| Identification |
|---|
| HMDB Protein ID
| CDBP02492 |
| Secondary Accession Numbers
| Not Available |
| Name
| Dual oxidase 1 |
| Description
| Not Available |
| Synonyms
|
- Large NOX 1
- Long NOX 1
- NADPH thyroid oxidase 1
- Thyroid oxidase 1
|
| Gene Name
| DUOX1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in calcium ion binding |
| Specific Function
| Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.
|
| GO Classification
|
| Biological Process |
| thyroid hormone generation |
| hydrogen peroxide catabolic process |
| response to cAMP |
| hydrogen peroxide biosynthetic process |
| cuticle development |
| cytokine-mediated signaling pathway |
| hormone biosynthetic process |
| superoxide anion generation |
| Cellular Component |
| apical plasma membrane |
| integral to membrane |
| Component |
| cell part |
| membrane part |
| intrinsic to membrane |
| integral to membrane |
| Function |
| nucleoside binding |
| purine nucleoside binding |
| adenyl nucleotide binding |
| electron carrier activity |
| iron ion binding |
| antioxidant activity |
| heme binding |
| oxidoreductase activity |
| fad or fadh2 binding |
| calcium ion binding |
| peroxidase activity |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| catalytic activity |
| transition metal ion binding |
| Molecular Function |
| NADP binding |
| heme binding |
| NAD(P)H oxidase activity |
| peroxidase activity |
| calcium ion binding |
| Process |
| response to stress |
| response to oxidative stress |
| metabolic process |
| oxidation reduction |
| response to stimulus |
|
| Cellular Location
|
- Multi-pass membrane protein
- Apical cell membrane
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Tyrosine Metabolism |    |  | | thyroid hormone biosynthesis | Not Available | Not Available | | Thyroid hormone synthesis |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 15 |
| Locus
| 15q15.3 |
| SNPs
| DUOX1 |
| Gene Sequence
|
>4656 bp
ATGGGCTTCTGCCTGGCTCTAGCATGGACACTTCTGGTTGGGGCATGGACCCCTCTGGGA
GCTCAGAACCCCATTTCGTGGGAGGTGCAGCGATTTGATGGGTGGTACAACAACCTCATG
GAGCACAGATGGGGCAGCAAAGGCTCCCGGCTGCAGCGCCTGGTCCCAGCCAGCTATGCA
GATGGCGTGTACCAGCCCTTGGGAGAACCCCACCTGCCCAACCCCCGAGACCTTAGCAAC
