecular Weight
| 36035.11 |
Theoretical pI
| 8.535 |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
MAFVTRQFMRSVSSSSTASASAKKIIVKHVTVIGGGLMGAGIAQVAAATGHTVVLVDQTE
DILAKSKKGIEESLRKVAKKKFAENPKAGDEFVEKTLSTIATSTDAASVVHSTDLVVEAI
VENLKVKNELFKRLDKFAAEHTIFASNTSSLQITSIANATTRQDRFAGLHFFNPVPVMKL
VEVIKTPMTSQKTFESLVDFSKALGKHPVSCKDTPGFIVNRLLVPYLMEAIRLYERGDAS
KEDIDTAMKLGAGYPMGPFELLDYVGLDTTKFIVDGWHEMDAENPLHQPSPSLNKLVAEN
KFGKKTGEGFYKYK
|
External Links |
GenBank ID Protein
| 1483511 |
UniProtKB/Swiss-Prot ID
| Q16836 |
UniProtKB/Swiss-Prot Entry Name
| HCDH_HUMAN |
PDB IDs
|
|
GenBank Gene ID
| X96752 |
GeneCard ID
| HADH |
GenAtlas ID
| HADH |
HGNC ID
| HGNC:4799 |
References |
General References
| Not Available |