Identification
HMDB Protein ID CDBP00859
Secondary Accession Numbers Not Available
Name Poly [ADP-ribose] polymerase 2
Description Not Available
Synonyms
  1. ADPRT-2
  2. NAD(+) ADP-ribosyltransferase 2
  3. PARP-2
  4. Poly[ADP-ribose] synthase 2
  5. hPARP-2
  6. pADPRT-2
  7. ADP-ribosyltransferase diphtheria toxin-like 2
  8. ARTD2
Gene Name PARP2
Protein Type Enzyme
Biological Properties
General Function Involved in NAD+ ADP-ribosyltransferase activity
Specific Function Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks.
GO Classification
Biological Process
DNA repair
protein ADP-ribosylation
base-excision repair
Cellular Component
nucleolus
nucleoplasm
Function
catalytic activity
transferase activity
nad+ adp-ribosyltransferase activity
transferase activity, transferring pentosyl groups
transferase activity, transferring glycosyl groups
Molecular Function
DNA binding
NAD+ ADP-ribosyltransferase activity
Process
metabolic process
macromolecule metabolic process
protein amino acid adp-ribosylation
post-translational protein modification
macromolecule modification
protein modification process
Cellular Location
  1. Nucleus
Pathways
Gene Properties
Chromosome Location 14
Locus 14q11.2-q12
SNPs PARP2
Gene Sequence
>1752 bp
ATGGCGGCGCGGCGGCGACGGAGCACCGGCGGCGGCAGGGCGAGAGCATTAAATGAAAGC
AAAAGAGTTAATAATGGCAACACGGCTCCAGAAGACTCTTCCCCTGCCAAGAAAACTCGT
AGATGCCAGAGACAGGAGTCGAAAAAGATGCCTGTGGCTGGAGGAAAAGCTAATAAGGAC
AGGACAGAAGACAAGCAAGATGGTATGCCAGGAAGGTCATGGGCCAGCAAAAGGGTCTCT
GAATCTGTGAAGGCCTTGCTGTTAAAGGGCAAAGCTCCTGTGGACCCAGAGTGTACAGCC
AAGGTGGGGAAGGCTCATGTGTATTGTGAAGGAAATGATGTCTATGATGTCATGCTAAAT
CAGACCAATCTCCAGTTCAACAACAACAAGTACTATCTGATTCAGCTATTAGAAGATGAT
GCCCAGAGGAACTTCAGTGTTTGGATGAGATGGGGCCGAGTTGGGAAAATGGGACAGCAC
AGCCTGGTGGCTTGTTCAGGCAATCTCAACAAGGCCAAGGAAATCTTTCAGAAGAAATTC
CTTGACAAAACGAAAAACAATTGGGAAGATCGAGAAAAGTTTGAGAAGGTGCCTGGAAAA
TATGATATGCTACAGATGGACTATGCCACCAATACTCAGGATGAAGAGGAAACAAAGAAA
GAGGAATCTCTTAAATCTCCCTTGAAGCCAGAGTCACAGCTAGATCTTCGGGTACAGGAG
TTAATAAAGTTGATCTGTAATGTTCAGGCCATGGAAGAAATGATGATGGAAATGAAGTAT
AATACCAAGAAAGCCCCACTTGGGAAGCTGACAGTGGCACAAATCAAGGCAGGTTACCAG
TCTCTTAAGAAGATTGAGGATTGTATTCGGGCTGGCCAGCATGGACGAGCTCTCATGGAA
GCATGCAATGAATTCTACACCAGGATTCCGCATGACTTTGGACTCCGTACTCCTCCACTA
ATCCGGACACAGAAGGAACTGTCAGAAAAAATACAATTACTAGAGGCTTTGGGAGACATT
GAAATTGCTATTAAGCTGGTGAAAACAGAGCTACAAAGCCCAGAACACCCATTGGACCAA
CACTATAGAAACCTACATTGTGCCTTGCGCCCCCTTGACCATGAAAGTTATGAGTTCAAA
GTGATTTCCCAGTACCTACAATCTACCCATGCTCCCACACACAGCGACTATACCATGACC
TTGCTGGATTTGTTTGAAGTGGAGAAGGATGGTGAGAAAGAAGCCTTCAGAGAGGACCTT
CATAACAGGATGCTTCTATGGCATGGTTCCAGGATGAGTAACTGGGTGGGAATCTTGAGC
CATGGGCTTCGAATTGCCCCACCTGAAGCTCCCATCACAGGTTACATGTTTGGGAAAGGA
ATCTACTTTGCTGACATGTCTTCCAAGAGTGCCAATTACTGCTTTGCCTCTCGCCTAAAG
AATACAGGACTGCTGCTCTTATCAGAGGTAGCTCTAGGTCAGTGTAATGAACTACTAGAG
GCCAATCCTAAGGCCGAAGGATTGCTTCAAGGTAAACATAGCACCAAGGGGCTGGGCAAG
ATGGCTCCCAGTTCTGCCCACTTCGTCACCCTGAATGGGAGTACAGTGCCATTAGGACCA
GCAAGTGACACAGGAATTCTGAATCCAGATGGTTATACCCTCAACTACAATGAATATATT
GTATATAACCCCAACCAGGTCCGTATGCGGTACCTTTTAAAGGTTCAGTTTAATTTCCTT
CAGCTGTGGTGA
Protein Properties
Number of Residues 583
Molecular Weight 64804.695
Theoretical pI 8.676
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Poly [ADP-ribose] polymerase 2
MAARRRRSTGGGRARALNESKRVNNGNTAPEDSSPAKKTRRCQRQESKKMPVAGGKANKD
RTEDKQDGMPGRSWASKRVSESVKALLLKGKAPVDPECTAKVGKAHVYCEGNDVYDVMLN
QTNLQFNNNKYYLIQLLEDDAQRNFSVWMRWGRVGKMGQHSLVACSGNLNKAKEIFQKKF
LDKTKNNWEDREKFEKVPGKYDMLQMDYATNTQDEEETKKEESLKSPLKPESQLDLRVQE
LIKLICNVQAMEEMMMEMKYNTKKAPLGKLTVAQIKAGYQSLKKIEDCIRAGQHGRALME
ACNEFYTRIPHDFGLRTPPLIRTQKELSEKIQLLEALGDIEIAIKLVKTELQSPEHPLDQ
HYRNLHCALRPLDHESYEFKVISQYLQSTHAPTHSDYTMTLLDLFEVEKDGEKEAFREDL
HNRMLLWHGSRMSNWVGILSHGLRIAPPEAPITGYMFGKGIYFADMSSKSANYCFASRLK
NTGLLLLSEVALGQCNELLEANPKAEGLLQGKHSTKGLGKMAPSSAHFVTLNGSTVPLGP
ASDTGILNPDGYTLNYNEYIVYNPNQVRMRYLLKVQFNFLQLW
GenBank ID Protein 110825961
UniProtKB/Swiss-Prot ID Q9UGN5
UniProtKB/Swiss-Prot Entry Name PARP2_HUMAN
PDB IDs
GenBank Gene ID NM_005484.3
GeneCard ID PARP2
GenAtlas ID PARP2
HGNC ID HGNC:272
References
General References Not Available