ACCATCTCAAGGGGCCCTGCAGGGCTGGCCTCCCTGAGAAACCGCACAGTGTTGGGGGTC
TTCTTTGGCTATCACGTGCTTTCAGACCTGGTGAGCGTGGAAACTCCCGGCTGCCCCGCC
GAGTTCCTCAACATTCGCATCCCGCCCGGAGACCCCATGTTCGACCCCGACCAGCGCGGG
GACGTGGTGCTGCCCTTCCAGAGAAGCCGCTGGGACCCCGAGACCGGACGGAGTCCCAGC
AATCCCCGGGACCCGGCCAACCAGGTGACGGGCTGGCTGGACGGCAGCGCCATCTATGGT
TCCTCGCATTCCTGGAGCGACGCGCTGCGGAGCTTCTCCAGGGGACAGCTGGCGTCGGGG
CCCGACCCCGCTTTTCCCCGAGACTCGCAGAACCCCCTGCTCATGTGGGCGGCGCCCGAC
CCCGCCACCGGGCAGAACGGGCCCCGGGGGCTGTACGCCTTCGGGGCAGAGAGAGGGAAC
CGGGAACCCTTCCTGCAGGCGCTGGGCCTGCTCTGGTTCCGCTACCACAACCTGTGGGCG
CAGAGGCTGGCCCGCCAGCACCCAGACTGGGAGGACGAGGAGCTGTTCCAGCACGCACGC
AAGAGGGTCATCGCCACCTACCAGAACATCGCTGTGTATGAGTGGCTGCCCAGCTTCCTG
CAGAAAACACTCCCGGAGTATACAGGATACCGGCCATTTCTGGACCCCAGCATCTCCTCA
GAGTTCGTGGCGGCCTCTGAGCAGTTCCTGTCCACCATGGTGCCCCCTGGCGTCTACATG
AGAAATGCCAGCTGCCACTTCCAGGGGGTCATCAATCGGAACTCAAGTGTCTCCAGAGCT
CTCCGGGTCTGCAACAGCTACTGGAGCCGTGAGCACCCAAGCCTACAAAGTGCTGAAGAT
GTGGATGCACTGCTGCTGGGCATGGCCTCCCAGATCGCAGAGCGAGAGGACCATGTGTTG
GTTGAAGATGTGCGGGATTTCTGGCCTGGGCCACTGAAGTTTTCCCGCACAGACCACCTG
GCCAGCTGCCTGCAGCGGGGCCGGGATCTGGGCCTGCCCTCTTACACCAAGGCCAGGGCA
GCACTGGGCTTGTCTCCCATTACCCGCTGGCAGGACATCAACCCTGCACTCTCCCGGAGC
AATGACACTGTACTGGAGGCCACAGCTGCCCTGTACAACCAGGACTTATCCTGGCTAGAG
CTGCTCCCTGGGGGACTCCTGGAGAGCCACCGGGACCCTGGACCTCTGTTCAGCACCATC
GTCCTTGAACAATTTGTGCGGCTACGGGATGGTGACCGCTACTGGTTTGAGAACACCAGG
AATGGGCTGTTCTCCAAGAAGGAGATTGAAGAAATCCGAAATACCACCCTGCAGGACGTG
CTGGTCGCTGTTATCAACATTGACCCCAGTGCTCTGCAGCCCAATGTCTTTGTCTGGCAT
AAAGGAGACCCCTGTCCGCAGCCGAGACAGCTCAGCACTGAAGGCCTGCCAGCGTGTGCT
CCCTCTGTTGTTCGTGACTATTTTGAGGGCAGTGGATTTGGCTTCGGGGTCACCATCGGG
ACCCTCTGTTGCTTCCCTTTGGTGAGCCTGCTCAGTGCCTGGATTGTTGCCCGGCTCCGG
ATGAGAAATTTCAAGAGGCTCCAGGGCCAGGACCGCCAGAGCATCGTGTCTGAGAAGCTC
GTGGGAGGCATGGAAGCTTTGGAATGGCAAGGCCACAAGGAGCCCTGCCGGCCCGTGCTT
GTGTACCTGCAGCCCGGGCAGATCCGTGTGGTAGATGGCAGGCTCACCGTGCTCCGCACC
ATCCAGCTGCAGCCTCCACAGAAGGTCAACTTCGTCCTGTCCAGCAACCGTGGACGCCGC
ACTCTGCTGCTCAAGATCCCCAAGGAGTATGACCTGGTGCTGCTGTTTAACTTGGAGGAA
GAGCGGCAGGCGCTGGTGGAAAATCTCCGGGGAGCTCTGAAGGAGAGCGGGTTGAGCATC
CAGGAGTGGGAGCTGCGGGAGCAGGAGCTGATGAGAGCAGCTGTGACACGGGAGCAGCGG
AGGCACCTCCTGGAGACCTTTTTCAGGCACCTTTTCTCCCAGGTGCTGGACATCAACCAG
GCCGACGCAGGGACCCTGCCCCTGGACTCCTCCCAGAAGGTGCGGGAGGCCCTGACCTGT
