Cannabis Compound Database: Showing Protein 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 (CDBP02412)

Identification Biological properties Gene properties Protein properties External links References XML Show 5 compounds

Identification

HMDB Protein ID

CDBP02412

Secondary Accession Numbers

Not Available

Name

3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2

Description

Not Available

Synonyms

3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II
3-beta-HSD II
3-beta-hydroxy-5-ene steroid dehydrogenase
3-beta-hydroxy-Delta(5)-steroid dehydrogenase
Delta-5-3-ketosteroid isomerase
Progesterone reductase
Steroid Delta-isomerase
Hydroxy-delta-5-steroid dehydrogenase, 3 beta-and steroid delta-isomerase 2, isoform CRA_a
3-beta-HSD adrenal and gonadal type

Gene Name

HSD3B2

Protein Type

Enzyme

Biological Properties

General Function

Involved in 3-beta-hydroxy-delta5-steroid dehydrogenase activity

Specific Function

3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids.

GO Classification

Biological Process
glucocorticoid biosynthetic process
mineralocorticoid biosynthetic process
small molecule metabolic process
androgen biosynthetic process
Cellular Component
integral to membrane
mitochondrial inner membrane
mitochondrial intermembrane space
smooth endoplasmic reticulum membrane
Function
steroid dehydrogenase activity, acting on the ch-oh group of donors, nad or nadp as acceptor
3-beta-hydroxy-delta5-steroid dehydrogenase activity
binding
catalytic activity
oxidoreductase activity, acting on the ch-oh group of donors, nad or nadp as acceptor
intramolecular oxidoreductase activity, transposing c=c bonds
oxidoreductase activity, acting on ch-oh group of donors
oxidoreductase activity
isomerase activity
intramolecular oxidoreductase activity
steroid delta-isomerase activity
steroid dehydrogenase activity
Molecular Function
3-beta-hydroxy-delta5-steroid dehydrogenase activity
nucleotide binding
steroid delta-isomerase activity
Process
steroid biosynthetic process
metabolic process
cellular lipid metabolism
primary metabolism
lipid metabolism
primary metabolic process
physiological process
metabolism
lipid metabolic process
steroid metabolism
steroid biosynthesis
steroid metabolic process

Cellular Location

Endoplasmic reticulum membrane
Mitochondrion membrane
Single-pass membrane protein
Single-pass membrane protein

Pathways

Name	SMPDB/Pathwhiz	KEGG
Steroid hormone biosynthesis	Not Available
Steroidogenesis
Adrenal Hyperplasia Type 3 or Congenital Adrenal Hyperplasia due to 21-hydroxylase Deficiency		Not Available
Congenital Lipoid Adrenal Hyperplasia (CLAH) or Lipoid CAH		Not Available
Adrenal Hyperplasia Type 5 or Congenital Adrenal Hyperplasia due to 17 Alpha-hydroxylase Deficiency		Not Available

Gene Properties

Chromosome Location

Locus

1p13.1

SNPs

HSD3B2

Gene Sequence

>1119 bp
ATGGGCTGGAGCTGCCTTGTGACAGGAGCAGGAGGGCTTCTGGGTCAGAGGATCGTCCGC
CTGTTGGTGGAAGAGAAGGAACTGAAGGAGATCAGGGCCTTGGACAAGGCCTTCAGACCA
GAATTGAGAGAGGAATTTTCTAAGCTCCAGAACAGGACCAAGCTGACTGTACTTGAAGGA
GACATTCTGGATGAGCCATTCCTGAAAAGAGCCTGCCAGGACGTCTCGGTCGTCATCCAC
ACCGCCTGTATCATTGATGTCTTTGGTGTCACTCACAGAGAGTCCATCATGAATGTCAAT
GTGAAAGGTACCCAGCTACTGTTGGAGGCCTGTGTCCAAGCCAGTGTGCCAGTCTTCATC
TACACCAGTAGCATAGAGGTAGCCGGGCCCAACTCCTACAAGGAAATCATCCAGAACGGC
CACGAAGAAGAGCCTCTGGAAAACACATGGCCCACTCCATACCCGTACAGCAAAAAGCTT
GCTGAGAAGGCTGTGCTGGCGGCTAATGGGTGGAATCTAAAAAATGGTGATACCTTGTAC
ACTTGTGCGTTAAGACCCACATATATCTATGGGGAAGGAGGCCCATTCCTTTCTGCCAGT
ATAAATGAGGCCCTGAACAACAATGGGATCCTGTCAAGTGTTGGAAAGTTCTCTACAGTC
AACCCAGTCTATGTTGGCAACGTGGCCTGGGCCCACATTCTGGCCTTGAGGGCTCTGCGG
GACCCCAAGAAGGCCCCAAGTGTCCGAGGTCAATTCTATTACATCTCAGATGACACGCCT
CACCAAAGCTATGATAACCTTAATTACATCCTGAGCAAAGAGTTTGGCCTCCGCCTTGAT
TCCAGATGGAGCCTTCCTTTAACCCTGATGTACTGGATTGGCTTCCTGCTGGAAGTAGTG
AGCTTCCTACTCAGCCCAATTTACTCCTATCAACCCCCCTTCAACCGCCACACAGTCACA
TTATCAAATAGTGTGTTCACCTTCTCTTACAAGAAGGCTCAGCGAGATCTGGCGTATAAG
CCACTCTACAGCTGGGAGGAAGCCAAGCAGAAAACCGTGGAGTGGGTTGGTTCCCTTGTG
GACCGGCACAAGGAGACCCTGAAGTCCAAGACTCAGTGA

Protein Properties

Number of Residues

372

Molecular Weight

42051.845

Theoretical pI

8.025

Pfam Domain Function

3Beta_HSD (PF01073 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2
MGWSCLVTGAGGLLGQRIVRLLVEEKELKEIRALDKAFRPELREEFSKLQNRTKLTVLEG
DILDEPFLKRACQDVSVVIHTACIIDVFGVTHRESIMNVNVKGTQLLLEACVQASVPVFI
YTSSIEVAGPNSYKEIIQNGHEEEPLENTWPTPYPYSKKLAEKAVLAANGWNLKNGDTLY
TCALRPTYIYGEGGPFLSASINEALNNNGILSSVGKFSTVNPVYVGNVAWAHILALRALR
DPKKAPSVRGQFYYISDDTPHQSYDNLNYILSKEFGLRLDSRWSLPLTLMYWIGFLLEVV
SFLLSPIYSYQPPFNRHTVTLSNSVFTFSYKKAQRDLAYKPLYSWEEAKQKTVEWVGSLV
DRHKETLKSKTQ

External Links

GenBank ID Protein

124297709

UniProtKB/Swiss-Prot ID

P26439

UniProtKB/Swiss-Prot Entry Name

3BHS2_HUMAN

PDB IDs

Not Available

GenBank Gene ID

M67466

GeneCard ID