| Identification |
|---|
| HMDB Protein ID
| CDBP00805 |
| Secondary Accession Numbers
| Not Available |
| Name
| Malate dehydrogenase, cytoplasmic |
| Description
| Not Available |
| Synonyms
|
- Cytosolic malate dehydrogenase
- Diiodophenylpyruvate reductase
|
| Gene Name
| MDH1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| Specific Function
| Not Available |
| GO Classification
|
| Biological Process |
| small molecule metabolic process |
| malate metabolic process |
| cellular carbohydrate metabolic process |
| tricarboxylic acid cycle |
| gluconeogenesis |
| Cellular Component |
| cytosol |
| centrosome |
| Function |
| l-malate dehydrogenase activity |
| binding |
| catalytic activity |
| oxidoreductase activity, acting on the ch-oh group of donors, nad or nadp as acceptor |
| oxidoreductase activity, acting on ch-oh group of donors |
| oxidoreductase activity |
| malate dehydrogenase activity |
| Molecular Function |
| diiodophenylpyruvate reductase activity |
| L-malate dehydrogenase activity |
| malic enzyme activity |
| nucleotide binding |
| Process |
| organic acid metabolic process |
| oxoacid metabolic process |
| carboxylic acid metabolic process |
| oxidation reduction |
| dicarboxylic acid metabolic process |
| malate metabolic process |
| metabolic process |
| primary metabolic process |
| carbohydrate metabolic process |
| cellular carbohydrate metabolic process |
| cellular metabolic process |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Citrate cycle (TCA cycle) | Not Available |  | | Glyoxylate and dicarboxylate metabolism | Not Available |  | | Proximal tubule bicarbonate reclamation | Not Available |  | | Pyruvate Metabolism |    |  | | Leigh Syndrome |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 2 |
| Locus
| 2p13.3 |
| SNPs
| MDH1 |
| Gene Sequence
|
>1005 bp
ATGTCTGAACCAATCAGAGTCCTTGTGACTGGAGCAGCTGGTCAAATTGCATATTCACTG
CTGTACAGTATTGGAAATGGATCTGTCTTTGGTAAAGATCAGCCTATAATTCTTGTGCTG
TTGGATATCACCCCCATGATGGGTGTCCTGGACGGTGTCCTAATGGAACTGCAAGACTGT
GCCCTTCCCCTCCTGAAAGATGTCATCGCAACAGATAAAGAAGACGTTGCCTTCAAAGAC
CTGGATGTGGCCATTCTTGTGGGCTCCATGCCAAGAAGGGAAGGCATGGAGAGAAAAGAT
TTACTGAAAGCAAATGTGAAAATCTTCAAATCCCAGGGTGCAGCCTTAGATAAATACGCC
AAGAAGTCAGTTAAGGTTATTGTTGTGGGTAATCCAGCCAATACCAACTGCCTGACTGCT
TCCAAGTCAGCTCCATCCATCCCCAAGGAGAACTTCAGTTGCTTGACTCGTTTGGATCAC
AACCGAGCTAAAGCTCAAATTGCTCTTAAACTTGGTGTGACTGCTAATGATGTAAAGAAT
GTCATTATCTGGGGAAACCATTCCTCGACTCAGTATCCAGATGTCAACCATGCCAAGGTG
AAATTGCAAGGAAAGGAAGTTGGTGTTTATGAAGCTCTGAAAGATGACAGCTGGCTCAAG
GGAGAATTTGTCACGACTGTGCAGCAGCGTGGCGCTGCTGTCATCAAGGCTCGAAAACTA
TCCAGTGCCATGTCTGCTGCAAAAGCCATCTGTGACCACGTCAGGGACATCTGGTTTGGA
ACCCCAGAGGGAGAGTTTGTGTCCATGGGTGTTATCTCTGATGGCAACTCCTATGGTGTT
CCTGATGATCTGCTCTACTCATTCCCTGTTGTAATCAAGAATAAGACCTGGAAGTTTGTT
GAAGGTCTCCCTATTAATGATTTCTCACGTGAGAAGATGGATCTTACTGCAAAGGAACTG
ACAGAAGAAAAAGAAAGTGCTTTTGAATTTCTTTCCTCTGCCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 334 |
| Molecular Weight
| 38627.255 |
| Theoretical pI
| 7.711 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Malate dehydrogenase, cytoplasmic
MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDC
ALPLLKDVIATDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYA
KKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKN
VIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKL
SSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFV
EGLPINDFSREKMDLTAKELTEEKESAFEFLSSA
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P40925 |
| UniProtKB/Swiss-Prot Entry Name
| MDHC_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| D55654 |
| GeneCard ID
| MDH1 |
| GenAtlas ID
| MDH1 |
| HGNC ID
| HGNC:6970 |
| References |
|---|
| General References
| Not Available |