| Identification |
|---|
| HMDB Protein ID
| CDBP04092 |
| Secondary Accession Numbers
| Not Available |
| Name
| NAD-dependent protein deacylase sirtuin-5, mitochondrial |
| Description
| Not Available |
| Synonyms
|
- SIR2-like protein 5
- Regulatory protein SIR2 homolog 5
|
| Gene Name
| SIRT5 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in zinc ion binding |
| Specific Function
| NAD-dependent lysine demalonylase and desuccinylase that specifically removes malonyl and succinyl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro.
|
| GO Classification
|
| Biological Process |
| protein deacetylation |
| protein ADP-ribosylation |
| chromatin silencing |
| Cellular Component |
| mitochondrial matrix |
| mitochondrial intermembrane space |
| Function |
| nad binding |
| hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| nucleotide binding |
| catalytic activity |
| hydrolase activity |
| hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds |
| transition metal ion binding |
| zinc ion binding |
| nad or nadh binding |
| Molecular Function |
| protein-malonyllysine demalonylase activity |
| protein-succinyllysine desuccinylase activity |
| metal ion binding |
| NAD+ ADP-ribosyltransferase activity |
| zinc ion binding |
| NAD+ binding |
| Process |
| regulation of metabolic process |
| regulation of macromolecule metabolic process |
| regulation of gene expression |
| regulation of transcription |
| post-translational protein modification |
| macromolecule modification |
| protein modification process |
| metabolic process |
| macromolecule metabolic process |
| protein amino acid deacetylation |
| gene silencing |
| chromatin silencing |
| cellular process |
| biological regulation |
| regulation of biological process |
|
| Cellular Location
|
- Mitochondrion matrix
- Mitochondrion intermembrane space (Potential)
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 6 |
| Locus
| 6p23 |
| SNPs
| SIRT5 |
| Gene Sequence
|
>933 bp
ATGCGACCTCTCCAGATTGTCCCAAGTCGATTGATTTCCCAGCTATATTGTGGCCTGAAG
CCTCCAGCGTCCACACGAAACCAGATTTGCCTGAAAATGGCTCGGCCAAGTTCAAGTATG
GCAGATTTTCGAAAGTTTTTTGCAAAAGCAAAGCACATAGTCATCATCTCAGGAGCTGGT
GTTAGTGCAGAAAGTGGTGTTCCGACCTTCAGAGGAGCTGGAGGTTATTGGAGAAAATGG
CAAGCCCAGGACCTGGCGACTCCCCTGGCCTTTGCCCACAACCCGTCCCGGGTGTGGGAG
TTCTACCACTACCGGCGGGAGGTCATGGGGAGCAAGGAGCCCAACGCCGGGCACCGCGCC
ATAGCCGAGTGTGAGACCCGGCTGGGCAAGCAGGGCCGGCGAGTCGTGGTCATCACCCAG
AACATCGATGAGCTGCACCGCAAGGCTGGCACCAAGAACCTTCTGGAGATCCATGGTAGC
TTATTTAAAACTCGATGTACCTCTTGTGGAGTTGTGGCTGAGAATTACAAGAGTCCAATT
TGTCCAGCTTTATCAGGAAAAGGTGCTCCAGAACCTGGAACTCAAGATGCCAGCATCCCA
GTTGAGAAACTTCCCCGGTGTGAAGAGGCAGGCTGCGGGGGCTTGCTGCGACCTCACGTC
GTGTGGTTTGGAGAAAACCTGGATCCTGCCATTCTGGAGGAGGTTGACAGAGAGCTCGCC
CACTGTGATTTATGTCTAGTGGTGGGCACTTCCTCTGTGGTGTACCCAGCAGCCATGTTT
GCCCCCCAGGTGGCTGCCAGGGGCGTGCCAGTGGCTGAATTTAACACGGAGACCACCCCA
GCTACGAACAGATTCAGGTTTCATTTCCAGGGACCCTGTGGAACGACTCTTCCTGAAGCC
CTTGCCTGTCATGAAAATGAAACTGTTTCTTAA
|
| Protein Properties |
|---|
| Number of Residues
| 310 |
| Molecular Weight
| 31993.505 |
| Theoretical pI
| 8.584 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>NAD-dependent deacetylase sirtuin-5
MRPLQIVPSRLISQLYCGLKPPASTRNQICLKMARPSSSMADFRKFFAKAKHIVIISGAG
VSAESGVPTFRGAGGYWRKWQAQDLATPLAFAHNPSRVWEFYHYRREVMGSKEPNAGHRA
IAECETRLGKQGRRVVVITQNIDELHRKAGTKNLLEIHGSLFKTRCTSCGVVAENYKSPI
CPALSGKGAPEPGTQDASIPVEKLPRCEEAGCGGLLRPHVVWFGENLDPAILEEVDRELA
HCDLCLVVGTSSVVYPAAMFAPQVAARGVPVAEFNTETTPATNRFRFHFQGPCGTTLPEA
LACHENETVS
|
| External Links |
|---|
| GenBank ID Protein
| 5225326 |
| UniProtKB/Swiss-Prot ID
| Q9NXA8 |
| UniProtKB/Swiss-Prot Entry Name
| SIRT5_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AF083110 |
| GeneCard ID
| SIRT5 |
| GenAtlas ID
| SIRT5 |
| HGNC ID
| HGNC:14933 |
| References |
|---|
| General References
| Not Available |