Cannabis Compound Database: Showing Protein Nicotinate phosphoribosyltransferase (CDBP04086)

Identification Biological properties Gene properties Protein properties External links References XML Show 4 compounds

Identification

HMDB Protein ID

CDBP04086

Secondary Accession Numbers

Not Available

Name

Nicotinate phosphoribosyltransferase

Description

Not Available

Synonyms

FHA-HIT-interacting protein
NAPRTase
Nicotinate phosphoribosyltransferase domain-containing protein 1

Gene Name

NAPRT1

Protein Type

Enzyme

Biological Properties

General Function

Involved in nicotinate phosphoribosyltransferase activity

Specific Function

Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN). Essential for NA to increase cellular NAD levels and prevent oxidative stress of the cells.

GO Classification

Biological Process
NAD biosynthetic process
response to oxidative stress
nicotinamide metabolic process
nicotinate nucleotide salvage
water-soluble vitamin metabolic process
NAD metabolic process
Cellular Component
cytosol
Golgi apparatus
nucleus
Component
cell part
intracellular part
cytoplasm
Function
transferase activity, transferring glycosyl groups
nicotinate phosphoribosyltransferase activity
catalytic activity
transferase activity
transferase activity, transferring pentosyl groups
Molecular Function
nicotinate-nucleotide diphosphorylase (carboxylating) activity
nicotinate phosphoribosyltransferase activity
Process
cellular metabolic process
cofactor metabolic process
nicotinate nucleotide biosynthetic process
coenzyme metabolic process
nicotinate nucleotide salvage
metabolic process
nitrogen compound metabolic process
cellular nitrogen compound metabolic process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
nucleobase, nucleoside and nucleotide metabolic process
nucleoside phosphate metabolic process
nucleotide metabolic process
nucleotide biosynthetic process
coenzyme biosynthetic process
pyridine nucleotide biosynthetic process
nicotinamide nucleotide biosynthetic process
nad biosynthetic process

