Identification
HMDB Protein ID CDBP00144
Secondary Accession Numbers Not Available
Name NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4
Description Not Available
Synonyms
  1. CI-B15
  2. Complex I-B15
  3. NADH-ubiquinone oxidoreductase B15 subunit
Gene Name NDUFB4
Protein Type Enzyme
Biological Properties
General Function Involved in NADH dehydrogenase (ubiquinone) activity
Specific Function Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
GO Classification
Component
mitochondrion
organelle
membrane-bounded organelle
intracellular membrane-bounded organelle
Function
catalytic activity
nadh dehydrogenase activity
nadh dehydrogenase (quinone) activity
nadh dehydrogenase (ubiquinone) activity
oxidoreductase activity
oxidoreductase activity, acting on nadh or nadph
Cellular Location
  1. Single-pass membrane protein
  2. Mitochondrion inner membrane
  3. Matrix side
Pathways
Gene Properties
Chromosome Location Chromosome:3
Locus 3q13.33
SNPs NDUFB4
Gene Sequence
>390 bp
ATGTCGTTCCCAAAGTATAAGCCGTCGAGCCTGCGCACTCTGCCTGAGACCCTCGACCCA
GCCGAATACAACATATCTCCGGAAACCCGGCGGGCGCAAGCCGAGCGGTTGGCCATAAGA
GCCCAGCTGAAACGAGAGTACCTGCTTCAGTACAACGATCCCAACCGCCGAGGGCTCATC
GAAAATCCTGCCTTGCTTCGTTGGGCCTATGCAAGAACAATAAATGTCTATCCTAATTTC
AGACCCACTCCTAAAAACTCACTCATGGGAGCTCTGTGTGGATTTGGGCCCCTCATCTTC
ATTTATTATATTATCAAAACTGAGAGGGATAGGAAAGAAAAACTTATCCAGGAAGGAAAA
TTGGATCGAACATTTCACCTCTCATATTAA
Protein Properties
Number of Residues 129
Molecular Weight 15208.4
Theoretical pI 10.24
Pfam Domain Function Not Available
Signals
  • ["None"]
Transmembrane Regions
  • ["88-105"]
Protein Sequence
>NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4
MSFPKYKPSSLRTLPETLDPAEYNISPETRRAQAERLAIRAQLKREYLLQYNDPNRRGLI
ENPALLRWAYARTINVYPNFRPTPKNSLMGALCGFGPLIFIYYIIKTERDRKEKLIQEGK
LDRTFHLSY
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID O95168
UniProtKB/Swiss-Prot Entry Name NDUB4_HUMAN
PDB IDs Not Available
GenBank Gene ID AF044957
GeneCard ID NDUFB4
GenAtlas ID NDUFB4
HGNC ID HGNC:7699
References
General References Not Available