| Identification |
|---|
| HMDB Protein ID
| CDBP03507 |
| Secondary Accession Numbers
| Not Available |
| Name
| Metalloreductase STEAP2 |
| Description
| Not Available |
| Synonyms
|
- PUMPCn
- Prostate cancer-associated protein 1
- Protein upregulated in metastatic prostate cancer
- Six-transmembrane epithelial antigen of prostate 2
- SixTransMembrane protein of prostate 1
|
| Gene Name
| STEAP2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in iron ion binding |
| Specific Function
| Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor |
| GO Classification
|
| Component |
| cell part |
| membrane part |
| intrinsic to membrane |
| integral to membrane |
| Function |
| transition metal ion binding |
| nucleoside binding |
| purine nucleoside binding |
| adenyl nucleotide binding |
| electron carrier activity |
| iron ion binding |
| oxidoreductase activity |
| fad or fadh2 binding |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| catalytic activity |
| Process |
| metabolic process |
|
| Cellular Location
|
- Cell membrane
- Endosome membrane
- Multi-pass membrane protein
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:7 |
| Locus
| 7q21 |
| SNPs
| STEAP2 |
| Gene Sequence
|
>1473 bp
ATGGAATCAATCTCTATGATGGGAAGCCCTAAGAGCCTTAGTGAAACTTTTTTACCTAAT
GGCATAAATGGTATCAAAGATGCAAGGAAGGTCACTGTAGGTGTGATTGGAAGTGGAGAT
TTTGCCAAATCCTTGACCATTCGACTTATTAGATGCGGCTATCATGTGGTCATAGGAAGT
AGAAATCCTAAGTTTGCTTCTGAATTTTTTCCTCATGTGGTAGATGTCACTCATCATGAA
GATGCTCTCACAAAAACAAATATAATATTTGTTGCTATACACAGAGAACATTATACCTCC
CTGTGGGACCTGAGACATCTGCTTGTGGGTAAAATCCTGATTGATGTGAGCAATAACATG
AGGATAAACCAGTACCCAGAATCCAATGCTGAATATTTGGCTTCATTATTCCCAGATTCT
TTGATTGTCAAAGGATTTAATGTTGTCTCAGCTTGGGCACTTCAGTTAGGACCTAAGGAT
GCCAGCCGGCAGGTTTATATATGCAGCAACAATATTCAAGCGCGACAACAGGTTATTGAA
CTTGCCCGCCAGTTGAATTTCATTCCCATTGACTTGGGATCCTTATCATCAGCCAGAGAG
ATTGAAAATTTACCCCTACGACTCTTTACTCTCTGGAGAGGGCCAGTGGTGGTAGCTATA
AGCTTGGCCACATTTTTTTTCCTTTATTCCTTTGTCAGAGATGTGATTCATCCATATGCT
AGAAACCAACAGAGTGACTTTTACAAAATTCCTATAGAGATTGTGAATAAAACCTTACCT
ATAGTTGCCATTACTTTGCTCTCCCTAGTATACCTCGCAGGTCTTCTGGCAGCTGCTTAT
CAACTTTATTACGGCACCAAGTATAGGAGATTTCCACCTTGGTTGGAAACCTGGTTACAG
TGTAGAAAACAGCTTGGATTACTAAGTTTTTTCTTCGCTATGGTCCATGTTGCCTACAGC
CTCTGCTTACCGATGAGAAGGTCAGAGAGATATTTGTTTCTCAACATGGCTTATCAGCAG
GTTCATGCAAATATTGAAAACTCTTGGAATGAGGAAGAAGTTTGGAGAATTGAAATGTAT
ATCTCCTTTGGCATAATGAGCCTTGGCTTACTTTCCCTCCTGGCAGTCACTTCTATCCCT
TCAGTGAGCAATGCTTTAAACTGGAGAGAATTCAGTTTTATTCAGTCTACACTTGGATAT
GTCGCTCTGCTCATAAGTACTTTCCATGTTTTAATTTATGGATGGAAACGAGCTTTTGAG
GAAGAGTACTACAGATTTTATACACCACCAAACTTTGTTCTTGCTCTTGTTTTGCCCTCA
ATTGTAATTCTGGGTAAGATTATTTTATTCCTTCCATGTATAAGCCGAAAGCTAAAACGA
ATTAAAAAAGGCTGGGAAAAGAGCCAATTTCTGGAAGAAGGTATGGGAGGAACAATTCCT
CATGTCTCCCCGGAGAGGGTCACAGTAATGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 490 |
| Molecular Weight
| 56055.0 |
| Theoretical pI
| 9.52 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["208-228", "259-279", "305-325", "359-379", "393-413", "432-452"]
|
| Protein Sequence
|
>Metalloreductase STEAP2
MESISMMGSPKSLSETFLPNGINGIKDARKVTVGVIGSGDFAKSLTIRLIRCGYHVVIGS
RNPKFASEFFPHVVDVTHHEDALTKTNIIFVAIHREHYTSLWDLRHLLVGKILIDVSNNM
RINQYPESNAEYLASLFPDSLIVKGFNVVSAWALQLGPKDASRQVYICSNNIQARQQVIE
LARQLNFIPIDLGSLSSAREIENLPLRLFTLWRGPVVVAISLATFFFLYSFVRDVIHPYA
RNQQSDFYKIPIEIVNKTLPIVAITLLSLVYLAGLLAAAYQLYYGTKYRRFPPWLETWLQ
CRKQLGLLSFFFAMVHVAYSLCLPMRRSERYLFLNMAYQQVHANIENSWNEEEVWRIEMY
ISFGIMSLGLLSLLAVTSIPSVSNALNWREFSFIQSTLGYVALLISTFHVLIYGWKRAFE
EEYYRFYTPPNFVLALVLPSIVILGKIILFLPCISRKLKRIKKGWEKSQFLEEGMGGTIP
HVSPERVTVM
|
| External Links |
|---|
| GenBank ID Protein
| 100913194 |
| UniProtKB/Swiss-Prot ID
| Q8NFT2 |
| UniProtKB/Swiss-Prot Entry Name
| STEA2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_001040665.1 |
| GeneCard ID
| STEAP2 |
| GenAtlas ID
| STEAP2 |
| HGNC ID
| HGNC:17885 |
| References |
|---|
| General References
| Not Available |