GAGCTGAGCAGGGCCGAGTTTGCCGAGTCCCTGGGCCTCAAGCCCCAGGACATGTTTGTG
GAGTCCATGTTCTCTCTGGCTGACAAGGATGGCAATGGCTACCTGTCCTTCCGAGAGTTC
CTGGACATCCTGGTGGTCTTCATGAAAGGCTCTCCTGAGGAAAAGTCTCGCCTTATGTTC
CGCATGTACGACTTTGATGGGAATGGCCTCATTTCCAAGGATGAGTTCATCAGGATGCTG
AGATCCTTCATCGAGATCTCCAACAACTGCCTGTCCAAGGCCCAGCTGGCTGAGGTGGTG
GAGTCCATGTTCCGGGAGTCGGGATTCCAGGACAAGGAGGAACTGACATGGGAAGATTTT
CACTTCATGCTGCGGGACCACAATAGCGAGCTCCGCTTCACGCAGCTCTGTGTCAAAGGG
GTGGAGGTGCCTGAAGTCATCAAGGACCTCTGCCGGCGAGCCTCCTACATCAGCCAGGAT
ATGATCTGTCCCTCTCCCAGAGTGAGTGCCCGCTGTTCCCGCAGCGACATTGAGACTGAG
TTGACACCTCAGAGACTGCAGTGCCCCATGGACACAGACCCTCCCCAGGAGATTCGGCGG
AGGTTTGGCAAGAAGGTAACGTCATTCCAGCCCTTGCTGTTCACTGAGGCGCACCGAGAG
AAGTTCCAACGCAGCTGTCTCCACCAGACGGTGCAACAGTTCAAGCGCTTCATTGAGAAC
TACCGGCGCCACATCGGCTGCGTGGCCGTGTTCTACGCCATCGCTGGGGGGCTTTTCCTG
GAGAGGGCCTACTACTACGCCTTTGCCGCACATCACACGGGCATCACAGACACCACCCGC
GTGGGAATCATCCTGTCGCGGGGCACAGCAGCCAGCATCTCTTTCATGTTCTCCTACATC
TTGCTCACCATGTGCCGCAACCTCATCACCTTCCTGCGAGAAACCTTCCTCAACCGCTAC
GTGCCCTTCGACGCCGCCGTGGACTTCCATCGCCTCATTGCCTCCACCGCCATCGTCCTC
ACAGTCTTACACAGTGTGGGCCATGTGGTGAATGTGTACCTGTTCTCCATCAGCCCCCTC
AGCGTCCTCTCTTGCCTCTTTCCTGGCCTCTTCCATGATGATGGGTCTGAGCTCCCCCAG
AAGTATTACTGGTGGTTCTTCCAGACCGTACCAGGCCTCACGGGGGTTGTGCTGCTCCTG
ATCCTGGCCATCATGTATGTCTTTGCCTCCCACCACTTCCGCCGCCGCAGTTTCCGGGGC
TTCTGGCTGACCCACCACCTCTACATCCTGCTCTATGTCCTGCTCATCATCCATGGTAGC
TTTGCCCTGATCCAGCTGCCCCGTTTCCACATCTTCTTCCTGGTCCCAGCAATCATCTAT
GGGGGCGACAAGCTGGTGAGCCTGAGCCGGAAGAAGGTGGAGATCAGCGTGGTGAAGGCG
GAGCTGCTGCCCTCAGGAGTGACCCACCTGCGGTTCCAGCGGCCCCAGGGCTTTGAGTAC
AAGTCAGGGCAGTGGGTGCGGATCGCTTGCCTGGCTCTGGGGACCACCGAGTACCACCCC
TTCACACTGACCTCTGCGCCCCATGAGGACACGCTTAGCCTGCACATCCGGGCAGCAGGG
CCCTGGACCACTCGCCTCAGGGAGATCTACTCAGCCCCGACGGGTGACAGATGTGCCAGA
TACCCAAAGCTGTACCTTGATGGACCATTTGGAGAGGGCCACCAGGAGTGGCATAAGTTT
GAGGTGTCAGTGTTAGTGGGAGGGGGCATTGGGGTCACCCCTTTTGCCTCCATCCTCAAA
GACCTGGTCTTCAAGTCATCCGTCAGCTGCCAAGTGTTCTGTAAGAAGATCTACTTCATC
TGGGTGACGCGGACCCAGCGTCAGTTTGAGTGGCTGGCTGACATCATCCGAGAGGTGGAG
GAGAATGACCACCAGGACCTGGTGTCTGTGCACATCTACATCACCCAGCTGGCTGAGAAG
TTCGACCTCAGGACCACTATGCTGTACATCTGTGAGCGGCACTTCCAGAAGGTTCTGAAC
CGGAGTCTATTCACAGGCCTGCGCTCCATCACCCACTTTGGCCGTCCCCCCTTTGAGCCC
TTCTTCAACTCCCTGCAGGAGGTCCACCCCCAGGTCCGGAAGATCGGGGTGTTTAGCTGT
