Cannabis Compound Database: Showing Protein Aldo-keto reductase family 1 member C4 (CDBP00071)

Identification Biological properties Gene properties Protein properties External links References XML Show 6 compounds

Identification

HMDB Protein ID

CDBP00071

Secondary Accession Numbers

Not Available

Name

Aldo-keto reductase family 1 member C4

Description

Not Available

Synonyms

3-alpha-HSD1
3-alpha-hydroxysteroid dehydrogenase type I
CDR
Chlordecone reductase
DD-4
DD4
Dihydrodiol dehydrogenase 4
HAKRA

Gene Name

AKR1C4

Protein Type

Enzyme

Biological Properties

General Function

Involved in oxidoreductase activity

Specific Function

Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha-androstan-3-alpha,17-beta-diol (3-alpha-diol). Also has some 20-alpha-hydroxysteroid dehydrogenase activity. The biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leads to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route.

GO Classification

Biological Process
bile acid biosynthetic process
daunorubicin metabolic process
doxorubicin metabolic process
cellular response to jasmonic acid stimulus
androgen metabolic process
Cellular Component
cytosol
Function
catalytic activity
oxidoreductase activity
Molecular Function
retinal dehydrogenase activity
androsterone dehydrogenase (B-specific) activity
oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor
androsterone dehydrogenase activity
bile acid transmembrane transporter activity
chlordecone reductase activity
electron carrier activity
aldo-keto reductase (NADP) activity
Process
metabolic process
oxidation reduction

Cellular Location

Cytoplasm

Pathways

Name	SMPDB/Pathwhiz	KEGG
Primary bile acid biosynthesis	Not Available
Steroid hormone biosynthesis	Not Available
Metabolism of xenobiotics by cytochrome P450	Not Available
Steroidogenesis
Adrenal Hyperplasia Type 3 or Congenital Adrenal Hyperplasia due to 21-hydroxylase Deficiency		Not Available

Gene Properties

Chromosome Location

Locus

10p15.1

SNPs

AKR1C4

Gene Sequence

>972 bp
ATGGATCCCAAATATCAGCGTGTAGAGCTAAATGATGGTCACTTCATGCCCGTATTGGGA
TTTGGCACCTATGCACCTCCAGAGGTTCCGAGGAACAGAGCTGTAGAGGTCACCAAATTA
GCAATAGAAGCTGGCTTCCGCCATATTGATTCTGCTTATTTATACAATAATGAGGAGCAG
GTTGGACTGGCCATCCGAAGCAAGATTGCAGATGGCAGTGTGAAGAGAGAAGACATATTC
TACACTTCAAAGCTTTGGTGCACTTTCTTTCAACCACAGATGGTCCAACCAGCCTTGGAA
AGCTCACTGAAAAAACTTCAACTGGACTATGTTGACCTCTATCTTCTTCATTTCCCAATG
GCTCTCAAGCCAGGTGAGACGCCACTACCAAAAGATGAAAATGGAAAAGTAATATTCGAC
ACAGTGGATCTCTCTGCCACATGGGAGGTCATGGAGAAGTGTAAGGATGCAGGATTGGCC
AAGTCCATCGGGGTGTCAAACTTCAACTGCAGGCAGCTGGAGATGATCCTCAACAAGCCA
GGACTCAAGTACAAGCCTGTCTGCAACCAGGTAGAATGTCATCCTTACCTCAACCAGAGC
AAACTGCTGGATTTCTGCAAGTCAAAAGACATTGTTCTGGTTGCCCACAGTGCTCTGGGA
ACCCAACGACATAAACTATGGGTGGACCCAAACTCCCCAGTTCTTTTGGAGGACCCAGTT
CTTTGTGCCTTAGCAAAGAAACACAAACGAACCCCAGCCCTGATTGCCCTGCGCTACCAG
CTGCAGCGTGGGGTTGTGGTCCTGGCCAAGAGCTACAATGAGCAGCGGATCAGAGAGAAC
ATCCAGGTTTTTGAATTCCAGTTGACATCAGAGGATATGAAAGTTCTAGATGGTCTAAAC
AGAAATTATCGATATGTTGTCATGGATTTTCTTATGGACCATCCTGATTATCCATTTTCA
GATGAATATTAG

Protein Properties

Number of Residues

323

Molecular Weight

37094.57

Theoretical pI

7.164

Pfam Domain Function

Aldo_ket_red (PF00248 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Aldo-keto reductase family 1 member C4
MDPKYQRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQ
VGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPM
ALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKP
GLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPV
LCALAKKHKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLN
RNYRYVVMDFLMDHPDYPFSDEY

External Links

GenBank ID Protein

7328948

UniProtKB/Swiss-Prot ID

P17516

UniProtKB/Swiss-Prot Entry Name

AK1C4_HUMAN

PDB IDs