Cannabis Compound Database: Showing Protein Estradiol 17-beta-dehydrogenase 1 (CDBP00792)

Identification Biological properties Gene properties Protein properties External links References XML Show 5 compounds

Identification

HMDB Protein ID

CDBP00792

Secondary Accession Numbers

Not Available

Name

Estradiol 17-beta-dehydrogenase 1

Description

Not Available

Synonyms

17-beta-HSD 1
17-beta-hydroxysteroid dehydrogenase type 1
20 alpha-hydroxysteroid dehydrogenase
20-alpha-HSD
E2DH
Placental 17-beta-hydroxysteroid dehydrogenase

Gene Name

HSD17B1

Protein Type

Enzyme

Biological Properties

General Function

Involved in estradiol 17-beta-dehydrogenase activity

Specific Function

Favors the reduction of estrogens and androgens. Also has 20-alpha-HSD activity. Uses preferentially NADH.

GO Classification

Biological Process
small molecule metabolic process
estrogen biosynthetic process
Cellular Component
cytosol
Component
cell part
intracellular part
cytoplasm
Function
steroid dehydrogenase activity, acting on the ch-oh group of donors, nad or nadp as acceptor
estradiol 17-beta-dehydrogenase activity
binding
catalytic activity
oxidoreductase activity
steroid dehydrogenase activity
Molecular Function
estradiol 17-beta-dehydrogenase activity
nucleotide binding
Process
metabolic process
primary metabolic process
oxidation reduction
lipid metabolic process
steroid metabolic process
steroid biosynthetic process
estrogen biosynthetic process

Cellular Location

Cytoplasm

Pathways

Name	SMPDB/Pathwhiz	KEGG
Androgen and Estrogen Metabolism
estrogen biosynthesis	Not Available	Not Available
Steroid hormone biosynthesis	Not Available
17-Beta Hydroxysteroid Dehydrogenase III Deficiency		Not Available
Aromatase deficiency		Not Available

Gene Properties

Chromosome Location

Locus

17q11-q21

SNPs

HSD17B1

Gene Sequence

>987 bp
ATGGCCCGCACCGTGGTGCTCATCACCGGCTGTTCCTCGGGCATCGGCCTGCACTTGGCC
GTACGTCTGGCTTCAGATCCATCCCAGAGCTTCAAAGTGTATGCCACGTTGAGGGACCTG
AAAACACAGGGCCGGCTGTGGGAGGCGGCCCGGGCCCTGGCATGCCCTCCGGGATCCCTG
GAGACGTTGCAGCTGGACGTAAGGGACTCAAAATCCGTGGCCGCTGCCCGGGAACGCGTG
ACTGAGGGCCGCGTGGACGTGCTGGTGTGTAACGCAGGCCTGGGCCTGCTGGGGCCGCTG
GAGGCGCTGGGGGAGGACGCCGTGGCCTCTGTGCTGGACGTGAATGTAGTAGGGACTGTG
CGGATGCTGCAGGCCTTCCTGCCAGACATGAAGAGGCGCGGTTCGGGACGCGTGTTGGTG
ACCGGGAGCGTGGGAGGATTGATGGGGCTGCCTTTCAATGACGTTTATTGCGCCAGCAAG
TTCGCGCTCGAAGGCTTATGCGAGAGTCTGGCGGTTCTGCTGCTGCCCTTTGGGGTCCAC
TTGAGCCTGATCGAGTGCGGCCCAGTGCACACCGCCTTCATGGAGAAGGTGTTGGGCAGC
CCAGAGGAGGTGCTGGACCGCACGGACATCCACACCTTCCACCGCTTCTACCAATACCTC
GCCCACAGCAAGCAAGTCTTTCGCGAGGCGGCGCAGAACCCTGAGGAGGTGGCGGAGGTC
TTCCTCACCGCTTTGCGCGCCCCGAAGCCGACCCTGCGCTACTTCACCACCGAGCGCTTC
CTGCCCCTGCTGCGGATGCGCCTGGACGACCCCAGCGGCTCCAACTACGTCACCGCCATG
CACCGGGAAGTGTTCGGCGACGTTCCGGCAAAGGCCGAGGCTGGGGCCGAGGCTGGGGGC
GGGGCCGGGCCTGGGGCAGAGGACGAGGCCGGGCGCAGTGCGGTGGGGGACCCTGAGCTC
GGCGATCCTCCGGCCGCCCCGCAGTAA

Protein Properties

Number of Residues

328

Molecular Weight

34949.715

Theoretical pI

5.69

Pfam Domain Function

adh_short (PF00106 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Estradiol 17-beta-dehydrogenase 1
MARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSL
ETLQLDVRDSKSVAAARERVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGTV
RMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFGVH
LSLIECGPVHTAFMEKVLGSPEEVLDRTDIHTFHRFYQYLAHSKQVFREAAQNPEEVAEV
FLTALRAPKPTLRYFTTERFLPLLRMRLDDPSGSNYVTAMHREVFGDVPAKAEAGAEAGG
GAGPGAEDEAGRSAVGDPELGDPPAAPQ

External Links

GenBank ID Protein

23365

UniProtKB/Swiss-Prot ID

P14061

UniProtKB/Swiss-Prot Entry Name

DHB1_HUMAN

PDB IDs