Showing Protein Aldo-keto reductase family 1 member C1 (CDBP00378)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 8 compounds
Identification
HMDB Protein ID CDBP00378
Secondary Accession Numbers Not Available
Name Aldo-keto reductase family 1 member C1
Description Not Available
Synonyms
  1. 20-alpha-HSD
  2. 20-alpha-hydroxysteroid dehydrogenase
  3. Chlordecone reductase homolog HAKRC
  4. DD1/DD2
  5. Dihydrodiol dehydrogenase 1/2
  6. HBAB
  7. High-affinity hepatic bile acid-binding protein
  8. Indanol dehydrogenase
  9. Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
Gene Name AKR1C1
Protein Type Enzyme
Biological Properties
General Function Involved in oxidoreductase activity
Specific Function Converts progesterone to its inactive form, 20-alpha-dihydroxyprogesterone (20-alpha-OHP). In the liver and intestine, may have a role in the transport of bile. May have a role in monitoring the intrahepatic bile acid concentration. Has a low bile-binding ability. May play a role in myelin formation.
GO Classification
Biological Process
retinal metabolic process
cholesterol homeostasis
daunorubicin metabolic process
doxorubicin metabolic process
xenobiotic metabolic process
bile acid and bile salt transport
bile acid metabolic process
cellular response to jasmonic acid stimulus
intestinal cholesterol absorption
progesterone metabolic process
protein homooligomerization
response to organophosphorus
Cellular Component
cytosol
Function
catalytic activity
oxidoreductase activity
Molecular Function
alditol:NADP+ 1-oxidoreductase activity
indanol dehydrogenase activity
17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity
androsterone dehydrogenase (B-specific) activity
bile acid binding
ketosteroid monooxygenase activity
oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor
phenanthrene 9,10-monooxygenase activity
trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
Process
metabolic process
oxidation reduction
Cellular Location
  1. Cytoplasm
Pathways
Gene Properties
Chromosome Location 10
Locus 10p15-p14
SNPs AKR1C1
Gene Sequence 
>972 bp
ATGGATTCGAAATATCAGTGTGTGAAGCTGAATGATGGTCACTTCATGCCTGTCCTGGGA
TTTGGCACCTATGCGCCTGCAGAGGTTCCTAAAAGTAAAGCTTTAGAGGCCACCAAATTG
GCAATTGAAGCTGGCTTCCGCCATATTGATTCTGCTCATTTATACAATAATGAGGAGCAG
GTTGGACTGGCCATCCGAAGCAAGATTGCAGATGGCAGTGTGAAGAGAGAAGACATATTC
TACACTTCAAAGCTTTGGTGCAATTCCCATCGACCAGAGTTGGTCCGACCAGCCTTGGAA
AGGTCACTGAAAAATCTTCAATTGGATTATGTTGACCTCTACCTTATTCATTTTCCAGTG
TCTGTAAAGCCAGGTGAGGAAGTGATCCCAAAAGATGAAAATGGAAAAATACTATTTGAC
ACAGTGGATCTCTGTGCCACGTGGGAGGCCGTGGAGAAGTGTAAAGATGCAGGATTGGCC
AAGTCCATCGGGGTGTCCAACTTCAACCGCAGGCAGCTGGAGATGATCCTCAACAAGCCA
GGGCTCAAGTACAAGCCTGTCTGCAACCAGGTGGAATGTCATCCTTACTTCAACCAGAGA
AAACTGCTGGATTTCTGCAAGTCAAAAGACATTGTTCTGGTTGCCTATAGTGCTCTGGGA
TCCCACCGAGAAGAACCATGGGTGGACCCGAACTCCCCGGTGCTCTTGGAGGACCCAGTC
CTTTGTGCCTTGGCAAAAAAGCACAAGCGAACCCCAGCCCTGATTGCCCTGCGCTACCAG
CTACAGCGTGGGGTTGTGGTCCTGGCCAAGAGCTACAATGAGCAGCGCATCAGACAGAAC
GTGCAGGTGTTTGAATTCCAGTTGACTTCAGAGGAGATGAAAGCCATAGATGGCCTAAAC
AGAAATGTGCGATATTTGACCCTTGATATTTTTGCTGGCCCCCCTAATTATCCATTTTCT
GATGAATATTAA
Protein Properties
Number of Residues 323
Molecular Weight 36788.02
Theoretical pI 7.891
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence 
>Aldo-keto reductase family 1 member C1
MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEATKLAIEAGFRHIDSAHLYNNEEQ
VGLAIRSKIADGSVKREDIFYTSKLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPV
SVKPGEEVIPKDENGKILFDTVDLCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMILNKP
GLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPV
LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN
RNVRYLTLDIFAGPPNYPFSDEY
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q04828
UniProtKB/Swiss-Prot Entry Name AK1C1_HUMAN
PDB IDs
GenBank Gene ID M86609
GeneCard ID AKR1C1
GenAtlas ID AKR1C1
HGNC ID HGNC:384
References
General References Not Available