Cannabis Compound Database: Showing Protein Metalloreductase STEAP4 (CDBP03508)

Identification Biological properties Gene properties Protein properties External links References XML Show 3 compounds

Identification

HMDB Protein ID

CDBP03508

Secondary Accession Numbers

Not Available

Name

Metalloreductase STEAP4

Description

Not Available

Synonyms

Six-transmembrane epithelial antigen of prostate 4
SixTransMembrane protein of prostate 2
Tumor necrosis factor, alpha-induced protein 9

Gene Name

STEAP4

Protein Type

Enzyme

Biological Properties

General Function

Involved in iron ion binding

Specific Function

Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor. Play a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses. Associated with obesity and insulin-resistance. Involved in inflammatory arthritis, through the regulation of inflammatory cytokines. Inhibits anchorage-independent cell proliferation

GO Classification

Component
cell part
membrane part
intrinsic to membrane
integral to membrane
Function
oxidoreductase activity
fad or fadh2 binding
ion binding
cation binding
metal ion binding
binding
catalytic activity
transition metal ion binding
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
electron carrier activity
iron ion binding
Process
metabolic process

Cellular Location

Cell membrane
Golgi apparatus membrane
Multi-pass membrane protein

Pathways

Not Available

Gene Properties

Chromosome Location

Chromosome:7

Locus

7q21.12

SNPs

STEAP4

Gene Sequence

>1380 bp
ATGGAGAAAACTTGTATAGATGCACTTCCTCTTACTATGAATTCTTCAGAAAAGCAAGAG
ACTGTATGTATTTTTGGAACTGGTGATTTTGGAAGATCACTGGGATTGAAAATGCTCCAG
TGTGGTTATTCTGTTGTTTTTGGAAGTCGAAACCCCCAGAAGACCACCCTACTGCCCAGT
GGTGCAGAAGTCTTGAGCTATTCAGAAGCAGCCAAGAAGTCTGGCATCATAATCATAGCA
ATCCACAGAGAGCATTATGATTTTCTCACAGAATTAACTGAGGTTCTCAATGGAAAAATA
TTGGTAGACATCAGCAACAACCTCAAAATCAATCAATATCCAGAATCTAATGCAGAGTAC
CTTGCTCATTTGGTGCCAGGAGCCCACGTGGTAAAAGCATTTAACACCATCTCAGCCTGG
GCTCTCCAGTCAGGAGCACTGGATGCAAGTCGGCAGGTGTTTGTGTGTGGAAATGACAGC
AAAGCCAAGCAAAGAGTGATGGATATTGTTCGTAATCTTGGACTTACTCCAATGGATCAA
GGATCACTCATGGCAGCCAAAGAAATTGAAAAGTACCCCCTGCAGCTATTTCCAATGTGG
AGGTTCCCCTTCTATTTGTCTGCTGTGCTGTGTGTCTTCTTGTTTTTCTATTGTGTTATA
AGAGACGTAATCTACCCTTATGTTTATGAAAAGAAAGATAATACATTTCGTATGGCTATT
TCCATTCCAAATCGTATCTTTCCAATAACAGCACTTACACTGCTTGCTTTGGTTTACCTC
CCTGGTGTTATTGCTGCCATTCTACAACTGTACCGAGGCACAAAATACCGTCGATTCCCA
GACTGGCTTGACCACTGGATGCTTTGCCGAAAGCAGCTTGGCTTGGTAGCTCTGGGATTT
GCCTTCCTTCATGTCCTCTACACACTTGTGATTCCTATTCGATATTATGTACGATGGAGA
TTGGGAAACTTAACCGTTACCCAGGCAATACTCAAGAAGGAGAATCCATTTAGCACCTCC
TCAGCCTGGCTCAGTGATTCATATGTGGCTTTGGGAATACTTGGGTTTTTTCTGTTTGTA
CTCTTGGGAATCACTTCTTTGCCATCTGTTAGCAATGCAGTCAACTGGAGAGAGTTCCGA
TTTGTCCAGTCCAAACTGGGTTATTTGACCCTGATCTTGTGTACAGCCCACACCCTGGTG
TACGGTGGGAAGAGATTCCTCAGCCCTTCAAATCTCAGATGGTATCTTCCTGCAGCCTAC
GTGTTAGGGCTTATCATTCCTTGCACTGTGCTGGTGATCAAGTTTGTCCTAATCATGCCA
TGTGTAGACAACACCCTTACAAGGATCCGCCAGGGCTGGGAAAGGAACTCAAAACACTAG

Protein Properties

Number of Residues

459

Molecular Weight

51980.7

Theoretical pI

9.61

Pfam Domain Function

F420_oxidored (PF03807 )
Ferric_reduct (PF01794 )

Signals

["None"]

Transmembrane Regions

["196-216", "246-266", "293-313", "348-368", "381-401", "419-439"]

Protein Sequence

>Metalloreductase STEAP4
MEKTCIDALPLTMNSSEKQETVCIFGTGDFGRSLGLKMLQCGYSVVFGSRNPQKTTLLPS
GAEVLSYSEAAKKSGIIIIAIHREHYDFLTELTEVLNGKILVDISNNLKINQYPESNAEY
LAHLVPGAHVVKAFNTISAWALQSGALDASRQVFVCGNDSKAKQRVMDIVRNLGLTPMDQ
GSLMAAKEIEKYPLQLFPMWRFPFYLSAVLCVFLFFYCVIRDVIYPYVYEKKDNTFRMAI
SIPNRIFPITALTLLALVYLPGVIAAILQLYRGTKYRRFPDWLDHWMLCRKQLGLVALGF
AFLHVLYTLVIPIRYYVRWRLGNLTVTQAILKKENPFSTSSAWLSDSYVALGILGFFLFV
LLGITSLPSVSNAVNWREFRFVQSKLGYLTLILCTAHTLVYGGKRFLSPSNLRWYLPAAY
VLGLIIPCTVLVIKFVLIMPCVDNTLTRIRQGWERNSKH

External Links

GenBank ID Protein

33312462

UniProtKB/Swiss-Prot ID

Q687X5

UniProtKB/Swiss-Prot Entry Name

STEA4_HUMAN

PDB IDs

Not Available

GenBank Gene ID

AF423422

GeneCard ID