Cannabis Compound Database: Showing Protein Adenosylhomocysteinase (CDBP00627)

Identification Biological properties Gene properties Protein properties External links References XML Show 8 compounds

Identification

HMDB Protein ID

CDBP00627

Secondary Accession Numbers

Not Available

Name

Adenosylhomocysteinase

Description

Not Available

Synonyms

AdoHcyase
S-adenosyl-L-homocysteine hydrolase

Gene Name

AHCY

Protein Type

Enzyme

Biological Properties

General Function

Involved in adenosylhomocysteinase activity

Specific Function

Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.

GO Classification

Biological Process
methylation
one-carbon metabolic process
cellular nitrogen compound metabolic process
sulfur amino acid metabolic process
xenobiotic metabolic process
Cellular Component
cytosol
melanosome
Function
catalytic activity
hydrolase activity
hydrolase activity, acting on ether bonds
trialkylsulfonium hydrolase activity
adenosylhomocysteinase activity
Molecular Function
adenosylhomocysteinase activity
nucleotide binding
Process
metabolic process
cellular metabolic process
one-carbon metabolic process

Cellular Location

Cytoplasm
Melanosome

Pathways

Name	SMPDB/Pathwhiz	KEGG
Selenoamino Acid Metabolism
Betaine Metabolism
L-homocysteine biosynthesis	Not Available	Not Available
Cysteine and methionine metabolism	Not Available
Methionine Metabolism

Gene Properties

Chromosome Location

Locus

20q11.22

SNPs

AHCY

Gene Sequence

>1299 bp
ATGTCTGACAAACTGCCCTACAAAGTCGCCGACATCGGCCTGGCTGCCTGGGGACGCAAG
GCCCTGGACATTGCTGAGAACGAGATGCCGGGCCTGATGCGTATGCGGGAGCGGTACTCG
GCCTCCAAGCCACTGAAGGGCGCCCGCATCGCTGGCTGCCTGCACATGACCGTGGAGACG
GCCGTCCTCATTGAGACCCTCGTCACCCTGGGTGCTGAGGTGCAGTGGTCCAGCTGCAAC
ATCTTCTCCACCCAGAACCATGCGGCGGCTGCCATTGCCAAGGCTGGCATTCCGGTGTAT
GCCTGGAAGGGCGAAACGGACGAGGAGTACCTGTGGTGCATTGAGCAGACCCTGTACTTC
AAGGACGGGCCCCTCAACATGATTCTGGACGACGGGGGCGACCTCACCAACCTCATCCAC
ACCAAGTACCCGCAGCTTCTGCCAGGCATCCGAGGCATCTCTGAGGAGACCACGACTGGG
GTCCACAACCTCTACAAGATGATGGCCAATGGGATCCTCAAGGTGCCTGCCATCAATGTC
AATGACTCCGTCACCAAGAGCAAGTTTGACAACCTCTATGGCTGCCGGGAGTCCCTCATA
GATGGCATCAAGCGGGCCACAGATGTGATGATTGCCGGCAAGGTAGCGGTGGTAGCAGGC
TATGGTGATGTGGGCAAGGGCTGTGCCCAGGCCCTGCGGGGTTTCGGAGCCCGCGTCATC
ATCACCGAGATTGACCCCATCAACGCACTGCAGGCTGCCATGGAGGGCTATGAGGTGACC
ACCATGGATGAGGCCTGTCAGGAGGGCAACATCTTTGTCACCACCACAGGCTGTATTGAC
ATCATCCTTGGCCGGCACTTTGAGCAGATGAAGGATGATGCCATTGTGTGTAACATTGGA
CACTTTGACGTGGAGATCGATGTCAAGTGGCTCAACGAGAACGCCGTGGAGAAGGTGAAC
ATCAAGCCGCAGGTGGACCGGTATCGGTTGAAGAATGGGCGCCGCATCATCCTGCTGGCC
GAGGGTCGGCTGGTCAACCTGGGTTGTGCCATGGGCCACCCCAGCTTCGTGATGAGTAAC
TCCTTCACCAACCAGGTGATGGCGCAGATCGAGCTGTGGACCCATCCAGACAAGTACCCC
GTTGGGGTTCATTTCCTGCCCAAGAAGCTGGATGAGGCAGTGGCTGAAGCCCACCTGGGC
AAGCTGAATGTGAAGTTGACCAAGCTAACTGAGAAGCAAGCCCAGTACCTGGGCATGTCC
TGTGATGGCCCCTTCAAGCCGGATCACTACCGCTACTGA

Protein Properties

Number of Residues

432

Molecular Weight

47715.715

Theoretical pI

6.341

Pfam Domain Function

AdoHcyase (PF05221 )
AdoHcyase_NAD (PF00670 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Adenosylhomocysteinase
MSDKLPYKVADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVET
AVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVYAWKGETDEEYLWCIEQTLYF
KDGPLNMILDDGGDLTNLIHTKYPQLLPGIRGISEETTTGVHNLYKMMANGILKVPAINV
NDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVI
ITEIDPINALQAAMEGYEVTTMDEACQEGNIFVTTTGCIDIILGRHFEQMKDDAIVCNIG
HFDVEIDVKWLNENAVEKVNIKPQVDRYRLKNGRRIILLAEGRLVNLGCAMGHPSFVMSN
SFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMS
CDGPFKPDHYRY

External Links

GenBank ID Protein

178277

UniProtKB/Swiss-Prot ID

P23526

UniProtKB/Swiss-Prot Entry Name

SAHH_HUMAN

PDB IDs

GenBank Gene ID

M61831

GeneCard ID

AHCY