GGCCCCCCTGGCATGACCAAGAATGTGGAAAAGGCCTGTCAGCTCATCAACAGGCAGGAC
CGGACTCACTTCTCCCACCATTATGAGAACTTCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 1551 |
| Molecular Weight
| 177233.45 |
| Theoretical pI
| 7.904 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Dual oxidase 1
MGFCLALAWTLLVGAWTPLGAQNPISWEVQRFDGWYNNLMEHRWGSKGSRLQRLVPASYA
DGVYQPLGEPHLPNPRDLSNTISRGPAGLASLRNRTVLGVFFGYHVLSDLVSVETPGCPA
EFLNIRIPPGDPMFDPDQRGDVVLPFQRSRWDPETGRSPSNPRDPANQVTGWLDGSAIYG
SSHSWSDALRSFSRGQLASGPDPAFPRDSQNPLLMWAAPDPATGQNGPRGLYAFGAERGN
REPFLQALGLLWFRYHNLWAQRLARQHPDWEDEELFQHARKRVIATYQNIAVYEWLPSFL
QKTLPEYTGYRPFLDPSISSEFVAASEQFLSTMVPPGVYMRNASCHFQGVINRNSSVSRA
LRVCNSYWSREHPSLQSAEDVDALLLGMASQIAEREDHVLVEDVRDFWPGPLKFSRTDHL
ASCLQRGRDLGLPSYTKARAALGLSPITRWQDINPALSRSNDTVLEATAALYNQDLSWLE
LLPGGLLESHRDPGPLFSTIVLEQFVRLRDGDRYWFENTRNGLFSKKEIEEIRNTTLQDV
LVAVINIDPSALQPNVFVWHKGDPCPQPRQLSTEGLPACAPSVVRDYFEGSGFGFGVTIG
TLCCFPLVSLLSAWIVARLRMRNFKRLQGQDRQSIVSEKLVGGMEALEWQGHKEPCRPVL
VYLQPGQIRVVDGRLTVLRTIQLQPPQKVNFVLSSNRGRRTLLLKIPKEYDLVLLFNLEE
ERQALVENLRGALKESGLSIQEWELREQELMRAAVTREQRRHLLETFFRHLFSQVLDINQ
ADAGTLPLDSSQKVREALTCELSRAEFAESLGLKPQDMFVESMFSLADKDGNGYLSFREF
LDILVVFMKGSPEEKSRLMFRMYDFDGNGLISKDEFIRMLRSFIEISNNCLSKAQLAEVV
ESMFRESGFQDKEELTWEDFHFMLRDHNSELRFTQLCVKGVEVPEVIKDLCRRASYISQD
MICPSPRVSARCSRSDIETELTPQRLQCPMDTDPPQEIRRRFGKKVTSFQPLLFTEAHRE
KFQRSCLHQTVQQFKRFIENYRRHIGCVAVFYAIAGGLFLERAYYYAFAAHHTGITDTTR
VGIILSRGTAASISFMFSYILLTMCRNLITFLRETFLNRYVPFDAAVDFHRLIASTAIVL
TVLHSVGHVVNVYLFSISPLSVLSCLFPGLFHDDGSELPQKYYWWFFQTVPGLTGVVLLL
ILAIMYVFASHHFRRRSFRGFWLTHHLYILLYVLLIIHGSFALIQLPRFHIFFLVPAIIY
GGDKLVSLSRKKVEISVVKAELLPSGVTHLRFQRPQGFEYKSGQWVRIACLALGTTEYHP
FTLTSAPHEDTLSLHIRAAGPWTTRLREIYSAPTGDRCARYPKLYLDGPFGEGHQEWHKF
EVSVLVGGGIGVTPFASILKDLVFKSSVSCQVFCKKIYFIWVTRTQRQFEWLADIIREVE
ENDHQDLVSVHIYITQLAEKFDLRTTMLYICERHFQKVLNRSLFTGLRSITHFGRPPFEP
FFNSLQEVHPQVRKIGVFSCGPPGMTKNVEKACQLINRQDRTHFSHHYENF
|
| External Links |
|---|
| GenBank ID Protein
| 20149640 |
| UniProtKB/Swiss-Prot ID
| Q9NRD9 |
| UniProtKB/Swiss-Prot Entry Name
| DUOX1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_017434.3 |
| GeneCard ID
| DUOX1 |
| GenAtlas ID
| DUOX1 |
| HGNC ID
| HGNC:3062 |
| References |
|---|
| General References
| Not Available |