Cannabis Compound Database: Showing Protein Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (CDBP00044)

Identification Biological properties Gene properties Protein properties External links References XML Show 10 compounds

Identification

HMDB Protein ID

CDBP00044

Secondary Accession Numbers

Not Available

Name

Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

Description

Not Available

Synonyms

PDHE1-A type I

Gene Name

PDHA1

Protein Type

Enzyme

Biological Properties

General Function

Involved in oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor

Specific Function

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.

GO Classification

Biological Process
regulation of acetyl-CoA biosynthetic process from pyruvate
glycolysis
tricarboxylic acid cycle
acetyl-CoA biosynthetic process from pyruvate
Cellular Component
pyruvate dehydrogenase complex
mitochondrial matrix
Component
organelle
membrane-bounded organelle
intracellular membrane-bounded organelle
Function
catalytic activity
oxidoreductase activity
pyruvate dehydrogenase activity
pyruvate dehydrogenase (acetyl-transferring) activity
oxidoreductase activity, acting on the aldehyde or oxo group of donors
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Molecular Function
pyruvate dehydrogenase (acetyl-transferring) activity
pyruvate dehydrogenase activity
Process
hexose metabolic process
glucose metabolic process
oxidation reduction
glucose catabolic process
glycolysis
metabolic process
small molecule metabolic process
alcohol metabolic process
monosaccharide metabolic process

Cellular Location

Mitochondrion matrix

Pathways

Name	SMPDB/Pathwhiz	KEGG
Glycolysis / Gluconeogenesis	Not Available
Citrate cycle (TCA cycle)	Not Available
Butanoate metabolism	Not Available
HIF-1 signaling pathway	Not Available
Citric Acid Cycle

Gene Properties

Chromosome Location

Locus

Xp22.1

SNPs

PDHA1

Gene Sequence

>1173 bp
ATGAGGAAGATGCTCGCCGCCGTCTCCCGCGTGCTGTCTGGCGCTTCTCAGAAGCCGGCA
AGCAGAGTGCTGGTAGCATCCCGTAATTTTGCAAATGATGCTACATTTGAAATTAAGAAA
TGTGACCTTCACCGGCTGGAAGAAGGCCCTCCTGTCACAACAGTGCTCACCAGGGAGGAT
GGGCTCAAATACTACAGGATGATGCAGACTGTACGCCGAATGGAGTTGAAAGCAGATCAG
CTGTATAAACAGAAAATTATTCGTGGTTTCTGTCACTTGTGTGATGGTCAGGAAGCTTGC
TGTGTGGGCCTGGAGGCCGGCATCAACCCCACAGACCATCTCATCACAGCCTACCGGGCT
CACGGCTTTACTTTCACCCGGGGCCTTTCCGTCCGAGAAATTCTCGCAGAGCTTACAGGA
CGAAAAGGAGGTTGTGCTAAAGGGAAAGGAGGATCGATGCACATGTATGCCAAGAACTTC
TACGGGGGCAATGGCATCGTGGGAGCGCAGGTGCCCCTGGGCGCTGGGATTGCTCTAGCC
TGTAAGTATAATGGAAAAGATGAGGTCTGCCTGACTTTATATGGCGATGGTGCTGCTAAC
CAGGGCCAGATATTCGAAGCTTACAACATGGCAGCTTTGTGGAAATTACCTTGTATTTTC
ATCTGTGAGAATAATCGCTATGGAATGGGAACGTCTGTTGAGAGAGCGGCAGCCAGCACT
GATTACTACAAGAGAGGCGATTTCATTCCTGGGCTGAGAGTGGATGGAATGGATATCCTG
TGCGTCCGAGAGGCAACAAGGTTTGCTGCTGCCTATTGTAGATCTGGGAAGGGGCCCATC
CTGATGGAGCTGCAGACTTACCGTTACCACGGACACAGTATGAGTGACCCTGGAGTCAGT
TACCGTACACGAGAAGAAATTCAGGAAGTAAGAAGTAAGAGTGACCCTATTATGCTTCTC
AAGGACAGGATGGTGAACAGCAATCTTGCCAGTGTGGAAGAACTAAAGGAAATTGATGTG
GAAGTGAGGAAGGAGATTGAGGATGCTGCCCAGTTTGCCACGGCCGATCCTGAGCCACCT
TTGGAAGAGCTGGGCTACCACATCTACTCCAGCGACCCACCTTTTGAAGTTCGTGGTGCC
AATCAGTGGATCAAGTTTAAGTCAGTCAGTTAA

Protein Properties

Number of Residues

390

Molecular Weight

43295.255

Theoretical pI

8.063

Pfam Domain Function

E1_dh (PF00676 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
MRKMLAAVSRVLSGASQKPASRVLVASRNFANDATFEIKKCDLHRLEEGPPVTTVLTRED
GLKYYRMMQTVRRMELKADQLYKQKIIRGFCHLCDGQEACCVGLEAGINPTDHLITAYRA
HGFTFTRGLSVREILAELTGRKGGCAKGKGGSMHMYAKNFYGGNGIVGAQVPLGAGIALA
CKYNGKDEVCLTLYGDGAANQGQIFEAYNMAALWKLPCIFICENNRYGMGTSVERAAAST
DYYKRGDFIPGLRVDGMDILCVREATRFAAAYCRSGKGPILMELQTYRYHGHSMSDPGVS
YRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKEIDVEVRKEIEDAAQFATADPEPP
LEELGYHIYSSDPPFEVRGANQWIKFKSVS

External Links

GenBank ID Protein

Not Available

UniProtKB/Swiss-Prot ID

P08559

UniProtKB/Swiss-Prot Entry Name

ODPA_HUMAN

PDB IDs