Cellular Location

Cytoplasm
cytosol

Pathways

Name	SMPDB/Pathwhiz	KEGG
NAD(+) biosynthesis	Not Available	Not Available

Gene Properties

Chromosome Location

Locus

8q24.3

SNPs

NAPRT1

Gene Sequence

>1617 bp
ATGGCGGCGGAGCAGGACCCCGAGGCGCGCGCGGCGGCGCGGCCGCTGCTCACTGACCTC
TACCAGGCCACCATGGCGTTGGGCTATTGGCGCGCGGGCCGGGCGCGGGACGCCGCCGAG
TTCGAGCTCTTCTTCCGCCGCTGCCCGTTCGGCGGCGCCTTCGCCTTGGCCGCCGGCTTG
CGCGACTGTGTGCGCTTCCTGCGCGCCTTCCGCCTGCGGGACGCCGACGTGCAGTTCCTG
GCCTCGGTGCTGCCCCCAGACACGGATCCTGCGTTCTTCGAGCACCTTCGGGCCCTCGAC
TGCTCCGAGGTGACGGTGCGAGCCCTGCCCGAGGGCTCCCTCGCCTTCCCCGGAGTGCCG
CTCCTGCAGGTGTCCGGGCCGCTCCTGGTGGTGCAGCTGCTGGAGACACCGCTGCTCTGC
CTGGTCAGCTACGCCAGCCTGGTGGCCACCAACGCAGCGCGGCTTCGCTTGATCGCAGGA
CCAGAGAAGCGGCTGCTAGAGATGGGCCTGAGGCGGGCTCAGGGCCCCGATGGGGGCCTG
ACAGCCTCCACCTACAGCTACCTGGGCGGCTTCGACAGCAGCAGCAACGTGCTAGCGGGC
CAGCTGCGAGGTGTGCCGGTGGCCGGGACCCTGGCCCACTCCTTCGTCACTTCCTTTTCA
GGCAGCGAGGCGCCCCCTGACCCGATGTTGGCGCCAGCAGCTGGTGAGGGCCCTGGGGTG
GACCTGGCGGCCAAAACCCAGGTGTGGCTGGAGCAGGTGTGTGCCCACCTGGGGCTGGGG
GTGCAGGAGCCGCATCCAGGCGAGCGGGCAGCCTTTGTGGCCTATGCCTTGGCTTTTCCC
CGGGCCTTCCAGGGCCTCCTGGACACCTACAGCGTGTGGAGGAGTGGTCTCCCCAACTTC
CTAGCAGTCGCCTTGGCCCTGGGAGAGCTGGGCTACCGGGCAGTGGGCGTGAGGCTGGAC
AGTGGTGACCTGCTACAGCAGGCTCAGGAGATCCGCAAGGTCTTCCGAGCTGCTGCAGCC
CAGTTCCAGGTGCCCTGGCTGGAGTCAGTCCTCATCGTAGTCAGCAACAACATTGACGAG
GAGGCGCTGGCCCGACTGGCCCAAGAGGGCAGTGAGGTGAATGCCATTGGCATTGGCACC
AGTGTGGTCACCTGCCCCCAACAGCCTTCCCTGGGTGGCGTCTATAAGCTGGTGGCCGTG
GGGGGCCAGCCACGAATGAAGCTGACCGAGGACCCCGAGAAGCAGACGTTGCCTGGGAGC
AAGGCTGCTTTCCGGCTCCTGGGCTCTGACGGGTCTCCACTCATGGACATGCTGCAGTTA
GCAGAAGAGCCAGTGCCACAGGCTGGGCAGGAGCTGAGGGTGTGGCCTCCAGGGGCCCAG
GAGCCCTGCACCGTGAGGCCAGCCCAGGTGGAGCCACTACTGCGGCTCTGCCTCCAGCAG
GGACAGCTGTGTGAGCCGCTCCCATCCCTGGCAGAGTCTAGAGCCTTGGCCCAGCTGTCC
CTGAGCCGACTCAGCCCTGAGCACAGGCGGCTGCGGAGCCCTGCACAGTACCAGGTGGTG
CTGTCCGAGAGGCTGCAGGCCCTGGTGAACAGTCTGTGTGCGGGGCAGTCCCCCTGA

Protein Properties

Number of Residues

538

Molecular Weight

57577.575

Theoretical pI

5.675

Pfam Domain Function

NAPRTase (PF04095 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Nicotinate phosphoribosyltransferase
MAAEQDPEARAAARPLLTDLYQATMALGYWRAGRARDAAEFELFFRRCPFGGAFALAAGL
RDCVRFLRAFRLRDADVQFLASVLPPDTDPAFFEHLRALDCSEVTVRALPEGSLAFPGVP
LLQVSGPLLVVQLLETPLLCLVSYASLVATNAARLRLIAGPEKRLLEMGLRRAQGPDGGL
TASTYSYLGGFDSSSNVLAGQLRGVPVAGTLAHSFVTSFSGSEVPPDPMLAPAAGEGPGV
DLAAKAQVWLEQVCAHLGLGVQEPHPGERAAFVAYALAFPRAFQGLLDTYSVWRSGLPNF
LAVALALGELGYRAVGVRLDSGDLLQQAQEIRKVFRAAAAQFQVPWLESVLIVVSNNIDE
EALARLAQEGSEVNVIGIGTSVVTCPQQPSLGGVYKLVAVGGQPRMKLTEDPEKQTLPGS
KAAFRLLGSDGSPLMDMLQLAEEPVPQAGQELRVWPPGAQEPCTVRPAQVEPLLRLCLQQ
GQLCEPLPSLAESRALAQLSLSRLSPEHRRLRSPAQYQVVLSERLQALVNSLCAGQSP

External Links

GenBank ID Protein

154936864

UniProtKB/Swiss-Prot ID

Q6XQN6

UniProtKB/Swiss-Prot Entry Name

PNCB_HUMAN

PDB IDs

Not Available

GenBank Gene ID

AB242230

GeneCard ID