Cannabis Compound Database: Showing Protein Dihydrofolate reductase (CDBP00735)

Identification Biological properties Gene properties Protein properties External links References XML Show 6 compounds

Identification

HMDB Protein ID

CDBP00735

Secondary Accession Numbers

Not Available

Name

Dihydrofolate reductase

Description

Not Available

Synonyms

Not Available

Gene Name

DHFR

Protein Type

Enzyme

Biological Properties

General Function

Involved in dihydrofolate reductase activity

Specific Function

Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1.

GO Classification

Biological Process
folic acid metabolic process
tetrahydrofolate metabolic process
nitric oxide metabolic process
one-carbon metabolic process
glycine biosynthetic process
tetrahydrofolate biosynthetic process
regulation of nitric-oxide synthase activity
nucleotide biosynthetic process
response to methotrexate
regulation of transcription involved in G1/S phase of mitotic cell cycle
Cellular Component
cytosol
nucleoplasm
Function
dihydrofolate reductase activity
binding
nucleotide binding
catalytic activity
oxidoreductase activity, acting on the ch-nh group of donors
nadp or nadph binding
oxidoreductase activity, acting on the ch-nh group of donors, nad or nadp as acceptor
oxidoreductase activity
Molecular Function
NADP binding
drug binding
dihydrofolate reductase activity
mRNA binding
Process
oxidation reduction
cellular amino acid and derivative metabolic process
glycine biosynthetic process
cellular amino acid metabolic process
metabolic process
nitrogen compound metabolic process
cellular nitrogen compound metabolic process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
nucleobase, nucleoside and nucleotide metabolic process
nucleoside phosphate metabolic process
nucleotide metabolic process
nucleotide biosynthetic process
cellular metabolic process
serine family amino acid metabolic process
glycine metabolic process

Cellular Location

Not Available

Pathways

Name	SMPDB/Pathwhiz	KEGG
tetrahydrofolate biosynthesis	Not Available	Not Available
One carbon pool by folate	Not Available
Folate biosynthesis	Not Available
Folate Metabolism
Methotrexate Action Pathway		Not Available

Gene Properties

Chromosome Location

Locus

5q11.2-q13.2

SNPs

DHFR

Gene Sequence

>564 bp
ATGGTTGGTTCGCTAAACTGCATCGTCGCTGTGTCCCAGAACATGGGCATCGGCAAGAAC
GGGGACCTGCCCTGGCCACCGCTCAGGAATGAATTCAGATATTTCCAGAGAATGACCACA
ACCTCTTCAGTAGAAGGTAAACAGAATCTGGTGATTATGGGTAAGAAGACCTGGTTCTCC
ATTCCTGAGAAGAATCGACCTTTAAAGGGTAGAATTAATTTAGTTCTCAGCAGAGAACTC
AAGGAACCTCCACAAGGAGCTCATTTTCTTTCCAGAAGTCTAGATGATGCCTTAAAACTT
ACTGAACAACCAGAATTAGCAAATAAAGTAGACATGGTCTGGATAGTTGGTGGCAGTTCT
GTTTATAAGGAAGCCATGAATCACCCAGGCCATCTTAAACTATTTGTGACAAGGATCATG
CAAGACTTTGAAAGTGACACGTTTTTTCCAGAAATTGATTTGGAGAAATATAAACTTCTG
CCAGAATACCCAGGTGTTCTCTCTGATGTCCAGGAGGAGAAAGGCATTAAGTACAAATTT
GAAGTATATGAGAAGAATGATTAA

Protein Properties

Number of Residues

187

Molecular Weight

21452.61

Theoretical pI

7.42

Pfam Domain Function

DHFR_1 (PF00186 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Dihydrofolate reductase
MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND

External Links

GenBank ID Protein

182724

UniProtKB/Swiss-Prot ID

P00374

UniProtKB/Swiss-Prot Entry Name

DYR_HUMAN

PDB IDs