Showing Protein Dihydrofolate reductase (CDBP00735)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 6 compounds
Identification
HMDB Protein ID CDBP00735
Secondary Accession Numbers Not Available
Name Dihydrofolate reductase
Description Not Available
Synonyms Not Available
Gene Name DHFR
Protein Type Enzyme
Biological Properties
General Function Involved in dihydrofolate reductase activity
Specific Function Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1.
GO Classification
Biological Process
folic acid metabolic process
tetrahydrofolate metabolic process
nitric oxide metabolic process
one-carbon metabolic process
glycine biosynthetic process
tetrahydrofolate biosynthetic process
regulation of nitric-oxide synthase activity
nucleotide biosynthetic process
response to methotrexate
regulation of transcription involved in G1/S phase of mitotic cell cycle
Cellular Component
cytosol
nucleoplasm
Function
dihydrofolate reductase activity
binding
nucleotide binding
catalytic activity
oxidoreductase activity, acting on the ch-nh group of donors
nadp or nadph binding
oxidoreductase activity, acting on the ch-nh group of donors, nad or nadp as acceptor
oxidoreductase activity
Molecular Function
NADP binding
drug binding
dihydrofolate reductase activity
mRNA binding
Process
oxidation reduction
cellular amino acid and derivative metabolic process
glycine biosynthetic process
cellular amino acid metabolic process
metabolic process
nitrogen compound metabolic process
cellular nitrogen compound metabolic process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
nucleobase, nucleoside and nucleotide metabolic process
nucleoside phosphate metabolic process
nucleotide metabolic process
nucleotide biosynthetic process
cellular metabolic process
serine family amino acid metabolic process
glycine metabolic process
Cellular Location Not Available
Pathways
Gene Properties
Chromosome Location 5
Locus 5q11.2-q13.2
SNPs DHFR
Gene Sequence 
>564 bp
ATGGTTGGTTCGCTAAACTGCATCGTCGCTGTGTCCCAGAACATGGGCATCGGCAAGAAC
GGGGACCTGCCCTGGCCACCGCTCAGGAATGAATTCAGATATTTCCAGAGAATGACCACA
ACCTCTTCAGTAGAAGGTAAACAGAATCTGGTGATTATGGGTAAGAAGACCTGGTTCTCC
ATTCCTGAGAAGAATCGACCTTTAAAGGGTAGAATTAATTTAGTTCTCAGCAGAGAACTC
AAGGAACCTCCACAAGGAGCTCATTTTCTTTCCAGAAGTCTAGATGATGCCTTAAAACTT
ACTGAACAACCAGAATTAGCAAATAAAGTAGACATGGTCTGGATAGTTGGTGGCAGTTCT
GTTTATAAGGAAGCCATGAATCACCCAGGCCATCTTAAACTATTTGTGACAAGGATCATG
CAAGACTTTGAAAGTGACACGTTTTTTCCAGAAATTGATTTGGAGAAATATAAACTTCTG
CCAGAATACCCAGGTGTTCTCTCTGATGTCCAGGAGGAGAAAGGCATTAAGTACAAATTT
GAAGTATATGAGAAGAATGATTAA
Protein Properties
Number of Residues 187
Molecular Weight 21452.61
Theoretical pI 7.42
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence 
>Dihydrofolate reductase
MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
GenBank ID Protein 182724
UniProtKB/Swiss-Prot ID P00374
UniProtKB/Swiss-Prot Entry Name DYR_HUMAN
PDB IDs
GenBank Gene ID J00140
GeneCard ID DHFR
GenAtlas ID DHFR
HGNC ID HGNC:2861
References
General References Not Available